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MKAVSCVHGTLEVVDLPSPRPGEGQLVLDVLRCGICGSDLHAKDHADELTEVMAEGGYHDFVRSDTPVVM GHEFCGVVADRGRKVGKEFKPGSTVVAFPLMRAHGGVHLTGLSPLAPGGYAEQVVAEAALTFVVPNGLDP ATAALTEPMAVAYHAVRRSDVTTKDVAIVLGCGPVGLAVICHLKALGVRTIVASDFSPGRRALAARCGAD VVVDPAVDSPYEAVPAKQRGLTELPALYELGVGSMEKLRKIPGWSHVYRVADRLGGTAPKRPVIFECVGV PGMIDGIIGAAPLASRVVVVGVCMGDDKLRPAMAIGKEIDLRFVFGYTPLEFRDTLHMLADGKLDASALV TGTVGLGGVAAAFDALGDPETHAKILIDPAGTAVTP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5762 | - | - | 100% (386) | alcohol dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_0527 | - | 3e-27 | 26.94% (386) | alcohol dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_0490 | - | 1e-25 | 28.17% (394) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3753 | - | 1e-142 | 64.45% (391) | putative dehydrogenase |
M. gilvum PYR-GCK | Mflv_0638 | - | 2e-27 | 26.94% (386) | alcohol dehydrogenase |
M. tuberculosis H37Rv | Rv3726 | - | 1e-142 | 64.45% (391) | dehydrogenase |
M. leprae Br4923 | MLBr_01784 | adhE2 | 3e-13 | 24.74% (384) | putative alcohol dehydrogenase (Zn dependent) |
M. abscessus ATCC 19977 | MAB_0526c | - | 5e-73 | 43.09% (369) | hypothetical protein MAB_0526c |
M. marinum M | MMAR_3328 | adhE2_1 | 1e-78 | 45.00% (380) | zinc-dependent alcohol dehydrogenase AdhE2_1 |
M. avium 104 | MAV_0537 | - | 3e-72 | 41.30% (368) | zinc-binding dehydrogenase |
M. smegmatis MC2 155 | MSMEG_6108 | - | 1e-71 | 41.19% (369) | zinc-binding dehydrogenase |
M. thermoresistible (build 8) | TH_4627 | - | 1e-16 | 25.63% (398) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
M. ulcerans Agy99 | MUL_1292 | adhE2 | 2e-16 | 25.58% (387) | zinc-dependent alcohol dehydrogenase AdhE2 |
CLUSTAL 2.0.9 multiple sequence alignment Mb3753|M.bovis_AF2122/97 ----MKAVTCTN--AKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL Rv3726|M.tuberculosis_H37Rv ----MKAVTCTN--AKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARL Mvan_5762|M.vanbaalenii_PYR-1 ----MKAVSCVH--GTLEVVDLPSPRPGEGQLVLDVLRCGICGSDLHAKD MAV_0537|M.avium_104 ----MRAAVLRDG-RMVYRDDVPEPIPETGQVLVGVRACGICGSDLHFAA MSMEG_6108|M.smegmatis_MC2_155 ----MRAAVLRQG-RMVVRDDVAEPVPGPGQVLVEVKACGICGSDLHFAQ MAB_0526c|M.abscessus_ATCC_199 ----MRASVLRNG-SMVYRDDVPSPTPGEGQVLVKVSACGICGSDLHFAK MMAR_3328|M.marinum_M ----MRAVLMQD--SQLQVAEVPEPVPGPGEVLVDVLACGICGSDLHCAA MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE MUL_1292|M.ulcerans_Agy99 MSQTVRGVISRKKGEPVELVDIVVPDPGPGEAVVDISACGVCHTDLTYRE TH_4627|M.thermoresistible__bu MSQSVRGVIARKKDEPVEVVDIVIPDPGPGEVVVKVTACGVCHTDLHYRE Mflv_0638|M.gilvum_PYR-GCK ----MRAAIYHGR-EDVRIEELPDPSPRAGEVVIEVARAGICGTDLHEYI ::. : : * * *: :: : .*:* :** Mb3753|M.bovis_AF2122/97 HC-DELADVMAESGY----HAFMRSNQQVVFGHEFCGEVVDYGPGTRRTP Rv3726|M.tuberculosis_H37Rv HC-DELADVMAESGY----HAFMRSNQQVVFGHEFCGEVVDYGPGTRRTP Mvan_5762|M.vanbaalenii_PYR-1 HA-DELTEVMAEGGY----HDFVRSDTPVVMGHEFCGVVADRGRKVGKEF MAV_0537|M.avium_104 HG-AQVLQMSDRVAGGAAGMR-VDLDHDIFMGHEFSAEILEAGPDTETHP MSMEG_6108|M.smegmatis_MC2_155 HG-EDLLASTAQLEGVANQNDDVDLSRDIFMGHEFSAEILEAGPSTDTYA MAB_0526c|M.abscessus_ATCC_199 HG-ARAIELSKQMVGMPSLTDGVDLSTDVFMGHEFAAEVIEAGPRTQAPA MMAR_3328|M.marinum_M HG-PEFNSATQAAGG----FDMMDLSRPVVFGHEFVGRIAAYGPDTVQRI MLBr_01784|M.leprae_Br4923 GG-INDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQCRAC MUL_1292|M.ulcerans_Agy99 GG-INDEYPFLLGHEAAGTVEAVGPGVTNVEPGDFVILNWRAVCGQCRAC TH_4627|M.thermoresistible__bu GG-INDEFPFLLGHEAAGTVESVGSGVTNVEPGDFVVLNWRAVCGQCRAC Mflv_0638|M.gilvum_PYR-GCK AGPMHAAPGVVIGHEYSGTVVGVGSGVREFTEGDRVCGVGVFGCGECGFC : . . : Mb3753|M.bovis_AF2122/97 RRGTPVVAMPLLRRGNKE---VHGIGLSTMAPGAYAERLVVEQSLTFPVP Rv3726|M.tuberculosis_H37Rv RRGTPVVAMPLLRRGNKE---VHGIGLSTMAPGAYAERLVVEQSLTFPVP Mvan_5762|M.vanbaalenii_PYR-1 KPGSTVVAFPLMR-AHGG---VHLTGLSPLAPGGYAEQVVAEAALTFVVP MAV_0537|M.avium_104 P-GTLVTSLPVLLSAKG----VEPIVYSNTTIGGYAERMLLSAPLLLPIP MSMEG_6108|M.smegmatis_MC2_155 P-GTLVTSVPVLISPQG----MDMIVYSNTTLGGYAERMLLSAPLLLPVP MAB_0526c|M.abscessus_ATCC_199 S-GTAVTSIPILLSAKG----LEPIVYSNTTLGGYAEQMLLSAPLLLPIP MMAR_3328|M.marinum_M PVGRRVVSAPFLLREQK----VTLGFAGPEAPGGYSERMLLSEPLLIEVP MLBr_01784|M.leprae_Br4923 KRGRPSYCFDTFNAQQKMTLIDGTELTPALGIGAFADKTLVHSGQCTKVD MUL_1292|M.ulcerans_Agy99 KRGRPSYCFDTFNAEQKMTLTDGTELTPALGIGAFADKTLVHSGQCTKVD TH_4627|M.thermoresistible__bu KRGRPHLCFDTFNATQKMTLGDGTELTPALGIGAFAEKTLVHEGQCTKVD Mflv_0638|M.gilvum_PYR-GCK KQGAEALCG-------------AVGFIGFAVNGALARYASLPTKALFRIP * . *. : : Mb3753|M.bovis_AF2122/97 NGLAPEIAALTEP--MAVGWHAVRRGEVGKGDVAIVIGCGPIGLAVICML Rv3726|M.tuberculosis_H37Rv NGLAPEIAALTEP--MAVGWHAVRRGEVGKGDVAIVIGCGPIGLAVICML Mvan_5762|M.vanbaalenii_PYR-1 NGLDPATAALTEP--MAVAYHAVRRSDVTTKDVAIVLGCGPVGLAVICHL MAV_0537|M.avium_104 NGLDVKHAALTEP--MAVGLHAVNKSNITPAETALVLGCGPIGIAIIAAL MSMEG_6108|M.smegmatis_MC2_155 NGLDAGPAALTEP--MAVGLHAVNTSRIERNETALVIGCGPVGIAVIAAL MAB_0526c|M.abscessus_ATCC_199 NGLDPRHAALTEP--MAVGLHAVNKSAIQPGTGAIVIGCGPVGIAVIAAL MMAR_3328|M.marinum_M DHVPTEVAALTEP--LAVAYRTVARVDTTTDDVALVVGCGPIGLAVIAVL MLBr_01784|M.leprae_Br4923 PAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVGDAAISGA MUL_1292|M.ulcerans_Agy99 PAADPAVAGLLGCGVMAGLGAAVNTGGVTRDDTVAVIGCGGVGDAAIAGA TH_4627|M.thermoresistible__bu PAADPAVAGLLGCGVMAGVGAAINTGAVSRDDTVAVIGCGGVGDAAIAGA Mflv_0638|M.gilvum_PYR-GCK DEISLAEAAVVEP--IASAYHAVRRSGLAAGGTVFIAGAGPIGLALVQFS *.: :* :: . : *.* :* * : Mb3753|M.bovis_AF2122/97 KSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRH Rv3726|M.tuberculosis_H37Rv KSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRH Mvan_5762|M.vanbaalenii_PYR-1 KALGVRTIVASDFSPGRRALAARCGADVVVDPAVDSPYEAVPAKQRG--- MAV_0537|M.avium_104 ATRGVESIVASDFSPKRRQLATAMGAHRTLDPAQGSPFDSVK-------- MSMEG_6108|M.smegmatis_MC2_155 KLLGVEDIVASDFSPTRRRLAAAMGAHVTLDPAQDSPFHQCR-------- MAB_0526c|M.abscessus_ATCC_199 HNLGIEPIVASDYSSARRDLAQRMGAHQVVDPKIEPTFHAWSRIGA---- MMAR_3328|M.marinum_M KMKGVGPIVASDFSPERRALATQLGADVVLDPNENSPFEAFMAAAVTDDP MLBr_01784|M.leprae_Br4923 ALVGANRIIAVDIDDTKLEWARTFGATHTVNALELEVVKTIQDLTSG--- MUL_1292|M.ulcerans_Agy99 ALVGAKKIIAVDTDNTKLEWARAFGATHTVNARELDVVETIQDLTGG--- TH_4627|M.thermoresistible__bu ALVGAKKIIAVDTDAKKLDWAREFGATHTIDASSTDVVEAIQELTDG--- Mflv_0638|M.gilvum_PYR-GCK LAQGATQVIVSEVSATRRVAAHRVGATRVIDPLAEDAVEVVRTLTNG--- * ::. : . : * ** .::. Mb3753|M.bovis_AF2122/97 LQSILDAFDLAVGTVESLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVG Rv3726|M.tuberculosis_H37Rv LQSILDAFDLAVGTVERLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVG Mvan_5762|M.vanbaalenii_PYR-1 LTELPALYELGVGSMEKLRKIPG-WSHVYRVADRLGGTAPKRPVIFECVG MAV_0537|M.avium_104 -----------------------------------------PAVVFEAVG MSMEG_6108|M.smegmatis_MC2_155 -----------------------------------------PAVVFEAVG MAB_0526c|M.abscessus_ATCC_199 ----------------------------------------GAPVIFEAVG MMAR_3328|M.marinum_M ARMAPAHTVFGQ-------------------------LPLRPTVAFECVG MLBr_01784|M.leprae_Br4923 ---------------------------------------FGVDVVIDTVG MUL_1292|M.ulcerans_Agy99 ---------------------------------------FGVDVVIDAVG TH_4627|M.thermoresistible__bu ---------------------------------------FGADVVVDAVG Mflv_0638|M.gilvum_PYR-GCK ---------------------------------------NGVDISFDAAG : .: .* Mb3753|M.bovis_AF2122/97 VPGIIDGIIASAPLFSRVVVVGVCMGSDHIRP----AMAINKEINLRFVL Rv3726|M.tuberculosis_H37Rv VPGIIDGIIASAPLFSRVVVVGVCMGSDHIRP----AMAINKEINLRFVL Mvan_5762|M.vanbaalenii_PYR-1 VPGMIDGIIGAAPLASRVVVVGVCMGDDKLRP----AMAIGKEIDLRFVF MAV_0537|M.avium_104 VPGIIDDVLLRARPGTRLVVAGVCMQPDTVHP----FFAIAKEINVQFVL MSMEG_6108|M.smegmatis_MC2_155 APGIIDDILRRCPAGTRVVVAGVCMQPDTVHP----LYAAVKQISVSFVF MAB_0526c|M.abscessus_ATCC_199 VPGILNEVLRDAPRSARVVVVGVCMEPDAITP----YFGIAKEVAVQFVL MMAR_3328|M.marinum_M VPGLIQQLIAGVPPGTRIGVAGINMSSDHFEP----AQCIAKELDIRFSL MLBr_01784|M.leprae_Br4923 RPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYG MUL_1292|M.ulcerans_Agy99 RPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPLVDFFSRGGALKSSWYG TH_4627|M.thermoresistible__bu RPETWEQAFYARDLAGTVVLVGVPTPDMRIDMPLIDFFSRGGSLKSSWYG Mflv_0638|M.gilvum_PYR-GCK VQPALDAALGVLRPRGRLMVVAIWEAPAGIDIN----RSVMREANIGFSF . : : :..: . : Mb3753|M.bovis_AF2122/97 GYTP-LEFRDTLHMLADGKVNAAPLITGTVGLPGVAAA-FDALGD-PEAH Rv3726|M.tuberculosis_H37Rv GYTP-LEFRDTLHMLADGKVNAAPLITGTVGLPGVAAA-FDALGD-PEAH Mvan_5762|M.vanbaalenii_PYR-1 GYTP-LEFRDTLHMLADGKLDASALVTGTVGLGGVAAA-FDALGD-PETH MAV_0537|M.avium_104 AYTP-EEFGDSLRALAEGDIDVAPLITGEVGLDGVGAA-FDDLAD-PERH MSMEG_6108|M.smegmatis_MC2_155 GYDP-AEFASSLRAIAEGDIDVRPMITGSVPLDGMADA-FDELAT-PDAH MAB_0526c|M.abscessus_ATCC_199 AYEP-AEFSETLRRIAHGEIDVAPLVTGEVGLEDVGSA-FADLGD-PERH MMAR_3328|M.marinum_M YYTL-EEFAQTFAHLAAGDFDVAPLLTGTVALEGVADA-FERLRN-NPHD MLBr_01784|M.leprae_Br4923 DCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEA-FHKIHG-GKVL MUL_1292|M.ulcerans_Agy99 DCLPERDFPTLIDLYLQGRLPLDKFVSEQIGLGGIEEA-FEKMHA-GKVL TH_4627|M.thermoresistible__bu DCLPERDFPTLINLYLQGRLPLEKFVTERIALDEVEGA-FEKMQR-GEVL Mflv_0638|M.gilvum_PYR-GCK CYEAQRQVPAILDLLATGAINLGELITDEIPLDAVVSQGLEELRVNRDAH :. . * . ::: : * : : : Mb3753|M.bovis_AF2122/97 AKIMIDPKSNAASPQPFRVE Rv3726|M.tuberculosis_H37Rv AKIMIDPKSNAASPQPFRVE Mvan_5762|M.vanbaalenii_PYR-1 AKILIDPAGTAVTP------ MAV_0537|M.avium_104 CKVLVTP------------- MSMEG_6108|M.smegmatis_MC2_155 CKILVTP------------- MAB_0526c|M.abscessus_ATCC_199 CKILVVP------------- MMAR_3328|M.marinum_M AKILLDPTR----------- MLBr_01784|M.leprae_Br4923 RSVVML-------------- MUL_1292|M.ulcerans_Agy99 RSVVVL-------------- TH_4627|M.thermoresistible__bu RSVVVLK------------- Mflv_0638|M.gilvum_PYR-GCK VKILIDPSA----------- .:::