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MRASVLRNGHMTYRDDVAEPTPGQGQVLVGVRACGICGSDLHFAAHGPEVLAMSSRLSHGDGYTNTDLSR DVFMGHEFCAEVIEAGPDTDTYPAGTLVTSIPVLLSAKGVEPIFSSNDTIGGYAERMLLSAPLLLPVPNG LDFRHAALTEPMAVGLHAVNKAGVDVGDTALVLGCGPIGIAIIAALRMRGVETIVASDFSQKRRELASIM GAHQTVDPAVSSPFEHVKATVVFEAVGVPGMIDEVILRARPGTRLIVAGVCMQPDTVHPFFAITKEINVQ FVLAYDPEEFATSLRALAEGLIDVSPLITGEVDLVGVGAAFDDLADPERHCKVLVTP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5116 | - | - | 100% (337) | dehydrogenase |
| M. marinum M | MMAR_3328 | adhE2_1 | 5e-75 | 44.75% (362) | zinc-dependent alcohol dehydrogenase AdhE2_1 |
| M. marinum M | MMAR_2790 | - | 6e-20 | 26.49% (336) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3753 | - | 2e-72 | 42.09% (373) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0638 | - | 4e-31 | 26.32% (361) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3726 | - | 2e-72 | 42.09% (373) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 9e-11 | 28.44% (218) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0526c | - | 1e-123 | 63.85% (343) | hypothetical protein MAB_0526c |
| M. avium 104 | MAV_0537 | - | 1e-152 | 78.93% (337) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6108 | - | 1e-128 | 65.98% (341) | zinc-binding dehydrogenase |
| M. thermoresistible (build 8) | TH_4631 | - | 9e-17 | 27.72% (202) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 3e-19 | 25.89% (336) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5762 | - | 4e-71 | 42.39% (368) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5116|M.marinum_M ----MRASVLRNGHMTYRDDVAEPT-PGQGQVLVGVRACGICGSDLHFAA
MAV_0537|M.avium_104 ----MRAAVLRDGRMVYRDDVPEPI-PETGQVLVGVRACGICGSDLHFAA
MSMEG_6108|M.smegmatis_MC2_155 ----MRAAVLRQGRMVVRDDVAEPV-PGPGQVLVEVKACGICGSDLHFAQ
MAB_0526c|M.abscessus_ATCC_199 ----MRASVLRNGSMVYRDDVPSPT-PGEGQVLVKVSACGICGSDLHFAK
Mb3753|M.bovis_AF2122/97 ----MKAVTCTNAKLEVVD-RPSPA-PAKGQLLLDVLRCGICGSDLHARL
Rv3726|M.tuberculosis_H37Rv ----MKAVTCTNAKLEVVD-RPSPA-PAKGQLLLDVLRCGICGSDLHARL
Mvan_5762|M.vanbaalenii_PYR-1 ----MKAVSCVHGTLEVVD-LPSPR-PGEGQLVLDVLRCGICGSDLHAKD
Mflv_0638|M.gilvum_PYR-GCK ----MRAAIYHGREDVRIEELPDPS-PRAGEVVIEVARAGICGTDLHEYI
TH_4631|M.thermoresistible__bu ----------------------------------------VNGXXXEETR
MUL_2962|M.ulcerans_Agy99 ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLHFYE
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
:
MMAR_5116|M.marinum_M HGPEVLAMSSRLSHGDGYTN-TDLSRDVFMGHEFCAEVIEAGPDT-DTYP
MAV_0537|M.avium_104 HGAQVLQMSDRVAGGAAGMR-VDLDHDIFMGHEFSAEILEAGPDT-ETHP
MSMEG_6108|M.smegmatis_MC2_155 HGEDLLASTAQLEGVANQNDDVDLSRDIFMGHEFSAEILEAGPST-DTYA
MAB_0526c|M.abscessus_ATCC_199 HGARAIELSKQMVGMPSLTDGVDLSTDVFMGHEFAAEVIEAGPRT-QAPA
Mb3753|M.bovis_AF2122/97 HCDELADVMAESG----YHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPR
Rv3726|M.tuberculosis_H37Rv HCDELADVMAESG----YHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPR
Mvan_5762|M.vanbaalenii_PYR-1 HADELTEVMAEGG----YHDFVRSDTPVVMGHEFCGVVADRGRKVGKEFK
Mflv_0638|M.gilvum_PYR-GCK AGP------------------MHAAPGVVIGHEYSGTVVGVGSGV-REFT
TH_4631|M.thermoresistible__bu RGR----------------------------YNLCPHMRFYGTPP-----
MUL_2962|M.ulcerans_Agy99 GEYP-------------------LAEPVALGHEAVGTVVEKGPDV-HTVE
MLBr_01784|M.leprae_Br4923 GGIN-------------------DRYPFLLGHEAAGTVEVVGPGV-TAVE
:: : *
MMAR_5116|M.marinum_M AGTLVTSIPVLL------SAKGVEPIFSSN------------------DT
MAV_0537|M.avium_104 PGTLVTSLPVLL------SAKGVEPIVYSN------------------TT
MSMEG_6108|M.smegmatis_MC2_155 PGTLVTSVPVLI------SPQGMDMIVYSN------------------TT
MAB_0526c|M.abscessus_ATCC_199 SGTAVTSIPILL------SAKGLEPIVYSN------------------TT
Mb3753|M.bovis_AF2122/97 RGTPVVAMPLLRR-----GNKEVHGIGLST------------------MA
Rv3726|M.tuberculosis_H37Rv RGTPVVAMPLLRR-----GNKEVHGIGLST------------------MA
Mvan_5762|M.vanbaalenii_PYR-1 PGSTVVAFPLMR------AHGGVHLTGLSP------------------LA
Mflv_0638|M.gilvum_PYR-GCK EGDRVCGVGVFGCGECGFCKQGAEALCGAVG-----------FIG--FAV
TH_4631|M.thermoresistible__bu -------------------------------------------------V
MUL_2962|M.ulcerans_Agy99 VGDQVMVSSVAGCGACAGCATRDPAMCVSGP-----------QIFGSGAL
MLBr_01784|M.leprae_Br4923 PGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG
MMAR_5116|M.marinum_M IGGYAERMLLSAP--LLLPVPNGLDFRHAALTEP-MAVGL-HAVNKAGVD
MAV_0537|M.avium_104 IGGYAERMLLSAP--LLLPIPNGLDVKHAALTEP-MAVGL-HAVNKSNIT
MSMEG_6108|M.smegmatis_MC2_155 LGGYAERMLLSAP--LLLPVPNGLDAGPAALTEP-MAVGL-HAVNTSRIE
MAB_0526c|M.abscessus_ATCC_199 LGGYAEQMLLSAP--LLLPIPNGLDPRHAALTEP-MAVGL-HAVNKSAIQ
Mb3753|M.bovis_AF2122/97 PGAYAERLVVEQS--LTFPVPNGLAPEIAALTEP-MAVGW-HAVRRGEVG
Rv3726|M.tuberculosis_H37Rv PGAYAERLVVEQS--LTFPVPNGLAPEIAALTEP-MAVGW-HAVRRGEVG
Mvan_5762|M.vanbaalenii_PYR-1 PGGYAEQVVAEAA--LTFVVPNGLDPATAALTEP-MAVAY-HAVRRSDVT
Mflv_0638|M.gilvum_PYR-GCK NGALARYASLPTK--ALFRIPDEISLAEAAVVEP-IASAY-HAVRRSGLA
TH_4631|M.thermoresistible__bu DGALCEYVTIGAA--FAHPVPAEMTDNAAALCEP-LSVAI-ATVDKAAVA
MUL_2962|M.ulcerans_Agy99 GGAQADLLAVPATDFQVLKIPAAITTEQALLLTDNLATGW-AAARRADIP
MLBr_01784|M.leprae_Br4923 IGAFADKTLVHSG--QCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVS
*. . : * : : . : . :
MMAR_5116|M.marinum_M VGDTALVLGCGPIGIAIIAALRMRGVETIVASDFSQKRRELASIMGAHQT
MAV_0537|M.avium_104 PAETALVLGCGPIGIAIIAALATRGVESIVASDFSPKRRQLATAMGAHRT
MSMEG_6108|M.smegmatis_MC2_155 RNETALVIGCGPVGIAVIAALKLLGVEDIVASDFSPTRRRLAAAMGAHVT
MAB_0526c|M.abscessus_ATCC_199 PGTGAIVIGCGPVGIAVIAALHNLGIEPIVASDYSSARRDLAQRMGAHQV
Mb3753|M.bovis_AF2122/97 KGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSV
Rv3726|M.tuberculosis_H37Rv KGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSV
Mvan_5762|M.vanbaalenii_PYR-1 TKDVAIVLGCGPVGLAVICHLKALGVRTIVASDFSPGRRALAARCGADVV
Mflv_0638|M.gilvum_PYR-GCK AGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSATRRVAAHRVGATRV
TH_4631|M.thermoresistible__bu GGSRVLIAGAGPIGLMTAQVARAYGATDIVVTDLDPHRRRLAHRFGATTT
MUL_2962|M.ulcerans_Agy99 FGATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEWGATAV
MLBr_01784|M.leprae_Br4923 RDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHT
. : * * :* * :.. : : * ** .
MMAR_5116|M.marinum_M VDPAVSSPFEHVK-------------------------------------
MAV_0537|M.avium_104 LDPAQGSPFDSVK-------------------------------------
MSMEG_6108|M.smegmatis_MC2_155 LDPAQDSPFHQCR-------------------------------------
MAB_0526c|M.abscessus_ATCC_199 VDPKIEPTFHAWSR------------------------------------
Mb3753|M.bovis_AF2122/97 VDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVESLQRLRLPWWHLW
Rv3726|M.tuberculosis_H37Rv VDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVERLQRLRLPWWHLW
Mvan_5762|M.vanbaalenii_PYR-1 VDPAVDSPYEAVPAKQRG---LTELPALYELGVGSMEKLRKIPG-WSHVY
Mflv_0638|M.gilvum_PYR-GCK IDPLAEDAVEVVRTLTNG--------------------------------
TH_4631|M.thermoresistible__bu LDPQTDDVTGLRVD------------------------------------
MUL_2962|M.ulcerans_Agy99 ASPAAEAIVAATSG------------------------------------
MLBr_01784|M.leprae_Br4923 VNALELEVVKTIQDLTSG--------------------------------
..
MMAR_5116|M.marinum_M ------------ATVVFEAVGVPGMIDEVILRARPGTRLIVAGVC----M
MAV_0537|M.avium_104 ------------PAVVFEAVGVPGIIDDVLLRARPGTRLVVAGVC----M
MSMEG_6108|M.smegmatis_MC2_155 ------------PAVVFEAVGAPGIIDDILRRCPAGTRVVVAGVC----M
MAB_0526c|M.abscessus_ATCC_199 --------IGAGAPVIFEAVGVPGILNEVLRDAPRSARVVVVGVC----M
Mb3753|M.bovis_AF2122/97 RAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVC----M
Rv3726|M.tuberculosis_H37Rv RAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVC----M
Mvan_5762|M.vanbaalenii_PYR-1 RVADRLGGTAPKRPVIFECVGVPGMIDGIIGAAPLASRVVVVGVC----M
Mflv_0638|M.gilvum_PYR-GCK ----------NGVDISFDAAGVQPALDAALGVLRPRGRLMVVAIW----E
TH_4631|M.thermoresistible__bu --------------AFIDASGAPAAVMSGLAAVRPAGRAVLVGMG----A
MUL_2962|M.ulcerans_Agy99 ----------RGADSVIDAVDTDASMTDALNAVRAGGTVSVVGVHD---L
MLBr_01784|M.leprae_Br4923 ----------FGVDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPDMR
:: . : :..:
MMAR_5116|M.marinum_M QPDTVHPFFAITKEINVQFVLAYDPE-EFATSLRALAEGLIDVSPLITGE
MAV_0537|M.avium_104 QPDTVHPFFAIAKEINVQFVLAYTPE-EFGDSLRALAEGDIDVAPLITGE
MSMEG_6108|M.smegmatis_MC2_155 QPDTVHPLYAAVKQISVSFVFGYDPA-EFASSLRAIAEGDIDVRPMITGS
MAB_0526c|M.abscessus_ATCC_199 EPDAITPYFGIAKEVAVQFVLAYEPA-EFSETLRRIAHGEIDVAPLVTGE
Mb3753|M.bovis_AF2122/97 GSDHIRPAMAINKEINLRFVLGYTPL-EFRDTLHMLADGKVNAAPLITGT
Rv3726|M.tuberculosis_H37Rv GSDHIRPAMAINKEINLRFVLGYTPL-EFRDTLHMLADGKVNAAPLITGT
Mvan_5762|M.vanbaalenii_PYR-1 GDDKLRPAMAIGKEIDLRFVFGYTPL-EFRDTLHMLADGKLDASALVTGT
Mflv_0638|M.gilvum_PYR-GCK APAGIDINRSVMREANIGFSFCYEAQRQVPAILDLLATGAINLGELITDE
TH_4631|M.thermoresistible__bu ETMELPVQTIQNRELILTGVFRYANT--WPAAIALIRTGRVDVDALITGR
MUL_2962|M.ulcerans_Agy99 QPFPLPALTCLLRSITLRLTIAPVQR-TWSELIPLLESGRLDVDGIFTTS
MLBr_01784|M.leprae_Br4923 LDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSER
: . : * : :.:
MMAR_5116|M.marinum_M VDLVGVGAA-FDDLAD-PERHCKVLVTP-------------
MAV_0537|M.avium_104 VGLDGVGAA-FDDLAD-PERHCKVLVTP-------------
MSMEG_6108|M.smegmatis_MC2_155 VPLDGMADA-FDELAT-PDAHCKILVTP-------------
MAB_0526c|M.abscessus_ATCC_199 VGLEDVGSA-FADLGD-PERHCKILVVP-------------
Mb3753|M.bovis_AF2122/97 VGLPGVAAA-FDALGD-PEAHAKIMIDPKSNAASPQPFRVE
Rv3726|M.tuberculosis_H37Rv VGLPGVAAA-FDALGD-PEAHAKIMIDPKSNAASPQPFRVE
Mvan_5762|M.vanbaalenii_PYR-1 VGLGGVAAA-FDALGD-PETHAKILIDPAGTAVTP------
Mflv_0638|M.gilvum_PYR-GCK IPLDAVVSQGLEELRVNRDAHVKILIDPSA-----------
TH_4631|M.thermoresistible__bu YPLEKTAEA-LESDRIPGNIKSVVEVGTS------------
MUL_2962|M.ulcerans_Agy99 LPLDEAAKG-YSIAGSRSGNDVKVLLKV-------------
MLBr_01784|M.leprae_Br4923 IGLGDVEEA-FHKIHGGKVLRSVVML---------------
* : :