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EFAGVDGITLVADEWNRGSDGAGRPSILMLHGGGQNRFSWKNTGQTLADEGLHVVALDSRGHGDSDRSPQ ADYQIETLTADVLRVLDAIGRPVTIIGASMGGLTGILAAHRAGPAKVTRLVLVDVVPRFEKDGSARIRDF MISGLDGFDSLEQAADAVAAYLPYRSKPRSPEGLKKNLRLRDGRWYWHWDPAFMTKPGDDPELRTESFEQ AAKNLSIPVLLIRGKLSDVVSPEGVRHFLATVPRAEFVELSNAGHTAAGDDNDAFSDAVVAFVKRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1254 | - | - | 100% (277) | hydrolase, alpha/beta fold family protein |
| M. avium 104 | MAV_1846 | - | 9e-66 | 47.29% (277) | hydrolase, alpha/beta fold family protein |
| M. avium 104 | MAV_0677 | - | 7e-58 | 42.14% (280) | hydrolase, alpha/beta fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1154c | bpoB | 1e-121 | 75.72% (276) | peroxidase BpoB |
| M. gilvum PYR-GCK | Mflv_2096 | - | 1e-116 | 72.86% (280) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1123c | bpoB | 1e-121 | 75.72% (276) | peroxidase BpoB |
| M. leprae Br4923 | MLBr_02269 | - | 1e-08 | 25.38% (264) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 6e-65 | 48.77% (285) | putative hydrolase (alpha/beta fold) |
| M. marinum M | MMAR_4337 | bpoB | 1e-130 | 79.78% (277) | peroxidase BpoB |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 1e-120 | 73.29% (277) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 1e-102 | 69.77% (258) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 1e-128 | 78.70% (277) | peroxidase BpoB |
| M. vanbaalenii PYR-1 | Mvan_4609 | - | 1e-115 | 71.13% (284) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1154c|M.bovis_AF2122/97 MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAAD--
Rv1123c|M.tuberculosis_H37Rv MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAAD--
MMAR_4337|M.marinum_M --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASG--
MUL_0147|M.ulcerans_Agy99 --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASG--
MAV_1254|M.avium_104 ------------------------MEFAGVDGITLVADEWNRGSDGAG--
Mflv_2096|M.gilvum_PYR-GCK --------------MSIEHREPKTVTFRGADGLALVADEWNNPAQTEA--
Mvan_4609|M.vanbaalenii_PYR-1 --------------MSTVSSEPTTVTFRGAEDLALVADEWNNPAEAASSG
MSMEG_5209|M.smegmatis_MC2_155 --------------MSTAQTESQTVAFRGVDDLTLVGDEWNKGAERAA--
TH_2112|M.thermoresistible__bu --------------LNSTHSKPQTVRFRGAQGLTLVADQWNRGSGPKD--
MAB_2045|M.abscessus_ATCC_1997 ----------MSAKRTGDSSAPVVERVPTADGLALAVDLYHCDAP-----
MLBr_02269|M.leprae_Br4923 -------------------------------MINLAYEDRG-----TG--
: *. :
Mb1154c|M.bovis_AF2122/97 ------RPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDR
Rv1123c|M.tuberculosis_H37Rv ------RPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDR
MMAR_4337|M.marinum_M ------RPTILMLHGGGQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR
MUL_0147|M.ulcerans_Agy99 ------RPTILMLHGGCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR
MAV_1254|M.avium_104 ------RPSILMLHGGGQNRFSWKNTGQTLADEGLHVVALDSRGHGDSDR
Mflv_2096|M.gilvum_PYR-GCK --FDRSRPSVLMMHGGGQNRFSWKKTGQILGEQGLHVVALDSRGHGDSDR
Mvan_4609|M.vanbaalenii_PYR-1 RDFDASRPSVLMLHGGGQNRFSWKKTGQTLASQGLHVVALDSRGHGDSDR
MSMEG_5209|M.smegmatis_MC2_155 -----DRPTVLLLHGGGQNRYSWKNTGQILADQGFHVIALDARGHGDSDR
TH_2112|M.thermoresistible__bu ------RPTILLLHGGGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDR
MAB_2045|M.abscessus_ATCC_1997 ------RAVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDW
MLBr_02269|M.leprae_Br4923 ------EPVVFIAGRGGAGRTWQPHQVPAFLAAGYRVITFDNRGIGATEN
.. ::: * .* : * * : * ** * ::
Mb1154c|M.bovis_AF2122/97 APGADYAVETPTTDVLHV--VEAIG-RRVVVVEASMGGLTGILVAERAGP
Rv1123c|M.tuberculosis_H37Rv APGADYAVETPTTDVLHV--VEAIG-RRVVVVEASMGGLTGILVAERAGP
MMAR_4337|M.marinum_M APDADYAIETLTSDILHV--LDAIG-RPVVLIGASMGGLTGILVADSAGP
MUL_0147|M.ulcerans_Agy99 APDADYAIETLTSDIRHV--LDAIG-RPVVLIGASMGGLTGILVADSAGP
MAV_1254|M.avium_104 SPQADYQIETLTADVLRV--LDAIG-RPVTIIGASMGGLTGILAAHRAGP
Mflv_2096|M.gilvum_PYR-GCK SPDARYTVEALCEDTLRV--LEQIG-RPTVLIGASMGGLTGILAARRAGP
Mvan_4609|M.vanbaalenii_PYR-1 SPDANYTVEALCADTLAV--LRQIG-RPTVLIGASMGGLTGILASRQAGP
MSMEG_5209|M.smegmatis_MC2_155 SPSANYSVDAMCGDVLAV--LYQIS-RPVALIGASMGGLTGLLAAHEAGP
TH_2112|M.thermoresistible__bu SPTADYQLDDLCADTLSV--VDQIG-RPVSLIGASMGGLTGILVADRAGA
MAB_2045|M.abscessus_ATCC_1997 DPDGRYDMDRLGSDLLAVRSYADSG-RPVAAIGASLGGLTILGTHLLAPP
MLBr_02269|M.leprae_Br4923 TEG--FTTQTMVADTAVL--IESLGAVPARIVGVSMGSFIAQELMVAR-P
: : * : . . : .*:*.: .
Mb1154c|M.bovis_AF2122/97 QTVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPH
Rv1123c|M.tuberculosis_H37Rv QTVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPH
MMAR_4337|M.marinum_M DRVTGLVLVDVVPKYEKDGSARIRDFMFTNLHGFATLEEAADAVATYLPH
MUL_0147|M.ulcerans_Agy99 DRVTGLVLVDVVPKYEKDGSARIRDFMFTNLHGFATLEEAADAVATYLPH
MAV_1254|M.avium_104 AKVTRLVLVDVVPRFEKDGSARIRDFMISGLDGFDSLEQAADAVAAYLPY
Mflv_2096|M.gilvum_PYR-GCK EVVTRLVLVDVVPRYEKGGSARIRDFMFSHVHGFDSLEQAADAVAEYLPH
Mvan_4609|M.vanbaalenii_PYR-1 ELVTRLILVDVVPRYEKDGSARIREFMFSHVHGFESLEQAAEAVAAYLPH
MSMEG_5209|M.smegmatis_MC2_155 ERVTQLVLVDVVPNFEKSGSARIRDFMASNVDGFDTLEEAADAVAAYLPH
TH_2112|M.thermoresistible__bu DKVTELVLVDVVPRVEQAGTDRIRDFMMTNVAGFETLEEAADAVAAYLPH
MAB_2045|M.abscessus_ATCC_1997 DLWQAVVLVDVTPRMEMDGARRVVAFMSAHPEGFDSLESAADVIAAYNPH
MLBr_02269|M.leprae_Br4923 ELVRAAVLMATRGRLDRTRQFFHAAEAEFHDSGIQ-LPSGYNAKVRLLEN
:*: . . : *: * .. :. .
Mb1154c|M.bovis_AF2122/97 RDKPRSPEGLKRNLRLR-DGRWHWHWDPAMMT----APGHDPQLRTENFE
Rv1123c|M.tuberculosis_H37Rv RDKPRSPEGLKRNLRLR-DGRWHWHWDPAMMT----APGHDPQLRTENFE
MMAR_4337|M.marinum_M RTKPRSPEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFE
MUL_0147|M.ulcerans_Agy99 RTKPRSPEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFE
MAV_1254|M.avium_104 RSKPRSPEGLKKNLRLR-DGRWYWHWDPAFMT----KPGDDPELRTESFE
Mflv_2096|M.gilvum_PYR-GCK RAKPRSPEGLKKNLRRR-NGRWYWHWDPAFLT----KPSEDPFARVEQLE
Mvan_4609|M.vanbaalenii_PYR-1 RTKPRSPEGLKKNLRHR-HGRWYWHWDPAFLT----KPNEDPFVRVEQLE
MSMEG_5209|M.smegmatis_MC2_155 RRRPRNPEGLKKNLRLR-DGRWYWHWDPAFLG----KPHDDPFVRVERLE
TH_2112|M.thermoresistible__bu RRRPRSPEGLKKNLRHR-DGRWHWHWDPAFVT----RVG-EQFVDVDVLE
MAB_2045|M.abscessus_ATCC_1997 RPRPENLDGLRKVLARREDGRWSWRWDPAFVTSNFQFLQGDPDEGAEYFE
MLBr_02269|M.leprae_Br4923 LSRKTLNDDVAVADWIAMFNMWPIKSTPGLRC------QTDVAPQNNRLP
: :.: . * : *.: : : :
Mb1154c|M.bovis_AF2122/97 RA-------AMGLTIPVLLIRGKLSDVVSSDGARDFLAKVPNAEFVELSN
Rv1123c|M.tuberculosis_H37Rv RA-------AMGLTIPVLLIRGKLSDVVSSDGARDFLAKVPNAEFVELSN
MMAR_4337|M.marinum_M RA-------AMNLTIPILLIRGKLSDVVSSEGVQDFLDKVPHAEFVELSN
MUL_0147|M.ulcerans_Agy99 RA-------AMNLTIPILLIRGKLSDVVTSEGVQDFLDKVPHAEFVELSN
MAV_1254|M.avium_104 QA-------AKNLSIPVLLIRGKLSDVVSPEGVRHFLATVPRAEFVELSN
Mflv_2096|M.gilvum_PYR-GCK QA-------ATELTVPILLIRGKLSDVVSEEAVQDFLAKVPGAEFAELSG
Mvan_4609|M.vanbaalenii_PYR-1 QA-------AIELTIPILLIRGKLSDVVSEEAVQDFLTKVPNAEFVELPG
MSMEG_5209|M.smegmatis_MC2_155 QA-------AVNLTVPILLIRGKLSDVVSPEGVAEFLEKVPAAEFVELSD
TH_2112|M.thermoresistible__bu RA-------ALRLTVPILLVRGKLSDVVSAEGVEEFLAKVPSAEFVELSA
MAB_2045|M.abscessus_ATCC_1997 MMSAFLLDGARQVSAPTLLVRGLLSDIVSEETVRHFLTVVPHAQTVDVSG
MLBr_02269|M.leprae_Br4923 AY--------RSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGRYLQIPD
:: * *:: . :.. . .. :* .. ::.
Mb1154c|M.bovis_AF2122/97 AGRTAAGDDNDAFTDVVVDFVRRLS-------------------------
Rv1123c|M.tuberculosis_H37Rv AGRTAAGDDNDAFTDVVVDFVRRLS-------------------------
MMAR_4337|M.marinum_M AGHTAAGDDNDAFTEVVVDFVKRRAATG----------------------
MUL_0147|M.ulcerans_Agy99 AGHTAAGDDNDAFTEVVVDFVKRRAATG----------------------
MAV_1254|M.avium_104 AGHTAAGDDNDAFSDAVVAFVKRR--------------------------
Mflv_2096|M.gilvum_PYR-GCK AGHTAAGDDNDAFSEVVTRFVLR---------------------------
Mvan_4609|M.vanbaalenii_PYR-1 AGHTAAGDDNDAFSEVVAQFVLR---------------------------
MSMEG_5209|M.smegmatis_MC2_155 AGHTAAGDDNDAFTQVVVEFVNR---------------------------
TH_2112|M.thermoresistible__bu AXXXATIPARGSPRRCVTSPVCRRRPPTSRPAPSPRSAPRHGNVAGPGAN
MAB_2045|M.abscessus_ATCC_1997 AGHMIAGDNNDAFSTAVVEFLDRTI-------------------------
MLBr_02269|M.leprae_Br4923 AGHLGFFERPEAVNAAALQFFAGVKGEWP---------------------
* : . .
Mb1154c|M.bovis_AF2122/97 ----
Rv1123c|M.tuberculosis_H37Rv ----
MMAR_4337|M.marinum_M ----
MUL_0147|M.ulcerans_Agy99 ----
MAV_1254|M.avium_104 ----
Mflv_2096|M.gilvum_PYR-GCK ----
Mvan_4609|M.vanbaalenii_PYR-1 ----
MSMEG_5209|M.smegmatis_MC2_155 ----
TH_2112|M.thermoresistible__bu AVRR
MAB_2045|M.abscessus_ATCC_1997 ----
MLBr_02269|M.leprae_Br4923 ----