For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
GGTSSRSLVLTGATSGLGLALARLLAESDAYRLILLCRNEERRDELISWLGAHAAHYVVCDLSALASIRG AAAEIARAVRVGDLAPVGAVVLNAAVHPGHLAGSTAEGLDATMITNLVGPHLLLALMSPYMSPGARTVLV GSGAHDRKRWWTGLPEPAALALADACTPGTLSGPQAYVTSKRGMVYLGQAYAERFPEHSAVLAYDPGIMP ATGITRNMNAVSRWLFRRVLTKFVGAKGFSTPERSARWLCAYLTREDPPVLSYAKVDRYQPWPSAACPPE AAGLLFSEANDIAGITADVTATWWFLGSPRQSG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3966c | - | - | 100% (314) | dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_0717 | - | 4e-14 | 29.44% (214) | dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_3438 | - | 3e-11 | 30.38% (260) | putative short-chain dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0311 | - | 2e-19 | 31.00% (229) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2120 | - | 1e-11 | 35.62% (146) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0303 | - | 2e-19 | 31.00% (229) | dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00315 | - | 3e-06 | 28.38% (148) | short chain dehydrogenase |
| M. marinum M | MMAR_1680 | - | 7e-12 | 30.45% (220) | dehydrogenase/reductase |
| M. avium 104 | MAV_3824 | - | 6e-11 | 32.88% (146) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0876 | - | 2e-08 | 31.08% (148) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3199 | - | 1e-07 | 35.17% (145) | PUTATIVE retinol dehydrogenase 13 |
| M. ulcerans Agy99 | MUL_1918 | - | 2e-12 | 28.32% (279) | dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_4584 | - | 4e-12 | 37.16% (148) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1680|M.marinum_M ---MSVVDGIRSLLDTTLDRALDRTIVGGYTRVGYQLRHSGWSDDPSPAA
MUL_1918|M.ulcerans_Agy99 MISMSVVDGIRSLLDTTLDRALDRTIVGGYTRVGYQLRHSGWSGDPSPAA
Mflv_2120|M.gilvum_PYR-GCK ---------------------------------MTTTSETTALDIVAGAD
Mvan_4584|M.vanbaalenii_PYR-1 -------------MGVIVGPGEHDPAAACDPHVVTATSAPTALDIVEGVD
MLBr_00315|M.leprae_Br4923 ---------------------------------------MAKWTTADIPD
MSMEG_0876|M.smegmatis_MC2_155 ---------------------------------------MTKWTTARIPD
MAV_3824|M.avium_104 --------------------------------------MTIPWTPDRLGD
TH_3199|M.thermoresistible__bu -----------------------------------------MWTAADLPS
Mb0311|M.bovis_AF2122/97 --------------------------------------------------
Rv0303|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3966c|M.abscessus_ATCC_199 -----------------------------------------------MGG
MMAR_1680|M.marinum_M LRGRTAMVTGANRGLGKAIAAGLAELGA--TVVLTVRDRDSGQRARDEIA
MUL_1918|M.ulcerans_Agy99 LRGRTAMVTGANRGLGKAIAAGLAELGA--TVVLTVRDRDSGQRARDEIA
Mflv_2120|M.gilvum_PYR-GCK LGGKTCVITGASSGLGRESARALASTGA--HVILAARNLEALSDTEAWVR
Mvan_4584|M.vanbaalenii_PYR-1 LSGKTCVITGASSGLGRESARALAKAGA--HVILAARNAAAMSETEAWLR
MLBr_00315|M.leprae_Br4923 QTGRVAVITGANTGLGYQTALALAEHGA--HVVLAVRNLDKGKDAAARIT
MSMEG_0876|M.smegmatis_MC2_155 QTGRVAIVTGANTGLGLETAKALAAKGA--HVVLAVRNLDKGKAAVDWIA
MAV_3824|M.avium_104 LTGKRVIVTGATNGVGLGTARALAKAGA--EVILAVRNTELGKQRAAQMG
TH_3199|M.thermoresistible__bu FSDRTVIVTGANSGLGLVTARELARVGA--RVIIAVRNTTKGEAAAEQMT
Mb0311|M.bovis_AF2122/97 MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDPARGRAAMEELG
Rv0303|M.tuberculosis_H37Rv MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDPARGRAAMEELG
MAB_3966c|M.abscessus_ATCC_199 TSSRSLVLTGATSGLGLALARLLAESDAY-RLILLCRNEERRDELISWLG
::***. *:* * * .* ::: *: :
MMAR_1680|M.marinum_M AASG-ADVRVEVCDVSSLSAVRAFATDLRTRVSR-----LDVLVHNAGLL
MUL_1918|M.ulcerans_Agy99 AASG-ADVRVEVCDVSSLSVVRASATDLCTRVSR-----LDVLVHNAGLL
Mflv_2120|M.gilvum_PYR-GCK AEVADAELSIVPLDLTSLASVASAAAQISELTPA-----VHVLMNNAGVM
Mvan_4584|M.vanbaalenii_PYR-1 AQLPDALLSVVDLDLTSLASIAAAAAEISELTPV-----VHVLMNNAGVM
MLBr_00315|M.leprae_Br4923 ATSAQNNVALQELDLASLESVRAAAKQLRSDYDH-----IDLLINNAGVM
MSMEG_0876|M.smegmatis_MC2_155 RSAPTADLELQQLDLGSLASVRAAADDLKGKFDR-----IDLLVNNAGVM
MAV_3824|M.avium_104 -----GSTAVEKLDLADLSSVRAFADRIEAP--------VDILINNAGAL
TH_3199|M.thermoresistible__bu G-PGHGPVEVRALDLQNLASVREFAAGVEGD--------VDVLVNNAGIM
Mb0311|M.bovis_AF2122/97 E---PNRCSVLEVDLASVRSVRSFVETVRTTPLPP----IRALVCNAGLQ
Rv0303|M.tuberculosis_H37Rv E---PNRCSVLEVDLASVRSVRSFVETVRTTPLPP----IRALVCNAGLQ
MAB_3966c|M.abscessus_ATCC_199 A----HAAHYVVCDLSALASIRGAAAEIARAVRVGDLAPVGAVVLNAAVH
*: : : . : : :: **.
MMAR_1680|M.marinum_M PAA-RAETVEGHEITLATHVLGPILLTELLVPMLAESDDPRVILMSSGGM
MUL_1918|M.ulcerans_Agy99 PAA-RAETDEGHEITLATHVLGPILLTSLLVPMLAESDDPRVILMSSGGM
Mflv_2120|M.gilvum_PYR-GCK FTP-FGRTAEGFETQFGTNHLGHFEFTRLLFPALVAADGARVVNLSSEGH
Mvan_4584|M.vanbaalenii_PYR-1 FTP-FGRTVDGFEIQFGTNHLGHFELTRLLFPALVAADGARVVNLSSEGH
MLBr_00315|M.leprae_Br4923 WTP-KSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRVITVSSLSH
MSMEG_0876|M.smegmatis_MC2_155 WPP-RQTTADGFELQFGTNHLGHFALTGLLLDRMLTVPGSRVVTVSSQGH
MAV_3824|M.avium_104 TDR-RTETVDGFEMTLGTNLLGPFALTNLLLPKVR----SQIINVGSDAH
TH_3199|M.thermoresistible__bu AVP-LARTVDGFESQIGTNHLGHFALTNLLLPQIT----DRVVTVSSLMH
Mb0311|M.bovis_AF2122/97 VVSGIAFTDDGVEMTFGVNHLGHFALVTGILDWLARP--ARIVVVSSGTH
Rv0303|M.tuberculosis_H37Rv VVSGIAFTDDGVEMTFGVNHLGHFALVTGILDWLARP--ARIVVVSSGTH
MAB_3966c|M.abscessus_ATCC_199 PGHLAGSTAEGLDATMITNLVGPHLLLALMSPYMSPG--ARTVLVGSGAH
* :* : : .: :* : : : : : :.*
MMAR_1680|M.marinum_M Y--TQPLPIEDP------------EYRAGGYRGAVAYARTKRMQVAFTPL
MUL_1918|M.ulcerans_Agy99 Y--TQPLPIEDP------------EYRAGGYRGAVAYARTKRMQVAFTPL
Mflv_2120|M.gilvum_PYR-GCK R--ISDVDFEDP------------NWETRDYDKFAAYGASKTANVLHAVE
Mvan_4584|M.vanbaalenii_PYR-1 R--MGDVDFDDP------------NWEHRDYDKFAAYGASKTANVLHAVE
MLBr_00315|M.leprae_Br4923 RL-FADIHFNDL------------QWECN-YNRVAAYGQSKLANLLFTYE
MSMEG_0876|M.smegmatis_MC2_155 RI-LAAIHFDDL------------QWERR-YNRVAAYGQSKLANLLFTYE
MAV_3824|M.avium_104 R--SATLHLDDL------------HLRRHKWTRLGAYAQSKLAVMLWGLE
TH_3199|M.thermoresistible__bu W--FGYLSLNDL------------NWKARPYSAWLAYAQSKLANLLFTSE
Mb0311|M.bovis_AF2122/97 DP-SKHTGMPDPRYTCAADLAHPPTDQNTPAEGRRRYTTSKLCNVLFTYE
Rv0303|M.tuberculosis_H37Rv DP-SKHTGMPDPRYTCAADLAHPPTDQNTPAEGRRRYTTSKLCNVLFTYE
MAB_3966c|M.abscessus_ATCC_199 DRKRWWTGLPEP-----AALALADACTPGTLSGPQAYVTSKRGMVYLGQA
: : * :* :
MMAR_1680|M.marinum_M LARRWSGERIR--VYSMHPGWA-DTPG--------VATSLPGFRAVTGPL
MUL_1918|M.ulcerans_Agy99 LARRWSGERIR--VYSMHPGWA-DTPG--------VATSLPGFRAVIGPL
Mflv_2120|M.gilvum_PYR-GCK LDRRLRDSGVR--AFAVHPGIV-ATSLARHMTNDDFASLNKSTASRNPDK
Mvan_4584|M.vanbaalenii_PYR-1 LDRRLRDSGVR--AFAVHPGIV-ATSLARHMTNDDFASLNAASSTRNSDK
MLBr_00315|M.leprae_Br4923 LQRRLATRQTTI-AVAAHPGGS-RTELTRTLP----ALIAPIFSVAELFL
MSMEG_0876|M.smegmatis_MC2_155 LQRRLTGHQTT--ALAAHPGAS-NTELARHLP----GALERLVTP----L
MAV_3824|M.avium_104 LDRRLRAAGSPIVTQLTHPGWV-ASNLSNLGDAPLKAAAHKAVKMVADRL
TH_3199|M.thermoresistible__bu LQRRLDTVGSPVRAVAAHPGYS-STNLQGHTG---RRFGDALARIGNRYL
Mb0311|M.bovis_AF2122/97 LDRRLDHGEQGVMVNAFDPGLM-PGSGLARDYPPILRLAYRLLSPMLRVL
Rv0303|M.tuberculosis_H37Rv LDRRLDHGEQGVMVNAFDPGLM-PGSGLARDYPPILRLAYRLLSPMLRVL
MAB_3966c|M.abscessus_ATCC_199 YAERFPEHSAV---LAYDPGIMPATGITRNMNAVSRWLFRRVLTKFVGAK
.* .**
MMAR_1680|M.marinum_M LRTAEQGADTAVWLAATRPAPLSGTFWHDRRTRPEHYLPWTRFSD-----
MUL_1918|M.ulcerans_Agy99 LRTAEQGADTAVWLAATRPAPLSGTFWHDRRTRPEHYLPWTRYSD-----
Mflv_2120|M.gilvum_PYR-GCK PTTDFRKQFTTPEHGAATQVWAAVSDDLDGQGGLYLSDCRIREAAPYAAD
Mvan_4584|M.vanbaalenii_PYR-1 PATDFRKQFTTPEYGAATQVWAAVSTDLDDAGGVYLSDCEVRRAAAYAVD
MLBr_00315|M.leprae_Br4923 TQDAATGALPTLRAATDAAVLGGQYFGPDGFAEIRGHPKVVASNG-KSHD
MSMEG_0876|M.smegmatis_MC2_155 AQDAALGALPTLRAATDPGALGGQYFGPDGIGETRGYPKVVASSA-QSHD
MAV_3824|M.avium_104 ANDIDEGAAPTLYCISEP-IPPGSYVGVSGRFGLRGGPVLIGRTP-LACD
TH_3199|M.thermoresistible__bu ATDAEFGARQTLYAVARD-VPGDSFIGP--RFAMHGPTEQVGRSP-LARS
Mb0311|M.bovis_AF2122/97 PFVHSTRVSGEHLAALAVDPRFAGVTGQYFAGAKAIRSSAESYDR-----
Rv0303|M.tuberculosis_H37Rv PFVHSTRVSGEHLAALAVDPRFAGVTGQYFAGAKAIRSSAESYDR-----
MAB_3966c|M.abscessus_ATCC_199 GFSTPERSARWLCAYLTREDPPVLSYAKVDRYQPWPSAACPPEAA--GLL
MMAR_1680|M.marinum_M -DDRQRLWRYCADAIGID----------
MUL_1918|M.ulcerans_Agy99 -DDRQRLWRYCADAIGID----------
Mflv_2120|M.gilvum_PYR-GCK ETRALTLWALSEHLCTASSAT-------
Mvan_4584|M.vanbaalenii_PYR-1 EARALALWDLSERLCTRSSPSLGSGA--
MLBr_00315|M.leprae_Br4923 VDRQLRLWAVSEELTGVVYPVG------
MSMEG_0876|M.smegmatis_MC2_155 ADLQRRLWAVSEELTGVTFPVGEALQQA
MAV_3824|M.avium_104 YDTAARLVAFAERETGTELRV-------
TH_3199|M.thermoresistible__bu AGTARALWELSEQLTDTKFPL-------
Mb0311|M.bovis_AF2122/97 -AKALDLWETSERLLAQVT---------
Rv0303|M.tuberculosis_H37Rv -AKALDLWETSERLLAQVT---------
MAB_3966c|M.abscessus_ATCC_199 FSEANDIAGITADVTATWWFLGSPRQSG
: