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VKISEKVAEKVQATIPIDLQIQGAHAYDKTRRWVTGTNGKKLFVERPIPPAEEVELADIDLSNPFLYRQG RWQSYYERLRNEAPVHYQRHSAFGPFWSVTRHADIVAVDKNHEVFSAEPLIVIGVPPRFLDIKMFIAMDP PRHDLQRAAVQGVVAPKNLREMEGLIRSRVREVLDNLPVDQPFDWVHDVSIELTARMLATLLDFPYEQRR KLVEWSDLATSMEQTNGGPSDLDETFVGMRAMARDLSRHWHDKAARTGAGEEPGFDLITMLQSNESTKDL IDRPMEFLGNLLLLIVGGNDTTRNSMSGGVLALNRYPDQFEKLKANPDLIPNMNSEIIRWQTPLAYMRRI AKADTMLNGQFIRKGDKVVMWYASGNRDERVFDRPDDFIIDRDNARNHISFGFGVHRCMGNRLAEMQLRI LWEELLPRFEKIEVIGEPEYVQSNFVRGISKLMVRLTPKAGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4592 | - | - | 100% (463) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_1908 | - | 7e-52 | 32.54% (421) | cytochrome P450 |
| M. gilvum PYR-GCK | Mflv_3307 | - | 2e-50 | 32.80% (439) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 2e-50 | 33.33% (420) | cytochrome P450 126 |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | 2e-50 | 33.33% (420) | cytochrome P450 126 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-37 | 29.57% (345) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_2048c | - | 0.0 | 83.77% (462) | cytochrome P450 |
| M. marinum M | MMAR_3154 | cyp153A16 | 0.0 | 86.74% (460) | cytochrome P450 153A16 Cyp153A16 |
| M. avium 104 | MAV_2174 | - | 3e-49 | 31.18% (433) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_1429 | - | 1e-49 | 30.39% (408) | cytochrome P450-terp |
| M. thermoresistible (build 8) | TH_4556 | - | 9e-55 | 34.76% (397) | PUTATIVE putative cytochrome P450 |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 3e-46 | 28.68% (401) | cytochrome P450 108B4 Cyp108B4 |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | 4e-50 | 32.51% (446) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4592|M.gilvum_PYR-GCK MVKISEKVAEKVQATIPIDLQIQGAHAYDKTRRWVTGTNGKKLFVERPIP
MMAR_3154|M.marinum_M MSNIREAVTAKAQATIPMDRIIQGAHLYDRTRRWVTGTNGEKIFIERPIP
MAB_2048c|M.abscessus_ATCC_199 -MSIPAAVAAKAQSAVPLELQIRGAHLYDKTRRWVTGTNGKKIFTETPIP
Mb0801|M.bovis_AF2122/97 --------------------------------------------------
Rv0778|M.tuberculosis_H37Rv --------------------------------------------------
TH_4556|M.thermoresistible__bu --------------------------------------------------
MAV_2174|M.avium_104 ------------------------------MSLKTRPKKGLATRINGAPP
Mvan_3029|M.vanbaalenii_PYR-1 ------------------------------MSLGMGIEKSAVTRTNGVAP
MSMEG_1429|M.smegmatis_MC2_155 -----------------------------------------------MST
MUL_3863|M.ulcerans_Agy99 -----------------------------------------------MSA
MLBr_02088|M.leprae_Br4923 ----------------------------------MRTCVPTRTCVYAFIE
Mflv_4592|M.gilvum_PYR-GCK PAEEVELADIDLSNPFLYRQGRWQSYYERLRNEAPVHYQRHSAFGP----
MMAR_3154|M.marinum_M PADEVELTDIDLSNPFLYRQGRWKSYYERLRNEAPVHYQAHSAFGP----
MAB_2048c|M.abscessus_ATCC_199 PVEDVDIADIDLSNPFLYRQGRWKSYFERVRNEAPVHYQARSPFGP----
Mb0801|M.bovis_AF2122/97 MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEHTPDGE-
Rv0778|M.tuberculosis_H37Rv MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEHTPDGE-
TH_4556|M.thermoresistible__bu ---------MDMLDLRWRADGPPHGLFKRMRTEAPVYWYE----RPDGI-
MAV_2174|M.avium_104 PRVPLADIHLESLDFWGYDDDFRDGAFATLRREAPISFWPAIEMDGFVAG
Mvan_3029|M.vanbaalenii_PYR-1 PEVPLADIDLGSWDFWGLDDDYRDGAFATLRREAPISFHEAYVIDPDNEV
MSMEG_1429|M.smegmatis_MC2_155 PTMDDAAKALADPTAY-ADDARLHEALARLRAENPVAWVDQAPYRP----
MUL_3863|M.ulcerans_Agy99 PTMDEAA-LLADPLAY-TDETRLHAALTRLRAQAPVALVDVPNYRR----
MLBr_02088|M.leprae_Br4923 YLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADPFPVYRALIDYGPMQLP
* :
Mflv_4592|M.gilvum_PYR-GCK ---FWSVTRHADIVAVDKNHEVFSAEPLIVIGVPP----------RFLDI
MMAR_3154|M.marinum_M ---FWSVTRHADIVAVDKNHEVFSSEPFIVIGSPP----------RFLDI
MAB_2048c|M.abscessus_ATCC_199 ---FWSVTRHADIIAVDKNHEAFSAEPFIIIGRPP----------RFMDI
Mb0801|M.bovis_AF2122/97 --GFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVL-----QDLPVAG
Rv0778|M.tuberculosis_H37Rv --GFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVL-----QDLPVAG
TH_4556|M.thermoresistible__bu --GYWSVFRHADIHRISHDTETFSSARGG-VYLHPDQQ-----VPLELMR
MAV_2174|M.avium_104 -NGYWALTKHEDVHFASRHPEIFSSVPNITINDQT--------PELAEYF
Mvan_3029|M.vanbaalenii_PYR-1 -AGHWALTRHDDVFYASRHPEIFSSALGITVGDQT--------PELAEYF
MSMEG_1429|M.smegmatis_MC2_155 ---FWAITKHADIMAIERANDLWLSAPRPLLATAEADDLGRSQQEMGIGL
MUL_3863|M.ulcerans_Agy99 ---FWAITRHADVMDIERDNTLFTNWPRPVLATVAGDEL-----QAAAGV
MLBr_02088|M.leprae_Br4923 GMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQAIAAG---AEPRPFYA
. . : :
Mflv_4592|M.gilvum_PYR-GCK KMFIAMDPPRHDLQRAAVQGVVAPKNLREMEGLIRSRVREVLDNLPVDQP
MMAR_3154|M.marinum_M AMFIAMDPPKHDRQRQAVQGVVAPKNLREMEGLIRERVVDVLDALPLGEP
MAB_2048c|M.abscessus_ATCC_199 AMFIAMDPPQHDLQRASVQGVVAPKNLREMEGLIRSRVQEVLDDLPVDQP
Mb0801|M.bovis_AF2122/97 QVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAP
Rv0778|M.tuberculosis_H37Rv QVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAP
TH_4556|M.thermoresistible__bu SMMLVMDPPQHTRYRRIVSKVFTPLAVAKMEDDIRARVNRTIDNFIEKGS
MAV_2174|M.avium_104 GSMIVLDDPRHQRLRSIVSRAFTPKVVARIEASVRERARRLVSSLVANHP
Mvan_3029|M.vanbaalenii_PYR-1 GSMIAMDDPRHTRLRNIVRSAFTPRVLALIEDSVRQRARSLVQQMVAAHP
MSMEG_1429|M.smegmatis_MC2_155 RTLIHMDDPHHRKVRAIGADWFRPKAMRELKVRVDELARIYVDKMREIGP
MUL_3863|M.ulcerans_Agy99 RTLIHLDDPQHRVARAIGADWFRPKAMRALKVRVDELAKNYVDAMMAAGP
MLBr_02088|M.leprae_Br4923 SSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAGQ
: :* * * * . * : :: : . :.
Mflv_4592|M.gilvum_PYR-GCK ---FDWVHDVSIELTARMLATLLDFPYEQRRKLVEWSDLATSMEQTNGGP
MMAR_3154|M.marinum_M ---FNWVQHVSIELTARMLATLLDFPFEQRRKLVQWSDLATSMEQANGGP
MAB_2048c|M.abscessus_ATCC_199 ---FNWVHHVSIELTARMLATLLDFPYEQRHKLVEWSDLATSMEQANGGP
Mb0801|M.bovis_AF2122/97 ---FDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSR---
Rv0778|M.tuberculosis_H37Rv ---FDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSR---
TH_4556|M.thermoresistible__bu ---CDFVEDFAVPVPLGVLLEMMGVPQQDAGVFSDWTER---LEQAQ---
MAV_2174|M.avium_104 NGEAELVSELAGPLPLQVICDMMGIPEEDHQRVFHWTNVILGFGDP----
Mvan_3029|M.vanbaalenii_PYR-1 DGNGELVAELAGPLPLQIICDMMGIPEEDHQKIFHWTNVILGFGDP----
MSMEG_1429|M.smegmatis_MC2_155 --ECDFVTDIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEY--
MUL_3863|M.ulcerans_Agy99 --ECDFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGSDDSEF--
MLBr_02088|M.leprae_Br4923 ---FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITI
: : ..: . :: ::..* : .
Mflv_4592|M.gilvum_PYR-GCK S-DLDETFVGMRAMARDLSRHWHDKAARTGAGEEPGFDLITMLQSNEST-
MMAR_3154|M.marinum_M S-DNDEIFRGMVDMARGLSAHWRDKAARTAAGELPGFDLITMLQSDEST-
MAB_2048c|M.abscessus_ATCC_199 S-DNDRVFRGMVDMAKGLSALWHDKAARTANGERPGFDLITMLQANEDT-
Mb0801|M.bovis_AF2122/97 --RATMPRLNVEDAGSRLYTYALELIAGK--RAEPADDMLSVVANATIDD
Rv0778|M.tuberculosis_H37Rv --RATMPRLNVEDAGSRLYTYALELIAGK--RAEPADDMLSVVANATIDD
TH_4556|M.thermoresistible__bu --RVPGP-LGAVDVFEEMSGYLAAQIEQQT-KAAVEDSLVMRLRNAEVD-
MAV_2174|M.avium_104 --DLATDFEEFLQVSMDIGAYATALAEDR--RVNHHDDLTTSLVEAEVD-
Mvan_3029|M.vanbaalenii_PYR-1 --DIATDFDEFVSVAMGIGAYATQLADDR--RDHPGDDLTTSLVAAELD-
MSMEG_1429|M.smegmatis_MC2_155 --KRGTTVEEQMAVLTDFFNYFSALTNSR--RENPTDDLASAIANGRVD-
MUL_3863|M.ulcerans_Agy99 --KRGSTSEDQLPALLDMFGYFNAVTTAR--RAHPTADLASAIANARID-
MLBr_02088|M.leprae_Br4923 TGEPPEATEERLRAGVWLRDYLEQLVKCR--RGTPGEDLISRLIELDES-
: .: :
Mflv_4592|M.gilvum_PYR-GCK -KDLIDRPMEFLGNLLLLIVGGNDTTRNSMSGGVLALNRYPDQFEKLKAN
MMAR_3154|M.marinum_M -KDLIDRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNEFPDQFEKLKAN
MAB_2048c|M.abscessus_ATCC_199 -KDLIDRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNQFPDQFEKLKAN
Mb0801|M.bovis_AF2122/97 PDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSD
Rv0778|M.tuberculosis_H37Rv PDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSD
TH_4556|M.thermoresistible__bu --GEKLNDMEIVAVFGLLAFAGNDTTRNTISTGLRALIDHPQAMQELRDN
MAV_2174|M.avium_104 --GERLTSSEIASFFILLVVAGNETTRNAISHGVLALSRYPDERDKWFSD
Mvan_3029|M.vanbaalenii_PYR-1 --GERLTSAEVASFFILLVVAGNETTRNAISHGVLALSRYPEQRQRWWSD
MSMEG_1429|M.smegmatis_MC2_155 --GELMSDMDTLSYYVIVASAGHDTTKDAISGGLHALIENPGELARLKAD
MUL_3863|M.ulcerans_Agy99 --GEPLSDIDTVSYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQAD
MLBr_02088|M.leprae_Br4923 --GDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSN
: :: .* :** :: .: *: * :
Mflv_4592|M.gilvum_PYR-GCK PDLIP-NMNSEIIRWQTPLAYMRRIAKADTMLNGQFIRKGDKVVMWYASG
MMAR_3154|M.marinum_M PELIP-NMVSEIIRWQTPLAHMRRIAKADTVLNGQFIRKGDKVLMWYASG
MAB_2048c|M.abscessus_ATCC_199 PDLIP-NMVSEIIRWQTPLAYMRRVAKKDIMLNGQFIRKGDKVVMWYASG
Mb0801|M.bovis_AF2122/97 FELLP-TAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSA
Rv0778|M.tuberculosis_H37Rv FELLP-TAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSA
TH_4556|M.thermoresistible__bu PALIP-TAIEEILRWTSVVQWFARTATRDVEVGGQRIAEGDKLVLWYGSG
MAV_2174|M.avium_104 FDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLRGTKMKAGDKVALWYNSA
Mvan_3029|M.vanbaalenii_PYR-1 YQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIAAGDKVSLWYGSA
MSMEG_1429|M.smegmatis_MC2_155 PGLMG-TAVEEMIRWSTPVKEFMRTAAEDTEVRGVPIAKGESVYLAYVSG
MUL_3863|M.ulcerans_Agy99 PALMS-LATEEMIRWVTPVKQFMRTASSDTVVRGIPIAAGESVLLSYVSA
MLBr_02088|M.leprae_Br4923 PQRAP-LVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAA
.* :*: . * : : *:.: : :.
Mflv_4592|M.gilvum_PYR-GCK NRDERVFDRPDDFIIDRDNARNHISFGFG-VHRCMGNRLAEMQLRILWEE
MMAR_3154|M.marinum_M NRDERVFDRPDDLIIDRANARNHISFGFG-VHRCMGNRLAEMQLRILWEE
MAB_2048c|M.abscessus_ATCC_199 NRDERVFERADELIIDRSNARNHISFGFG-VHRCMGNRLAELQLRILWEE
Mb0801|M.bovis_AF2122/97 NRDPSVFDRADEFDITR-KPNPHLGFGQG-VHYCLGANLARLELRVLFEE
Rv0778|M.tuberculosis_H37Rv NRDPSVFDRADEFDITR-KPNPHLGFGQG-VHYCLGANLARLELRVLFEE
TH_4556|M.thermoresistible__bu SRDEAVFENADTFDIHR-EKPNHMAFGGGGRHICLGASLARLELRIVFEE
MAV_2174|M.avium_104 NRDESTFDNPWLFDVAR-TPNPHLGFGGGGAHFCLGANLARREIRVVFDE
Mvan_3029|M.vanbaalenii_PYR-1 NRDESKFENPWLFDVGR-HPNPHVGFGGGGAHFCLGANLARREITVAFEE
MSMEG_1429|M.smegmatis_MC2_155 NRDEEVFTDPFRFDVGR-DPNKHLAFGYG-VHFCLGAALARMEMNSLFSE
MUL_3863|M.ulcerans_Agy99 NRDEEVFDQPFRFDIGR-EPNKHVAFGYG-VHFCMGAALARMEVASFFTE
MLBr_02088|M.leprae_Br4923 NRDPAVYSRPDEFDPDR-PSSRHLAFAVG-SHFCLGAALARLEATVTLSA
.** : . : * *:.*. * * *:* **. :
Mflv_4592|M.gilvum_PYR-GCK LLPRFEKIEVIGEPEYVQSNFVRGISKLMVRLTPKAGA--
MMAR_3154|M.marinum_M LLPRFENIEVVGEPEYVQSNFVRGISKLMVRLTPKGGA--
MAB_2048c|M.abscessus_ATCC_199 LLPRFENIEVVGEPEYVQSNFVRGISKLMVRLTPRPSA--
Mb0801|M.bovis_AF2122/97 LLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG-----
Rv0778|M.tuberculosis_H37Rv LLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG-----
TH_4556|M.thermoresistible__bu VLSRMRDIRLAGTPELVPTHWVYGYSKMPITFTPGSKLGA
MAV_2174|M.avium_104 LRHEIPDIVATEEPARLLSQFIHGIKRLPVAWTPPR----
Mvan_3029|M.vanbaalenii_PYR-1 LHRLVPGIRAVEEPDRLHSAFIHGIKRLPVSWSA------
MSMEG_1429|M.smegmatis_MC2_155 LLPRLDSIELAGEPELSATTFVGGLKHLPIRYSIR-----
MUL_3863|M.ulcerans_Agy99 LLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM-----
MLBr_02088|M.leprae_Br4923 ISARFPQVQLAGELVYKPNVAMRGMSALPVQV--------
: . : . * : :