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VRVSTYHPEMTSAPEQFLTDGHGGVRIVADRLGDPRARAVVFLHGGGQTRRSWGRAAAAVAHRGWQAVTV DMRGHGESDWSPDGDYRVSSFAADVREILDRLPPRPVLVGASLGGITSMLLAGELARGIAAAVVLVDIVP DMDPSGAERIHAFMADRMVDGFGSLDEVADMIAEFNPHRPRPADLDGLRNNLRRRGERWYWHWDPQFIDG SAANPPIEVTDTERLHSAVEAILADGVPVLLVRGQVSDLVSRERADAFVARFPQIAFVDVEGAGHMVAGD RNDLFADAVLDFLARSEIARP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1862 | - | - | 100% (301) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4609 | - | 5e-57 | 37.92% (298) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_0315 | - | 4e-56 | 43.05% (302) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3502c | bpoA | 1e-113 | 75.00% (256) | peroxidase BpoA |
| M. gilvum PYR-GCK | Mflv_4507 | - | 1e-144 | 82.94% (293) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3473c | bpoA | 1e-113 | 75.00% (256) | peroxidase BpoA |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-06 | 33.67% (98) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 2e-54 | 44.49% (272) | putative hydrolase (alpha/beta fold) |
| M. marinum M | MMAR_4960 | bpoA | 1e-128 | 75.52% (286) | peroxidase BpoA |
| M. avium 104 | MAV_0677 | - | 1e-133 | 79.86% (283) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 3e-57 | 43.36% (256) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 2e-51 | 40.23% (266) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 3e-57 | 37.59% (290) | peroxidase BpoB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1862|M.vanbaalenii_PYR-1 MRVSTYHPEMTSAPEQFLTDGHGGVRIVADRLGD-----PRARAVVFLHG
Mflv_4507|M.gilvum_PYR-GCK ------MTETLGAPEPFLTDGHGGIVIAADRRGE-----PTARAVVFLHG
MMAR_4960|M.marinum_M ---------MATAPERFSVQGPDGVRIVADRCGD-----PRGRAVVFLHG
MAV_0677|M.avium_104 -----------MAAEPFTIRGPGGVQIVADRLGD-----PRARAVVFLHG
Mb3502c|M.bovis_AF2122/97 --------------------------------------------MVFLHG
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------MVFLHG
MSMEG_5209|M.smegmatis_MC2_155 --MSTAQT----ESQTVAFRGVDDLTLVGDEWNKGAERAADRPTVLLLHG
MUL_0147|M.ulcerans_Agy99 --MSAMSN----NPRTVEFSGTEGITLVADEWNR-DTAASGRPTILMLHG
TH_2112|M.thermoresistible__bu --LNSTHS----KPQTVRFRGAQGLTLVADQWNR-GSGPKDRPTILLLHG
MAB_2045|M.abscessus_ATCC_1997 --MSAKRTGDSSAPVVERVPTADGLALAVDLYHC----DAPRAVVLLLHG
MLBr_00862|M.leprae_Br4923 ----MPATQSIHKVPHQFVESPDGVRLAIYQSGQ-----PEGPAIVLVHG
::::**
Mvan_1862|M.vanbaalenii_PYR-1 GGQTRRSWGRAAAAVAHRGWQAVTVDMRGHGESDW-SPDGDYRVSSFAAD
Mflv_4507|M.gilvum_PYR-GCK GGQTRRSWDRAAAAVAQRGWQSVTVDMRGHGESDW-SPDGDYRVASFAAD
MMAR_4960|M.marinum_M GGQTRRSWGRVAAVVAERGWQSVTVDLRGHGESDW-SPHGDYRVVSFAAD
MAV_0677|M.avium_104 GGQTRRSWGKAAAAVAARGWQAVTVDLRGHGESDW-SGDGDYRVVSFAAD
Mb3502c|M.bovis_AF2122/97 GGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDW-SSEGDYRLVSFAGD
Rv3473c|M.tuberculosis_H37Rv GGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDW-SSEGDYRLVSFAGD
MSMEG_5209|M.smegmatis_MC2_155 GGQNRYSWKNTGQILADQGFHVIALDARGHGDSDR-SPSANYSVDAMCGD
MUL_0147|M.ulcerans_Agy99 GCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR-APDADYAIETLTSD
TH_2112|M.thermoresistible__bu GGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDR-SPTADYQLDDLCAD
MAB_2045|M.abscessus_ATCC_1997 GGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDW-DPDGRYDMDRLGSD
MLBr_00862|M.leprae_Br4923 FPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYTMTRFADD
:.: * . : * ** *:*. . * : : *
Mvan_1862|M.vanbaalenii_PYR-1 VREI-------------------------------LDRLPPRPVLVGASL
Mflv_4507|M.gilvum_PYR-GCK VREI-------------------------------LAQLPPRPVLVGASL
MMAR_4960|M.marinum_M IQEV-------------------------------LRGLPPQPVLVGASL
MAV_0677|M.avium_104 VQAV-------------------------------LGTLPPKPVLVGASL
Mb3502c|M.bovis_AF2122/97 IQEV-------------------------------LRNLPGQPALVGASL
Rv3473c|M.tuberculosis_H37Rv IQEV-------------------------------LRNLPGQPALVGASL
MSMEG_5209|M.smegmatis_MC2_155 VLAV-------------------------------LYQISRPVALIGASM
MUL_0147|M.ulcerans_Agy99 IRHV-------------------------------LDAIGRPVVLIGASM
TH_2112|M.thermoresistible__bu TLSV-------------------------------VDQIGRPVSLIGASM
MAB_2045|M.abscessus_ATCC_1997 LLAVR-----------------------------SYADSGRPVAAIGASL
MLBr_00862|M.leprae_Br4923 FAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQ
: *.*
Mvan_1862|M.vanbaalenii_PYR-1 GGITSMLLAGELARGI----------------------------------
Mflv_4507|M.gilvum_PYR-GCK GGITAMLLAGELARGI----------------------------------
MMAR_4960|M.marinum_M GGFTSMLLAGELSPGI----------------------------------
MAV_0677|M.avium_104 GGFTSMLLAGELSPGI----------------------------------
Mb3502c|M.bovis_AF2122/97 GGFAAMLLAGELSPGI----------------------------------
Rv3473c|M.tuberculosis_H37Rv GGFAAMLLAGELSPGI----------------------------------
MSMEG_5209|M.smegmatis_MC2_155 GGLTGLLAAHEAGPER----------------------------------
MUL_0147|M.ulcerans_Agy99 GGLTGILVADSAGPDR----------------------------------
TH_2112|M.thermoresistible__bu GGLTGILVADRAGADK----------------------------------
MAB_2045|M.abscessus_ATCC_1997 GGLTILGTHLLAPPDL----------------------------------
MLBr_00862|M.leprae_Br4923 DQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIAL
. :.
Mvan_1862|M.vanbaalenii_PYR-1 -------------------AAAVVLVDIVPDMDPSGAERIHAFMADRMVD
Mflv_4507|M.gilvum_PYR-GCK -------------------ASAVVLVDIVPDMDPTGAERIHAFMADKMVD
MMAR_4960|M.marinum_M -------------------ASAVVLVDIVPNMDPSGASRIHAFMVERVES
MAV_0677|M.avium_104 -------------------ASAVVLVDIVPNMDQSGANRIHAFMADRVDS
Mb3502c|M.bovis_AF2122/97 -------------------ASAVVLVDIVPNMDLAGASRIHAFMAERVES
Rv3473c|M.tuberculosis_H37Rv -------------------ASAVVLVDIVPNMDLAGASRIHAFMAERVES
MSMEG_5209|M.smegmatis_MC2_155 -------------------VTQLVLVDVVPNFEKSGSARIRDFMASNVD-
MUL_0147|M.ulcerans_Agy99 -------------------VTGLVLVDVVPKYEKDGSARIRDFMFTNLH-
TH_2112|M.thermoresistible__bu -------------------VTELVLVDVVPRVEQAGTDRIRDFMMTNVA-
MAB_2045|M.abscessus_ATCC_1997 -------------------WQAVVLVDVTPRMEMDGARRVVAFMSAHPE-
MLBr_00862|M.leprae_Br4923 SSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGK
: * . . : . * .
Mvan_1862|M.vanbaalenii_PYR-1 GFGSLDEVADMIAEFNPHRPRPADLDGLRNNLRRR------GERWYWHWD
Mflv_4507|M.gilvum_PYR-GCK GFASLDEVADMIAEYNPHRPKPTDLDGLRKNLRHK------GGRWYWHWD
MMAR_4960|M.marinum_M GFGSLDEVADMIAAYNPHRPRPTDLEGLTTNLRRR------GDRWYWHWD
MAV_0677|M.avium_104 GFASLDEVADAIAEYNPHRPRPTDLEGLTTNLRRR------GDRWYWHWD
Mb3502c|M.bovis_AF2122/97 GFGSLDEVADVIANYNPHRPRPSDPDGLVANLRRR------GDRWYWHWD
Rv3473c|M.tuberculosis_H37Rv GFGSLDEVADVIANYNPHRPRPSDPDGLVANLRRR------GDRWYWHWD
MSMEG_5209|M.smegmatis_MC2_155 GFDTLEEAADAVAAYLPHRRRPRNPEGLKKNLRLR------DGRWYWHWD
MUL_0147|M.ulcerans_Agy99 GFATLEEAADAVATYLPHRTKPRSPEGLKKNLRLR------DGRWYWHWD
TH_2112|M.thermoresistible__bu GFETLEEAADAVAAYLPHRRRPRSPEGLKKNLRHR------DGRWHWHWD
MAB_2045|M.abscessus_ATCC_1997 GFDSLESAADVIAAYNPHRPRPENLDGLRKVLARRE-----DGRWSWRWD
MLBr_00862|M.leprae_Br4923 GVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSH
*. :: .: :. : :* . :. : :: .
Mvan_1862|M.vanbaalenii_PYR-1 PQFIDG----------------------------SAANPPIEVTDT----
Mflv_4507|M.gilvum_PYR-GCK PRFIDG----------------------------TAPHPPMEVTDT----
MMAR_4960|M.marinum_M PRFISG----------------------------TAAFPPIEVTEP----
MAV_0677|M.avium_104 PQFISG----------------------------TAAFPPFEVTDP----
Mb3502c|M.bovis_AF2122/97 PQFIGG----------------------------IAAFPPVEVTDV----
Rv3473c|M.tuberculosis_H37Rv PQFIGG----------------------------IAAFPPVEVTDV----
MSMEG_5209|M.smegmatis_MC2_155 PAFLG----------------------------KPHDDPFVRVERL----
MUL_0147|M.ulcerans_Agy99 PAMMT----------------------------APGDDPELRTENF----
TH_2112|M.thermoresistible__bu PAFVT----------------------------RVG-EQFVDVDVL----
MAB_2045|M.abscessus_ATCC_1997 PAFVTSNFQ------------------------FLQGDPDEGAEYF----
MLBr_00862|M.leprae_Br4923 PQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGI
* .: .
Mvan_1862|M.vanbaalenii_PYR-1 -------------ERLHS-AVEAILADGVPVLLVRG--------QVSDLV
Mflv_4507|M.gilvum_PYR-GCK -------------DRLHA-AVGRIVDDGVPVLLVRG--------QVSDLV
MMAR_4960|M.marinum_M -------------HRLYA-AVDTILRGGVPMLLIRG--------QMSDLV
MAV_0677|M.avium_104 -------------DRMHA-AVEAILRDGVPILMIRG--------QMSDLV
Mb3502c|M.bovis_AF2122/97 -------------DRMNA-AVATILRDEVPVLLVRG--------QVSDIV
Rv3473c|M.tuberculosis_H37Rv -------------DRMNA-AVATILRDEVPVLLVRG--------QVSDIV
MSMEG_5209|M.smegmatis_MC2_155 -------------EQA-------AVNLTVPILLIRG--------KLSDVV
MUL_0147|M.ulcerans_Agy99 -------------ERA-------AMNLTIPILLIRG--------KLSDVV
TH_2112|M.thermoresistible__bu -------------ERA-------ALRLTVPILLVRG--------KLSDVV
MAB_2045|M.abscessus_ATCC_1997 -------------EMMSAFLLDGARQVSAPTLLVRG--------LLSDIV
MLBr_00862|M.leprae_Br4923 GRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAA
. . :: * :** .
Mvan_1862|M.vanbaalenii_PYR-1 SRERADAFVARFPQIAFVDVEGAGHMVAGDRNDLFADAVLDFLARSEIAR
Mflv_4507|M.gilvum_PYR-GCK SRDRAAAFLSRFPQIDFVDVDGAGHMVAGDRNDLFADAVLSFLTRREVAK
MMAR_4960|M.marinum_M SQERAEEFLARFPNVEFTDVRGAGHMVAGDRNDIFAAAVLDFLSRHLDAG
MAV_0677|M.avium_104 SQERADEFLARFPQVEFTDVRGAGHMVAGDRNDVFADAVLDFLARHLDVE
Mb3502c|M.bovis_AF2122/97 RQESADQFLSRFPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR
Rv3473c|M.tuberculosis_H37Rv RQESADQFLSRFPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR
MSMEG_5209|M.smegmatis_MC2_155 SPEGVAEFLEKVPAAEFVELSDAGHTAAGDDNDAFTQVVVEFVNR-----
MUL_0147|M.ulcerans_Agy99 TSEGVQDFLDKVPHAEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG
TH_2112|M.thermoresistible__bu SAEGVEEFLAKVPSAEFVELSAAXXXATIPARGSPRRCVTSPVCRRRPPT
MAB_2045|M.abscessus_ATCC_1997 SEETVRHFLTVVPHAQTVDVSGAGHMIAGDNNDAFSTAVVEFLDRTI---
MLBr_00862|M.leprae_Br4923 AVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGV
: : : * : . . :
Mvan_1862|M.vanbaalenii_PYR-1 P-------------------------------------------------
Mflv_4507|M.gilvum_PYR-GCK P-------------------------------------------------
MMAR_4960|M.marinum_M --------------------------------------------------
MAV_0677|M.avium_104 --------------------------------------------------
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5209|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0147|M.ulcerans_Agy99 --------------------------------------------------
TH_2112|M.thermoresistible__bu SRPAPSPRSAPRHGNVAGPGANAVRR------------------------
MAB_2045|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSD
Mvan_1862|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4507|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4960|M.marinum_M --------------------------------------------------
MAV_0677|M.avium_104 --------------------------------------------------
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5209|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0147|M.ulcerans_Agy99 --------------------------------------------------
TH_2112|M.thermoresistible__bu --------------------------------------------------
MAB_2045|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 CLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDM
Mvan_1862|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4507|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4960|M.marinum_M --------------------------------------------------
MAV_0677|M.avium_104 --------------------------------------------------
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5209|M.smegmatis_MC2_155 --------------------------------------------------
MUL_0147|M.ulcerans_Agy99 --------------------------------------------------
TH_2112|M.thermoresistible__bu --------------------------------------------------
MAB_2045|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRST
Mvan_1862|M.vanbaalenii_PYR-1 ------
Mflv_4507|M.gilvum_PYR-GCK ------
MMAR_4960|M.marinum_M ------
MAV_0677|M.avium_104 ------
Mb3502c|M.bovis_AF2122/97 ------
Rv3473c|M.tuberculosis_H37Rv ------
MSMEG_5209|M.smegmatis_MC2_155 ------
MUL_0147|M.ulcerans_Agy99 ------
TH_2112|M.thermoresistible__bu ------
MAB_2045|M.abscessus_ATCC_1997 ------
MLBr_00862|M.leprae_Br4923 ARIRVI