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VFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYRLVSFAGDIQEVLRNLPGQPALVG ASLGGFAAMLLAGELSPGIASAVVLVDIVPNMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRP RPSDPDGLVANLRRRGDRWYWHWDPQFIGGIAAFPPVEVTDVDRMNAAVATILRDEVPVLLVRGQVSDIV RQESADQFLSRFPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3473c | bpoA | - | 100% (261) | POSSIBLE PEROXIDASE BPOA (NON-HAEM PEROXIDASE) |
| M. tuberculosis H37Rv | Rv1123c | bpoB | 3e-52 | 38.67% (256) | peroxidase BpoB |
| M. tuberculosis H37Rv | Rv0045c | - | 2e-19 | 30.68% (251) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3502c | bpoA | 1e-151 | 100.00% (261) | peroxidase BpoA |
| M. gilvum PYR-GCK | Mflv_4507 | - | 1e-109 | 72.27% (256) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_02297 | - | 3e-06 | 25.39% (256) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 9e-54 | 44.36% (266) | putative hydrolase (alpha/beta fold) |
| M. marinum M | MMAR_4960 | bpoA | 1e-123 | 81.01% (258) | peroxidase BpoA |
| M. avium 104 | MAV_0677 | - | 1e-124 | 80.77% (260) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 3e-60 | 44.14% (256) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 2e-51 | 41.88% (234) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 1e-54 | 39.06% (256) | peroxidase BpoB |
| M. vanbaalenii PYR-1 | Mvan_1862 | - | 1e-113 | 75.00% (256) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4507|M.gilvum_PYR-GCK ------MTETLGAPEPFLTDGHGGIVIAADRRGE------------PTAR
Mvan_1862|M.vanbaalenii_PYR-1 MRVSTYHPEMTSAPEQFLTDGHGGVRIVADRLGD------------PRAR
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4960|M.marinum_M ---------MATAPERFSVQGPDGVRIVADRCGD------------PRGR
MAV_0677|M.avium_104 -----------MAAEPFTIRGPGGVQIVADRLGD------------PRAR
MSMEG_5209|M.smegmatis_MC2_155 --MSTAQT----ESQTVAFRGVDDLTLVGDEWNKGAER-------AADRP
MUL_0147|M.ulcerans_Agy99 --MSAMSN----NPRTVEFSGTEGITLVADEWNR-DTA-------ASGRP
TH_2112|M.thermoresistible__bu --LNSTHS----KPQTVRFRGAQGLTLVADQWNR-GSG-------PKDRP
MAB_2045|M.abscessus_ATCC_1997 --MSAKRTGDSSAPVVERVPTADGLALAVDLYHC-----------DAPRA
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSATARP
Mflv_4507|M.gilvum_PYR-GCK AVVFLHGGGQTRRSWDRAAAAVAQRGWQSVTVDMRGHGESDWSPDGDYRV
Mvan_1862|M.vanbaalenii_PYR-1 AVVFLHGGGQTRRSWGRAAAAVAHRGWQAVTVDMRGHGESDWSPDGDYRV
Rv3473c|M.tuberculosis_H37Rv -MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYRL
Mb3502c|M.bovis_AF2122/97 -MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYRL
MMAR_4960|M.marinum_M AVVFLHGGGQTRRSWGRVAAVVAERGWQSVTVDLRGHGESDWSPHGDYRV
MAV_0677|M.avium_104 AVVFLHGGGQTRRSWGKAAAAVAARGWQAVTVDLRGHGESDWSGDGDYRV
MSMEG_5209|M.smegmatis_MC2_155 TVLLLHGGGQNRYSWKNTGQILADQGFHVIALDARGHGDSDRSPSANYSV
MUL_0147|M.ulcerans_Agy99 TILMLHGGCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDRAPDADYAI
TH_2112|M.thermoresistible__bu TILLLHGGGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDRSPTADYQL
MAB_2045|M.abscessus_ATCC_1997 VVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDWDPDGRYDM
MLBr_02297|M.leprae_Br4923 LVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDKPPRG-YDG
:::*** . :* : : * **:* ** . *
Mflv_4507|M.gilvum_PYR-GCK ASFAADVREI--LAQLPPR-PVLVGASLGGITAMLLAGELARGIASAVVL
Mvan_1862|M.vanbaalenii_PYR-1 SSFAADVREI--LDRLPPR-PVLVGASLGGITSMLLAGELARGIAAAVVL
Rv3473c|M.tuberculosis_H37Rv VSFAGDIQEV--LRNLPGQ-PALVGASLGGFAAMLLAGELSPGIASAVVL
Mb3502c|M.bovis_AF2122/97 VSFAGDIQEV--LRNLPGQ-PALVGASLGGFAAMLLAGELSPGIASAVVL
MMAR_4960|M.marinum_M VSFAADIQEV--LRGLPPQ-PVLVGASLGGFTSMLLAGELSPGIASAVVL
MAV_0677|M.avium_104 VSFAADVQAV--LGTLPPK-PVLVGASLGGFTSMLLAGELSPGIASAVVL
MSMEG_5209|M.smegmatis_MC2_155 DAMCGDVLAV--LYQISRP-VALIGASMGGLTGLLAAHEAGPERVTQLVL
MUL_0147|M.ulcerans_Agy99 ETLTSDIRHV--LDAIGRP-VVLIGASMGGLTGILVADSAGPDRVTGLVL
TH_2112|M.thermoresistible__bu DDLCADTLSV--VDQIGRP-VSLIGASMGGLTGILVADRAGADKVTELVL
MAB_2045|M.abscessus_ATCC_1997 DRLGSDLLAVRSYADSGRP-VAAIGASLGGLTILGTHLLAPPDLWQAVVL
MLBr_02297|M.leprae_Br4923 WTLAGDTAGL--IRALGHSSATLVGHAEGGLACWATALLHPR-------L
: .* : :* : **:: *
Mflv_4507|M.gilvum_PYR-GCK VDIVPDMDPTGAERIHAFMADKMVDGFASLDEVADMIAEYNPHRPKPTD-
Mvan_1862|M.vanbaalenii_PYR-1 VDIVPDMDPSGAERIHAFMADRMVDGFGSLDEVADMIAEFNPHRPRPAD-
Rv3473c|M.tuberculosis_H37Rv VDIVPNMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSD-
Mb3502c|M.bovis_AF2122/97 VDIVPNMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSD-
MMAR_4960|M.marinum_M VDIVPNMDPSGASRIHAFMVERVESGFGSLDEVADMIAAYNPHRPRPTD-
MAV_0677|M.avium_104 VDIVPNMDQSGANRIHAFMADRVDSGFASLDEVADAIAEYNPHRPRPTD-
MSMEG_5209|M.smegmatis_MC2_155 VDVVPNFEKSGSARIRDFMASNVD-GFDTLEEAADAVAAYLPHRRRPRN-
MUL_0147|M.ulcerans_Agy99 VDVVPKYEKDGSARIRDFMFTNLH-GFATLEEAADAVATYLPHRTKPRS-
TH_2112|M.thermoresistible__bu VDVVPRVEQAGTDRIRDFMMTNVA-GFETLEEAADAVAAYLPHRRRPRS-
MAB_2045|M.abscessus_ATCC_1997 VDVTPRMEMDGARRVVAFMSAHPE-GFDSLESAADVIAAYNPHRPRPEN-
MLBr_02297|M.leprae_Br4923 VRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTRNN
* . : . : * . *: * *.* . .
Mflv_4507|M.gilvum_PYR-GCK LDGLRKNLRHK-GGRWYWHWDPRFIDG----TAPHPPMEVTDTDRLHA-A
Mvan_1862|M.vanbaalenii_PYR-1 LDGLRNNLRRR-GERWYWHWDPQFIDG----SAANPPIEVTDTERLHS-A
Rv3473c|M.tuberculosis_H37Rv PDGLVANLRRR-GDRWYWHWDPQFIGG----IAAFPPVEVTDVDRMNA-A
Mb3502c|M.bovis_AF2122/97 PDGLVANLRRR-GDRWYWHWDPQFIGG----IAAFPPVEVTDVDRMNA-A
MMAR_4960|M.marinum_M LEGLTTNLRRR-GDRWYWHWDPRFISG----TAAFPPIEVTEPHRLYA-A
MAV_0677|M.avium_104 LEGLTTNLRRR-GDRWYWHWDPQFISG----TAAFPPFEVTDPDRMHA-A
MSMEG_5209|M.smegmatis_MC2_155 PEGLKKNLRLR-DGRWYWHWDPAFLG----KPHDDPFVRVERLEQA----
MUL_0147|M.ulcerans_Agy99 PEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFERA----
TH_2112|M.thermoresistible__bu PEGLKKNLRHR-DGRWHWHWDPAFVT----RVG-EQFVDVDVLERA----
MAB_2045|M.abscessus_ATCC_1997 LDGLRKVLARREDGRWSWRWDPAFVTSNFQFLQGDPDEGAEYFEMMSAFL
MLBr_02297|M.leprae_Br4923 AAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRWAV
: : : . :* * . .
Mflv_4507|M.gilvum_PYR-GCK VGRIVDDG------------VPVLLVRGQVSDLVSRDRAAAFLSRFPQID
Mvan_1862|M.vanbaalenii_PYR-1 VEAILADG------------VPVLLVRGQVSDLVSRERADAFVARFPQIA
Rv3473c|M.tuberculosis_H37Rv VATILRDE------------VPVLLVRGQVSDIVRQESADQFLSRFPQVE
Mb3502c|M.bovis_AF2122/97 VATILRDE------------VPVLLVRGQVSDIVRQESADQFLSRFPQVE
MMAR_4960|M.marinum_M VDTILRGG------------VPMLLIRGQMSDLVSQERAEEFLARFPNVE
MAV_0677|M.avium_104 VEAILRDG------------VPILMIRGQMSDLVSQERADEFLARFPQVE
MSMEG_5209|M.smegmatis_MC2_155 ---AVNLT------------VPILLIRGKLSDVVSPEGVAEFLEKVPAAE
MUL_0147|M.ulcerans_Agy99 ---AMNLT------------IPILLIRGKLSDVVTSEGVQDFLDKVPHAE
TH_2112|M.thermoresistible__bu ---ALRLT------------VPILLVRGKLSDVVSAEGVEEFLAKVPSAE
MAB_2045|M.abscessus_ATCC_1997 LDGARQVS------------APTLLVRGLLSDIVSEETVRHFLTVVPHAQ
MLBr_02297|M.leprae_Br4923 RSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRRYAPHGR
* * :** . : : . *
Mflv_4507|M.gilvum_PYR-GCK FVDVDGAGHMVAGDRNDLFADAVLSFLTRREVAKP---------------
Mvan_1862|M.vanbaalenii_PYR-1 FVDVEGAGHMVAGDRNDLFADAVLDFLARSEIARP---------------
Rv3473c|M.tuberculosis_H37Rv FTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR----------------
Mb3502c|M.bovis_AF2122/97 FTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR----------------
MMAR_4960|M.marinum_M FTDVRGAGHMVAGDRNDIFAAAVLDFLSRHLDAG----------------
MAV_0677|M.avium_104 FTDVRGAGHMVAGDRNDVFADAVLDFLARHLDVE----------------
MSMEG_5209|M.smegmatis_MC2_155 FVELSDAGHTAAGDDNDAFTQVVVEFVNR---------------------
MUL_0147|M.ulcerans_Agy99 FVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------------
TH_2112|M.thermoresistible__bu FVELSAAXXXATIPARGSPRRCVTSPVCRRRPPTSRPAPSPRSAPRHGNV
MAB_2045|M.abscessus_ATCC_1997 TVDVSGAGHMIAGDNNDAFSTAVVEFLDRTI-------------------
MLBr_02297|M.leprae_Br4923 YVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS--------------
..: * : : :
Mflv_4507|M.gilvum_PYR-GCK ----------
Mvan_1862|M.vanbaalenii_PYR-1 ----------
Rv3473c|M.tuberculosis_H37Rv ----------
Mb3502c|M.bovis_AF2122/97 ----------
MMAR_4960|M.marinum_M ----------
MAV_0677|M.avium_104 ----------
MSMEG_5209|M.smegmatis_MC2_155 ----------
MUL_0147|M.ulcerans_Agy99 ----------
TH_2112|M.thermoresistible__bu AGPGANAVRR
MAB_2045|M.abscessus_ATCC_1997 ----------
MLBr_02297|M.leprae_Br4923 ----------