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VTEFTVVMTGATAGLGAYAAKLLAEQPNTRVIAGARGSGRDVPGAQVLPLDLASLDSVTQFADEVKNELG QTPIDVLVLNAGIQFRDTNHRTVDGFETTFTVNHLAHYLLARLLVPSIADGGRLVITTSDTHDPEIIPFG PRALDPAHLAHPESGGAIAGLRAYAGSKLCNLLTARSFAASDEIVRRRIDVVAYNPGLTLGTNLVGASMS GRVVTGALRPVLRLLSAARPAFYPGRVETAGEALADLSIGAVKPPEGRLYASLVKGQLTFPDPAPLARDD RAADGLWRASAAMVGI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0717 | - | - | 100% (296) | dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_1144c | - | 2e-16 | 30.03% (303) | short-chain dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_3966c | - | 4e-14 | 29.44% (214) | dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0311 | - | 1e-22 | 34.48% (261) | dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_1940 | - | 3e-17 | 30.94% (307) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0303 | - | 1e-22 | 34.48% (261) | dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00315 | - | 3e-11 | 29.61% (206) | short chain dehydrogenase |
| M. marinum M | MMAR_3998 | - | 9e-14 | 32.22% (180) | short chain dehydrogenase |
| M. avium 104 | MAV_1153 | - | 7e-17 | 33.73% (255) | retinol dehydrogenase 13 |
| M. smegmatis MC2 155 | MSMEG_5430 | - | 2e-17 | 32.90% (310) | retinol dehydrogenase 13 |
| M. thermoresistible (build 8) | TH_3199 | - | 5e-18 | 32.89% (298) | PUTATIVE retinol dehydrogenase 13 |
| M. ulcerans Agy99 | MUL_1288 | - | 3e-13 | 30.14% (219) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4786 | - | 4e-17 | 31.80% (305) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1940|M.gilvum_PYR-GCK MSDWTAADLPSFAGRTVIVTGANSGLGLVTARELARVGA--TTILAVRNL
Mvan_4786|M.vanbaalenii_PYR-1 MSDWTAADLPSFAGRTVIVTGANSGLGLITARELARVGA--RTILAVRNL
MSMEG_5430|M.smegmatis_MC2_155 MTQWTSADLPSFRGRTVVITGANSGLGLVTARELARVGA--KVIVAVRNL
TH_3199|M.thermoresistible__bu --MWTAADLPSFSDRTVIVTGANSGLGLVTARELARVGA--RVIIAVRNT
MAV_1153|M.avium_104 MTGWTAADLPSFAQRTVVITGANSGLGAVTARELARRGA--TVIMAVRDT
MLBr_00315|M.leprae_Br4923 MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGA--HVVLAVRNL
MUL_1288|M.ulcerans_Agy99 MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGA--DVVMAIRNR
Mb0311|M.bovis_AF2122/97 -----------MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDP
Rv0303|M.tuberculosis_H37Rv -----------MNTGTAVITGASSGLGLQCARALLRRDASWHVVLAVRDP
MMAR_3998|M.marinum_M -----------MTGKTIVITGASDGIGAAAARRLTQNGE--KVVVVGRSE
MAB_0717|M.abscessus_ATCC_1997 -----------MTEFTVVMTGATAGLGAYAAKLLAEQPN-------TRVI
::***. *:* * * *
Mflv_1940|M.gilvum_PYR-GCK DKGRAAADSMSG-----DVEVRRLDLQDLSSVREFADGVD------SVDV
Mvan_4786|M.vanbaalenii_PYR-1 DKGNTAAATMTG-----DVEVRSLDLQNLASVRAFADGVD------SVDV
MSMEG_5430|M.smegmatis_MC2_155 DKGTAAAETMPG----GIVEVRKLDLQDLASVHEFADTVE------TVDV
TH_3199|M.thermoresistible__bu TKGEAAAEQMTGPG-HGPVEVRALDLQNLASVREFAAGVEG-----DVDV
MAV_1153|M.avium_104 RKGEAAARTMAG-----QVEVRELDLQDLSSVRRFADGVS------GADV
MLBr_00315|M.leprae_Br4923 DKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSD--YDHIDL
MUL_1288|M.ulcerans_Agy99 AKGEAAIEEIRSAVPDAKLSTKALDLSSLASVAALGDQLNSE--GRPIDI
Mb0311|M.bovis_AF2122/97 ARGRAAMEELGEPN---RCSVLEVDLASVRSVRSFVETVRTTP-LPPIRA
Rv0303|M.tuberculosis_H37Rv ARGRAAMEELGEPN---RCSVLEVDLASVRSVRSFVETVRTTP-LPPIRA
MMAR_3998|M.marinum_M SKTTAVAAQLRA-------DYFVADFADLSQVRALADKIRS-E-YPRIDV
MAB_0717|M.abscessus_ATCC_1997 AGARGSGRDVPG------AQVLPLDLASLDSVTQFADEVKNELGQTPIDV
: *: .: .* :
Mflv_1940|M.gilvum_PYR-GCK LVNNAGIMAVP-YALTADGFESQIGTNHLGHFALTNLLLPKIS----DRV
Mvan_4786|M.vanbaalenii_PYR-1 LVNNAGIMAVP-YAQTVDGFESQIGTNHLGHFALTNLLLPKIS----DRV
MSMEG_5430|M.smegmatis_MC2_155 LVNNAGIMAVP-LARTVDGFESQIGTNHLGHFALTNLLLPKIS----DRV
TH_3199|M.thermoresistible__bu LVNNAGIMAVP-LARTVDGFESQIGTNHLGHFALTNLLLPQIT----DRV
MAV_1153|M.avium_104 LINNAGIMAVP-YALTVDGFESQIGTNHLGHFALTNLLLPRLT----DRV
MLBr_00315|M.leprae_Br4923 LINNAGVMWTP-KSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVGSRV
MUL_1288|M.ulcerans_Agy99 LINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQGARV
Mb0311|M.bovis_AF2122/97 LVCNAGLQVVSGIAFTDDGVEMTFGVNHLGHFALVTGILDWLAR--PARI
Rv0303|M.tuberculosis_H37Rv LVCNAGLQVVSGIAFTDDGVEMTFGVNHLGHFALVTGILDWLAR--PARI
MMAR_3998|M.marinum_M LANNAGAMCHE-IQFTADGYEKTYQVNYLSPFLLTTLLLDVLVQS-RATV
MAB_0717|M.abscessus_ATCC_1997 LVLNAGIQFRDTNHRTVDGFETTFTVNHLAHYLLARLLVPSIAD--GGRL
* *** * ** * *:*. : :. :: : :
Mflv_1940|M.gilvum_PYR-GCK VTVSSMMHLF-GRINLNDLNWKSRPYLAWPAYGQ------------SKLA
Mvan_4786|M.vanbaalenii_PYR-1 VTVSSMMHLM-GRVNLKDLNWKSRPYLAWPAYGQ------------SKLA
MSMEG_5430|M.smegmatis_MC2_155 VTVSSMMHWI-GRINLRDLNWKARPYSAWLAYGQ------------SKLA
TH_3199|M.thermoresistible__bu VTVSSLMHWF-GYLSLNDLNWKARPYSAWLAYAQ------------SKLA
MAV_1153|M.avium_104 VTVSSMAHWP-GRINLEDLNWRSRRYSPWLAYSQ------------SKLA
MLBr_00315|M.leprae_Br4923 ITVSSLSHRLFADIHFNDLQWECN-YNRVAAYGQ------------SKLA
MUL_1288|M.ulcerans_Agy99 VSLSSLAARR-GRIHFDDLQFEKS-YAAMTAYGQ------------SKLA
Mb0311|M.bovis_AF2122/97 VVVSSGTHDPSKHTGMPDPRYTCAADLAHPPTDQNTPAEGRRRYTTSKLC
Rv0303|M.tuberculosis_H37Rv VVVSSGTHDPSKHTGMPDPRYTCAADLAHPPTDQNTPAEGRRRYTTSKLC
MMAR_3998|M.marinum_M VNTTSSSQRLLPKVTLAELESTAQRRPSVAYALT-------------KLA
MAB_0717|M.abscessus_ATCC_1997 VITTSDTHDP-EIIPFGPRALDPAHLAHPESGGAIAG---LRAYAGSKLC
: :* : **.
Mflv_1940|M.gilvum_PYR-GCK NLLFTSELQRRLSRAGSPVRAVAAHPGYSATNLQG---HSGNPLGEKIAR
Mvan_4786|M.vanbaalenii_PYR-1 NLLFTGELQRRLAAAGSPVRAVAAHPGYSATNLQG---HSGNPLGEKIAR
MSMEG_5430|M.smegmatis_MC2_155 NLMFTSELQRRLVASGSSVRALAAHPGYSATNLQG---HSGNRFGTAAAA
TH_3199|M.thermoresistible__bu NLLFTSELQRRLDTVGSPVRAVAAHPGYSSTNLQG---HTGRRFGDALAR
MAV_1153|M.avium_104 NLLFTSELQRRLTAAGSPLRALAAHPGYSHTNLQG---ASGRKLGDALMS
MLBr_00315|M.leprae_Br4923 NLLFTYELQRR-LATRQTTIAVAAHPGGSRTELT-------RTLPALIAP
MUL_1288|M.ulcerans_Agy99 VLMFARELDRRSRAAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQR
Mb0311|M.bovis_AF2122/97 NVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLA------RDYPPILRL
Rv0303|M.tuberculosis_H37Rv NVLFTYELDRRLDHGEQGVMVNAFDPGLMPGSGLA------RDYPPILRL
MMAR_3998|M.marinum_M IVLFTRELHRRYHAKG--LSAATFHPGYVDSNFGEAS---GSRALAFMKY
MAB_0717|M.abscessus_ATCC_1997 NLLTARSFAASDEIVRRRIDVVAYNPGLTLGTNLVGASMSGRVVTGALRP
:: : .: : .**
Mflv_1940|M.gilvum_PYR-GCK AGNR-------MATDADFGARQTLYAVAR-DVAGDSFIGPR--FTMFG--
Mvan_4786|M.vanbaalenii_PYR-1 AGNR-------IATDADFGARQTLYAVAA-DIPGDSFIGPR--FSMFG--
MSMEG_5430|M.smegmatis_MC2_155 LGNRH------LATDVTFGARQTLYAVSQ-DLPGDTFVGPR--FGQWG--
TH_3199|M.thermoresistible__bu IGNRY------LATDAEFGARQTLYAVAR-DVPGDSFIGPR--FAMHG--
MAV_1153|M.avium_104 AATRV------VATDADFGARQTLYAASQ-DLTGDTFVGPR--FGYLG--
MLBr_00315|M.leprae_Br4923 IFSVA---ELFLTQDAATGALPTLRAATDAAVLGGQYFGPDGFAEIRG--
MUL_1288|M.ulcerans_Agy99 FYTTSWRFAPFLWQEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGG
Mb0311|M.bovis_AF2122/97 AYRLLSP----MLRVLPFVHSTRVSGEHLAALAVDPRFAGVTGQYFAG--
Rv0303|M.tuberculosis_H37Rv AYRLLSP----MLRVLPFVHSTRVSGEHLAALAVDPRFAGVTGQYFAG--
MMAR_3998|M.marinum_M HVPLVAR----LTSTAEQGAEQLVWLASS---AAGTDWTSG---EYYS--
MAB_0717|M.abscessus_ATCC_1997 VLRLLS-----AARPAFYPGRVETAGEALADLSIGAVKPPEG-RLYASLV
. .
Mflv_1940|M.gilvum_PYR-GCK --PTVTTWRSPLARNRTTAAQLWTLSEQLTGVEFPL--
Mvan_4786|M.vanbaalenii_PYR-1 --PTVATWRSPLARDRGKAAGLWTLSEQLTGTEFPL--
MSMEG_5430|M.smegmatis_MC2_155 --PTGSVGRSPLARRTDTQRALWELSEQLTGTTYPL--
TH_3199|M.thermoresistible__bu --PTEQVGRSPLARSAGTARALWELSEQLTDTKFPL--
MAV_1153|M.avium_104 --RTQPVGRSRRAKDAGMAAALWALSEQLTKTEFPL--
MLBr_00315|M.leprae_Br4923 --HPKVVASNGKSHDVDRQLRLWAVSEELTGVVYPVG-
MUL_1288|M.ulcerans_Agy99 VRAAKVPARAGNDADCQR---LWEVSERLTGVGYPTSS
Mb0311|M.bovis_AF2122/97 ---AKAIRSSAESYDRAKALDLWETSERLLAQVT----
Rv0303|M.tuberculosis_H37Rv ---AKAIRSSAESYDRAKALDLWETSERLLAQVT----
MMAR_3998|M.marinum_M --RHKIAKANRAAYDPRLASELWDRTLAKLR-------
MAB_0717|M.abscessus_ATCC_1997 KGQLTFPDPAPLARDDRAADGLWRASAAMVGI------
** :