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TTVAVIGGGQAGIAAGYFLRRRGLEPLSRRQPADAPGHRFVILDHSPGPGGAWQFRWPTLTLDNTNRIYQ LPGLPFDEMGTIRASTAMPRYFGEYEDRYALDVRRPVHVRAVRPARRGFTIDTSVGEFPVDGLINATGTW DKPFVPFVPGAGTFRGRQLHTHDYQRPEEFTGQHVLVVGGGISAVQLLMEISGIASVTTSWVTRREPVFV TDLTVERLRAAVAGVDERSRRGEPQRSVVSATGLPWTAETAEASRRGVLTRRPMFSRITPTGVTWPDGSS LEVDVILWCTGFRHALDHLAPLHLRNGRGGITMTGRLLTQVAGQPAIHLLGYGSSASTIGANRASRAAVV ELMNYLEGRTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0958c | - | - | 100% (362) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1527 | - | 6e-20 | 27.27% (363) | monooxygenase |
| M. abscessus ATCC 19977 | MAB_0140c | - | 8e-15 | 25.46% (381) | monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0916 | - | 4e-11 | 27.75% (209) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_3867 | - | 7e-20 | 27.75% (400) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0892 | - | 5e-11 | 27.75% (209) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0403 | - | 1e-12 | 27.60% (221) | monooxygenase |
| M. avium 104 | MAV_2172 | - | 3e-12 | 26.56% (241) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_1682 | - | 4e-14 | 29.74% (195) | flavin-containing monooxygenase FMO |
| M. thermoresistible (build 8) | TH_4273 | - | 9e-20 | 26.18% (382) | PUTATIVE FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_1053 | - | 2e-11 | 25.34% (363) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_0721 | - | 4e-14 | 25.84% (356) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2172|M.avium_104 MVTDRFDAIIVGAGFGGIGAAIQLKRLGFDNIV-------------ILDR
Mvan_0721|M.vanbaalenii_PYR-1 MISEHFDAVIVGAGFAGIGAAIQFKRMGIENFV-------------ILER
Mb0916|M.bovis_AF2122/97 MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVC-------------IYEK
Rv0892|M.tuberculosis_H37Rv MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVC-------------IYEK
MMAR_0403|M.marinum_M MTS-PLSVGIIGAGPGGLALGILLKNRGFENFT-------------IFDR
MUL_1053|M.ulcerans_Agy99 MTS-PLSVGIIGAGPGGLALGILLKNRGFENFN-------------IFDR
Mflv_3867|M.gilvum_PYR-GCK -------MVVLGAGPAGLGIARELKHRHGVDPL-------------IVDR
TH_4273|M.thermoresistible__bu --MNDHQVAVIGAGPSGVAAAVSLRDR-GIRPL-------------LIDR
MAB_0958c|M.abscessus_ATCC_199 ----MTTVAVIGGGQAGIAAGYFLRRRGLEPLSRRQPADAPGHRFVILDH
MSMEG_1682|M.smegmatis_MC2_155 MSIEQTEVLVVGGGQAGIAMSEHLGLQGVPHVV---------------VE
::*.* .*: . : .
MAV_2172|M.avium_104 EDDLGGTWHVNHYPGIAVDIPSTTYSYWFEPNPGWSRLFAPGGEVKQYAA
Mvan_0721|M.vanbaalenii_PYR-1 EDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPNWSRLFSTGAEIKQYAD
Mb0916|M.bovis_AF2122/97 ADDVGGTWRDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEIQDYLR
Rv0892|M.tuberculosis_H37Rv ADDVGGTWRDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEIQDYLR
MMAR_0403|M.marinum_M ESDVGGTWRINTYPGLACDVKSHLYSYSFDLNPGWSRLWSGQPEILAYFQ
MUL_1053|M.ulcerans_Agy99 ESDVGGTWRINTYPGLACDVKSHLYSYSFDLNPGWSGLWSGQPEILAYFQ
Mflv_3867|M.gilvum_PYR-GCK SDAPAASWRAR-YDGFRLNTCGFWSHLPGQRIPLSFGRWPTRDQMVEYFD
TH_4273|M.thermoresistible__bu AEHVGASWRAR-YDRLRLNTGRLTSHLPNRPYPAGTAVFPTRDQVVAHLD
MAB_0958c|M.abscessus_ATCC_199 SPGPGGAWQFR-WPTLTLDNTNRIYQLPGLPFDEMGTIRAS-TAMPRYFG
MSMEG_1682|M.smegmatis_MC2_155 RDRIAERWRSWRWDSLVANGPAWHDRFPGMEFNIDPDAFADKEQVADYLV
. * : : : . : :
MAV_2172|M.avium_104 DVADKYDVRRHMRFNTTVEGAQWDEDAEVWRVALAGGESLTTRFLITATG
Mvan_0721|M.vanbaalenii_PYR-1 DVADKYDVRRHIRFGVTVGGARWDDDAQLWRVNLADGETVDARYLVTATG
Mb0916|M.bovis_AF2122/97 GIAERYGLRHRIRFGATVVSARFD--DGRWVLRTDSGTESTVDFLISATG
Rv0892|M.tuberculosis_H37Rv GIAERYGLRHRIRFGATVVSARFD--DGRWVLRTDSGTESTVDFLISATG
MMAR_0403|M.marinum_M RCADRYGLRPHLRLSTEIRSARWESQTRQWTLSTADGEQHQFSVVVSAVG
MUL_1053|M.ulcerans_Agy99 RCADRYELRPHLRLGTEIRSARWESQTRQWTLSTADGEQHQFSVVVSVVG
Mflv_3867|M.gilvum_PYR-GCK DYVR----RQGLRLRLGVRAERIDRDGAGWSITTDDED-VRASAVVVALG
TH_4273|M.thermoresistible__bu RHAR----EDGIDLLLGTTVARVDRDGEGWRLWTSGGD-VCARHVVVATG
MAB_0958c|M.abscessus_ATCC_199 EYED----RYALDVRRPVHVRAVRPARRGFTIDTSVGE-FPVDGLINATG
MSMEG_1682|M.smegmatis_MC2_155 SYAEK--IDAPIRTGVEVRSVRKIHGRPGFHAETSAGT-IDARYVVAATG
: : :: . *
MAV_2172|M.avium_104 FLSQPHTPDIPGIGSFGGKVVHTTAWDHDYRYQGRRIAVIGTGASAVQVV
Mvan_0721|M.vanbaalenii_PYR-1 FLSQPHMPDIPGIAEFDGRVIHTTAWDDSYDPTGEKIGIIGTGATAVQLI
Mb0916|M.bovis_AF2122/97 VLHHPRIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGSTGVQLV
Rv0892|M.tuberculosis_H37Rv VLHHPRIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGSTGVQLV
MMAR_0403|M.marinum_M IFSRPAYPDLVEQQRFTGTVMHSSRWDHSVPLAGARIAVLGTGSTAAQLV
MUL_1053|M.ulcerans_Agy99 IFSRPAYPDLVEQQRFTGTVMHSSRWDHSVPLAGARIAVLGTGSTAAQLV
Mflv_3867|M.gilvum_PYR-GCK NHNTPGLPPWPGMDGFTGQLLHAADYRSAEPFGGQEVLVVGSGNSAVDIA
TH_4273|M.thermoresistible__bu YEHTPNIPDWPGADGFTGRLLHSSAYRNPIPFSGLRVLVVGAGSSAMEIV
MAB_0958c|M.abscessus_ATCC_199 TWDKPFVPFVPGAGTFRGRQLHTHDYQRPEEFTGQHVLVVGGGISAVQLL
MSMEG_1682|M.smegmatis_MC2_155 AFQKPVIPRLIP-DHAGIHQIHSSSYHNPDQLPAGAVLVVGAGSSGVQIA
* * .*: : . : ::* * :. ::
MAV_2172|M.avium_104 PELAK-EAEELTVYQRTATHVLPKVDFEFDPAVRRLFARVPAAQRALRWV
Mvan_0721|M.vanbaalenii_PYR-1 PELAE-KAADLTVYQRTPIWVVPKIDFRFSERAKQLFARIPLTQRLIRVI
Mb0916|M.bovis_AF2122/97 CGLAG-VAGKVTMFQRTAQWVLPWPNPRYSKLARVFHRAFPCLGSLAYKA
Rv0892|M.tuberculosis_H37Rv CGLAG-VAGKVTMFQRTAQWVLPWPNPRYSKLARVFHRAFPCLGSLAYKA
MMAR_0403|M.marinum_M PELAK-VADRVYSIQRSPTWILPKPDRPYSRWERWVFAHVPFAARLYRTR
MUL_1053|M.ulcerans_Agy99 PELAK-VADRVYSIQRSPTWILPKPDRPYSRWERWVFAHVPFAARLYRTR
Mflv_3867|M.gilvum_PYR-GCK LQLSSAVAAKVWMSVRTPPQLVPR--------------STAG-LPIDTLG
TH_4273|M.thermoresistible__bu HDVATGGAAQAWLAVRTPPNIMLR--------------ALPGGFPSDYLA
MAB_0958c|M.abscessus_ATCC_199 MEISG-------IASVTTSWVTRR--------------------------
MSMEG_1682|M.smegmatis_MC2_155 DELQQ---SGHRVYLSVGPHDRPPRRYRGRDFCWWLGVLGKWDMAAPPRG
:
MAV_2172|M.avium_104 TDVLLEIIMIVGALHFKESRGRGNISASDLAKINRFRWIRDKELRAKLTP
Mvan_0721|M.vanbaalenii_PYR-1 TDTIYELMVWVAVLHNRQTRGRFNIAAGDLAKMHRFATIRDKELRAKLTP
Mb0916|M.bovis_AF2122/97 YSLSFET-FAVALSNPGLHR-----KLVGAVCRASLRRVRDPRLRRALTP
Rv0892|M.tuberculosis_H37Rv YSLSFET-FAVALSNPGLHR-----KLVGAVCRASLRRVRDPRLRRALTP
MMAR_0403|M.marinum_M LWLRSESNISVIEHGSPKTK-----EFTELALRMLENTVSDPQLRRQLTP
MUL_1053|M.ulcerans_Agy99 LWLRSESNISVIEHGSPKTK-----EFTELALRMLENTVSDPQLRRQLTP
Mflv_3867|M.gilvum_PYR-GCK PLLATLPVWLLDGAAAAMRR----------VWFGELAGVGLPPPRQGIYT
TH_4273|M.thermoresistible__bu TPLFDAPVGLVDRMARLAQR----------ATIGDLSEYGLPTPREGVFA
MAB_0958c|M.abscessus_ATCC_199 ------EPVFVTDLTVERLR-------------AAVAGVDERSRRG--EP
MSMEG_1682|M.smegmatis_MC2_155 AEHVTIAVSGAHGGHTVDFR-------SLAASGITLLGRADRFENGEMRF
: .
MAV_2172|M.avium_104 DYDCGCKRPTFSNSFYRVLTQPNVHLETNPIERIEP--DGIVTADGRKNV
Mvan_0721|M.vanbaalenii_PYR-1 DYDFGCKRPTFSNSYYRTFTKPHVHLQDSGIARIES--DGIVGNDGTKTP
Mb0916|M.bovis_AF2122/97 DYEPMCKRLVMSGGFYRAIQRDDVELVTAGIDHVEH--RGIVTDDGVLHE
Rv0892|M.tuberculosis_H37Rv DYEPMCKRLVMSGGFYRAIQRDDVELVTAGIDHVEH--RGIVTDDGVLHE
MMAR_0403|M.marinum_M DHPMGCKRLVFSSEFLTALARPNVELVTSPARYLRQ--RSLVTADGAEYD
MUL_1053|M.ulcerans_Agy99 DHPMGCKRLVFSSEFLTALTRPNVELVTSPARYLRQ--RSLVTADGAEYD
Mflv_3867|M.gilvum_PYR-GCK ALRAQAKVPTIAD-ELVPRVKDGRIEIVSAVESFET--NRVVLADGTALA
TH_4273|M.thermoresistible__bu RGKRLGRAPVIVDREVVDAIRARRFEVVRTIGRFDG--GTVVLTDGRRLQ
MAB_0958c|M.abscessus_ATCC_199 QRSVVSATGLPWTAETAEASRRGVLTRRPMFSRITP--TGVTWPDGSSLE
MSMEG_1682|M.smegmatis_MC2_155 APDLRTNIENGDANYLSMLDEADAYIARNGLDLPEEPGARIFGPDPDCVT
. : *
MAV_2172|M.avium_104 IDTLVLATGFDLWEANFPAIEVIGRKGRNLGKWWRETRFQAYQGVSMPYF
Mvan_0721|M.vanbaalenii_PYR-1 IDTLVLATGFDLWEANFPAIEVIGRDGRNLGKWWRETRFQAYQGVSMPHF
Mb0916|M.bovis_AF2122/97 VDVIVLATGFDSHAF-FRPMQLTGRDGIRIDDVWQDG-PHAHQTVAIPGF
Rv0892|M.tuberculosis_H37Rv VDVIVLATGFDSHAF-FRPMQLTGRDGIRIDDVWQDG-PHAHQTVAIPGF
MMAR_0403|M.marinum_M VDVVVCATGYAAADY-LGQLEVLGEDGAGLHEVWRDG-AHAYLGMAVPGF
MUL_1053|M.ulcerans_Agy99 VDVVVCATGYAAADY-LGQLEVLGEDGAGLHEVWRDG-AHAYLGMAVPGF
Mflv_3867|M.gilvum_PYR-GCK PQVVIGATGYRRGLD-----ALVGHLG----------------VLTDDGH
TH_4273|M.thermoresistible__bu PDAVICATGYSRGLE-----PLVGHLG----------------VLDDRGL
MAB_0958c|M.abscessus_ATCC_199 VDVILWCTGFRHALDHLAPLHLRNGRG----------------GITMTGR
MSMEG_1682|M.smegmatis_MC2_155 NPILELDLATAGITSVIWAVGFASDYG-----------WLQVDAFDDAGK
: . . . * .
MAV_2172|M.avium_104 PNYLSLASPFAFSG-LSFFHTIEYQMRHMDRLLGEVKRRGATTFEVTEEA
Mvan_0721|M.vanbaalenii_PYR-1 PNFLSLASPFAFLG-LNFFNTVEYQMRHMDRLFGELRRRGATTFEITEEA
Mb0916|M.bovis_AF2122/97 PNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAA
Rv0892|M.tuberculosis_H37Rv PNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAA
MMAR_0403|M.marinum_M PNFFMLYGPNTNVGSNSVIFMLEAQARYIVAALAHLRRKSKTYIAVRPGV
MUL_1053|M.ulcerans_Agy99 PNFFMLCGPNTNVGSNSVIFMLEAQARYIVAALAHLRRKSKTYIAVRPGV
Mflv_3867|M.gilvum_PYR-GCK PVVNGPPAAAPGLWFAGYEEPLIGPLRAFRRHAPDVAE-VVSHLAASSAA
TH_4273|M.thermoresistible__bu PRSAGEVAAALGLWFIGFQS-RPGLISFAAKQSQRIAKRIAAELVAAPAI
MAB_0958c|M.abscessus_ATCC_199 LLTQVAGQPAIHLLGYGSSASTIGANRASRAAVVELMNYLEGRTA-----
MSMEG_1682|M.smegmatis_MC2_155 PIHQRGVSSEPGVYFLGLPWQSRRGSSFLWG-VWHDAKYIADHIAIQRSY
. .
MAV_2172|M.avium_104 NDRFMERMTKLLDNSVFYAGNCATSRSYYFSPSGEASLLRPTSTLNSIRE
Mvan_0721|M.vanbaalenii_PYR-1 NARYLARMTALLGDSLFTNGSCATARSYYFNPSGEPTLLRPTSTRAAIRE
Mb0916|M.bovis_AF2122/97 TEAYNTVLRAAMPNTVWTTG----CDSWYLNKDG-IPEVWPFAPAKHRAM
Rv0892|M.tuberculosis_H37Rv TEAYNTVLRAAMPNTVWTTG----CDSWYLNKDG-IPEVWPFAPAKHRAM
MMAR_0403|M.marinum_M LAEFMAKVDRWMTGTVWTTE----CSNYFRAPNGRVVTQWPRSARSFWGM
MUL_1053|M.ulcerans_Agy99 LAEFIAKVDRWMTGTVWTTE----CSNYFRAPNGRVVTQWPRSARSFWGM
Mflv_3867|M.gilvum_PYR-GCK SQTLSR--------------------------------------------
TH_4273|M.thermoresistible__bu TPVADGG-------------------------------------------
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_1682|M.smegmatis_MC2_155 LTYHATHEKKGR--------------------------------------
MAV_2172|M.avium_104 ASSFPLSDYVIA--------------------------------------
Mvan_0721|M.vanbaalenii_PYR-1 ATDFPIDDYRIV--------------------------------------
Mb0916|M.bovis_AF2122/97 LANLHPEEYDLRRYAAVRATSRPQSA------------------------
Rv0892|M.tuberculosis_H37Rv LANLHPEEYDLRRYAAVRATSRPQSA------------------------
MMAR_0403|M.marinum_M TRRFKPADFSFQPAAVFAADGGDRNAGQR---------------------
MUL_1053|M.ulcerans_Agy99 TRRFKPADFSFQPAAVFAADGGDRNAGQRWPNPRPSIGWTPCCAPSRRRE
Mflv_3867|M.gilvum_PYR-GCK --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_1682|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2172|M.avium_104 --------
Mvan_0721|M.vanbaalenii_PYR-1 --------
Mb0916|M.bovis_AF2122/97 --------
Rv0892|M.tuberculosis_H37Rv --------
MMAR_0403|M.marinum_M --------
MUL_1053|M.ulcerans_Agy99 STSPRSRS
Mflv_3867|M.gilvum_PYR-GCK --------
TH_4273|M.thermoresistible__bu --------
MAB_0958c|M.abscessus_ATCC_199 --------
MSMEG_1682|M.smegmatis_MC2_155 --------