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ATAPERFSVQGPDGVRIVADRCGDPRGRAVVFLHGGGQTRRSWGRVAAVVAERGWQSVTVDLRGHGESDW SPHGDYRVVSFAADIQEVLRGLPPQPVLVGASLGGFTSMLLAGELSPGIASAVVLVDIVPNMDPSGASRI HAFMVERVESGFGSLDEVADMIAAYNPHRPRPTDLEGLTTNLRRRGDRWYWHWDPRFISGTAAFPPIEVT EPHRLYAAVDTILRGGVPMLLIRGQMSDLVSQERAEEFLARFPNVEFTDVRGAGHMVAGDRNDIFAAAVL DFLSRHLDAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4960 | bpoA | - | 100% (291) | peroxidase BpoA |
| M. marinum M | MMAR_4337 | bpoB | 2e-59 | 40.21% (291) | peroxidase BpoB |
| M. marinum M | MMAR_4837 | - | 4e-59 | 45.10% (286) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3502c | bpoA | 1e-123 | 81.01% (258) | peroxidase BpoA |
| M. gilvum PYR-GCK | Mflv_4507 | - | 1e-121 | 72.44% (283) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3473c | bpoA | 1e-123 | 81.01% (258) | peroxidase BpoA |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-08 | 36.73% (98) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 5e-57 | 43.05% (295) | putative hydrolase (alpha/beta fold) |
| M. avium 104 | MAV_0677 | - | 1e-142 | 84.27% (286) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 9e-61 | 42.56% (289) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 1e-54 | 41.89% (265) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 1e-58 | 39.52% (291) | peroxidase BpoB |
| M. vanbaalenii PYR-1 | Mvan_1862 | - | 1e-128 | 75.52% (286) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4507|M.gilvum_PYR-GCK ------MTETLGAPEPFLTDGHGGIVIAADRRGE-----PTARAVVFLHG
Mvan_1862|M.vanbaalenii_PYR-1 MRVSTYHPEMTSAPEQFLTDGHGGVRIVADRLGD-----PRARAVVFLHG
Mb3502c|M.bovis_AF2122/97 --------------------------------------------MVFLHG
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------MVFLHG
MMAR_4960|M.marinum_M ---------MATAPERFSVQGPDGVRIVADRCGD-----PRGRAVVFLHG
MAV_0677|M.avium_104 -----------MAAEPFTIRGPGGVQIVADRLGD-----PRARAVVFLHG
MSMEG_5209|M.smegmatis_MC2_155 --MSTAQT----ESQTVAFRGVDDLTLVGDEWNKGAERAADRPTVLLLHG
MUL_0147|M.ulcerans_Agy99 --MSAMSN----NPRTVEFSGTEGITLVADEWNR-DTAASGRPTILMLHG
TH_2112|M.thermoresistible__bu --LNSTHS----KPQTVRFRGAQGLTLVADQWNR-GSGPKDRPTILLLHG
MAB_2045|M.abscessus_ATCC_1997 --MSAKRTGDSSAPVVERVPTADGLALAVDLYHC----DAPRAVVLLLHG
MLBr_00862|M.leprae_Br4923 ----MPATQSIHKVPHQFVESPDGVRLAIYQSGQ-----PEGPAIVLVHG
::::**
Mflv_4507|M.gilvum_PYR-GCK GGQTRRSWDRAAAAVAQRGWQSVTVDMRGHGESDW-SPDGDYRVASFAAD
Mvan_1862|M.vanbaalenii_PYR-1 GGQTRRSWGRAAAAVAHRGWQAVTVDMRGHGESDW-SPDGDYRVSSFAAD
Mb3502c|M.bovis_AF2122/97 GGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDW-SSEGDYRLVSFAGD
Rv3473c|M.tuberculosis_H37Rv GGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDW-SSEGDYRLVSFAGD
MMAR_4960|M.marinum_M GGQTRRSWGRVAAVVAERGWQSVTVDLRGHGESDW-SPHGDYRVVSFAAD
MAV_0677|M.avium_104 GGQTRRSWGKAAAAVAARGWQAVTVDLRGHGESDW-SGDGDYRVVSFAAD
MSMEG_5209|M.smegmatis_MC2_155 GGQNRYSWKNTGQILADQGFHVIALDARGHGDSDR-SPSANYSVDAMCGD
MUL_0147|M.ulcerans_Agy99 GCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR-APDADYAIETLTSD
TH_2112|M.thermoresistible__bu GGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDR-SPTADYQLDDLCAD
MAB_2045|M.abscessus_ATCC_1997 GGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDW-DPDGRYDMDRLGSD
MLBr_00862|M.leprae_Br4923 FPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYTMTRFADD
:.: * . : * ** *:*. . * : : *
Mflv_4507|M.gilvum_PYR-GCK VREI-------------------------------LAQLPPRPVLVGASL
Mvan_1862|M.vanbaalenii_PYR-1 VREI-------------------------------LDRLPPRPVLVGASL
Mb3502c|M.bovis_AF2122/97 IQEV-------------------------------LRNLPGQPALVGASL
Rv3473c|M.tuberculosis_H37Rv IQEV-------------------------------LRNLPGQPALVGASL
MMAR_4960|M.marinum_M IQEV-------------------------------LRGLPPQPVLVGASL
MAV_0677|M.avium_104 VQAV-------------------------------LGTLPPKPVLVGASL
MSMEG_5209|M.smegmatis_MC2_155 VLAV-------------------------------LYQISRPVALIGASM
MUL_0147|M.ulcerans_Agy99 IRHV-------------------------------LDAIGRPVVLIGASM
TH_2112|M.thermoresistible__bu TLSV-------------------------------VDQIGRPVSLIGASM
MAB_2045|M.abscessus_ATCC_1997 LLAVR-----------------------------SYADSGRPVAAIGASL
MLBr_00862|M.leprae_Br4923 FAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQ
: *.*
Mflv_4507|M.gilvum_PYR-GCK GGITAMLLAGELARGI----------------------------------
Mvan_1862|M.vanbaalenii_PYR-1 GGITSMLLAGELARGI----------------------------------
Mb3502c|M.bovis_AF2122/97 GGFAAMLLAGELSPGI----------------------------------
Rv3473c|M.tuberculosis_H37Rv GGFAAMLLAGELSPGI----------------------------------
MMAR_4960|M.marinum_M GGFTSMLLAGELSPGI----------------------------------
MAV_0677|M.avium_104 GGFTSMLLAGELSPGI----------------------------------
MSMEG_5209|M.smegmatis_MC2_155 GGLTGLLAAHEAGPER----------------------------------
MUL_0147|M.ulcerans_Agy99 GGLTGILVADSAGPDR----------------------------------
TH_2112|M.thermoresistible__bu GGLTGILVADRAGADK----------------------------------
MAB_2045|M.abscessus_ATCC_1997 GGLTILGTHLLAPPDL----------------------------------
MLBr_00862|M.leprae_Br4923 DQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIAL
. :.
Mflv_4507|M.gilvum_PYR-GCK -------------------ASAVVLVDIVPDMDPTGAERIHAFMADKMVD
Mvan_1862|M.vanbaalenii_PYR-1 -------------------AAAVVLVDIVPDMDPSGAERIHAFMADRMVD
Mb3502c|M.bovis_AF2122/97 -------------------ASAVVLVDIVPNMDLAGASRIHAFMAERVES
Rv3473c|M.tuberculosis_H37Rv -------------------ASAVVLVDIVPNMDLAGASRIHAFMAERVES
MMAR_4960|M.marinum_M -------------------ASAVVLVDIVPNMDPSGASRIHAFMVERVES
MAV_0677|M.avium_104 -------------------ASAVVLVDIVPNMDQSGANRIHAFMADRVDS
MSMEG_5209|M.smegmatis_MC2_155 -------------------VTQLVLVDVVPNFEKSGSARIRDFMASNVD-
MUL_0147|M.ulcerans_Agy99 -------------------VTGLVLVDVVPKYEKDGSARIRDFMFTNLH-
TH_2112|M.thermoresistible__bu -------------------VTELVLVDVVPRVEQAGTDRIRDFMMTNVA-
MAB_2045|M.abscessus_ATCC_1997 -------------------WQAVVLVDVTPRMEMDGARRVVAFMSAHPE-
MLBr_00862|M.leprae_Br4923 SSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGK
: * . . : . * .
Mflv_4507|M.gilvum_PYR-GCK GFASLDEVADMIAEYNPHRPKPTDLDGLRKNLRHK------GGRWYWHWD
Mvan_1862|M.vanbaalenii_PYR-1 GFGSLDEVADMIAEFNPHRPRPADLDGLRNNLRRR------GERWYWHWD
Mb3502c|M.bovis_AF2122/97 GFGSLDEVADVIANYNPHRPRPSDPDGLVANLRRR------GDRWYWHWD
Rv3473c|M.tuberculosis_H37Rv GFGSLDEVADVIANYNPHRPRPSDPDGLVANLRRR------GDRWYWHWD
MMAR_4960|M.marinum_M GFGSLDEVADMIAAYNPHRPRPTDLEGLTTNLRRR------GDRWYWHWD
MAV_0677|M.avium_104 GFASLDEVADAIAEYNPHRPRPTDLEGLTTNLRRR------GDRWYWHWD
MSMEG_5209|M.smegmatis_MC2_155 GFDTLEEAADAVAAYLPHRRRPRNPEGLKKNLRLR------DGRWYWHWD
MUL_0147|M.ulcerans_Agy99 GFATLEEAADAVATYLPHRTKPRSPEGLKKNLRLR------DGRWYWHWD
TH_2112|M.thermoresistible__bu GFETLEEAADAVAAYLPHRRRPRSPEGLKKNLRHR------DGRWHWHWD
MAB_2045|M.abscessus_ATCC_1997 GFDSLESAADVIAAYNPHRPRPENLDGLRKVLARRE-----DGRWSWRWD
MLBr_00862|M.leprae_Br4923 GVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSH
*. :: .: :. : :* . :. : :: .
Mflv_4507|M.gilvum_PYR-GCK PRFIDG----------------------------TAPHPPMEVTDT----
Mvan_1862|M.vanbaalenii_PYR-1 PQFIDG----------------------------SAANPPIEVTDT----
Mb3502c|M.bovis_AF2122/97 PQFIGG----------------------------IAAFPPVEVTDV----
Rv3473c|M.tuberculosis_H37Rv PQFIGG----------------------------IAAFPPVEVTDV----
MMAR_4960|M.marinum_M PRFISG----------------------------TAAFPPIEVTEP----
MAV_0677|M.avium_104 PQFISG----------------------------TAAFPPFEVTDP----
MSMEG_5209|M.smegmatis_MC2_155 PAFLG----------------------------KPHDDPFVRVERL----
MUL_0147|M.ulcerans_Agy99 PAMMT----------------------------APGDDPELRTENF----
TH_2112|M.thermoresistible__bu PAFVT----------------------------RVG-EQFVDVDVL----
MAB_2045|M.abscessus_ATCC_1997 PAFVTSNFQ------------------------FLQGDPDEGAEYF----
MLBr_00862|M.leprae_Br4923 PQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGI
* .: .
Mflv_4507|M.gilvum_PYR-GCK -------------DRLHA-AVGRIVDDGVPVLLVRG--------QVSDLV
Mvan_1862|M.vanbaalenii_PYR-1 -------------ERLHS-AVEAILADGVPVLLVRG--------QVSDLV
Mb3502c|M.bovis_AF2122/97 -------------DRMNA-AVATILRDEVPVLLVRG--------QVSDIV
Rv3473c|M.tuberculosis_H37Rv -------------DRMNA-AVATILRDEVPVLLVRG--------QVSDIV
MMAR_4960|M.marinum_M -------------HRLYA-AVDTILRGGVPMLLIRG--------QMSDLV
MAV_0677|M.avium_104 -------------DRMHA-AVEAILRDGVPILMIRG--------QMSDLV
MSMEG_5209|M.smegmatis_MC2_155 -------------EQA-------AVNLTVPILLIRG--------KLSDVV
MUL_0147|M.ulcerans_Agy99 -------------ERA-------AMNLTIPILLIRG--------KLSDVV
TH_2112|M.thermoresistible__bu -------------ERA-------ALRLTVPILLVRG--------KLSDVV
MAB_2045|M.abscessus_ATCC_1997 -------------EMMSAFLLDGARQVSAPTLLVRG--------LLSDIV
MLBr_00862|M.leprae_Br4923 GRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAA
. . :: * :** .
Mflv_4507|M.gilvum_PYR-GCK SRDRAAAFLSRFPQIDFVDVDGAGHMVAGDRNDLFADAVLSFLTRREVAK
Mvan_1862|M.vanbaalenii_PYR-1 SRERADAFVARFPQIAFVDVEGAGHMVAGDRNDLFADAVLDFLARSEIAR
Mb3502c|M.bovis_AF2122/97 RQESADQFLSRFPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR
Rv3473c|M.tuberculosis_H37Rv RQESADQFLSRFPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR
MMAR_4960|M.marinum_M SQERAEEFLARFPNVEFTDVRGAGHMVAGDRNDIFAAAVLDFLSRHLDAG
MAV_0677|M.avium_104 SQERADEFLARFPQVEFTDVRGAGHMVAGDRNDVFADAVLDFLARHLDVE
MSMEG_5209|M.smegmatis_MC2_155 SPEGVAEFLEKVPAAEFVELSDAGHTAAGDDNDAFTQVVVEFVNR-----
MUL_0147|M.ulcerans_Agy99 TSEGVQDFLDKVPHAEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG
TH_2112|M.thermoresistible__bu SAEGVEEFLAKVPSAEFVELSAAXXXATIPARGSPRRCVTSPVCRRRPPT
MAB_2045|M.abscessus_ATCC_1997 SEETVRHFLTVVPHAQTVDVSGAGHMIAGDNNDAFSTAVVEFLDRTI---
MLBr_00862|M.leprae_Br4923 AVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGV
: : : * : . . :
Mflv_4507|M.gilvum_PYR-GCK P-------------------------------------------------
Mvan_1862|M.vanbaalenii_PYR-1 P-------------------------------------------------
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4960|M.marinum_M --------------------------------------------------
MAV_0677|M.avium_104 --------------------------------------------------
MSMEG_5209|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0147|M.ulcerans_Agy99 --------------------------------------------------
TH_2112|M.thermoresistible__bu SRPAPSPRSAPRHGNVAGPGANAVRR------------------------
MAB_2045|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSD
Mflv_4507|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1862|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4960|M.marinum_M --------------------------------------------------
MAV_0677|M.avium_104 --------------------------------------------------
MSMEG_5209|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0147|M.ulcerans_Agy99 --------------------------------------------------
TH_2112|M.thermoresistible__bu --------------------------------------------------
MAB_2045|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 CLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDM
Mflv_4507|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1862|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4960|M.marinum_M --------------------------------------------------
MAV_0677|M.avium_104 --------------------------------------------------
MSMEG_5209|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0147|M.ulcerans_Agy99 --------------------------------------------------
TH_2112|M.thermoresistible__bu --------------------------------------------------
MAB_2045|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRST
Mflv_4507|M.gilvum_PYR-GCK ------
Mvan_1862|M.vanbaalenii_PYR-1 ------
Mb3502c|M.bovis_AF2122/97 ------
Rv3473c|M.tuberculosis_H37Rv ------
MMAR_4960|M.marinum_M ------
MAV_0677|M.avium_104 ------
MSMEG_5209|M.smegmatis_MC2_155 ------
MUL_0147|M.ulcerans_Agy99 ------
TH_2112|M.thermoresistible__bu ------
MAB_2045|M.abscessus_ATCC_1997 ------
MLBr_00862|M.leprae_Br4923 ARIRVI