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QTHPPLRSPSFPLHSPDFYAGNPYPAYRELRATAPVCWNDVTNFWALLKYEDIRFVSSNPALFTSTRGIT IPDPQLPNPVQQGSLIFTDPPRHRQLRKLINSGFTRRRVSVLEPKIREIVRGILDGIERGAVHEFAEQIA APLPTRMIAELIGAPPDDWEQFRAWSDAATGTADPEIELDPAVAAGQLYEYFQRLIAARRARPRADLLSV LAEAEIDEHRLTDEDLLNFAFLLLVAGNETTRNLIALGTLALIAHPDQYRLLVEEPARIPLAVEEMLRWN SPVVHMARTATADVEIRGQRIRAGEVVVMLYGSANRDEDVFGPDSEEFDVTRHPNPHIAFGCGEHSCVGA QLARLEATVFFEELLRRYPRIELVGEVDRMRATMVPGVKRMPVRMGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1339 | - | - | 100% (398) | cytochrome P450 superfamily protein |
| M. avium 104 | MAV_0641 | - | 2e-69 | 40.32% (377) | P450 heme-thiolate protein |
| M. avium 104 | MAV_2811 | - | 1e-68 | 36.70% (406) | putative cytochrome P450 124 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 2e-65 | 38.75% (400) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_1321 | - | 1e-158 | 70.18% (389) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 2e-67 | 38.94% (398) | cytochrome P450 monooxygenase 142 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-51 | 35.87% (329) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1211c | - | 6e-66 | 37.63% (396) | cytochrome P450 |
| M. marinum M | MMAR_4833 | cyp123B1 | 1e-69 | 39.90% (386) | cytochrome P450 123B1 Cyp123B1 |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 9e-71 | 40.21% (388) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_2649 | - | 1e-177 | 77.20% (386) | PUTATIVE cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 1e-64 | 38.21% (390) | cytochrome P450 124A1, Cyp124A1 |
| M. vanbaalenii PYR-1 | Mvan_5481 | - | 1e-159 | 70.08% (391) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1339|M.avium_104 -----------------------MQTHPPLRSPSFPLHSPDFYA---GNP
TH_2649|M.thermoresistible__bu ------------------------------VLTTVPLHSPDFYA---GNP
Mflv_1321|M.gilvum_PYR-GCK --------------------------------MPPPLHSPAFYA---GDP
Mvan_5481|M.vanbaalenii_PYR-1 -----------------------------MSRLSNPLHSPAFYA---GDP
MSMEG_3551|M.smegmatis_MC2_155 ---------------MGIAPRVNGAAPPDVPLSEINLGSWDFWALDDDIR
MUL_1282|M.ulcerans_Agy99 -------MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFR
MAB_1211c|M.abscessus_ATCC_199 ------------------MTAMKTAAELGLPEG-FDFTDPELYG--NRMP
Mb0801|M.bovis_AF2122/97 ---------------------MTTAAG----LSGIDLTDLDNFA--DGFP
Rv3518c|M.tuberculosis_H37Rv ----------------------------MTEAPDVDLADGNFYAS--REA
MMAR_4833|M.marinum_M -------------------------MWQETLMSTVQLRYDPFDPEIQDDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:
MAV_1339|M.avium_104 YPAYRELRATAPVCWN----------DVTNFWALLKYEDIRFVSSNPALF
TH_2649|M.thermoresistible__bu YPAYRELRATTPVVYN----------DVTNFWALLKYEDIRYVSSHPQLF
Mflv_1321|M.gilvum_PYR-GCK FPAYRELRATDPVTWN----------EEHGFWALLKYEDIRYVSTNPALF
Mvan_5481|M.vanbaalenii_PYR-1 FPVYRELRATDPVCWN----------DEHEFWALLKYEDIRYVSTNPALF
MSMEG_3551|M.smegmatis_MC2_155 DGAFATLRREAPISFHPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELF
MUL_1282|M.ulcerans_Agy99 DGAFATLRREAPISFWPPIELAG-LTAGKGHWALTKHDDIHFASRHPEIF
MAB_1211c|M.abscessus_ATCC_199 HEEFATLRREAPVWWNPQPRTVGGFAD-EGYWVISKHRDVREVSLHTDTF
Mb0801|M.bovis_AF2122/97 HHLFAIHRREAPVYWHRPTEHTP---DGEGFWSVATYAETLEVLRDPVTY
Rv3518c|M.tuberculosis_H37Rv RAAYRWMRANQPVFRD-----------RNGLAAASTYQAVIDAERQPELF
MMAR_4833|M.marinum_M YPVYRQLRDDAPVYHA----------TDTNTWVLSRHADVISALLDHHSY
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLP-----------GMPLTVFSSFSDCDEALRHPLSA
: *: . . .
MAV_1339|M.avium_104 TSTRG-----ITIPDPQLPNPVQQGSLIFTDPPRHRQLRKLINSGFTRRR
TH_2649|M.thermoresistible__bu SSTKG-----ITIPDPDQPEPVQEGNLIFTDPPRHRQLRKLINTAFTRRQ
Mflv_1321|M.gilvum_PYR-GCK SSARG-----ITVPDPAIENPVMEGSLIFTDPPRHRRLRKLINSGFTRRQ
Mvan_5481|M.vanbaalenii_PYR-1 SSARG-----VTVPDPALENPVMEGSLIFTDPPRHRQLRKLINSGFTRRQ
MSMEG_3551|M.smegmatis_MC2_155 SSA-----SGIVIGDQTPELAEYFGSMIAMDDPRHTRLRNIVRSAFTPRV
MUL_1282|M.ulcerans_Agy99 HSS-----PNIVIHDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKV
MAB_1211c|M.abscessus_ATCC_199 SSGRKGAIPRLEDHISPEEFQATLSVLINKDAPEHTQLRGLVSRMFTPRS
Mb0801|M.bovis_AF2122/97 SSVTGG--QRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRM
Rv3518c|M.tuberculosis_H37Rv SNAGG-----------IRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKR
MMAR_4833|M.marinum_M SSVDG----VFPTPPGSTFRESLLPMMILMDPPRHDQLRALVSKAFTPRR
MLBr_02088|M.leprae_Br4923 SDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKV
. : * * * * :: :: :
MAV_1339|M.avium_104 VSVLEPKIREIVRGILDGIERGA---VHEFAEQIAAPLPTRMIAELIGAP
TH_2649|M.thermoresistible__bu VALLEPKVREIVYGIFEGVAPGS---EQEFAESFAAPLPTRMIAELLGAS
Mflv_1321|M.gilvum_PYR-GCK VAILEPKLRAFARTALDAIDPAG---GTEFAERIAAPLPTRMIAELLGAP
Mvan_5481|M.vanbaalenii_PYR-1 VAILEPKLRAFARAALDAIDPS----ATEFAEQVAAPLPTRMIAELLGAP
MSMEG_3551|M.smegmatis_MC2_155 LAVIEDSVRDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGIP
MUL_1282|M.ulcerans_Agy99 VARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIP
MAB_1211c|M.abscessus_ATCC_199 IAALRITLEERAERIVRAALEG---GHGEFVREVASELPMQAIAELIGVP
Mb0801|M.bovis_AF2122/97 IRRVEDDLRRRARGLLDGVEPG---APFDFVVEIAAELPMQMICILLGVP
Rv3518c|M.tuberculosis_H37Rv VKDKEASIAALCDTLIDAVCERG---ECDFVRDLAAPLPMAVIGDMLGVR
MMAR_4833|M.marinum_M IAALTSAIEDLADHLTGGLIQEAG--SADFVADFAAVLPAMVIADLLGVP
MLBr_02088|M.leprae_Br4923 VQALEGDIAALVDSLLDKGAAAG---QFDVIADLAFPLAVAVICRLLGVP
: : :. .* *. * ::*
MAV_1339|M.avium_104 PDDWEQFRAWSDAATGTADPE-IELDP--------AVAAGQLYEYFQRLI
TH_2649|M.thermoresistible__bu PEDWERFRRWSDACTGTADPE-IELDA--------MEAIGELYEYFQQLI
Mflv_1321|M.gilvum_PYR-GCK DEDWEQFRRWSDAAVGMDDPD-VELDT--------FTAMGELYQYFEKLI
Mvan_5481|M.vanbaalenii_PYR-1 DEDWEQFRTWSDATVGMDDPD-VELDT--------FAAMGELYQYFEAQI
MSMEG_3551|M.smegmatis_MC2_155 ESDHQQIFHWTNVILGFGDPD-LTTDFD-----EFVTVAMDIGAYATALA
MUL_1282|M.ulcerans_Agy99 EEDHEQIFHWTNVILGFGDPD-LTTDFD-----DFLQVSMAIGGYATALA
MAB_1211c|M.abscessus_ATCC_199 EEDRVKLFEWSNQMTGYDEAD-VEIDP--------RVGAAQILGYSYQLA
Mb0801|M.bovis_AF2122/97 ETDRHWLFEAVEPGFDFRGSRRATMPRL-----NVEDAGSRLYTYALELI
Rv3518c|M.tuberculosis_H37Rv PEQRDMFLRWSDDLVTFLSSHVSQEDFQ-----ITMDAFAAYNDFTRATI
MMAR_4833|M.marinum_M REDRTQFRQWSNALVQSNPTHGETGEA--------LAAAAAIYGYFTDFL
MLBr_02088|M.leprae_Br4923 YEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLV
: : . :
MAV_1339|M.avium_104 AARR---ARPRADLLSVLAEAEID---EHRLTDEDLLNFAFLLLVAGNET
TH_2649|M.thermoresistible__bu AARR---TEPRDDMMSVLAQAEVD---GARLSDEDLLNFAFLLLVAGNET
Mflv_1321|M.gilvum_PYR-GCK ALRRNGALRDSDDLLSVLVAAEVD---GVRLSDQDLLQFCLLLLVAGNET
Mvan_5481|M.vanbaalenii_PYR-1 ARRRDGTLRDSDDLLSVLVAAEVD---GVRLTDQDLLQFCLLLLVAGNET
MSMEG_3551|M.smegmatis_MC2_155 DQRR---SAPADDLTTSLVQAEVD---GERLTSAEVASFFILLVVAGNET
MUL_1282|M.ulcerans_Agy99 DDRR---VNHHGDLTTSLVEAEVD---GERLSSSEIAMFFILLVVAGNET
MAB_1211c|M.abscessus_ATCC_199 EQRR---DCPGNDVVSRLLTGTVD---GEQLTPEQFGFFVVMLSVAGNET
Mb0801|M.bovis_AF2122/97 AGKR---AEPADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAET
Rv3518c|M.tuberculosis_H37Rv AARR---ADPTDDLVSVLVSSEVD---GERLSDDELVMETLLILIGGDET
MMAR_4833|M.marinum_M ADRR---RQPRDDLMSALVCAEID---GKHLSDDELLGFCLLLLIAGHET
MLBr_02088|M.leprae_Br4923 KCRR---GTPGEDLISRLIELDES---GDQLTEEEIIATCGLLLVAGHET
:* *: : : . *: :. :: .* **
MAV_1339|M.avium_104 TRNLIALGTLALIAHPDQYRLLVEEP-ARIPLAVEEMLRWNSPVVHMART
TH_2649|M.thermoresistible__bu TRNLIALGTLALIEHPDQCRKLIENP-TLIPGAVEEMLRYTSPVTHMARQ
Mflv_1321|M.gilvum_PYR-GCK TRNLIALGTLALIEHPQQFRLLREHP-ELIPTAVEEFLRYTSPVANMTRC
Mvan_5481|M.vanbaalenii_PYR-1 TRNLVALGTLALIENPDQFRLLRQRR-DLVPTAVEEMLRYASPVANMTRC
MSMEG_3551|M.smegmatis_MC2_155 TRNAISHGVLALTRYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRT
MUL_1282|M.ulcerans_Agy99 TRNTISHGMLALSRYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRT
MAB_1211c|M.abscessus_ATCC_199 TRNATTMGMMAFLEHPGQWELFKS---ARPSTTVDEIVRYTSPLISQQRT
Mb0801|M.bovis_AF2122/97 TRNSIAGGLLALAENPDQLQTLRSDF-ELLPTAIEEIVRWTSPSPSKRRT
Rv3518c|M.tuberculosis_H37Rv TRHTLSGGTEQLLRNRDQWDLLQRDP-SLLPGAIEEMLRWTAPVKNMCRV
MMAR_4833|M.marinum_M TSNLLANAAVVLADYRDTRRQLAGDE-SLLGAAVEELLRYDSPAQGLSRT
MLBr_02088|M.leprae_Br4923 TVNLIANAVLAMLRNPSQWKALSSNP-QRAPLVVEETLRYDPAIHLIGRV
* : : . : .::* :*: .. *
MAV_1339|M.avium_104 ATADVEIRGQRIRAGEVVVMLYGSANRDEDVFGPDSEEFDVTRHPNPHIA
TH_2649|M.thermoresistible__bu ATEDVEIRGRHIRKGDTVVMLYGSANRDEEIFGDDAEDFRIDRQPNPHIA
Mflv_1321|M.gilvum_PYR-GCK ATRDVEMRGRLIREGQYVTMLYGSANRDEDIFGPTSEQLDVTRNPNPHLA
Mvan_5481|M.vanbaalenii_PYR-1 ATRDVDIRGRSIRAGQYVTMLYGSANRDKDVFGPTSEQFDITRNPNPHLA
MSMEG_3551|M.smegmatis_MC2_155 VTRDTELAGTALPAGSKVTLWYGSANRDETKFDN-PWMFDVQRHPNPHVG
MUL_1282|M.ulcerans_Agy99 LNQDVDLRGTKMAAGDKVTLWYCSANRDEEKFAD-PWTFDVTRNPNPQVG
MAB_1211c|M.abscessus_ATCC_199 ALQDTVISDVRIRAGERVVMLYPSANFDEEVFEN-PHTFDITRDPNPHLG
Mb0801|M.bovis_AF2122/97 ASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDR-ADEFDITRKPNPHLG
Rv3518c|M.tuberculosis_H37Rv LTADTEFHGTALCAGEKMMLLFESANFDEAVFCE-PEKFDVQRNPNSHLA
MMAR_4833|M.marinum_M LTRDVTVHGVRMSAGESVLLLFGSANRDERVFAD-PDVFDIGRKPEHQVA
MLBr_02088|M.leprae_Br4923 AAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSR-PDEFDPDRPSSRHLA
. : *. : : :** * : . : * .. ::.
MAV_1339|M.avium_104 FG-CGEHSCVGAQLARLEATVFFEELLRRYPRIELVGEV---DRMRATMV
TH_2649|M.thermoresistible__bu FG-CGEHSCIGAQLARLEACVFFEVLLGRFPDLELVGTV---DRMRATMV
Mflv_1321|M.gilvum_PYR-GCK FG-CGEHSCLGAQLARLEARVLFEELLARFEHIEPAGEV---LRMQATMV
Mvan_5481|M.vanbaalenii_PYR-1 FG-CGEHSCLGAQLARLEARVLFEELLNRFDHIELDGDV---LRMQATMV
MSMEG_3551|M.smegmatis_MC2_155 FGGGGAHFCLGANLARREITVLFSELHRHLPDIVATEEP---DRLQSAFI
MUL_1282|M.ulcerans_Agy99 FGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEP---ARLLSQFI
MAB_1211c|M.abscessus_ATCC_199 FGGTGAHYCLGANLAKAELEIIFNKIADRMPDISRIGDA---PRFHSGWI
Mb0801|M.bovis_AF2122/97 FG-QGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPA---EWTRSNRH
Rv3518c|M.tuberculosis_H37Rv FG-FGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFV
MMAR_4833|M.marinum_M FG-RGIHFCLGASLARMEARIALRALLARVPNWEVDLER--AQRLRSGPI
MLBr_02088|M.leprae_Br4923 FA-VGSHFCLGAALARLEATVTLSAISARFPQVQLAGEL---VYKPNVAM
*. * * *:* **: * : : :
MAV_1339|M.avium_104 PGVKRMPVRMGA---------------
TH_2649|M.thermoresistible__bu PGVKRMPVRLGAGR-------------
Mflv_1321|M.gilvum_PYR-GCK PGVRAMPVRLRAATDPRRAKARAG---
Mvan_5481|M.vanbaalenii_PYR-1 PGVRQMPVRLSATAAEPRETGTAAVSV
MSMEG_3551|M.smegmatis_MC2_155 HGIKRLPVAWR----------------
MUL_1282|M.ulcerans_Agy99 HGIKRLPVAWSR---------------
MAB_1211c|M.abscessus_ATCC_199 NGIKKFDTAYCPVTH------------
Mb0801|M.bovis_AF2122/97 TGIRHLVVELRGG--------------
Rv3518c|M.tuberculosis_H37Rv SGLESMPVVFTPSPPLG----------
MMAR_4833|M.marinum_M RGYLSLPISWSAN--------------
MLBr_02088|M.leprae_Br4923 RGMSALPVQV-----------------
* :