For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SIPAAVAAKAQSAVPLELQIRGAHLYDKTRRWVTGTNGKKIFTETPIPPVEDVDIADIDLSNPFLYRQGR WKSYFERVRNEAPVHYQARSPFGPFWSVTRHADIIAVDKNHEAFSAEPFIIIGRPPRFMDIAMFIAMDPP QHDLQRASVQGVVAPKNLREMEGLIRSRVQEVLDDLPVDQPFNWVHHVSIELTARMLATLLDFPYEQRHK LVEWSDLATSMEQANGGPSDNDRVFRGMVDMAKGLSALWHDKAARTANGERPGFDLITMLQANEDTKDLI DRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNQFPDQFEKLKANPDLIPNMVSEIIRWQTPLAYMRRVA KKDIMLNGQFIRKGDKVVMWYASGNRDERVFERADELIIDRSNARNHISFGFGVHRCMGNRLAELQLRIL WEELLPRFENIEVVGEPEYVQSNFVRGISKLMVRLTPRPSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2048c | - | - | 100% (462) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_0613 | - | 2e-43 | 29.43% (418) | putative cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 3e-40 | 28.17% (426) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 3e-49 | 32.62% (420) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_4592 | - | 0.0 | 83.77% (462) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | 3e-49 | 32.62% (420) | cytochrome P450 126 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-35 | 29.23% (349) | putative cytochrome p450 |
| M. marinum M | MMAR_3154 | cyp153A16 | 0.0 | 84.16% (461) | cytochrome P450 153A16 Cyp153A16 |
| M. avium 104 | MAV_1339 | - | 3e-47 | 32.83% (399) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_1429 | - | 1e-48 | 30.64% (421) | cytochrome P450-terp |
| M. thermoresistible (build 8) | TH_4556 | - | 1e-56 | 33.83% (399) | PUTATIVE putative cytochrome P450 |
| M. ulcerans Agy99 | MUL_0491 | cyp126A3 | 2e-46 | 32.06% (418) | cytochrome P450 126A3 Cyp126A3 |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | 8e-49 | 31.58% (437) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4592|M.gilvum_PYR-GCK MVKISEKVAEKVQATIPIDLQIQGAHAYDKTRRWVTGTNGKKLFVERPIP
MMAR_3154|M.marinum_M MSNIREAVTAKAQATIPMDRIIQGAHLYDRTRRWVTGTNGEKIFIERPIP
MAB_2048c|M.abscessus_ATCC_199 -MSIPAAVAAKAQSAVPLELQIRGAHLYDKTRRWVTGTNGKKIFTETPIP
Mb0801|M.bovis_AF2122/97 ---------------------------------------------MTTAA
Rv0778|M.tuberculosis_H37Rv ---------------------------------------------MTTAA
MUL_0491|M.ulcerans_Agy99 ---------------------------------------------MTSAG
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------MSLGMGIEKSAVTRTNGV
TH_4556|M.thermoresistible__bu --------------------------------------------------
MSMEG_1429|M.smegmatis_MC2_155 --------------------------------------------MSTPTM
MAV_1339|M.avium_104 -------------------------------------------MQTHPPL
MLBr_02088|M.leprae_Br4923 ---------------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPP
Mflv_4592|M.gilvum_PYR-GCK PAEEVELADIDLSN--PFLYRQGRWQSYYERLRNEAPVHYQRHSAFGP--
MMAR_3154|M.marinum_M PADEVELTDIDLSN--PFLYRQGRWKSYYERLRNEAPVHYQAHSAFGP--
MAB_2048c|M.abscessus_ATCC_199 PVEDVDIADIDLSN--PFLYRQGRWKSYFERVRNEAPVHYQARSPFGP--
Mb0801|M.bovis_AF2122/97 GLSGIDLTDLDN-------FADGFPHHLFAIHRREAPVYWHRPTEHTPDG
Rv0778|M.tuberculosis_H37Rv GLSGIDLTDLDN-------FADGFPHHLFAIHRREAPVYWHRPTEHTPDG
MUL_0491|M.ulcerans_Agy99 VLSKIDFTDLDN-------FADGFPHALFAIHRREAPVYWHEPTDNTPDG
Mvan_3029|M.vanbaalenii_PYR-1 APPEVPLADIDLGSWDFWGLDDDYRDGAFATLRREAPISFHEAYVIDPDN
TH_4556|M.thermoresistible__bu ----MDMLDLRWR-------ADGPPHGLFKRMRTEAPVYWYE----RPDG
MSMEG_1429|M.smegmatis_MC2_155 DDAAKALADPTAYA------DDARLHEALARLRAENPVAWVDQAPYRP--
MAV_1339|M.avium_104 RSPSFPLHSPDFYA--------GNPYPAYRELRATAPVCWNDVTN-----
MLBr_02088|M.leprae_Br4923 SLVEAQMLLLRLIDP----GTRADPFPVYRALIDYGPMQLPGMP------
: *:
Mflv_4592|M.gilvum_PYR-GCK ----FWSVTRHADIVAVDKNHEVFS----------AEPLIVIGVPPRFLD
MMAR_3154|M.marinum_M ----FWSVTRHADIVAVDKNHEVFS----------SEPFIVIGSPPRFLD
MAB_2048c|M.abscessus_ATCC_199 ----FWSVTRHADIIAVDKNHEAFS----------AEPFIIIGRPPRFMD
Mb0801|M.bovis_AF2122/97 E--GFWSVATYAETLEVLRDPVTYSSV-----TGGQRRFGGTVLQDLPVA
Rv0778|M.tuberculosis_H37Rv E--GFWSVATYAETLEVLRDPVTYSSV-----TGGQRRFGGTVLQDLPVA
MUL_0491|M.ulcerans_Agy99 E--GFWSVATYPETLEVLRDPVTYSSV-----TGGQRPFGGTLLQDLAIA
Mvan_3029|M.vanbaalenii_PYR-1 EVAGHWALTRHDDVFYASRHPEIFSSA-----LG---ITVGDQTPELAEY
TH_4556|M.thermoresistible__bu I--GYWSVFRHADIHRISHDTETFSSA-----RGGVYLHPDQQVP-LELM
MSMEG_1429|M.smegmatis_MC2_155 ----FWAITKHADIMAIERANDLWLSAPRPLLATAEADDLGRSQQEMGIG
MAV_1339|M.avium_104 ----FWALLKYEDIRFVSSNPALFTST--------RGITIPDPQLPNPVQ
MLBr_02088|M.leprae_Br4923 ----LTVFSSFSDCDEALRHPLSASDR---LKATLAQQAIAAGAEPRPFY
. . :
Mflv_4592|M.gilvum_PYR-GCK IKMFIAMDPPRHDLQRAAVQGVVAPKNLREMEGLIRSRVREVLDNLPVDQ
MMAR_3154|M.marinum_M IAMFIAMDPPKHDRQRQAVQGVVAPKNLREMEGLIRERVVDVLDALPLGE
MAB_2048c|M.abscessus_ATCC_199 IAMFIAMDPPQHDLQRASVQGVVAPKNLREMEGLIRSRVQEVLDDLPVDQ
Mb0801|M.bovis_AF2122/97 GQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGA
Rv0778|M.tuberculosis_H37Rv GQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGA
MUL_0491|M.ulcerans_Agy99 GQVLNMMDDPRHAQIRRLVSSGLTPRMIRRVEDDLRARTRRLLDAVVPGE
Mvan_3029|M.vanbaalenii_PYR-1 FGSMIAMDDPRHTRLRNIVRSAFTPRVLALIEDSVRQRARSLVQQMVAAH
TH_4556|M.thermoresistible__bu RSMMLVMDPPQHTRYRRIVSKVFTPLAVAKMEDDIRARVNRTIDNFIEKG
MSMEG_1429|M.smegmatis_MC2_155 LRTLIHMDDPHHRKVRAIGADWFRPKAMRELKVRVDELARIYVDKMREIG
MAV_1339|M.avium_104 QGSLIFTDPPRHRQLRKLINSGFTRRRVSVLEPKIREIVRGILDGIERGA
MLBr_02088|M.leprae_Br4923 ASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAG
: * * * * . : :: : . ::
Mflv_4592|M.gilvum_PYR-GCK P---FDWVHDVSIELTARMLATLLDFPYEQRRKLVEWSDLATSMEQTNGG
MMAR_3154|M.marinum_M P---FNWVQHVSIELTARMLATLLDFPFEQRRKLVQWSDLATSMEQANGG
MAB_2048c|M.abscessus_ATCC_199 P---FNWVHHVSIELTARMLATLLDFPYEQRHKLVEWSDLATSMEQANGG
Mb0801|M.bovis_AF2122/97 P---FDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRA
Rv0778|M.tuberculosis_H37Rv P---FDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRA
MUL_0491|M.ulcerans_Agy99 P---FDFLVDVAAELPMQMICILLGVPESERHWLFEAIEPQFDFGGSRKA
Mvan_3029|M.vanbaalenii_PYR-1 PDGNGELVAELAGPLPLQIICDMMGIPEEDHQKIFHWTNVILGFGDPDIA
TH_4556|M.thermoresistible__bu S---CDFVEDFAVPVPLGVLLEMMGVPQQDAGVFSDWTER---LEQAQRV
MSMEG_1429|M.smegmatis_MC2_155 P--ECDFVTDIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYK
MAV_1339|M.avium_104 V---HEFAEQIAAPLPTRMIAELIGAPPDDWEQFRAWSDAATGTADPEIE
MLBr_02088|M.leprae_Br4923 Q---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFIT
: ..: .. :: ::. * : :
Mflv_4592|M.gilvum_PYR-GCK PSDLDETFVGMRAMARDLSRHWHDKAARTGAGEEPGFDLITMLQSNESTK
MMAR_3154|M.marinum_M PSDNDEIFRGMVDMARGLSAHWRDKAARTAAGELPGFDLITMLQSDESTK
MAB_2048c|M.abscessus_ATCC_199 PSDNDRVFRGMVDMAKGLSALWHDKAARTANGERPGFDLITMLQANEDTK
Mb0801|M.bovis_AF2122/97 TMPRLNV----EDAGSRLYTY--ALELIAGKRAEPADDMLSVVANATIDD
Rv0778|M.tuberculosis_H37Rv TMPRLNV----EDAGSRLYTY--ALELIAGKRAEPADDMLSVVANATIDD
MUL_0491|M.ulcerans_Agy99 AVSQLSVAQTAEEAASRMYSY--GQDLIASKRAAPTDDMLSVVANAMVDG
Mvan_3029|M.vanbaalenii_PYR-1 TDFDEFV-----SVAMGIGAY--ATQLADDRRDHPGDDLTTSLVAAELDG
TH_4556|M.thermoresistible__bu PGPLGAV-----DVFEEMSGYL-AAQIEQQTKAAVEDSLVMRLRNAEVDG
MSMEG_1429|M.smegmatis_MC2_155 RGTTVEE-----QMAVLTDFFNYFSALTNSRRENPTDDLASAIANGRVDG
MAV_1339|M.avium_104 LDPAVAAG----------QLYEYFQRLIAARRARPRADLLSVLAEAEIDE
MLBr_02088|M.leprae_Br4923 ITGEPPE-ATEERLRAGVWLRDYLEQLVKCRRGTPGEDLISRLIELDESG
.: :
Mflv_4592|M.gilvum_PYR-GCK --DLIDRPMEFLGNLLLLIVGGNDTTRNSMSGGVLALNRYPDQFEKLKAN
MMAR_3154|M.marinum_M --DLIDRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNEFPDQFEKLKAN
MAB_2048c|M.abscessus_ATCC_199 --DLIDRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNQFPDQFEKLKAN
Mb0801|M.bovis_AF2122/97 PDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSD
Rv0778|M.tuberculosis_H37Rv PDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSD
MUL_0491|M.ulcerans_Agy99 GDEPALSDLELYLFFSLLFSAGAETTRNAVAGGLLALAEHPEQLRALRGD
Mvan_3029|M.vanbaalenii_PYR-1 ---ERLTSAEVASFFILLVVAGNETTRNAISHGVLALSRYPEQRQRWWSD
TH_4556|M.thermoresistible__bu ---EKLNDMEIVAVFGLLAFAGNDTTRNTISTGLRALIDHPQAMQELR-D
MSMEG_1429|M.smegmatis_MC2_155 ---ELMSDMDTLSYYVIVASAGHDTTKDAISGGLHALIENPGELARLKAD
MAV_1339|M.avium_104 ---HRLTDEDLLNFAFLLLVAGNETTRNLIALGTLALIAHPDQYRLLVEE
MLBr_02088|M.leprae_Br4923 ---DQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSN
: :: .* :** : :: . *: * :
Mflv_4592|M.gilvum_PYR-GCK PD-LIPNMNSEIIRWQTPLAYMRRIAKADTMLNGQFIRKGDKVVMWYASG
MMAR_3154|M.marinum_M PE-LIPNMVSEIIRWQTPLAHMRRIAKADTVLNGQFIRKGDKVLMWYASG
MAB_2048c|M.abscessus_ATCC_199 PD-LIPNMVSEIIRWQTPLAYMRRVAKKDIMLNGQFIRKGDKVVMWYASG
Mb0801|M.bovis_AF2122/97 FE-LLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSA
Rv0778|M.tuberculosis_H37Rv FE-LLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSA
MUL_0491|M.ulcerans_Agy99 LD-LLPTAVEEMVRWTSPSPSKRRTATRDVTLAGCSIEAGQKVQIWEGSA
Mvan_3029|M.vanbaalenii_PYR-1 YQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIAAGDKVSLWYGSA
TH_4556|M.thermoresistible__bu NPALIPTAIEEILRWTSVVQWFARTATRDVEVGGQRIAEGDKLVLWYGSG
MSMEG_1429|M.smegmatis_MC2_155 PG-LMGTAVEEMIRWSTPVKEFMRTAAEDTEVRGVPIAKGESVYLAYVSG
MAV_1339|M.avium_104 PA-RIPLAVEEMLRWNSPVVHMARTATADVEIRGQRIRAGEVVVMLYGSA
MLBr_02088|M.leprae_Br4923 PQ-RAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAA
.* :*: . * * : : *: : : :.
Mflv_4592|M.gilvum_PYR-GCK NRDERVFD-RPDDFIIDRDNARNHISFGFG-VHRCMGNRLAEMQLRILWE
MMAR_3154|M.marinum_M NRDERVFD-RPDDLIIDRANARNHISFGFG-VHRCMGNRLAEMQLRILWE
MAB_2048c|M.abscessus_ATCC_199 NRDERVFE-RADELIIDRSNARNHISFGFG-VHRCMGNRLAELQLRILWE
Mb0801|M.bovis_AF2122/97 NRDPSVFD-RADEFDITR-KPNPHLGFGQG-VHYCLGANLARLELRVLFE
Rv0778|M.tuberculosis_H37Rv NRDPSVFD-RADEFDITR-KPNPHLGFGQG-VHYCLGANLARLELRVLFE
MUL_0491|M.ulcerans_Agy99 NRDARIFD-HADEFDITR-KPNPHLGFGQG-VHYCLGANLARLELRVLFE
Mvan_3029|M.vanbaalenii_PYR-1 NRDESKFE-NPWLFDVGR-HPNPHVGFGGGGAHFCLGANLARREITVAFE
TH_4556|M.thermoresistible__bu SRDEAVFE-NADTFDIHR-EKPNHMAFGGGGRHICLGASLARLELRIVFE
MSMEG_1429|M.smegmatis_MC2_155 NRDEEVFT-DPFRFDVGR-DPNKHLAFGYG-VHFCLGAALARMEMNSLFS
MAV_1339|M.avium_104 NRDEDVFGPDSEEFDVTR-HPNPHIAFGCG-EHSCVGAQLARLEATVFFE
MLBr_02088|M.leprae_Br4923 NRDPAVYS-RPDEFDPDR-PSSRHLAFAVG-SHFCLGAALARLEATVTLS
.** : . : * *:.*. * * *:* **. : .
Mflv_4592|M.gilvum_PYR-GCK ELLPRFEKIEVIGEPEYVQSNFVRGISKLMVRLTPKAGA--
MMAR_3154|M.marinum_M ELLPRFENIEVVGEPEYVQSNFVRGISKLMVRLTPKGGA--
MAB_2048c|M.abscessus_ATCC_199 ELLPRFENIEVVGEPEYVQSNFVRGISKLMVRLTPRPSA--
Mb0801|M.bovis_AF2122/97 ELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG-----
Rv0778|M.tuberculosis_H37Rv ELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG-----
MUL_0491|M.ulcerans_Agy99 ELLGRFGVVLVGQPVEWTRSNRHTGIRHLVVELFGG-----
Mvan_3029|M.vanbaalenii_PYR-1 ELHRLVPGIRAVEEPDRLHSAFIHGIKRLPVSWSA------
TH_4556|M.thermoresistible__bu EVLSRMRDIRLAGTPELVPTHWVYGYSKMPITFTPGSKLGA
MSMEG_1429|M.smegmatis_MC2_155 ELLPRLDSIELAGEPELSATTFVGGLKHLPIRYSIR-----
MAV_1339|M.avium_104 ELLRRYPRIELVGEVDRMRATMVPGVKRMPVRMGA------
MLBr_02088|M.leprae_Br4923 AISARFPQVQLAGELVYKPNVAMRGMSALPVQV--------
: : * : :