For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDPARGRAAMEELGEPNRCSVLEVDLASVRSVRS FVETVRTTPLPPIRALVCNAGLQVVSGIAFTDDGVEMTFGVNHLGHFALVTGILDWLARPARIVVVSSGT HDPSKHTGMPDPRYTCAADLAHPPTDQNTPAEGRRRYTTSKLCNVLFTYELDRRLDHGEQGVMVNAFDPG LMPGSGLARDYPPILRLAYRLLSPMLRVLPFVHSTRVSGEHLAALAVDPRFAGVTGQYFAGAKAIRSSAE SYDRAKALDLWETSERLLAQVT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0303 | - | - | 100% (302) | PROBABLE DEHYDROGENASE/REDUCTASE |
| M. tuberculosis H37Rv | Rv0439c | - | 1e-26 | 33.01% (309) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0068 | - | 2e-25 | 33.65% (315) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0311 | - | 1e-175 | 100.00% (302) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_0143 | - | 2e-26 | 36.07% (305) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 3e-26 | 33.55% (310) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0643 | - | 2e-27 | 33.76% (311) | short chain dehydrogenase |
| M. marinum M | MMAR_0757 | - | 8e-29 | 35.62% (306) | dehydrogenase/reductase |
| M. avium 104 | MAV_4710 | - | 5e-29 | 36.27% (306) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0876 | - | 3e-24 | 36.27% (306) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4179 | - | 1e-25 | 35.60% (309) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1391 | - | 7e-29 | 35.62% (306) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0762 | - | 7e-27 | 34.87% (304) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0757|M.marinum_M MSANGKAKSHWS---ASDIPDQSGRVVVVTGANTGLGYHTAEALAGRGA-
MUL_1391|M.ulcerans_Agy99 MSAKGKAKSHWS---ASDIPDQSGRVVVVTGANTGLGYHTAEALADRGA-
MAV_4710|M.avium_104 MAPHDKRHRDWS---EADVGDQSGRVVVITGANTGIGYETAAVLAHRGA-
TH_4179|M.thermoresistible__bu ------MTGKWT---ARDVPDQTGRTAVITGANTGLGFETAKVLAEKGA-
Mflv_0143|M.gilvum_PYR-GCK -------MTDWTNWNVADIPDQTGRTAVITGANTGLGFETAKALAEKGA-
Mvan_0762|M.vanbaalenii_PYR-1 -------MTDWT---TADIPDQTGRTAVITGANTGLGFETAKALAAGGA-
MAB_0643|M.abscessus_ATCC_1997 ------MTVHWT---TADIPDQTGRVAVVTGANTGLGLETARALAAAGA-
MSMEG_0876|M.smegmatis_MC2_155 -------MTKWT---TARIPDQTGRVAIVTGANTGLGLETAKALAAKGA-
MLBr_00315|M.leprae_Br4923 -------MAKWT---TADIPDQTGRVAVITGANTGLGYQTALALAEHGA-
Rv0303|M.tuberculosis_H37Rv ---------------------MNTGTAVITGASSGLGLQCARALLRRDAS
Mb0311|M.bovis_AF2122/97 ---------------------MNTGTAVITGASSGLGLQCARALLRRDAS
. ..::***.:*:* . * .* .*
MMAR_0757|M.marinum_M -HVVLAVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALR
MUL_1391|M.ulcerans_Agy99 -HVVLAVRNPEKGNAAVAQIVAAKPQADVTLQALDLSSLDSVRSAADALR
MAV_4710|M.avium_104 -HVVLAVRDLEKGNAALSRIVAASPNADVTLQQLDLASLASVRSAAEALR
TH_4179|M.thermoresistible__bu -HVVLAVRDPDKGRRAADRITAAAPHADVTVRQLDLTSLDNIRRAADDLR
Mflv_0143|M.gilvum_PYR-GCK -RVVIAVRNTDKGAQAAARIRG-----DVDVQELDLTSLSSIRTAAEALK
Mvan_0762|M.vanbaalenii_PYR-1 -RVVLAVRDTEKGAQAAAKMAG-----DVDVQQLDLTSLASIRSAADALK
MAB_0643|M.abscessus_ATCC_1997 -QVVLAVRDPDKGAAAADDITKGAAGSNLALQRLDLSSLSDIRSAARQLG
MSMEG_0876|M.smegmatis_MC2_155 -HVVLAVRNLDKGKAAVDWIARSAPTADLELQQLDLGSLASVRAAADDLK
MLBr_00315|M.leprae_Br4923 -HVVLAVRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLR
Rv0303|M.tuberculosis_H37Rv WHVVLAVRDPARGRAAMEELGEP---NRCSVLEVDLASVRSVRSFVETVR
Mb0311|M.bovis_AF2122/97 WHVVLAVRDPARGRAAMEELGEP---NRCSVLEVDLASVRSVRSFVETVR
:**:***: :* * : : :** *: .:* . :
MMAR_0757|M.marinum_M SA-YPRIDLLINNAGVMWTP-KQVTKDGFEMQFGTNHLGHFALTGLLLDH
MUL_1391|M.ulcerans_Agy99 SA-YPRIDLLINNAGVMWTP-KQVTKDGFEMQFGTNHLGHFALTGLLLDH
MAV_4710|M.avium_104 AA-YPRIDLLINNAGVMWTP-KQVTEDGFELQFGTNHLGHFALTGLLLDH
TH_4179|M.thermoresistible__bu AG-YPRIDLLINNAGVMYPP-RQTTRDGFELQFGTNHLGHFALTGQLLDN
Mflv_0143|M.gilvum_PYR-GCK AR-FDKIDLLINNAGVMTTP-KGTTADGFELQFGTNHLGHFALTGLLFDN
Mvan_0762|M.vanbaalenii_PYR-1 SR-FDHIDLLINNAGVMTTP-KGTTADGFELQFGTNHLGHFAFTGLLLDK
MAB_0643|M.abscessus_ATCC_1997 AD-YPRIDLLINNAGVMYPP-KSLTADGFELQFGTNHLGHFALTGLLLEN
MSMEG_0876|M.smegmatis_MC2_155 GK-FDRIDLLVNNAGVMWPP-RQTTADGFELQFGTNHLGHFALTGLLLDR
MLBr_00315|M.leprae_Br4923 SD-YDHIDLLINNAGVMWTP-KSTTKDGFELQFGTNHLGHFAFTGLLLDR
Rv0303|M.tuberculosis_H37Rv TTPLPPIRALVCNAGLQVVSGIAFTDDGVEMTFGVNHLGHFALVTGILDW
Mb0311|M.bovis_AF2122/97 TTPLPPIRALVCNAGLQVVSGIAFTDDGVEMTFGVNHLGHFALVTGILDW
* *: ***: . * **.*: **.*******:. :::
MMAR_0757|M.marinum_M LLPVPGSRVITVSSLGHRIRAAIHFDDLQWERSYNRVA------------
MUL_1391|M.ulcerans_Agy99 LLPVPGSRVITVSSLGHRIRAAIHFDDLQWERSYNRVA------------
MAV_4710|M.avium_104 LLGVRDSRVVTVSSLGHRLRAAIHFDDLHWERRYDRVA------------
TH_4179|M.thermoresistible__bu ILPVDGSRVVTVASIAHRNMADIHFDDLQWERGYHRVA------------
Mflv_0143|M.gilvum_PYR-GCK ILDIPGSRIVTVSSNGHKMGGAIHWDDLQWERSYNRMG------------
Mvan_0762|M.vanbaalenii_PYR-1 LLDVDGARIVTVSSNGHKMGGAIHWDDLQWERSYSRMG------------
MAB_0643|M.abscessus_ATCC_1997 LTAVPDSRVVIVSSNGHKFRAAIHFDDLQWERGYSRVG------------
MSMEG_0876|M.smegmatis_MC2_155 MLTVPGSRVVTVSSQGHRILAAIHFDDLQWERRYNRVA------------
MLBr_00315|M.leprae_Br4923 LLPIVGSRVITVSSLSHRLFADIHFNDLQWECNYNRVA------------
Rv0303|M.tuberculosis_H37Rv LARP--ARIVVVSSGTHDPSKHTGMPDPRYTCAADLAHPPTDQNTPAEGR
Mb0311|M.bovis_AF2122/97 LARP--ARIVVVSSGTHDPSKHTGMPDPRYTCAADLAHPPTDQNTPAEGR
: :*:: *:* * * ::
MMAR_0757|M.marinum_M -AYGQSKLANLLFTYELQRRLAADSQAATIAVAAHPGGSNTELARNLPRM
MUL_1391|M.ulcerans_Agy99 -AYGQSKLANLLFTYELQRRLAADSQAATIAVAAHPGDSNTELARNLPRM
MAV_4710|M.avium_104 -AYGQSKLANLLFTYELQRRLAAAPDAKTIAVAAHPGGSNTELARHLPGI
TH_4179|M.thermoresistible__bu -AYGQSKLANLMFAYELQRRLSAK-NAPTISVAAHPGVSNTELTRYIPGA
Mflv_0143|M.gilvum_PYR-GCK -AYTQSKLANLLFTYELQRRLAP--RGKTIAVAAHPGTSTTELARNLPRP
Mvan_0762|M.vanbaalenii_PYR-1 -AYSQSKLANLLFTYELQRRLAP--RGKTIAVAAHPGTSSTELGRNLPAA
MAB_0643|M.abscessus_ATCC_1997 -AYAQSKLANLLFTYELQRRLQAA-GAETVALAAHPGASGTELMRHIT--
MSMEG_0876|M.smegmatis_MC2_155 -AYGQSKLANLLFTYELQRRLT---GHQTTALAAHPGASNTELARHL---
MLBr_00315|M.leprae_Br4923 -AYGQSKLANLLFTYELQRRLAT--RQTTIAVAAHPGGSRTELTRTLPAL
Rv0303|M.tuberculosis_H37Rv RRYTTSKLCNVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLARDYPPI
Mb0311|M.bovis_AF2122/97 RRYTTSKLCNVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLARDYPPI
* ***.*::*:***:*** . : * *
MMAR_0757|M.marinum_M LVPLANILGP-ALFQSAQMGALPTLRAATDPSVAGGQYYGPDGFAEQRGH
MUL_1391|M.ulcerans_Agy99 LVPLANILGP-ALFQSAQMGALPTLRTATDPSAAGGQYYGPDGFAEQRGH
MAV_4710|M.avium_104 FRPVQAVLGP-VLFQSPAMGALPTLRAATDPAVQGAQYYGPDGFLEQRGR
TH_4179|M.thermoresistible__bu RLPGVSLLAG-LLTNSPAVGALATLRAATDPEVKGGQYYGPDGFQEIRGH
Mflv_0143|M.gilvum_PYR-GCK VERAFLAAAPVLFAQTADRGALPTLRAAADPGVLGGQYYGPDGLGQQRGA
Mvan_0762|M.vanbaalenii_PYR-1 LQPALNRLAP-LLAQSPAAGALPTLRAATDPSVLGGQYYGPDGIGQQRGN
MAB_0643|M.abscessus_ATCC_1997 FGPEALTAAALKIAQSPAMGALPSLRAATDPAAQGGQYYGPSGFGEFRGY
MSMEG_0876|M.smegmatis_MC2_155 --PGALERLVTPLAQDAALGALPTLRAATDPGALGGQYFGPDGIGETRGY
MLBr_00315|M.leprae_Br4923 IAPIFSVAEL-FLTQDAATGALPTLRAATDAAVLGGQYFGPDGFAEIRGH
Rv0303|M.tuberculosis_H37Rv LRLAYRLLSP-MLRVLPFVHSTRVSGEHLAALAVDPRFAGVTG--QYFAG
Mb0311|M.bovis_AF2122/97 LRLAYRLLSP-MLRVLPFVHSTRVSGEHLAALAVDPRFAGVTG--QYFAG
: . : . . . :: * * : .
MMAR_0757|M.marinum_M PKIVQSSAQSHDEDLQRRLWTVSEELTGVSFPV-------
MUL_1391|M.ulcerans_Agy99 PKIVQSSAQSHDEDLQRRLWTVSEELTGVSFPV-------
MAV_4710|M.avium_104 PKLVESSAQSHDEQLQRRLWAVSEELTGVHFPV-------
TH_4179|M.thermoresistible__bu PVLVGSSAKSRDEDIQRRLWTVSEELTGVTFPV-------
Mflv_0143|M.gilvum_PYR-GCK PVVVASSAQSYDVDQQRRLWEISEELTKVTFPDL------
Mvan_0762|M.vanbaalenii_PYR-1 PVVVASSNQSYDMALQRRLWTVSEELTGVTFPVPVLS---
MAB_0643|M.abscessus_ATCC_1997 PKVVRSSKQSHDKVLQQRLWSVSEELTGVRFPV-------
MSMEG_0876|M.smegmatis_MC2_155 PKVVASSAQSHDADLQRRLWAVSEELTGVTFPVGEALQQA
MLBr_00315|M.leprae_Br4923 PKVVASNGKSHDVDRQLRLWAVSEELTGVVYPVG------
Rv0303|M.tuberculosis_H37Rv AKAIRSSAESYDRAKALDLWETSERLLAQVT---------
Mb0311|M.bovis_AF2122/97 AKAIRSSAESYDRAKALDLWETSERLLAQVT---------
. : *. :* * ** **.*