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MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGAFATLRREAPISFHEAYVIDPDNEV AGHWALTRHDDVFYASRHPEIFSSALGITVGDQTPELAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAL IEDSVRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGIPEEDHQKIFHWTNVILGFGDPDIA TDFDEFVSVAMGIGAYATQLADDRRDHPGDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAI SHGVLALSRYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIAAGDKVSLWYGSA NRDESKFENPWLFDVGRHPNPHVGFGGGGAHFCLGANLARREITVAFEELHRLVPGIRAVEEPDRLHSAF IHGIKRLPVSWSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3029 | - | - | 100% (433) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_0012 | - | 7e-98 | 45.28% (413) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_2234 | - | 4e-88 | 41.63% (406) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 0.0 | 72.90% (428) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_3307 | - | 0.0 | 88.58% (429) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 0.0 | 72.90% (428) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 6e-44 | 32.58% (356) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1211c | - | 7e-79 | 40.25% (395) | cytochrome P450 |
| M. marinum M | MMAR_3361 | cyp124A1 | 0.0 | 70.37% (432) | cytochrome P450 124A1, Cyp124A1 |
| M. avium 104 | MAV_2174 | - | 0.0 | 72.22% (432) | P450 heme-thiolate protein |
| M. smegmatis MC2 155 | MSMEG_3551 | - | 0.0 | 81.15% (419) | linalool 8-monooxygenase |
| M. thermoresistible (build 8) | TH_4175 | - | 0.0 | 76.64% (411) | PUTATIVE linalool 8-monooxygenase |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 0.0 | 69.91% (432) | cytochrome P450 124A1, Cyp124A1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2289|M.bovis_AF2122/97 ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATL
Rv2266|M.tuberculosis_H37Rv ----MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATL
MMAR_3361|M.marinum_M MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATL
MUL_1282|M.ulcerans_Agy99 MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATL
MAV_2174|M.avium_104 MSLKTRPKKGLATRINGAPPPRVPLADIHLESLDFWGYDDDFRDGAFATL
Mvan_3029|M.vanbaalenii_PYR-1 MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGAFATL
Mflv_3307|M.gilvum_PYR-GCK -MDGMSLDAHPVRR-NGIAPPEVPLADIDLGSWEFWGLDDDFRDGAFATL
MSMEG_3551|M.smegmatis_MC2_155 ----MGIAP----RVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATL
TH_4175|M.thermoresistible__bu ----MGIAA----RVNGAAPPPVPLADINLGDWTFWALDDDIRDGAFATL
MAB_1211c|M.abscessus_ATCC_199 -----------MTAMKTAAELGLPEG-FDFTDPELYG--NRMPHEEFATL
MLBr_02088|M.leprae_Br4923 ----MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGT
: : .
Mb2289|M.bovis_AF2122/97 RREAPISFWPTIELPGFV-AGNGHWALTKYDDVFYASRHPDIFSSYPNIT
Rv2266|M.tuberculosis_H37Rv RREAPISFWPTIELPGFV-AGNGHWALTKYDDVFYASRHPDIFSSYPNIT
MMAR_3361|M.marinum_M RREAPISFWPPIELAGLT-AGKGHWALTKHDDIHFASRHPEIFHSSPNIV
MUL_1282|M.ulcerans_Agy99 RREAPISFWPPIELAGLT-AGKGHWALTKHDDIHFASRHPEIFHSSPNIV
MAV_2174|M.avium_104 RREAPISFWPAIEMDGFV-AGNGYWALTKHEDVHFASRHPEIFSSVPNIT
Mvan_3029|M.vanbaalenii_PYR-1 RREAPISFHEAYVIDPDN-EVAGHWALTRHDDVFYASRHPEIFSSALGIT
Mflv_3307|M.gilvum_PYR-GCK RREAPVSFHRAYITDEDA-EVAGHWALTRHDDVFFASRHPEIFSSALGIT
MSMEG_3551|M.smegmatis_MC2_155 RREAPISFHPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSASGIV
TH_4175|M.thermoresistible__bu RREAPISFHPEYVDGGGT----GHWALTRYDDVFHASRHPEVFSSASGIT
MAB_1211c|M.abscessus_ATCC_199 RREAPVWWNPQPRTVGGF-ADEGYWVISKHRDVREVSLHTDTFSSGRKGA
MLBr_02088|M.leprae_Br4923 RADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKAT
* :. : .:: . * . *. . .
Mb2289|M.bovis_AF2122/97 IN----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAA
Rv2266|M.tuberculosis_H37Rv IN----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAA
MMAR_3361|M.marinum_M IH----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAS
MUL_1282|M.ulcerans_Agy99 IH----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAS
MAV_2174|M.avium_104 IN----DQTPE-LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAS
Mvan_3029|M.vanbaalenii_PYR-1 VG----DQTPE-LAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLALIEDS
Mflv_3307|M.gilvum_PYR-GCK VG----DQTPE-LAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLALIEDS
MSMEG_3551|M.smegmatis_MC2_155 IG----DQTPE-LAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAVIEDS
TH_4175|M.thermoresistible__bu LG----EQNPD-LTEYFGSMIAMDDPRHGRLRGIVRSAFTPRVVARTEES
MAB_1211c|M.abscessus_ATCC_199 IPRLEDHISPEEFQATLSVLINKDAPEHTQLRGLVSRMFTPRSIAALRIT
MLBr_02088|M.leprae_Br4923 LAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGD
: .: . :: * * * :** :* *:*: : .
Mb2289|M.bovis_AF2122/97 VRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRI
Rv2266|M.tuberculosis_H37Rv VRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRI
MMAR_3361|M.marinum_M VRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHEQI
MUL_1282|M.ulcerans_Agy99 VRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHEQI
MAV_2174|M.avium_104 VRERARRLVSSLVANHPNGEAELVSELAGPLPLQVICDMMGIPEEDHQRV
Mvan_3029|M.vanbaalenii_PYR-1 VRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGIPEEDHQKI
Mflv_3307|M.gilvum_PYR-GCK VRQRARRLVEDMVAAHPDGRGELVSELAGPLPLQIICDMMGIPPRDHQKI
MSMEG_3551|M.smegmatis_MC2_155 VRDRARRLVAGMVDRNPDGHAELVTELAGPLPLQIICDMMGIPESDHQQI
TH_4175|M.thermoresistible__bu VRRRARRLVAAMVAGHPAGAAELVSAFAGPLPLQVICDMMGIPETDHQQI
MAB_1211c|M.abscessus_ATCC_199 LEERAERIVRAALEG---GHGEFVREVASELPMQAIAELIGVPEEDRVKL
MLBr_02088|M.leprae_Br4923 IAALVDSLLD---KGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEF
: . :: :.: .* *.: *. ::*:* * ..
Mb2289|M.bovis_AF2122/97 FHWTNVILGFGDPDLATDFDEFMQVSADIGA------YATALAEDRRVNH
Rv2266|M.tuberculosis_H37Rv FHWTNVILGFGDPDLATDFDEFMQVSADIGA------YATALAEDRRVNH
MMAR_3361|M.marinum_M FHWTNVILGFGDPDLTTDFDEFLQVSMAIGG------YATALADDRRVNH
MUL_1282|M.ulcerans_Agy99 FHWTNVILGFGDPDLTTDFDDFLQVSMAIGG------YATALADDRRVNH
MAV_2174|M.avium_104 FHWTNVILGFGDPDLATDFEEFLQVSMDIGA------YATALAEDRRVNH
Mvan_3029|M.vanbaalenii_PYR-1 FHWTNVILGFGDPDIATDFDEFVSVAMGIGA------YATQLADDRRDHP
Mflv_3307|M.gilvum_PYR-GCK FHWTNVILGFGDPDIATDFDEFVSVAMGIGA------YASELADDRRAHP
MSMEG_3551|M.smegmatis_MC2_155 FHWTNVILGFGDPDLTTDFDEFVTVAMDIGA------YATALADQRRSAP
TH_4175|M.thermoresistible__bu FHWTNVILGFGDPDLTTDYDEFVQVAVDIGG------YATDLAEQRRKNP
MAB_1211c|M.abscessus_ATCC_199 FEWSNQMTGYDEADVEIDP---RVGAAQILG------YSYQLAEQRRDCP
MLBr_02088|M.leprae_Br4923 GRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTP
. : : :. : : . * *.. **
Mb2289|M.bovis_AF2122/97 HDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALS
Rv2266|M.tuberculosis_H37Rv HDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALS
MMAR_3361|M.marinum_M HGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALS
MUL_1282|M.ulcerans_Agy99 HGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTISHGMLALS
MAV_2174|M.avium_104 HDDLTTSLVEAEVDGERLTSSEIASFFILLVVAGNETTRNAISHGVLALS
Mvan_3029|M.vanbaalenii_PYR-1 GDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAISHGVLALS
Mflv_3307|M.gilvum_PYR-GCK GDDLTTALIEAELDGERLTSAEVASFFILLVVAGNETTRNAISHGVLALS
MSMEG_3551|M.smegmatis_MC2_155 ADDLTTSLVQAEVDGERLTSAEVASFFILLVVAGNETTRNAISHGVLALT
TH_4175|M.thermoresistible__bu GPDLTTSLVQAEVDGEQLTSADIASFFILLVVAGNETTRNAISHGMLALT
MAB_1211c|M.abscessus_ATCC_199 GNDVVSRLLTGTVDGEQLTPEQFGFFVVMLSVAGNETTRNATTMGMMAFL
MLBr_02088|M.leprae_Br4923 GEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAML
*: : *: .*::*: :. :* ***:*** * : .::*:
Mb2289|M.bovis_AF2122/97 RYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMA
Rv2266|M.tuberculosis_H37Rv RYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMA
MMAR_3361|M.marinum_M RYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMA
MUL_1282|M.ulcerans_Agy99 RYPDERAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLNQDVDLRGTKMA
MAV_2174|M.avium_104 RYPDERDKWFSDFDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLRGTKMK
Mvan_3029|M.vanbaalenii_PYR-1 RYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIA
Mflv_3307|M.gilvum_PYR-GCK RYPEERDRWWSDYAGLAPTAVEEIVRWASPVAYMRRTATRDVEVGGQTIA
MSMEG_3551|M.smegmatis_MC2_155 RYPEQRRLWWSRFDELAPTAVEEIVRWASPVSYMRRTVTRDTELAGTALP
TH_4175|M.thermoresistible__bu RHPDQRQDWWDHFDEVTPTAVEEIVRWASPVTYMRRTVTRDTELRGVRMA
MAB_1211c|M.abscessus_ATCC_199 EHPGQWELFKS---ARPSTTVDEIVRYTSPLISQQRTALQDTVISDVRIR
MLBr_02088|M.leprae_Br4923 RNPSQWKALSSN-PQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLT
. * : . .. .*:* :*: ..: *. :* : :
Mb2289|M.bovis_AF2122/97 AGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANL
Rv2266|M.tuberculosis_H37Rv AGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANL
MMAR_3361|M.marinum_M AGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFCLGANL
MUL_1282|M.ulcerans_Agy99 AGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFGGGGAHFCLGANL
MAV_2174|M.avium_104 AGDKVALWYNSANRDESTFDNPWLFDVARTPNPHLGFGGGGAHFCLGANL
Mvan_3029|M.vanbaalenii_PYR-1 AGDKVSLWYGSANRDESKFENPWLFDVGRHPNPHVGFGGGGAHFCLGANL
Mflv_3307|M.gilvum_PYR-GCK AGDKVTLWYGSANRDETKFDNPWLFDVGRHPNPHVGFGGGGAHFCLGANL
MSMEG_3551|M.smegmatis_MC2_155 AGSKVTLWYGSANRDETKFDNPWMFDVQRHPNPHVGFGGGGAHFCLGANL
TH_4175|M.thermoresistible__bu AGDKVTLWYGSANRDESRFSDPWLFDVRRHPNPHVGFGGGGVHFCLGANL
MAB_1211c|M.abscessus_ATCC_199 AGERVVMLYPSANFDEEVFENPHTFDITRDPNPHLGFGGTGAHYCLGANL
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFCLGAAL
*. : : :** * : * ** * .. ::.*. *:**** *
Mb2289|M.bovis_AF2122/97 ARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKT------------
Rv2266|M.tuberculosis_H37Rv ARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKT------------
MMAR_3361|M.marinum_M ARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKR------------
MUL_1282|M.ulcerans_Agy99 ARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKR------------
MAV_2174|M.avium_104 ARREIRVVFDELRHEIPDIVATEEPARLLSQFIHGIKR------------
Mvan_3029|M.vanbaalenii_PYR-1 ARREITVAFEELHRLVPGIRAVEEPDRLHSAFIHGIKR------------
Mflv_3307|M.gilvum_PYR-GCK ARREITVAFEELHRLVPDIHATEEPGRLHSAFIHGIKT------------
MSMEG_3551|M.smegmatis_MC2_155 ARREITVLFSELHRHLPDIVATEEPDRLQSAFIHGIKR------------
TH_4175|M.thermoresistible__bu ARREIAVAFDELRRQVPDIEVTEEPDRLHSAFIHGIXXXAEPESLPEPPP
MAB_1211c|M.abscessus_ATCC_199 AKAELEIIFNKIADRMPDISRIGDAPRFHSGWINGIKK------------
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSA------------
*: * : :. : .* : : . :.*:
Mb2289|M.bovis_AF2122/97 --------------------------------LPVTWS------------
Rv2266|M.tuberculosis_H37Rv --------------------------------LPVTWS------------
MMAR_3361|M.marinum_M --------------------------------LPVAWSR-----------
MUL_1282|M.ulcerans_Agy99 --------------------------------LPVAWSR-----------
MAV_2174|M.avium_104 --------------------------------LPVAWTPPR---------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------LPVSWSA-----------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------LPVAWTPPTR--------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------LPVAWR------------
TH_4175|M.thermoresistible__bu VASPSEALVNPRFLVAPPEPPAVGPSAFVPPMLGVSSSAPTSTERSSSSE
MAB_1211c|M.abscessus_ATCC_199 --------------------------------FDTAYCPVTH--------
MLBr_02088|M.leprae_Br4923 --------------------------------LPVQV-------------
: .
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3361|M.marinum_M --------------------------------------------------
MUL_1282|M.ulcerans_Agy99 --------------------------------------------------
MAV_2174|M.avium_104 --------------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------------------------
TH_4175|M.thermoresistible__bu PASVSTTSTPPFSEVASVRAALLAFLAGLSTKPATSTVSASDPWPVLSPT
MAB_1211c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
Mb2289|M.bovis_AF2122/97 --------------------------------------------------
Rv2266|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3361|M.marinum_M --------------------------------------------------
MUL_1282|M.ulcerans_Agy99 --------------------------------------------------
MAV_2174|M.avium_104 --------------------------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3307|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3551|M.smegmatis_MC2_155 --------------------------------------------------
TH_4175|M.thermoresistible__bu ASPPLASPSPSSKPTATNSPLPVLGSPTPPAADGADFSAALNNPPKGFVG
MAB_1211c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
Mb2289|M.bovis_AF2122/97 -----------------------------------
Rv2266|M.tuberculosis_H37Rv -----------------------------------
MMAR_3361|M.marinum_M -----------------------------------
MUL_1282|M.ulcerans_Agy99 -----------------------------------
MAV_2174|M.avium_104 -----------------------------------
Mvan_3029|M.vanbaalenii_PYR-1 -----------------------------------
Mflv_3307|M.gilvum_PYR-GCK -----------------------------------
MSMEG_3551|M.smegmatis_MC2_155 -----------------------------------
TH_4175|M.thermoresistible__bu TPPEAPSASAIARGRVTVSTSTSPGIPSAPTRSPG
MAB_1211c|M.abscessus_ATCC_199 -----------------------------------
MLBr_02088|M.leprae_Br4923 -----------------------------------