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SNIREAVTAKAQATIPMDRIIQGAHLYDRTRRWVTGTNGEKIFIERPIPPADEVELTDIDLSNPFLYRQG RWKSYYERLRNEAPVHYQAHSAFGPFWSVTRHADIVAVDKNHEVFSSEPFIVIGSPPRFLDIAMFIAMDP PKHDRQRQAVQGVVAPKNLREMEGLIRERVVDVLDALPLGEPFNWVQHVSIELTARMLATLLDFPFEQRR KLVQWSDLATSMEQANGGPSDNDEIFRGMVDMARGLSAHWRDKAARTAAGELPGFDLITMLQSDESTKDL IDRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNEFPDQFEKLKANPELIPNMVSEIIRWQTPLAHMRRI AKADTVLNGQFIRKGDKVLMWYASGNRDERVFDRPDDLIIDRANARNHISFGFGVHRCMGNRLAEMQLRI LWEELLPRFENIEVVGEPEYVQSNFVRGISKLMVRLTPKGGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3154 | cyp153A16 | - | 100% (463) | cytochrome P450 153A16 Cyp153A16 |
| M. marinum M | MMAR_3761 | cyp268A2 | 1e-50 | 35.27% (414) | cytochrome P450 268A2 Cyp268A2 |
| M. marinum M | MMAR_3999 | cyp108B4 | 2e-48 | 31.25% (416) | cytochrome P450 108B4 Cyp108B4 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0801 | cyp126 | 2e-49 | 33.88% (425) | cytochrome P450 126 |
| M. gilvum PYR-GCK | Mflv_4592 | - | 0.0 | 86.74% (460) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0778 | cyp126 | 2e-49 | 33.88% (425) | cytochrome P450 126 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-35 | 28.65% (342) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_2048c | - | 0.0 | 84.16% (461) | cytochrome P450 |
| M. avium 104 | MAV_1339 | - | 4e-50 | 33.83% (399) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_1431 | - | 3e-49 | 30.66% (411) | cytochrome P450-terp |
| M. thermoresistible (build 8) | TH_4132 | - | 3e-53 | 32.12% (411) | PUTATIVE putative cytochrome P450 |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 2e-47 | 30.53% (416) | cytochrome P450 108B4 Cyp108B4 |
| M. vanbaalenii PYR-1 | Mvan_1302 | - | 6e-52 | 32.44% (410) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3154|M.marinum_M MSNIREAVTAKAQATIPMDRIIQGAHLYDRTRRWVTGTNGEKIFIERPIP
Mflv_4592|M.gilvum_PYR-GCK MVKISEKVAEKVQATIPIDLQIQGAHAYDKTRRWVTGTNGKKLFVERPIP
MAB_2048c|M.abscessus_ATCC_199 -MSIPAAVAAKAQSAVPLELQIRGAHLYDKTRRWVTGTNGKKIFTETPIP
Mb0801|M.bovis_AF2122/97 --------------------------------------------------
Rv0778|M.tuberculosis_H37Rv --------------------------------------------------
TH_4132|M.thermoresistible__bu --------------------------------------------MTVQPV
MSMEG_1431|M.smegmatis_MC2_155 ----------------------------------MFLTPVKFSPSEVPDM
Mvan_1302|M.vanbaalenii_PYR-1 -----------------------------------------MSTPVIDEA
MUL_3863|M.ulcerans_Agy99 -----------------------------------------MSAPTMDEA
MAV_1339|M.avium_104 ------------------------------------------------MQ
MLBr_02088|M.leprae_Br4923 ------------------------------------MRTCVPTRTCVYAF
MMAR_3154|M.marinum_M PADEVELTDIDLSNPFLYRQG-RWKSYYER-LRNEAPVHYQAHSAFGP--
Mflv_4592|M.gilvum_PYR-GCK PAEEVELADIDLSNPFLYRQG-RWQSYYER-LRNEAPVHYQRHSAFGP--
MAB_2048c|M.abscessus_ATCC_199 PVEDVDIADIDLSNPFLYRQG-RWKSYFER-VRNEAPVHYQARSPFGP--
Mb0801|M.bovis_AF2122/97 MTTAAGLSGIDLTDLDNFADG-FPHHLFAI-HRREAPVYWHRPTEHTPDG
Rv0778|M.tuberculosis_H37Rv MTTAAGLSGIDLTDLDNFADG-FPHHLFAI-HRREAPVYWHRPTEHTPDG
TH_4132|M.thermoresistible__bu TDTTWDVKHVNVFDPQWWVDG-PPHDLFKR-MRAESPVHWYQFADGEGYG
MSMEG_1431|M.smegmatis_MC2_155 STPVINDAARVLAEPRAYADEPRLHAALAE-LRSQTPVAYVDVPGYYP--
Mvan_1302|M.vanbaalenii_PYR-1 AS----DAARVLADPKAYTDEARLHAALAH-LRAHAPVSYVDVPDYRP--
MUL_3863|M.ulcerans_Agy99 AL---------LADPLAYTDETRLHAALTR-LRAQAPVALVDVPNYRR--
MAV_1339|M.avium_104 THPPLRSPSFPLHSPDFYAGN--PYPAYRE-LRATAPVCWNDVT------
MLBr_02088|M.leprae_Br4923 IEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADPFPVYRALIDYGPMQ
* .
MMAR_3154|M.marinum_M --FWSVTRHADIVAVDKNHEVFSSEP-----FIVIGSPPRF-----LDIA
Mflv_4592|M.gilvum_PYR-GCK --FWSVTRHADIVAVDKNHEVFSAEP-----LIVIGVPPRF-----LDIK
MAB_2048c|M.abscessus_ATCC_199 --FWSVTRHADIIAVDKNHEAFSAEP-----FIIIGRPPRF-----MDIA
Mb0801|M.bovis_AF2122/97 EGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLP-----VAGQ
Rv0778|M.tuberculosis_H37Rv EGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLP-----VAGQ
TH_4132|M.thermoresistible__bu PGYWSLFRHADIATVSHDTETFSSNRGG-LFIHPDQMLSLD-----VLTN
MSMEG_1431|M.smegmatis_MC2_155 --FWAITKHADVMAIERDNELFINAPRPMLITKEKDDLAKANLAAGGGIR
Mvan_1302|M.vanbaalenii_PYR-1 --FWAVTKHSDIMAIERDNELWINEPRPLLTTAATDDLSQANLAAGGGIR
MUL_3863|M.ulcerans_Agy99 --FWAITRHADVMDIERDNTLFTNWPRPVLATVAGDELQAA-----AGVR
MAV_1339|M.avium_104 -NFWALLKYEDIRFVSSNPALFTSTRG---ITIPDPQLPNP-----VQQG
MLBr_02088|M.leprae_Br4923 LPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQAIAAGAEPRPFYAS
.: . .
MMAR_3154|M.marinum_M MFIAMDPPKHDRQRQAVQGVVAPKNLREMEGLIRERVVDVLDALPLGEP-
Mflv_4592|M.gilvum_PYR-GCK MFIAMDPPRHDLQRAAVQGVVAPKNLREMEGLIRSRVREVLDNLPVDQP-
MAB_2048c|M.abscessus_ATCC_199 MFIAMDPPQHDLQRASVQGVVAPKNLREMEGLIRSRVQEVLDDLPVDQP-
Mb0801|M.bovis_AF2122/97 VLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAP-
Rv0778|M.tuberculosis_H37Rv VLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAP-
TH_4132|M.thermoresistible__bu MLNFMDPPTHTRYRKILARVFTPAAVAKMEDGIRARVNRIIDKVIEAGR-
MSMEG_1431|M.smegmatis_MC2_155 TLIHMDDPLHRDIRKIGADWFRPKAMRALKERVDELAKIYVDKLVEKGPE
Mvan_1302|M.vanbaalenii_PYR-1 TLIHMDDPLHRDIRKIGADWFRPKAMRDLKTRVDELAKIYVDKMVEKGPE
MUL_3863|M.ulcerans_Agy99 TLIHLDDPQHRVARAIGADWFRPKAMRALKVRVDELAKNYVDAMMAAGPE
MAV_1339|M.avium_104 SLIFTDPPRHRQLRKLINSGFTRRRVSVLEPKIREIVRGILDGIERGAV-
MLBr_02088|M.leprae_Br4923 SFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAALVDSLLDKGAAAGQ-
: * * * * . : :: : . :*
MMAR_3154|M.marinum_M FNWVQHVSIELTARMLATLLDFPFEQRRKLVQWSDLATSMEQANGGPSDN
Mflv_4592|M.gilvum_PYR-GCK FDWVHDVSIELTARMLATLLDFPYEQRRKLVEWSDLATSMEQTNGGPSDL
MAB_2048c|M.abscessus_ATCC_199 FNWVHHVSIELTARMLATLLDFPYEQRHKLVEWSDLATSMEQANGGPSDN
Mb0801|M.bovis_AF2122/97 FDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPR
Rv0778|M.tuberculosis_H37Rv FDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPR
TH_4132|M.thermoresistible__bu CDFVEDIAVPIPLGILMELMGAPEEDMPKFYYWTEA---IEQAIRDPEPN
MSMEG_1431|M.smegmatis_MC2_155 CDFVQEVAVNYPLYVILSLLGLPESDFDRMLKLTQELFGNDDDEMGRGSS
Mvan_1302|M.vanbaalenii_PYR-1 CDFVQEVAVNFPLYVILSLLGLPESDFGRMLKLTQEMFGGDDDELTRGKS
MUL_3863|M.ulcerans_Agy99 CDFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGSDDSEFKRGST
MAV_1339|M.avium_104 HEFAEQIAAPLPTRMIAELIGAPPDDWEQFRAWSDAATGTADPEIELDPA
MLBr_02088|M.leprae_Br4923 FDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALLVQSVDPFITITGE
: .:: . :: *:. * : :
MMAR_3154|M.marinum_M DE-IFRGMVDMARGLSAHWRDKAARTAAGELPGFDLITMLQSDESTKDLI
Mflv_4592|M.gilvum_PYR-GCK DE-TFVGMRAMARDLSRHWHDKAARTGAGEEPGFDLITMLQSNESTKDLI
MAB_2048c|M.abscessus_ATCC_199 DR-VFRGMVDMAKGLSALWHDKAARTANGERPGFDLITMLQANEDTKDLI
Mb0801|M.bovis_AF2122/97 -----LNVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPA
Rv0778|M.tuberculosis_H37Rv -----LNVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPA
TH_4132|M.thermoresistible__bu ------TGVEVFDEMGAYLTEQIERQTTEAVEDSLVMRLRNAEVDGEKLT
MSMEG_1431|M.smegmatis_MC2_155 A----EELNAVILDFFNYFTELTADRRANPTEDLASAIANAKLNGE---Y
Mvan_1302|M.vanbaalenii_PYR-1 P----EELHEVITDFFRYFTALTAERRANPTEDLASAIANAKLDGE---Y
MUL_3863|M.ulcerans_Agy99 S----EDQLPALLDMFGYFNAVTTARRAHPTADLASAIANARIDGE---P
MAV_1339|M.avium_104 V---------AAGQLYEYFQRLIAARRARPRADLLSVLAEAEIDEHR---
MLBr_02088|M.leprae_Br4923 PPEATEERLRAGVWLRDYLEQLVKCRRGTPGEDLISRLIELDESGDQ---
: .
MMAR_3154|M.marinum_M DRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNEFPDQFEKLKANPELIP
Mflv_4592|M.gilvum_PYR-GCK DRPMEFLGNLLLLIVGGNDTTRNSMSGGVLALNRYPDQFEKLKANPDLIP
MAB_2048c|M.abscessus_ATCC_199 DRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNQFPDQFEKLKANPDLIP
Mb0801|M.bovis_AF2122/97 LSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELLP
Rv0778|M.tuberculosis_H37Rv LSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELLP
TH_4132|M.thermoresistible__bu D--VEIVMFFGLLTFAGNDTTRNTASAGLRTLLEHPDALQQLYDDAALIP
MSMEG_1431|M.smegmatis_MC2_155 LNDVDCLSYYVIVASAGHDTTSAAISGGLLALTENQDQLARLKADMSLMP
Mvan_1302|M.vanbaalenii_PYR-1 LNDIDCLSYYVIVASAGHDTTSAAISGGMLALIENQDQLARLKAQPELMG
MUL_3863|M.ulcerans_Agy99 LSDIDTVSYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQADPALMS
MAV_1339|M.avium_104 LTDEDLLNFAFLLLVAGNETTRNLIALGTLALIAHPDQYRLLVEEPARIP
MLBr_02088|M.leprae_Br4923 LTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSSNPQRAP
: :: .* :** : . :: . * :
MMAR_3154|M.marinum_M NMVSEIIRWQTPLAHMRRIAKADTVLNGQFIRKGDKVLMWYASGNRDERV
Mflv_4592|M.gilvum_PYR-GCK NMNSEIIRWQTPLAYMRRIAKADTMLNGQFIRKGDKVVMWYASGNRDERV
MAB_2048c|M.abscessus_ATCC_199 NMVSEIIRWQTPLAYMRRVAKKDIMLNGQFIRKGDKVVMWYASGNRDERV
Mb0801|M.bovis_AF2122/97 TAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSV
Rv0778|M.tuberculosis_H37Rv TAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSV
TH_4132|M.thermoresistible__bu NAIEEILRYTSVVQWFARTATRDVELGGQKISEGDKVVMWYASGSRDEAV
MSMEG_1431|M.smegmatis_MC2_155 LATEEIIRWSAPVKEFMRTATRDTEVRGVPIKEGESVLLSYVSANRDEEI
Mvan_1302|M.vanbaalenii_PYR-1 TAVEEIIRWTTPVKEFMRTATADTEVRGVPIREGESVLLSYVSANRDEDI
MUL_3863|M.ulcerans_Agy99 LATEEMIRWVTPVKQFMRTASSDTVVRGIPIAAGESVLLSYVSANRDEEV
MAV_1339|M.avium_104 LAVEEMLRWNSPVVHMARTATADVEIRGQRIRAGEVVVMLYGSANRDEDV
MLBr_02088|M.leprae_Br4923 LVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAV
.* :*: . * * : : *: ::: :..** :
MMAR_3154|M.marinum_M FD-RPDDLIIDRANARNHISFGFGVHRCMGNRLAEMQLRILWEELLPRFE
Mflv_4592|M.gilvum_PYR-GCK FD-RPDDFIIDRDNARNHISFGFGVHRCMGNRLAEMQLRILWEELLPRFE
MAB_2048c|M.abscessus_ATCC_199 FE-RADELIIDRSNARNHISFGFGVHRCMGNRLAELQLRILWEELLPRFE
Mb0801|M.bovis_AF2122/97 FD-RADEFDITR-KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFG
Rv0778|M.tuberculosis_H37Rv FD-RADEFDITR-KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFG
TH_4132|M.thermoresistible__bu FD-DSDTFDIHRPKPDHQAFGGGGRHFCLGASLARLELRIIFEEVLGRMK
MSMEG_1431|M.smegmatis_MC2_155 FE-NADKFDVGR-DPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLE
Mvan_1302|M.vanbaalenii_PYR-1 FD-EPAKFDVGR-DPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLE
MUL_3863|M.ulcerans_Agy99 FD-QPFRFDIGR-EPNKHVAFGYGVHFCMGAALARMEVASFFTELLPRLK
MAV_1339|M.avium_104 FGPDSEEFDVTR-HPNPHIAFGCGEHSCVGAQLARLEATVFFEELLRRYP
MLBr_02088|M.leprae_Br4923 YS-RPDEFDPDR-PSSRHLAFAVGSHFCLGAALARLEATVTLSAISARFP
: . : * . : . * * *:* **.:: : *
MMAR_3154|M.marinum_M NIEVVGEPEYVQSNFVRGISKLMVRLTPKGGA--
Mflv_4592|M.gilvum_PYR-GCK KIEVIGEPEYVQSNFVRGISKLMVRLTPKAGA--
MAB_2048c|M.abscessus_ATCC_199 NIEVVGEPEYVQSNFVRGISKLMVRLTPRPSA--
Mb0801|M.bovis_AF2122/97 SVRVVEPAEWTRSNRHTGIRHLVVELRGG-----
Rv0778|M.tuberculosis_H37Rv SVRVVEPAEWTRSNRHTGIRHLVVELRGG-----
TH_4132|M.thermoresistible__bu NLQLAGTTEILPSNWAYGLTKLPVTFTAGRRLES
MSMEG_1431|M.smegmatis_MC2_155 SIELAGDPEFMATTFVGGLKHLPIRYSVR-----
Mvan_1302|M.vanbaalenii_PYR-1 SIELAGDPEYIATIFVGGLKHLPIRYSVR-----
MUL_3863|M.ulcerans_Agy99 SIELSGDPQFTATTFVGGLKRLPVSYSLM-----
MAV_1339|M.avium_104 RIELVGEVDRMRATMVPGVKRMPVRMGA------
MLBr_02088|M.leprae_Br4923 QVQLAGELVYKPNVAMRGMSALPVQV--------
:.: *: : :