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TIPWTPDRLGDLTGKRVIVTGATNGVGLGTARALAKAGAEVILAVRNTELGKQRAAQMGGSTAVEKLDLA DLSSVRAFADRIEAPVDILINNAGALTDRRTETVDGFEMTLGTNLLGPFALTNLLLPKVRSQIINVGSDA HRSATLHLDDLHLRRHKWTRLGAYAQSKLAVMLWGLELDRRLRAAGSPIVTQLTHPGWVASNLSNLGDAP LKAAAHKAVKMVADRLANDIDEGAAPTLYCISEPIPPGSYVGVSGRFGLRGGPVLIGRTPLACDYDTAAR LVAFAERETGTELRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3824 | - | - | 100% (296) | dehydrogenase |
| M. avium 104 | MAV_1153 | - | 5e-55 | 44.22% (294) | retinol dehydrogenase 13 |
| M. avium 104 | MAV_4124 | - | 4e-54 | 44.41% (295) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2286 | - | 9e-47 | 39.87% (301) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2288 | - | 1e-113 | 67.12% (292) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2263 | - | 9e-47 | 39.87% (301) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00315 | - | 6e-42 | 38.54% (301) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1144c | - | 1e-65 | 47.24% (290) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3355 | - | 2e-43 | 37.54% (301) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_6557 | - | 1e-121 | 73.15% (298) | dehydrogenase |
| M. thermoresistible (build 8) | TH_3199 | - | 7e-54 | 42.47% (299) | PUTATIVE retinol dehydrogenase 13 |
| M. ulcerans Agy99 | MUL_1288 | - | 3e-43 | 37.54% (301) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4378 | - | 1e-114 | 67.35% (294) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3355|M.marinum_M ------MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGADVVMA
MUL_1288|M.ulcerans_Agy99 ------MASDLIATVPDLSGKLAIVTGANSGLGFGLARRLSAAGADVVMA
Mb2286|M.bovis_AF2122/97 ------MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMA
Rv2263|M.tuberculosis_H37Rv ------MAKDLVATVPDLSGKLAIITGANSGLGFGLARRLSAAGADVIMA
MLBr_00315|M.leprae_Br4923 ------MAKWTTADIPDQTGRVAVITGANTGLGYQTALALAEHGAHVVLA
MAB_1144c|M.abscessus_ATCC_199 --MSKSTATWSAAKLPSFEGRTVIITGANSGLGLETARELARVGAHVIMA
TH_3199|M.thermoresistible__bu --------MWTAADLPSFSDRTVIVTGANSGLGLVTARELARVGARVIIA
MAV_3824|M.avium_104 -----MTIPWTPDRLGDLTGKRVIVTGATNGVGLGTARALAKAGAEVILA
MSMEG_6557|M.smegmatis_MC2_155 -----MTSTWSPDRLGDLGDKRIIVTGATNGVGLGTTRALVRAGAHVILA
Mflv_2288|M.gilvum_PYR-GCK MASTRTAATWTPARLGDMSGQRIIVTGATNGVGLATATALARAGAQVILA
Mvan_4378|M.vanbaalenii_PYR-1 -----MATMWSPARLGDMSGQRIIVTGATNGVGLATATALARAGAHVILA
: . .: ::***..*:* : * ** *::*
MMAR_3355|M.marinum_M IRNRAKGEAAIEEIRSAVPDAKLSIKALDLSSLASVAALGDQLNSEG-RP
MUL_1288|M.ulcerans_Agy99 IRNRAKGEAAIEEIRSAVPDAKLSTKALDLSSLASVAALGDQLNSEG-RP
Mb2286|M.bovis_AF2122/97 IRNRAKGEAAVEEIRTAVPDAKLTIKALDLSSLASVAALGEQLMADG-RP
Rv2263|M.tuberculosis_H37Rv IRNRAKGEAAVEEIRTAVPDAKLTIKALDLSSLASVAALGEQLMADG-RP
MLBr_00315|M.leprae_Br4923 VRNLDKGKDAAARITATSAQNNVALQELDLASLESVRAAAKQLRSDY-DH
MAB_1144c|M.abscessus_ATCC_199 VRNTEKGNAAQASIKG-----STEVRQVDVADLASVRAFADTVEG-----
TH_3199|M.thermoresistible__bu VRNTTKGEAAAEQMTGPG-HGPVEVRALDLQNLASVREFAAGVEGD----
MAV_3824|M.avium_104 VRNTELGKQRAAQMGG-----STAVEKLDLADLSSVRAFADRIEAP----
MSMEG_6557|M.smegmatis_MC2_155 VRNTDLGARRAAEVGG-----TTTVVEVDLADMSSVRAFPGRLTAAGIDD
Mflv_2288|M.gilvum_PYR-GCK VRNLELGAQRAAEMGG-----DTSVVELDLADQSSVRAFPSLFDGD----
Mvan_4378|M.vanbaalenii_PYR-1 VRNLELGAQRAAEMGG-----DTSVVKLDLADQSSVRAFPGLVDGD----
:** * : :*: . ** . .
MMAR_3355|M.marinum_M IDILINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQG
MUL_1288|M.ulcerans_Agy99 IDILINNAGVMTPPERDTTADGFELQFGSNHLGHFALTAHVLPLLRAAQG
Mb2286|M.bovis_AF2122/97 IDLLINNAGVMTPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRAAQR
Rv2263|M.tuberculosis_H37Rv IDLLINNAGVMTPPERVTTADGFELQFGSNHLGHFALTAHLLPLLRAAQR
MLBr_00315|M.leprae_Br4923 IDLLINNAGVMWTP-KSTTKDGFELQFGTNHLGHFAFTGLLLDRLLPIVG
MAB_1144c|M.abscessus_ATCC_199 ADILVNNAGIMMVP-PAKTVDGFESQIGTNHLGAFALTNLLLPKLT----
TH_3199|M.thermoresistible__bu VDVLVNNAGIMAVP-LARTVDGFESQIGTNHLGHFALTNLLLPQIT----
MAV_3824|M.avium_104 VDILINNAGALTDR-RTETVDGFEMTLGTNLLGPFALTNLLLPKVR----
MSMEG_6557|M.smegmatis_MC2_155 VDILINNAGALTQR-RTETVDGFETTLGTNLLGPFALTNLLLGRVR----
Mflv_2288|M.gilvum_PYR-GCK VDVLINNAGAVAQH-RTDTVDGFENTLGTNFLGPFALTNLLYGRVR----
Mvan_4378|M.vanbaalenii_PYR-1 VDVLINNAGQVAQH-RSDTVDGFEITLGTNFLGPFALTNLMFGRVR----
*:*:**** : * **** :*:* ** **:* : :
MMAR_3355|M.marinum_M ARVVSLSSLAARR-GRIHFDDLQFEKS-YAAMTAYGQSKLAVLMFARELD
MUL_1288|M.ulcerans_Agy99 ARVVSLSSLAARR-GRIHFDDLQFEKS-YAAMTAYGQSKLAVLMFARELD
Mb2286|M.bovis_AF2122/97 ARVVSLSSLAARR-GRIHFDDLQFERS-YAPMTAYGQSKLAVLMFARELD
Rv2263|M.tuberculosis_H37Rv ARVVSLSSLAARR-GRIHFDDLQFERS-YAPMTAYGQSKLAVLMFARELD
MLBr_00315|M.leprae_Br4923 SRVITVSSLSHRLFADIHFNDLQWECN-YNRVAAYGQSKLANLLFTYELQ
MAB_1144c|M.abscessus_ATCC_199 DRVIAVSSVAHRA-GKIDLTDLNYERRRYTRAGAYGASKLANLLFTKELQ
TH_3199|M.thermoresistible__bu DRVVTVSSLMHWF-GYLSLNDLNWKARPYSAWLAYAQSKLANLLFTSELQ
MAV_3824|M.avium_104 SQIINVGSDAHRS-ATLHLDDLHLRRHKWTRLGAYAQSKLAVMLWGLELD
MSMEG_6557|M.smegmatis_MC2_155 SQVIIVGSDAHRM-ATLRLDDMHLRRNRWTPLGAYGRAKLAVMLWGLELD
Mflv_2288|M.gilvum_PYR-GCK SKIVNVGSDAHKT-ASINFDDPHLRTDKWSPFPAYARSKLAVMLWGLELD
Mvan_4378|M.vanbaalenii_PYR-1 SKIVNVGSDAHKS-ASLAFDDLHLRSRRWSSFPAYARSKLAVMLWGLELD
::: :.* . : : * : . : **. :*** ::: **:
MMAR_3355|M.marinum_M RRSRAAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQRFYTTSWRFA
MUL_1288|M.ulcerans_Agy99 RRSRAAGWGVMSNAAHPGLTKTNLQISGPSHGREKPALMQRFYTTSWRFA
Mb2286|M.bovis_AF2122/97 RRSRAAGWGIISNAAHPGLTKTNLQIAGPSHGRDKPALMERLYKTSWRFA
Rv2263|M.tuberculosis_H37Rv RRSRAAGWGIISNAAHPGLTKTNLQIAGPSHGRDKPALMERLYKTSWRFA
MLBr_00315|M.leprae_Br4923 RR-LATRQTTIAVAAHPGGSRTELT-------RTLPALIAPIFSVA---E
MAB_1144c|M.abscessus_ATCC_199 RRLSAAGSPVRALTVHPGVAATELQS------HSGNPIFELALKTGN---
TH_3199|M.thermoresistible__bu RRLDTVGSPVRAVAAHPGYSSTNLQG------HTGRRFGDALARIGNR--
MAV_3824|M.avium_104 RRLRAAGSPIVTQLTHPGWVASNLSN------LGDAPLKAAAHKAVKMVA
MSMEG_6557|M.smegmatis_MC2_155 RRQRVARSPVVTHLTHPGWVASNLPN------VSQTRLMSVIQRGVTTVA
Mflv_2288|M.gilvum_PYR-GCK RRLRAAGSPVTTYLTHPGWVSSNLAK------VSDTRLMTRVHSVVTAAA
Mvan_4378|M.vanbaalenii_PYR-1 RRLRTAGSPVTTYLTHPGWVSSNLAK------VSDTALMTRVHSAVTAVA
** .. : .*** ::* :
MMAR_3355|M.marinum_M PFLWQEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGGVRAAKVPAR
MUL_1288|M.ulcerans_Agy99 PFLWQEIEDGILPALYAAVTPQAEGGAFYGPRGFYEAAGGGVRAAKVPAR
Mb2286|M.bovis_AF2122/97 PFLWQEIEEGILPALYAAATPQADGGAFYGPRGRYEVAGGGVREAKVPAA
Rv2263|M.tuberculosis_H37Rv PFLWQEIEEGILPALYAAATPQADGGAFYGPRGRYEVAGGGVREAKVPAA
MLBr_00315|M.leprae_Br4923 LFLTQDAATGALPTLRAATDAAVLGGQYFGPDGFAEIRG----HPKVVAS
MAB_1144c|M.abscessus_ATCC_199 -LFAQNAAHGALPTLYAASQ-DLPGDTYIGPDGPFEAKG----YPTRVGR
TH_3199|M.thermoresistible__bu -YLATDAEFGARQTLYAVAR-DVPGDSFIGPR--FAMHG----PTEQVGR
MAV_3824|M.avium_104 DRLANDIDEGAAPTLYCISEPIPPG-SYVGVSGRFGLRG----GPVLIGR
MSMEG_6557|M.smegmatis_MC2_155 DRFAASIDEGAAPTLYCISEPIPPG-SYVGVEGRLGLRG----APVLIGR
Mflv_2288|M.gilvum_PYR-GCK NVIGNDLDAGAAPSLYCLTEPIPPG-SYVGIAGRFGFKG----PPTLSGR
Mvan_4378|M.vanbaalenii_PYR-1 NVIGNDIDAGAAPTLYCLTEPIPPG-SYVGIAGRLGFKG----PPTLSGR
: . * :* . * : * * . .
MMAR_3355|M.marinum_M AGNDADCQ---RLWEVSERLTGVGYPTSS
MUL_1288|M.ulcerans_Agy99 AGNDADCQ---RLWEVSERLTGVGYPTSS
Mb2286|M.bovis_AF2122/97 ARNDADSK---RLWEVSEQLTGVSYPKSR
Rv2263|M.tuberculosis_H37Rv ARNDADSK---RLWEVSEQLTGVSYPKSR
MLBr_00315|M.leprae_Br4923 NGKSHDVDRQLRLWAVSEELTGVVYPVG-
MAB_1144c|M.abscessus_ATCC_199 SGRAQDTETAKGLWRLSEQLTGVSFPL--
TH_3199|M.thermoresistible__bu SPLARSAGTARALWELSEQLTDTKFPL--
MAV_3824|M.avium_104 TPLACDYDTAARLVAFAERETGTELRV--
MSMEG_6557|M.smegmatis_MC2_155 SAVACDYETAAAVVDFAERETGTAIPY--
Mflv_2288|M.gilvum_PYR-GCK APVACDYADARRLWEFAERETGTALPI--
Mvan_4378|M.vanbaalenii_PYR-1 APVACDYADAQRLWEFAERETGTTLPA--
. : .:*. *..