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M. vanbaalenii PYR-1 Mvan_5762 (-)

annotation: alcohol dehydrogenase
coordinates: 6150198 - 6151358
length: 386

MKAVSCVHGTLEVVDLPSPRPGEGQLVLDVLRCGICGSDLHAKDHADELTEVMAEGGYHDFVRSDTPVVM
GHEFCGVVADRGRKVGKEFKPGSTVVAFPLMRAHGGVHLTGLSPLAPGGYAEQVVAEAALTFVVPNGLDP
ATAALTEPMAVAYHAVRRSDVTTKDVAIVLGCGPVGLAVICHLKALGVRTIVASDFSPGRRALAARCGAD
VVVDPAVDSPYEAVPAKQRGLTELPALYELGVGSMEKLRKIPGWSHVYRVADRLGGTAPKRPVIFECVGV
PGMIDGIIGAAPLASRVVVVGVCMGDDKLRPAMAIGKEIDLRFVFGYTPLEFRDTLHMLADGKLDASALV
TGTVGLGGVAAAFDALGDPETHAKILIDPAGTAVTP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_5762--100% (386)alcohol dehydrogenase
M. vanbaalenii PYR-1Mvan_0527-3e-2726.94% (386) alcohol dehydrogenase
M. vanbaalenii PYR-1Mvan_0490-1e-2528.17% (394) alcohol dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3753-1e-14264.45% (391) putative dehydrogenase
M. gilvum PYR-GCKMflv_0638-2e-2726.94% (386) alcohol dehydrogenase
M. tuberculosis H37RvRv3726-1e-14264.45% (391) dehydrogenase
M. leprae Br4923MLBr_01784adhE23e-1324.74% (384) putative alcohol dehydrogenase (Zn dependent)
M. abscessus ATCC 19977MAB_0526c-5e-7343.09% (369) hypothetical protein MAB_0526c
M. marinum MMMAR_3328adhE2_11e-7845.00% (380) zinc-dependent alcohol dehydrogenase AdhE2_1
M. avium 104MAV_0537-3e-7241.30% (368) zinc-binding dehydrogenase
M. smegmatis MC2 155MSMEG_6108-1e-7141.19% (369) zinc-binding dehydrogenase
M. thermoresistible (build 8)TH_4627-1e-1625.63% (398) PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein
M. ulcerans Agy99MUL_1292adhE22e-1625.58% (387) zinc-dependent alcohol dehydrogenase AdhE2

CLUSTAL 2.0.9 multiple sequence alignment


Mb3753|M.bovis_AF2122/97            ----MKAVTCTN--AKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL
Rv3726|M.tuberculosis_H37Rv         ----MKAVTCTN--AKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL
Mvan_5762|M.vanbaalenii_PYR-1       ----MKAVSCVH--GTLEVVDLPSPRPGEGQLVLDVLRCGICGSDLHAKD
MAV_0537|M.avium_104                ----MRAAVLRDG-RMVYRDDVPEPIPETGQVLVGVRACGICGSDLHFAA
MSMEG_6108|M.smegmatis_MC2_155      ----MRAAVLRQG-RMVVRDDVAEPVPGPGQVLVEVKACGICGSDLHFAQ
MAB_0526c|M.abscessus_ATCC_199      ----MRASVLRNG-SMVYRDDVPSPTPGEGQVLVKVSACGICGSDLHFAK
MMAR_3328|M.marinum_M               ----MRAVLMQD--SQLQVAEVPEPVPGPGEVLVDVLACGICGSDLHCAA
MLBr_01784|M.leprae_Br4923          MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MUL_1292|M.ulcerans_Agy99           MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE
TH_4627|M.thermoresistible__bu      MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE
Mflv_0638|M.gilvum_PYR-GCK          ----MRAAIYHGR-EDVRIEELPDPSPRAGEVVIEVARAGICGTDLHEYI
                                        ::.         :   :   * *  *: :: :  .*:* :**    

Mb3753|M.bovis_AF2122/97            HC-DELADVMAESGY----HAFMRSNQQVVFGHEFCGEVVDYGPGTRRTP
Rv3726|M.tuberculosis_H37Rv         HC-DELADVMAESGY----HAFMRSNQQVVFGHEFCGEVVDYGPGTRRTP
Mvan_5762|M.vanbaalenii_PYR-1       HA-DELTEVMAEGGY----HDFVRSDTPVVMGHEFCGVVADRGRKVGKEF
MAV_0537|M.avium_104                HG-AQVLQMSDRVAGGAAGMR-VDLDHDIFMGHEFSAEILEAGPDTETHP
MSMEG_6108|M.smegmatis_MC2_155      HG-EDLLASTAQLEGVANQNDDVDLSRDIFMGHEFSAEILEAGPSTDTYA
MAB_0526c|M.abscessus_ATCC_199      HG-ARAIELSKQMVGMPSLTDGVDLSTDVFMGHEFAAEVIEAGPRTQAPA
MMAR_3328|M.marinum_M               HG-PEFNSATQAAGG----FDMMDLSRPVVFGHEFVGRIAAYGPDTVQRI
MLBr_01784|M.leprae_Br4923          GG-INDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRAC
MUL_1292|M.ulcerans_Agy99           GG-INDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILNWRAVCGQCRAC
TH_4627|M.thermoresistible__bu      GG-INDEFPFLLGHEAAGTVESVGSGVTNVEPGDFVVLNWRAVCGQCRAC
Mflv_0638|M.gilvum_PYR-GCK          AGPMHAAPGVVIGHEYSGTVVGVGSGVREFTEGDRVCGVGVFGCGECGFC
                                                          :  .   .   :                

Mb3753|M.bovis_AF2122/97            RRGTPVVAMPLLRRGNKE---VHGIGLSTMAPGAYAERLVVEQSLTFPVP
Rv3726|M.tuberculosis_H37Rv         RRGTPVVAMPLLRRGNKE---VHGIGLSTMAPGAYAERLVVEQSLTFPVP
Mvan_5762|M.vanbaalenii_PYR-1       KPGSTVVAFPLMR-AHGG---VHLTGLSPLAPGGYAEQVVAEAALTFVVP
MAV_0537|M.avium_104                P-GTLVTSLPVLLSAKG----VEPIVYSNTTIGGYAERMLLSAPLLLPIP
MSMEG_6108|M.smegmatis_MC2_155      P-GTLVTSVPVLISPQG----MDMIVYSNTTLGGYAERMLLSAPLLLPVP
MAB_0526c|M.abscessus_ATCC_199      S-GTAVTSIPILLSAKG----LEPIVYSNTTLGGYAEQMLLSAPLLLPIP
MMAR_3328|M.marinum_M               PVGRRVVSAPFLLREQK----VTLGFAGPEAPGGYSERMLLSEPLLIEVP
MLBr_01784|M.leprae_Br4923          KRGRPSYCFDTFNAQQKMTLIDGTELTPALGIGAFADKTLVHSGQCTKVD
MUL_1292|M.ulcerans_Agy99           KRGRPSYCFDTFNAEQKMTLTDGTELTPALGIGAFADKTLVHSGQCTKVD
TH_4627|M.thermoresistible__bu      KRGRPHLCFDTFNATQKMTLGDGTELTPALGIGAFAEKTLVHEGQCTKVD
Mflv_0638|M.gilvum_PYR-GCK          KQGAEALCG-------------AVGFIGFAVNGALARYASLPTKALFRIP
                                      *    .                        *. :            : 

Mb3753|M.bovis_AF2122/97            NGLAPEIAALTEP--MAVGWHAVRRGEVGKGDVAIVIGCGPIGLAVICML
Rv3726|M.tuberculosis_H37Rv         NGLAPEIAALTEP--MAVGWHAVRRGEVGKGDVAIVIGCGPIGLAVICML
Mvan_5762|M.vanbaalenii_PYR-1       NGLDPATAALTEP--MAVAYHAVRRSDVTTKDVAIVLGCGPVGLAVICHL
MAV_0537|M.avium_104                NGLDVKHAALTEP--MAVGLHAVNKSNITPAETALVLGCGPIGIAIIAAL
MSMEG_6108|M.smegmatis_MC2_155      NGLDAGPAALTEP--MAVGLHAVNTSRIERNETALVIGCGPVGIAVIAAL
MAB_0526c|M.abscessus_ATCC_199      NGLDPRHAALTEP--MAVGLHAVNKSAIQPGTGAIVIGCGPVGIAVIAAL
MMAR_3328|M.marinum_M               DHVPTEVAALTEP--LAVAYRTVARVDTTTDDVALVVGCGPIGLAVIAVL
MLBr_01784|M.leprae_Br4923          PAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVGDAAISGA
MUL_1292|M.ulcerans_Agy99           PAADPAVAGLLGCGVMAGLGAAVNTGGVTRDDTVAVIGCGGVGDAAIAGA
TH_4627|M.thermoresistible__bu      PAADPAVAGLLGCGVMAGVGAAINTGAVSRDDTVAVIGCGGVGDAAIAGA
Mflv_0638|M.gilvum_PYR-GCK          DEISLAEAAVVEP--IASAYHAVRRSGLAAGGTVFIAGAGPIGLALVQFS
                                           *.:     :*    ::          . : *.* :* * :   

Mb3753|M.bovis_AF2122/97            KSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRH
Rv3726|M.tuberculosis_H37Rv         KSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRH
Mvan_5762|M.vanbaalenii_PYR-1       KALGVRTIVASDFSPGRRALAARCGADVVVDPAVDSPYEAVPAKQRG---
MAV_0537|M.avium_104                ATRGVESIVASDFSPKRRQLATAMGAHRTLDPAQGSPFDSVK--------
MSMEG_6108|M.smegmatis_MC2_155      KLLGVEDIVASDFSPTRRRLAAAMGAHVTLDPAQDSPFHQCR--------
MAB_0526c|M.abscessus_ATCC_199      HNLGIEPIVASDYSSARRDLAQRMGAHQVVDPKIEPTFHAWSRIGA----
MMAR_3328|M.marinum_M               KMKGVGPIVASDFSPERRALATQLGADVVLDPNENSPFEAFMAAAVTDDP
MLBr_01784|M.leprae_Br4923          ALVGANRIIAVDIDDTKLEWARTFGATHTVNALELEVVKTIQDLTSG---
MUL_1292|M.ulcerans_Agy99           ALVGAKKIIAVDTDNTKLEWARAFGATHTVNARELDVVETIQDLTGG---
TH_4627|M.thermoresistible__bu      ALVGAKKIIAVDTDAKKLDWAREFGATHTIDASSTDVVEAIQELTDG---
Mflv_0638|M.gilvum_PYR-GCK          LAQGATQVIVSEVSATRRVAAHRVGATRVIDPLAEDAVEVVRTLTNG---
                                       *   ::. : .  :   *   **  .::.                  

Mb3753|M.bovis_AF2122/97            LQSILDAFDLAVGTVESLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVG
Rv3726|M.tuberculosis_H37Rv         LQSILDAFDLAVGTVERLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVG
Mvan_5762|M.vanbaalenii_PYR-1       LTELPALYELGVGSMEKLRKIPG-WSHVYRVADRLGGTAPKRPVIFECVG
MAV_0537|M.avium_104                -----------------------------------------PAVVFEAVG
MSMEG_6108|M.smegmatis_MC2_155      -----------------------------------------PAVVFEAVG
MAB_0526c|M.abscessus_ATCC_199      ----------------------------------------GAPVIFEAVG
MMAR_3328|M.marinum_M               ARMAPAHTVFGQ-------------------------LPLRPTVAFECVG
MLBr_01784|M.leprae_Br4923          ---------------------------------------FGVDVVIDTVG
MUL_1292|M.ulcerans_Agy99           ---------------------------------------FGVDVVIDAVG
TH_4627|M.thermoresistible__bu      ---------------------------------------FGADVVVDAVG
Mflv_0638|M.gilvum_PYR-GCK          ---------------------------------------NGVDISFDAAG
                                                                               : .: .*

Mb3753|M.bovis_AF2122/97            VPGIIDGIIASAPLFSRVVVVGVCMGSDHIRP----AMAINKEINLRFVL
Rv3726|M.tuberculosis_H37Rv         VPGIIDGIIASAPLFSRVVVVGVCMGSDHIRP----AMAINKEINLRFVL
Mvan_5762|M.vanbaalenii_PYR-1       VPGMIDGIIGAAPLASRVVVVGVCMGDDKLRP----AMAIGKEIDLRFVF
MAV_0537|M.avium_104                VPGIIDDVLLRARPGTRLVVAGVCMQPDTVHP----FFAIAKEINVQFVL
MSMEG_6108|M.smegmatis_MC2_155      APGIIDDILRRCPAGTRVVVAGVCMQPDTVHP----LYAAVKQISVSFVF
MAB_0526c|M.abscessus_ATCC_199      VPGILNEVLRDAPRSARVVVVGVCMEPDAITP----YFGIAKEVAVQFVL
MMAR_3328|M.marinum_M               VPGLIQQLIAGVPPGTRIGVAGINMSSDHFEP----AQCIAKELDIRFSL
MLBr_01784|M.leprae_Br4923          RPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYG
MUL_1292|M.ulcerans_Agy99           RPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPLVDFFSRGGALKSSWYG
TH_4627|M.thermoresistible__bu      RPETWEQAFYARDLAGTVVLVGVPTPDMRIDMPLIDFFSRGGSLKSSWYG
Mflv_0638|M.gilvum_PYR-GCK          VQPALDAALGVLRPRGRLMVVAIWEAPAGIDIN----RSVMREANIGFSF
                                         .  :        : :..:      .                 :  

Mb3753|M.bovis_AF2122/97            GYTP-LEFRDTLHMLADGKVNAAPLITGTVGLPGVAAA-FDALGD-PEAH
Rv3726|M.tuberculosis_H37Rv         GYTP-LEFRDTLHMLADGKVNAAPLITGTVGLPGVAAA-FDALGD-PEAH
Mvan_5762|M.vanbaalenii_PYR-1       GYTP-LEFRDTLHMLADGKLDASALVTGTVGLGGVAAA-FDALGD-PETH
MAV_0537|M.avium_104                AYTP-EEFGDSLRALAEGDIDVAPLITGEVGLDGVGAA-FDDLAD-PERH
MSMEG_6108|M.smegmatis_MC2_155      GYDP-AEFASSLRAIAEGDIDVRPMITGSVPLDGMADA-FDELAT-PDAH
MAB_0526c|M.abscessus_ATCC_199      AYEP-AEFSETLRRIAHGEIDVAPLVTGEVGLEDVGSA-FADLGD-PERH
MMAR_3328|M.marinum_M               YYTL-EEFAQTFAHLAAGDFDVAPLLTGTVALEGVADA-FERLRN-NPHD
MLBr_01784|M.leprae_Br4923          DCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEA-FHKIHG-GKVL
MUL_1292|M.ulcerans_Agy99           DCLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGGIEEA-FEKMHA-GKVL
TH_4627|M.thermoresistible__bu      DCLPERDFPTLINLYLQGRLPLEKFVTERIALDEVEGA-FEKMQR-GEVL
Mflv_0638|M.gilvum_PYR-GCK          CYEAQRQVPAILDLLATGAINLGELITDEIPLDAVVSQGLEELRVNRDAH
                                          :.   .     * .    :::  : *  :    :  :       

Mb3753|M.bovis_AF2122/97            AKIMIDPKSNAASPQPFRVE
Rv3726|M.tuberculosis_H37Rv         AKIMIDPKSNAASPQPFRVE
Mvan_5762|M.vanbaalenii_PYR-1       AKILIDPAGTAVTP------
MAV_0537|M.avium_104                CKVLVTP-------------
MSMEG_6108|M.smegmatis_MC2_155      CKILVTP-------------
MAB_0526c|M.abscessus_ATCC_199      CKILVVP-------------
MMAR_3328|M.marinum_M               AKILLDPTR-----------
MLBr_01784|M.leprae_Br4923          RSVVML--------------
MUL_1292|M.ulcerans_Agy99           RSVVVL--------------
TH_4627|M.thermoresistible__bu      RSVVVLK-------------
Mflv_0638|M.gilvum_PYR-GCK          VKILIDPSA-----------
                                     .:::