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MSVVDGIRSLLDTTLDRALDRTIVGGYTRVGYQLRHSGWSDDPSPAALRGRTAMVTGANRGLGKAIAAGL AELGATVVLTVRDRDSGQRARDEIAAASGADVRVEVCDVSSLSAVRAFATDLRTRVSRLDVLVHNAGLLP AARAETVEGHEITLATHVLGPILLTELLVPMLAESDDPRVILMSSGGMYTQPLPIEDPEYRAGGYRGAVA YARTKRMQVAFTPLLARRWSGERIRVYSMHPGWADTPGVATSLPGFRAVTGPLLRTAEQGADTAVWLAAT RPAPLSGTFWHDRRTRPEHYLPWTRFSDDDRQRLWRYCADAIGID
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1680 | - | - | 100% (325) | dehydrogenase/reductase |
| M. marinum M | MMAR_0757 | - | 2e-27 | 32.67% (303) | dehydrogenase/reductase |
| M. marinum M | MMAR_3998 | - | 2e-24 | 33.71% (264) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0069 | - | 4e-31 | 35.54% (287) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1940 | - | 1e-26 | 36.79% (212) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0068 | - | 3e-31 | 35.89% (287) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 1e-25 | 32.99% (291) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0646c | - | 5e-31 | 35.80% (257) | short chain dehydrogenase |
| M. avium 104 | MAV_4710 | - | 5e-30 | 33.22% (304) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0876 | - | 6e-32 | 35.56% (284) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4179 | - | 4e-31 | 35.40% (291) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1918 | - | 0.0 | 97.54% (325) | dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_0753 | - | 2e-28 | 33.68% (291) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0069|M.bovis_AF2122/97 --------------------------------------MTKWTAADIPDQ
Rv0068|M.tuberculosis_H37Rv --------------------------------------MTKWTAADIPDQ
MSMEG_0876|M.smegmatis_MC2_155 --------------------------------------MTKWTTARIPDQ
MLBr_00315|M.leprae_Br4923 --------------------------------------MAKWTTADIPDQ
MAB_0646c|M.abscessus_ATCC_199 ----------------------------------MSRSTTKWSTTDIPDQ
MAV_4710|M.avium_104 -------------------------------MAPHDKRHRDWSEADVGDQ
TH_4179|M.thermoresistible__bu -------------------------------------MTGKWTARDVPDQ
Mvan_0753|M.vanbaalenii_PYR-1 -------------------------------------MSSKWTAADVPDQ
Mflv_1940|M.gilvum_PYR-GCK --------------------------------------MSDWTAADLPSF
MMAR_1680|M.marinum_M ---MSVVDGIRSLLDTTLDRALDRTIVGGYTRVGYQLRHSGWSDDPSPAA
MUL_1918|M.ulcerans_Agy99 MISMSVVDGIRSLLDTTLDRALDRTIVGGYTRVGYQLRHSGWSGDPSPAA
*:
Mb0069|M.bovis_AF2122/97 T-GRTAVITGANTGLGFETAAALAAHGAHVVLAVRNLDKGKQAAARITEA
Rv0068|M.tuberculosis_H37Rv T-GRTAVITGANTGLGFETAAALAAHGAHVVLAVRNLDKGKQAAARITEA
MSMEG_0876|M.smegmatis_MC2_155 T-GRVAIVTGANTGLGLETAKALAAKGAHVVLAVRNLDKGKAAVDWIARS
MLBr_00315|M.leprae_Br4923 T-GRVAVITGANTGLGYQTALALAEHGAHVVLAVRNLDKGKDAAARITAT
MAB_0646c|M.abscessus_ATCC_199 T-GRIAIVTGANTGLGLETAKALAAHGAHVVLAVRNAEKGKAAAEAITAA
MAV_4710|M.avium_104 S-GRVVVITGANTGIGYETAAVLAHRGAHVVLAVRDLEKGNAALSRIVAA
TH_4179|M.thermoresistible__bu T-GRTAVITGANTGLGFETAKVLAEKGAHVVLAVRDPDKGRRAADRITAA
Mvan_0753|M.vanbaalenii_PYR-1 S-GRVAVVTGANSGIGYEAAAVLAGRGARVVVAVRNLDKGRQAVSRIRQL
Mflv_1940|M.gilvum_PYR-GCK A-GRTVIVTGANSGLGLVTARELARVGATTILAVRNLDKGRAAADSMSG-
MMAR_1680|M.marinum_M LRGRTAMVTGANRGLGKAIAAGLAELGATVVLTVRDRDSGQRARDEIAAA
MUL_1918|M.ulcerans_Agy99 LRGRTAMVTGANRGLGKAIAAGLAELGATVVLTVRDRDSGQRARDEIAAA
** .::**** *:* * ** ** .:::**: :.*. * :
Mb0069|M.bovis_AF2122/97 TPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAGVMYTPRQTT
Rv0068|M.tuberculosis_H37Rv TPGAEVELQELDLTSLASVRAAAAQLKSDHQRIDLLINNAGVMYTPRQTT
MSMEG_0876|M.smegmatis_MC2_155 APTADLELQQLDLGSLASVRAAADDLKGKFDRIDLLVNNAGVMWPPRQTT
MLBr_00315|M.leprae_Br4923 SAQNNVALQELDLASLESVRAAAKQLRSDYDHIDLLINNAGVMWTPKSTT
MAB_0646c|M.abscessus_ATCC_199 HSNADVTLQSLDLSSLESVRRASDELKGRYDKIDLLINNAGVMWTEKSST
MAV_4710|M.avium_104 SPNADVTLQQLDLASLASVRSAAEALRAAYPRIDLLINNAGVMWTPKQVT
TH_4179|M.thermoresistible__bu APHADVTVRQLDLTSLDNIRRAADDLRAGYPRIDLLINNAGVMYPPRQTT
Mvan_0753|M.vanbaalenii_PYR-1 HPGADVMLQELDLSSLASVRAAADDLRAAHPRIDLLINNAGVMYPPKQTT
Mflv_1940|M.gilvum_PYR-GCK ----DVEVRRLDLQDLSSVREFADGVDS----VDVLVNNAGIMAVPYALT
MMAR_1680|M.marinum_M SG-ADVRVEVCDVSSLSAVRAFATDLRTRVSRLDVLVHNAGLLPAARAET
MUL_1918|M.ulcerans_Agy99 SG-ADVRVEVCDVSSLSVVRASATDLCTRVSRLDVLVHNAGLLPAARAET
:: :. *: .* :* : : :*:*::***:: *
Mb0069|M.bovis_AF2122/97 ADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIHF
Rv0068|M.tuberculosis_H37Rv ADGFEMQFGTNHLGHFALTGLLIDRLLPVAGSRVVTISSVGHRIRAAIHF
MSMEG_0876|M.smegmatis_MC2_155 ADGFELQFGTNHLGHFALTGLLLDRMLTVPGSRVVTVSSQGHRILAAIHF
MLBr_00315|M.leprae_Br4923 KDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRVITVSSLSHRLFADIHF
MAB_0646c|M.abscessus_ATCC_199 ADGFELQFGTNHLGHYALTGLLLERLLPVEGSRVVTVSSIGHRIRADIHF
MAV_4710|M.avium_104 EDGFELQFGTNHLGHFALTGLLLDHLLGVRDSRVVTVSSLGHRLRAAIHF
TH_4179|M.thermoresistible__bu RDGFELQFGTNHLGHFALTGQLLDNILPVDGSRVVTVASIAHRNMADIHF
Mvan_0753|M.vanbaalenii_PYR-1 SDGFELQFGTNHLGHFALTGLLLDRLLPVEGSRVVSVASIAHNIQADIHF
Mflv_1940|M.gilvum_PYR-GCK ADGFESQIGTNHLGHFALTNLLLPKIS----DRVVTVSSMMH-LFGRINL
MMAR_1680|M.marinum_M VEGHEITLATHVLGPILLTELLVPMLAESDDPRVILMS-SGGMYTQPLPI
MUL_1918|M.ulcerans_Agy99 DEGHEITLATHVLGPILLTSLLVPMLAESDDPRVILMS-SGGMYTQPLPI
:*.* :.*: ** :* *: : **: :: : :
Mb0069|M.bovis_AF2122/97 DDLQWERR-YRRVAAYGQAKLANLLFTYELQRRLAP--GGTTIAVASHPG
Rv0068|M.tuberculosis_H37Rv DDLQWERR-YRRVAAYGQAKLANLLFTYELQRRLAP--GGTTIAVASHPG
MSMEG_0876|M.smegmatis_MC2_155 DDLQWERR-YNRVAAYGQSKLANLLFTYELQRRLT---GHQTTALAAHPG
MLBr_00315|M.leprae_Br4923 NDLQWECN-YNRVAAYGQSKLANLLFTYELQRRLAT--RQTTIAVAAHPG
MAB_0646c|M.abscessus_ATCC_199 DDLQWERD-YDRVAAYGQSKLANLLFTYELQRRLA---GTNTVALAAHPG
MAV_4710|M.avium_104 DDLHWERR-YDRVAAYGQSKLANLLFTYELQRRLAAAPDAKTIAVAAHPG
TH_4179|M.thermoresistible__bu DDLQWERG-YHRVAAYGQSKLANLMFAYELQRRLSAK-NAPTISVAAHPG
Mvan_0753|M.vanbaalenii_PYR-1 DDLQWERS-YNRVAAYGQSKLANLMFTYTLARRLAAK-GAPTIAVAAHPG
Mflv_1940|M.gilvum_PYR-GCK NDLNWKSRPYLAWPAYGQSKLANLLFTSELQRRLSR-AGSPVRAVAAHPG
MMAR_1680|M.marinum_M EDPEYRAGGYRGAVAYARTKRMQVAFTPLLARRWS---GERIRVYSMHPG
MUL_1918|M.ulcerans_Agy99 EDPEYRAGGYRGAVAYARTKRMQVAFTPLLARRWS---GERIRVYSMHPG
:* .:. * **.::* :: *: * ** : : ***
Mb0069|M.bovis_AF2122/97 VSNTELVRNMPRPLVAVAAILAP-LMQDAELGALPTLRAATDPAVRGGQY
Rv0068|M.tuberculosis_H37Rv VSNTEVVRNMPRPLVAVAAILAP-LMQDAELGALPTLRAATDPAVRGGQY
MSMEG_0876|M.smegmatis_MC2_155 ASNTELARHLPG---ALERLVTP-LAQDAALGALPTLRAATDPGALGGQY
MLBr_00315|M.leprae_Br4923 GSRTELTRTLPALIAPIFSVAELFLTQDAATGALPTLRAATDAAVLGGQY
MAB_0646c|M.abscessus_ATCC_199 GSNTELARNSPLWVRAVFDVVAPVLVQGADMGALPTLRAATDPAALGGQY
MAV_4710|M.avium_104 GSNTELARHLPGIFRPVQAVLGPVLFQSPAMGALPTLRAATDPAVQGAQY
TH_4179|M.thermoresistible__bu VSNTELTRYIPGARLPGVSLLAGLLTNSPAVGALATLRAATDPEVKGGQY
Mvan_0753|M.vanbaalenii_PYR-1 ISNTELMRHIPGSQLPGFAWLAGLVTNSPAVGSLATLRAATDPGVRGGQY
Mflv_1940|M.gilvum_PYR-GCK YSATNLQGHSGNPLGEKIARAGNRMATDADFGARQTLYAVAR-DVAGDSF
MMAR_1680|M.marinum_M WADTPG---VATSLPGFRAVTGPLLRTAEQGADTAVWLAATRPAPLSGTF
MUL_1918|M.ulcerans_Agy99 WADTPG---VATSLPGFRAVIGPLLRTAEQGADTAVWLAATRPAPLSGTF
: * : . . *.: . :
Mb0069|M.bovis_AF2122/97 FGPDGFGEIRGYPKVVASSAQSHDEQLQRRLWAVSEELTGVVYPVG----
Rv0068|M.tuberculosis_H37Rv FGPDGFGEIRGYPKVVASSAQSHDEQLQRRLWAVSEELTGVVYPVG----
MSMEG_0876|M.smegmatis_MC2_155 FGPDGIGETRGYPKVVASSAQSHDADLQRRLWAVSEELTGVTFPVGEALQ
MLBr_00315|M.leprae_Br4923 FGPDGFAEIRGHPKVVASNGKSHDVDRQLRLWAVSEELTGVVYPVG----
MAB_0646c|M.abscessus_ATCC_199 YGPDGFMEQRGNPKVVASSEQSYNLDLQRRLWSVSEELTDVVFPVK----
MAV_4710|M.avium_104 YGPDGFLEQRGRPKLVESSAQSHDEQLQRRLWAVSEELTGVHFPV-----
TH_4179|M.thermoresistible__bu YGPDGFQEIRGHPVLVGSSAKSRDEDIQRRLWTVSEELTGVTFPV-----
Mvan_0753|M.vanbaalenii_PYR-1 YGPSGVRELVGHPVLVQSNRKSHDVDVQERLWTVSEELTGVSYDL-----
Mflv_1940|M.gilvum_PYR-GCK IGPR--FTMFGPTVTTWRSPLARNRTTAAQLWTLSEQLTGVEFPL-----
MMAR_1680|M.marinum_M WHDRRTRPEHYLPWTRFSD------DDRQRLWRYCADAIGID--------
MUL_1918|M.ulcerans_Agy99 WHDRRTRPEHYLPWTRYSD------DDRQRLWRYCADAIGID--------
. . :** . : .:
Mb0069|M.bovis_AF2122/97 --
Rv0068|M.tuberculosis_H37Rv --
MSMEG_0876|M.smegmatis_MC2_155 QA
MLBr_00315|M.leprae_Br4923 --
MAB_0646c|M.abscessus_ATCC_199 --
MAV_4710|M.avium_104 --
TH_4179|M.thermoresistible__bu --
Mvan_0753|M.vanbaalenii_PYR-1 --
Mflv_1940|M.gilvum_PYR-GCK --
MMAR_1680|M.marinum_M --
MUL_1918|M.ulcerans_Agy99 --