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MATALSEIEEAGRVLADPAAYADELRLHAAMTLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALW INEPRPLLMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDMKLRTDELANRYVN KLLEAGGSCDFAQDIAVHFPLYVIMSLLGIPESDFDRMLKLTQELFGGDDSEFQRGTTPEEQLMALLDFF GYFSGLTASRRQHPTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEALLEHPDQL ARLRENPGLMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPITEGESVLLSYPSGNRDEDIFTDPFTFDI ARDPNKHLAFGFGVHFCLGAALARMEVNSFFSALLPRLESIEVDGNIERTSTIFVGGIKHLPIRYTLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3825 | - | - | 100% (418) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_0101 | - | 9e-58 | 35.25% (366) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_0613 | - | 9e-55 | 31.33% (415) | putative cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 7e-59 | 33.91% (407) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_4325 | - | 1e-170 | 70.17% (409) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 7e-59 | 33.91% (407) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-37 | 30.09% (349) | putative cytochrome p450 |
| M. marinum M | MMAR_3999 | cyp108B4 | 1e-162 | 66.83% (404) | cytochrome P450 108B4 Cyp108B4 |
| M. avium 104 | MAV_1609 | - | 1e-168 | 68.54% (410) | cytochrome P450 family protein |
| M. smegmatis MC2 155 | MSMEG_1429 | - | 1e-164 | 66.91% (411) | cytochrome P450-terp |
| M. thermoresistible (build 8) | TH_2733 | - | 1e-161 | 67.64% (411) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 1e-160 | 66.58% (404) | cytochrome P450 108B4 Cyp108B4 |
| M. vanbaalenii PYR-1 | Mvan_2021 | - | 1e-168 | 69.44% (409) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2289|M.bovis_AF2122/97 MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREA
Rv2266|M.tuberculosis_H37Rv MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREA
MMAR_3999|M.marinum_M --MSAPTMDEAA-LLADPLAYTDETR------------LHAALTRLRAQA
MUL_3863|M.ulcerans_Agy99 --MSAPTMDEAA-LLADPLAYTDETR------------LHAALTRLRAQA
MAV_1609|M.avium_104 --MSTTTMDEAAKLLADPMAYTDEQR------------LHAALTHLRANA
TH_2733|M.thermoresistible__bu --MSTPIIDEAARVFATPKAYTDERA------------LHAALTHLRAHA
Mflv_4325|M.gilvum_PYR-GCK --MSVRVADEAGKVFADPTAYADEQR------------LHAAMTHLRANA
Mvan_2021|M.vanbaalenii_PYR-1 --MSVRIADEAARVFADPSAYADEAR------------LHAAMTHLRANA
MSMEG_1429|M.smegmatis_MC2_155 --MSTPTMDDAAKALADPTAYADDAR------------LHEALARLRAEN
MAB_3825|M.abscessus_ATCC_1997 MATALSEIEEAGRVLADPAAYADELR------------LHAAMTLLRREQ
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
. . * .
Mb2289|M.bovis_AF2122/97 PISFWPTIELPGFVAG-NGHWALTKYDDVFYASRHPDIFSSYPNITINDQ
Rv2266|M.tuberculosis_H37Rv PISFWPTIELPGFVAG-NGHWALTKYDDVFYASRHPDIFSSYPNITINDQ
MMAR_3999|M.marinum_M PVALVDVPNYR-------RFWAITRHADVMDIERDNTLFTNWPRPVLATV
MUL_3863|M.ulcerans_Agy99 PVALVDVPNYR-------RFWAITRHADVMDIERDNTLFTNWPRPVLATV
MAV_1609|M.avium_104 PVSWVEVPNYK-------PFWAITKHADVMDIERENMLFTNWPRPVLTTA
TH_2733|M.thermoresistible__bu PVSWVEVDGYR-------PFWAITKHADIMAIERDNELFTNSPRPVLITA
Mflv_4325|M.gilvum_PYR-GCK PVSWVDVEGYN-------PFWAITKHADIMAIERDNTVFTNSPRPVLTTA
Mvan_2021|M.vanbaalenii_PYR-1 PVSWVEVPGYN-------PFWAITKHADIMAVERDNLVFTNSPRPVLTTA
MSMEG_1429|M.smegmatis_MC2_155 PVAWVDQAPYR-------PFWAITKHADIMAIERANDLWLSAPRPLLATA
MAB_3825|M.abscessus_ATCC_1997 PVTKVITDDYR-------PFWAVTKHDDIMAVERDNALWINEPRPLLMNL
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
..: . * * . . :
Mb2289|M.bovis_AF2122/97 TPE--------LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAV
Rv2266|M.tuberculosis_H37Rv TPE--------LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAV
MMAR_3999|M.marinum_M AGD-----ELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALKVRV
MUL_3863|M.ulcerans_Agy99 AGD-----ELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALKVRV
MAV_1609|M.avium_104 EGD-----EMQAAAGVRTLIHMDDPQHRVVRAIGSDWFRPKAMRALKVRV
TH_2733|M.thermoresistible__bu EAD-----ELQAGVGIRTLIHLDDPEHRDLRAIGADWFRPKAMRALKIRV
Mflv_4325|M.gilvum_PYR-GCK EGD-----AQHASMGVSTLIHMDDPQHRKVRAIGADWFRPKAMRALKVRV
Mvan_2021|M.vanbaalenii_PYR-1 EGD-----AQHEAMGISTLIHLDDPQHRKVRAIGADWFRPKAMRALKVRV
MSMEG_1429|M.smegmatis_MC2_155 EADDLGRSQQEMGIGLRTLIHMDDPHHRKVRAIGADWFRPKAMRELKVRV
MAB_3825|M.abscessus_ATCC_1997 EQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDMKLRT
MLBr_02088|M.leprae_Br4923 AIAAG---AEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
::: :* * * * : : * **.: ::
Mb2289|M.bovis_AF2122/97 RDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRIF
Rv2266|M.tuberculosis_H37Rv RDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRIF
MMAR_3999|M.marinum_M DELAKNYVDAMMAAGPE--CDFVQQIAVNYPLYVIMSLLGLPEADFPRML
MUL_3863|M.ulcerans_Agy99 DELAKNYVDAMMAAGPE--CDFVQQIAVNYPLYVIMSLLGLPEADFPRML
MAV_1609|M.avium_104 DELAKIYVDKMLAAGPE--CDFVQEVAVNYPLYVIMSLLGLPEADFPRML
TH_2733|M.thermoresistible__bu DELARIHVDKMLELGPE--CDFVQEVAVNYPLYVIMSLLGVPEADFPLML
Mflv_4325|M.gilvum_PYR-GCK DELAKTFVDQMYDRGGE--CDFVQEVAVNFPLYVIMSLLGIPESDFGRML
Mvan_2021|M.vanbaalenii_PYR-1 DELAKTFVDQMYERGGE--CDFVQEVAVNFPLYVIMSLLGIPESDFQRML
MSMEG_1429|M.smegmatis_MC2_155 DELARIYVDKMREIGPE--CDFVTDIAVNFPLYVILSLLGLPEEDFGRMH
MAB_3825|M.abscessus_ATCC_1997 DELANRYVNKLLEAGGS--CDFAQDIAVHFPLYVIMSLLGIPESDFDRML
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAGQF---DVIADLAFPLAVAVICRLLGVPYEDAPEFG
. :. . *. ::* .: :* ::*:* * :
Mb2289|M.bovis_AF2122/97 HWTNVILGFGDP--DLATD----FDEFMQVSADIGAYATALAEDRRVNHH
Rv2266|M.tuberculosis_H37Rv HWTNVILGFGDP--DLATD----FDEFMQVSADIGAYATALAEDRRVNHH
MMAR_3999|M.marinum_M KLTQELFGSDDSEFKRGST----SEDQLPALLDMFGYFNAVTTARREHPT
MUL_3863|M.ulcerans_Agy99 KLTQELFGSDDSEFKRGST----SEDQLPALLDMFGYFNAVTTARRAHPT
MAV_1609|M.avium_104 KLTQELFGSDDSEFKRGSS----NEDQLPALLDMFGYFNGVTAARREHPT
TH_2733|M.thermoresistible__bu KLTQELFGSDDEEFKRGAS----QEDQMTALLEMFEYFTKLTASRRENPT
Mflv_4325|M.gilvum_PYR-GCK TYTQELFGSDDAELQRGTT----MEERGLALFDMFTYFNELTASRRAQPT
Mvan_2021|M.vanbaalenii_PYR-1 TYTQELFGNDDAELQRGES----MEERGLALFDMFTYFNEITAARRARPT
MSMEG_1429|M.smegmatis_MC2_155 MLTQEMFGGDDDEYKRGTT----VEEQMAVLTDFFNYFSALTNSRRENPT
MAB_3825|M.abscessus_ATCC_1997 KLTQELFGGDDSEFQRGTT----PEEQLMALLDFFGYFSGLTASRRQHPT
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
: :. * :: . : * :. **
Mb2289|M.bovis_AF2122/97 DDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSR
Rv2266|M.tuberculosis_H37Rv DDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSR
MMAR_3999|M.marinum_M EDLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLHALIE
MUL_3863|M.ulcerans_Agy99 ADLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLHALIE
MAV_1609|M.avium_104 EDLASAIANARVDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIE
TH_2733|M.thermoresistible__bu EDLASAIANAKIDGEPLSDIDTMSYYAIVAAAGHDTTSATISGGLLALLE
Mflv_4325|M.gilvum_PYR-GCK EDLASAIANARINGEPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIE
Mvan_2021|M.vanbaalenii_PYR-1 EDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIE
MSMEG_1429|M.smegmatis_MC2_155 DDLASAIANGRVDGELMSDMDTLSYYVIVASAGHDTTKDAISGGLHALIE
MAB_3825|M.abscessus_ATCC_1997 DDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAGGLEALLE
MLBr_02088|M.leprae_Br4923 EDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLR
** * : : .* ::. : : :: **::** *: .: *: .
Mb2289|M.bovis_AF2122/97 YPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAA
Rv2266|M.tuberculosis_H37Rv YPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAA
MMAR_3999|M.marinum_M HPDQLARLQADPA-LIPLATEEMIRWVTPVKQFMRTASRDTVVRGIPIAA
MUL_3863|M.ulcerans_Agy99 HPDQLARLQADPA-LMSLATEEMIRWVTPVKQFMRTASSDTVVRGIPIAA
MAV_1609|M.avium_104 NPDQLQRLRDNLD-LMPLATEEMIRWVTPVKEFMRTAAKDTVVRGVPIAA
TH_2733|M.thermoresistible__bu HPDQHERLLADPE-LMPLAVEEMIRWVTPVKAFMRTAQRDTTVRDVPIKA
Mflv_4325|M.gilvum_PYR-GCK NPDQLARLQQAPE-LLPLAVEEMIRWVTPVKEFMRTAQQDTEVRGVPIAA
Mvan_2021|M.vanbaalenii_PYR-1 NPDQLQRLQQNPG-LMPLAVEEMIRWVTPVKEFMRTAQQDAEVRGVKIAA
MSMEG_1429|M.smegmatis_MC2_155 NPGELARLKADPG-LMGTAVEEMIRWSTPVKEFMRTAAEDTEVRGVPIAK
MAB_3825|M.abscessus_ATCC_1997 HPDQLARLRENPG-LMPLAVDEMIRWVTPVKEFMRTATADTEIRGVPITE
MLBr_02088|M.leprae_Br4923 NPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMTIGQTTLTE
* : ..:* :*: ..: : *. * : :
Mb2289|M.bovis_AF2122/97 GDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLA
Rv2266|M.tuberculosis_H37Rv GDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLA
MMAR_3999|M.marinum_M GESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYG-VHFCMGAALA
MUL_3863|M.ulcerans_Agy99 GESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYG-VHFCMGAALA
MAV_1609|M.avium_104 GESVLLSYVSANRDEDVFDEPFRFDVGRDPNKHLAFGYG-VHFCMGAALA
TH_2733|M.thermoresistible__bu GESVLLSYVSGNRDEEVFDDPFGFDVGRDPNKHISFGYG-VHFCLGAALA
Mflv_4325|M.gilvum_PYR-GCK GESVLLSYPSGNRDEDVFTDPFRFDIGRDPNKHVAFGYG-VHFCLGAALA
Mvan_2021|M.vanbaalenii_PYR-1 GESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKHVAFGYG-VHFCLGAALA
MSMEG_1429|M.smegmatis_MC2_155 GESVYLAYVSGNRDEEVFTDPFRFDVGRDPNKHLAFGYG-VHFCLGAALA
MAB_3825|M.abscessus_ATCC_1997 GESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFG-VHFCLGAALA
MLBr_02088|M.leprae_Br4923 GDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHFCLGAALA
*:.: * :.*** : * ** * .. *:.*. * ***:** **
Mb2289|M.bovis_AF2122/97 RREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS---
Rv2266|M.tuberculosis_H37Rv RREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS---
MMAR_3999|M.marinum_M RMEVGSFFTELLPRLKSIELSGDPQFTATTFVGGLKHLPVSYSLV-
MUL_3863|M.ulcerans_Agy99 RMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM-
MAV_1609|M.avium_104 RMEVNSFFTELLPRLKSIELTGDPELVATTFVGGLKHLPVRYSLA-
TH_2733|M.thermoresistible__bu RMEVNSFFTELLPRLKSVEPAGPAEFVATTFVGGPKHLPIRYELR-
Mflv_4325|M.gilvum_PYR-GCK RMEINSFFSELLPRLTSVELAGRPEHIATIFVGGLKHLPIRYSLTR
Mvan_2021|M.vanbaalenii_PYR-1 RMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYSLTR
MSMEG_1429|M.smegmatis_MC2_155 RMEMNSLFSELLPRLDSIELAGEPELSATTFVGGLKHLPIRYSIR-
MAB_3825|M.abscessus_ATCC_1997 RMEVNSFFSALLPRLESIEVDGNIERTSTIFVGGIKHLPIRYTLR-
MLBr_02088|M.leprae_Br4923 RLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV----
* * : : :: .: . : * . **: