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MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDPVTY SSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPG APFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELI AGKRAEPADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLR SDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKP NPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | - | 100% (414) | POSSIBLE CYTOCHROME P450 126 CYP126 |
| M. tuberculosis H37Rv | Rv3545c | cyp125 | 9e-64 | 36.17% (412) | cytochrome P450 125 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 1e-60 | 37.89% (417) | cytochrome P450 124 CYP124 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 0.0 | 100.00% (414) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_1908 | - | 1e-105 | 46.96% (411) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-42 | 32.19% (351) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0611 | - | 1e-59 | 36.10% (410) | putative cytochrome P450 |
| M. marinum M | MMAR_4915 | cyp126A3 | 0.0 | 79.19% (418) | cytochrome P450 126A3 Cyp126A3 |
| M. avium 104 | MAV_0723 | - | 0.0 | 79.61% (412) | P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_5846 | - | 0.0 | 78.25% (400) | NikQ protein |
| M. thermoresistible (build 8) | TH_4083 | - | 0.0 | 75.50% (404) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0491 | cyp126A3 | 0.0 | 78.95% (418) | cytochrome P450 126A3 Cyp126A3 |
| M. vanbaalenii PYR-1 | Mvan_5144 | - | 0.0 | 74.69% (407) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0778|M.tuberculosis_H37Rv -----MTTAAGLSGIDLTDLDNFADGFP----HHLFAIHRREAP------
Mb0801|M.bovis_AF2122/97 -----MTTAAGLSGIDLTDLDNFADGFP----HHLFAIHRREAP------
MMAR_4915|M.marinum_M -----MTSAGVLSKIDFTDLDNFADGFP----HALFAIHRREAP------
MUL_0491|M.ulcerans_Agy99 -----MTSAGVLSKIDFTDLDNFADGFP----HALFAIHRREAP------
MAV_0723|M.avium_104 -----MTLAGTLSQIDFTDLDNFANGFP----HHLFAVHRREAP------
MSMEG_5846|M.smegmatis_MC2_155 ------------MRADLTDLDNFADGFP----HALFEAHRREAP------
TH_4083|M.thermoresistible__bu ---------VSLAGVDLTDLDNFAAGFP----HELFAEHRAAAP------
Mvan_5144|M.vanbaalenii_PYR-1 -----MRVAGALAAVDFTDLDNFAAGFP----HGLFALHREQAP------
Mflv_1908|M.gilvum_PYR-GCK --------MPNLADVDLADLDRFTAGFP----FEVFDVLRREAP------
MAB_0611|M.abscessus_ATCC_1997 --MVQAQHPHLPDGIDFTDPELFVHGIP----ERELAELRHTEP------
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: . : * : * *
Rv0778|M.tuberculosis_H37Rv --VYWHRPTEHTP--DGEGFWSVATYAETLEVLRDPVTYSS--VTGGQRR
Mb0801|M.bovis_AF2122/97 --VYWHRPTEHTP--DGEGFWSVATYAETLEVLRDPVTYSS--VTGGQRR
MMAR_4915|M.marinum_M --VYWHEPTDNTP--DGEGFWSVATYPETLEVLRDPVTYSS--VTGGQRP
MUL_0491|M.ulcerans_Agy99 --VYWHEPTDNTP--DGEGFWSVATYPETLEVLRDPVTYSS--VTGGQRP
MAV_0723|M.avium_104 --VYWHEPTDNTP--DGEGFWSVASYAETLEVLKDPATYSS--VTGGERP
MSMEG_5846|M.smegmatis_MC2_155 --VYWHEPTEHTP--DGEGFWSVATYAETLAVLRDPVTFSS--VTGGSRP
TH_4083|M.thermoresistible__bu --VYWHEPTEHTP--DGEGFWSVATYLETLAVLRDPVTYSS--VTGGDRQ
Mvan_5144|M.vanbaalenii_PYR-1 --VYWHEPTENTP--DGEGFWSVATHAETLAVFRDPETYSS--VTGGERA
Mflv_1908|M.gilvum_PYR-GCK --VWWHPPTAHTP--GGEGFWVLSRHADIVAAAADSETFSS--ETGGGRD
MAB_0611|M.abscessus_ATCC_1997 --IWWNHTERGVAGFDDDGFWVVSKHKDVKEVSLRCEVFSSEQNTAIPRY
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
:: . : .: . : . *. : :
Rv0778|M.tuberculosis_H37Rv FGGTVLQDLP---VAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDL
Mb0801|M.bovis_AF2122/97 FGGTVLQDLP---VAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDL
MMAR_4915|M.marinum_M FGGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIRRVEDDL
MUL_0491|M.ulcerans_Agy99 FGGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIRRVEDDL
MAV_0723|M.avium_104 YGGTLLQDLA---IAGQVLNMMDDPRHSQIRRLVSSGLTPRMIRLVEDDL
MSMEG_5846|M.smegmatis_MC2_155 YGGTLLQDLA---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMIARVEEDL
TH_4083|M.thermoresistible__bu YGGTLLQDLP---IAGQVLNMMDDPRHAQIRRLVSSGLTPRMITRVEDDL
Mvan_5144|M.vanbaalenii_PYR-1 FGGTLLQDLP---IAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDL
Mflv_1908|M.gilvum_PYR-GCK GGGTTLEDMPRGFAVGALLNMMDDPRHAQFRRLLAPTTSPRALRAIETDL
MAB_0611|M.abscessus_ATCC_1997 LPTTPRERID---ATRLIMLNMDPPRHSRLRHIISRGFTPRAISRLRDDL
MLBr_02088|M.leprae_Br4923 AIAAGAEPRP---FYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
: : : :* * *: .*:::: :*: : :. *:
Rv0778|M.tuberculosis_H37Rv RRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDR-------
Mb0801|M.bovis_AF2122/97 RRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDR-------
MMAR_4915|M.marinum_M RARTRRLLDAVVPGEPFDFLVDVAAELPMQMICILLGVPESER-------
MUL_0491|M.ulcerans_Agy99 RARTRRLLDAVVPGEPFDFLVDVAAELPMQMICILLGVPESER-------
MAV_0723|M.avium_104 RARARRLLDAVVPGEPFDFLVDIAAELPMQMICILLGVPESER-------
MSMEG_5846|M.smegmatis_MC2_155 RVRARRLLDAVEPGVPLDFLVEVAAELPMQMICILLGVPESER-------
TH_4083|M.thermoresistible__bu RSRAARLFEAIEPGRPVDFVVEVAVELPMQMICILLGIPESER-------
Mvan_5144|M.vanbaalenii_PYR-1 RERARRLLDEVEPGTPVDFLTDIAAEVPMQMICILLGVPESER-------
Mflv_1908|M.gilvum_PYR-GCK RRRAIDIVDAALAKGECDFLVDVAAELPLQAVAELAGVPQEDR-------
MAB_0611|M.abscessus_ATCC_1997 NARAQGIARAAAQLRHGDFVEQVACELPLQAIAGLMGTPLDER-------
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVS
. : *.: ::* :.: :. * * * :
Rv0778|M.tuberculosis_H37Rv HWLFEAVEPGFDFRGSRRATMPRLNVE----DAGSRLYTYALELIAGKRA
Mb0801|M.bovis_AF2122/97 HWLFEAVEPGFDFRGSRRATMPRLNVE----DAGSRLYTYALELIAGKRA
MMAR_4915|M.marinum_M HWLFEAIEPQFDFGGSRKAAVSQLSVAQTAEEAASRMYSYGQELIASKRA
MUL_0491|M.ulcerans_Agy99 HWLFEAIEPQFDFGGSRKAAVSQLSVAQTAEEAASRMYSYGQDLIASKRA
MAV_0723|M.avium_104 HWLFQAIEPQFDFGGSRKAALSQLSEA----EAGSRMYEYGQQLIAAKRA
MSMEG_5846|M.smegmatis_MC2_155 HWLFHAIEPQFDFSGSRTASVGQLTPE----EAGNRMYRYGMELIAAKRA
TH_4083|M.thermoresistible__bu HWLFAAIEPSFDFGAARSASITRLSVE----EAGSRIYAFGQELIAAKRR
Mvan_5144|M.vanbaalenii_PYR-1 HWLFEAIEPSFDFGGARKASITRLSVE----EAGSRMFEYGQELIAAKRA
Mflv_1908|M.gilvum_PYR-GCK HELMNWANVTLDYEEREIGQTSDRVAA-----AQAQMFVYGTTLLERKRR
MAB_0611|M.abscessus_ATCC_1997 EQLFDWSN---RLVGSSDGEDDSAVAS-------AELLMYAMGVAARKTA
MLBr_02088|M.leprae_Br4923 ALLVQSVDPFITITGEPPEATEERLRA------GVWLRDYLEQLVKCRRG
*. : : : : :
Rv0778|M.tuberculosis_H37Rv EP-ADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAG
Mb0801|M.bovis_AF2122/97 EP-ADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAG
MMAR_4915|M.marinum_M AP-TDDMLSVVANAMVDGGDEPALSDLELYLFFSLLFSAGAETTRNAVAG
MUL_0491|M.ulcerans_Agy99 AP-TDDMLSVVANAMVDGGDEPALSDLELYLFFSLLFSAGAETTRNAVAG
MAV_0723|M.avium_104 EP-TDDMLSVVANATLDDAAAPALSDLELYLFFSLLFSAGAETTRNAVAG
MSMEG_5846|M.smegmatis_MC2_155 AP-TDDMLSVVAN-----AHDAELSDLELYLFFSLLFSAGAETTRNAVAG
TH_4083|M.thermoresistible__bu TP-TDDMLSVVANA----DLPDPVTDLEVYLFFNLLFSAGAETTRNAIAG
Mvan_5144|M.vanbaalenii_PYR-1 QP-GDDMLSVVVNS----GDPQ-LSDLESYLFFNLLFSAGAETTRNAIAG
Mflv_1908|M.gilvum_PYR-GCK EPPTEDLLSIVTHALID---GEPLSENEQRMFLSLIIAAGSETTRNSIAL
MAB_0611|M.abscessus_ATCC_1997 EP-GADICTDLVNADID---GQKLSDDEFGFFVMLLAVAGNETTRNSITH
MLBr_02088|M.leprae_Br4923 TP-GEDLISRLIELDES---GDQLTEEEIIATCGLLLVAGHETTVNLIAN
* *: : : . ::: * *: ** *** * ::
Rv0778|M.tuberculosis_H37Rv GLLALAENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLG
Mb0801|M.bovis_AF2122/97 GLLALAENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLG
MMAR_4915|M.marinum_M GLLALAEHPEQLRALRGDLDLLPTAVEEMVRWTSPSPSKRRTATRDVTLA
MUL_0491|M.ulcerans_Agy99 GLLALAEHPEQLRALRGDLDLLPTAVEEMVRWTSPSPSKRRTATRDVTLA
MAV_0723|M.avium_104 GLLALAEHPEQLRWLRDDLGALPRAVEEMVRWTSPSPSKRRTATRDATLG
MSMEG_5846|M.smegmatis_MC2_155 GLLALIEHPSQMALLRADLALLPTAVEEMVRWTSPSPSKRRTATRDVELG
TH_4083|M.thermoresistible__bu GLLALAERPDQFAALRADPGLLPTAVEEMVRWTSPSPSKRRTATRPATLG
Mvan_5144|M.vanbaalenii_PYR-1 GLLALIENPDAYRALRADPGLLPTAIEEMIRWTSPSPSKRRTATRRATLG
Mflv_1908|M.gilvum_PYR-GCK GMSALSREPEVWERIRRDRTLLPSAVEEMLRWASSTPYNRRTATRDVDLH
MAB_0611|M.abscessus_ATCC_1997 GMHAFTQFPEQWELYKKTR--PETAADEIVRWATPVTSFQRTALEDTELG
MLBr_02088|M.leprae_Br4923 AVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIG
.: *: . *. . :* :*: .. *.* . :
Rv0778|M.tuberculosis_H37Rv GQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFG-QGVHYC
Mb0801|M.bovis_AF2122/97 GQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFG-QGVHYC
MMAR_4915|M.marinum_M GCSIEAGQKVQIWEGSANRDARIFDHADEFDITRKPNPHLGFG-QGVHYC
MUL_0491|M.ulcerans_Agy99 GCSIEAGQKVQIWEGSANRDARIFDHADEFDITRKPNPHLGFG-QGVHYC
MAV_0723|M.avium_104 GQSIKAGQKVQIWEGSANRDASVFDRADEFDVTRKPNPHLGFG-QGVHYC
MSMEG_5846|M.smegmatis_MC2_155 GCRIAAGDKVQIWEGSANRDPLVFTDPDVFDITRKPNPHLGFG-QGVHYC
TH_4083|M.thermoresistible__bu GQHIEPGDKVLVWEASANRDGTVFDAPDVFDVTRKPNPHLGFG-QGVHYC
Mvan_5144|M.vanbaalenii_PYR-1 GHTIEAGQKVLVWEGSANRDAAVFASPDHFDITRKPNPHLGFG-QGVHYC
Mflv_1908|M.gilvum_PYR-GCK GHRIRAGDKVTLWWASANRDDAVFADPYAFDVSRNPNPHVAFG-RGTHFC
MAB_0611|M.abscessus_ATCC_1997 GVRIKKGQRVVMMYRSANFDEEVFENPFTFDIMRDPNPHVGFGGNGEHHC
MLBr_02088|M.leprae_Br4923 QTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFA-VGSHFC
: *: : : :** * :: . ** * .. *:.*. * *.*
Rv0778|M.tuberculosis_H37Rv LGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRG
Mb0801|M.bovis_AF2122/97 LGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRG
MMAR_4915|M.marinum_M LGANLARLELRVLFEELLGRFGAVLVGQPVEWTRSNRHTGIRHLVVELFG
MUL_0491|M.ulcerans_Agy99 LGANLARLELRVLFEELLGRFGVVLVGQPVEWTRSNRHTGIRHLVVELFG
MAV_0723|M.avium_104 LGANLARLELRVLFEELLSRFGAVRVVRPVEWARSNRHTGIRHLVVELRE
MSMEG_5846|M.smegmatis_MC2_155 LGANLARLELRVLFEELLSRFSAARLVKPVEWTRSNRHTGIRHLVVEFDA
TH_4083|M.thermoresistible__bu LGANLARLEIRVLFGELLRRFGSVRLAAPPEWTRSNRHTGLRHLMVEFGP
Mvan_5144|M.vanbaalenii_PYR-1 LGANLARLELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFAS
Mflv_1908|M.gilvum_PYR-GCK LGAALARMEMRVIFDVLLDRVAGVTVTGPVEYVRSNKHSGVRHMPVTLVG
MAB_0611|M.abscessus_ATCC_1997 VGANLARMTINLMFNAIADHMPDLASAGEPDRLRSGWLNGVKHWEVDFCP
MLBr_02088|M.leprae_Br4923 LGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV--
:** ***: : : : : . *: * .
Rv0778|M.tuberculosis_H37Rv G------
Mb0801|M.bovis_AF2122/97 G------
MMAR_4915|M.marinum_M G------
MUL_0491|M.ulcerans_Agy99 G------
MAV_0723|M.avium_104 EQ-----
MSMEG_5846|M.smegmatis_MC2_155 -------
TH_4083|M.thermoresistible__bu ND-----
Mvan_5144|M.vanbaalenii_PYR-1 R------
Mflv_1908|M.gilvum_PYR-GCK RS-----
MAB_0611|M.abscessus_ATCC_1997 AGYGRAS
MLBr_02088|M.leprae_Br4923 -------