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SIEQTEVLVVGGGQAGIAMSEHLGLQGVPHVVVERDRIAERWRSWRWDSLVANGPAWHDRFPGMEFNIDP DAFADKEQVADYLVSYAEKIDAPIRTGVEVRSVRKIHGRPGFHAETSAGTIDARYVVAATGAFQKPVIPR LIPDHAGIHQIHSSSYHNPDQLPAGAVLVVGAGSSGVQIADELQQSGHRVYLSVGPHDRPPRRYRGRDFC WWLGVLGKWDMAAPPRGAEHVTIAVSGAHGGHTVDFRSLAASGITLLGRADRFENGEMRFAPDLRTNIEN GDANYLSMLDEADAYIARNGLDLPEEPGARIFGPDPDCVTNPILELDLATAGITSVIWAVGFASDYGWLQ VDAFDDAGKPIHQRGVSSEPGVYFLGLPWQSRRGSSFLWGVWHDAKYIADHIAIQRSYLTYHATHEKKGR *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1682 | - | - | 100% (421) | flavin-containing monooxygenase FMO |
| M. smegmatis MC2 155 | MSMEG_0569 | - | 8e-75 | 38.82% (407) | flavoprotein involved in K+ transport |
| M. smegmatis MC2 155 | MSMEG_5022 | - | 1e-17 | 30.53% (190) | flavin-containing monooxygenase FMO |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0916 | - | 6e-08 | 27.87% (183) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_0126 | - | 1e-17 | 31.05% (190) | hypothetical protein Mflv_0126 |
| M. tuberculosis H37Rv | Rv0892 | - | 6e-08 | 27.87% (183) | monooxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0958c | - | 4e-14 | 29.74% (195) | putative oxidoreductase |
| M. marinum M | MMAR_2622 | - | 5e-10 | 27.23% (202) | flavin-binding monooxygenase |
| M. avium 104 | MAV_3029 | - | 3e-10 | 28.44% (225) | hypothetical protein MAV_3029 |
| M. thermoresistible (build 8) | TH_4273 | - | 4e-15 | 30.81% (185) | PUTATIVE FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_0256 | - | 3e-08 | 25.52% (192) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1222 | - | 4e-74 | 39.66% (406) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0916|M.bovis_AF2122/97 --------------------------------------------------
Rv0892|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0256|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2622|M.marinum_M --------------------MSMAFSDCGHAPSAVPAGPARLTGMPFHDS
MSMEG_1682|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3029|M.avium_104 ---------------------------------MPVTTESARAAGPDPYD
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
Mflv_0126|M.gilvum_PYR-GCK MTSTLDPQTTTELTPQQRVDGWLAAFESALAVRDIERITGMFAVDSFWRD
Mb0916|M.bovis_AF2122/97 --------------------------------------------------
Rv0892|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0256|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2622|M.marinum_M DDVIRAALAEASAPALLMSMVHMTGNLGLLDELPGPSMLIAMDIQGGMSE
MSMEG_1682|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3029|M.avium_104 VGELRANLRQADPGVLVAVLAQLTGDPAVADRFAPKITHVPDPPEQAGVT
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
Mflv_0126|M.gilvum_PYR-GCK LVSFTWNIKTVEGRDQIADMLEARLAETEPSAFRTREPAVLDGTGEDAVV
Mb0916|M.bovis_AF2122/97 --------------------------------------------------
Rv0892|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0256|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2622|M.marinum_M EDKQTVRERAFEVVRDYRDRGCP--APFLPNRVQLQTMLDVASAGQVTDE
MSMEG_1682|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1222|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3029|M.avium_104 DPETAAQLVDEIVTALRTPRRAD--AVPADDLDLFARVAPVALGGEVG--
MAB_0958c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
Mflv_0126|M.gilvum_PYR-GCK SAFIEFQTAAGRGTGHLRLRADDGTDRAWTLLTALQELKGHEERRGPSRV
Mb0916|M.bovis_AF2122/97 -------------------------MTGRCPTVAVVGAGMSGMCVAITLL
Rv0892|M.tuberculosis_H37Rv -------------------------MTGRCPTVAVVGAGMSGMCVAITLL
MUL_0256|M.ulcerans_Agy99 -------------------------MTRRDPSVAIVGAAMAGICMAITLL
MMAR_2622|M.marinum_M FIDYIAADLRISDADQDGPPLRSTPSQRSGFPVLVIGCGEAGLLAGIKLK
MSMEG_1682|M.smegmatis_MC2_155 -------------------------MSIEQTEVLVVGGGQAGIAMSEHLG
Mvan_1222|M.vanbaalenii_PYR-1 -------------------------MS-THVPVAVIGGGQAGLSVSWYLS
MAV_3029|M.avium_104 -PEYLGLLLEQGGFQPSQPVLPRTAKLPAGFRVVIIGAGIAGITAALACA
MAB_0958c|M.abscessus_ATCC_199 -----------------------------MTTVAVIGGGQAGIAAGYFLR
TH_4273|M.thermoresistible__bu ---------------------------MNDHQVAVIGAGPSGVAAAVSLR
Mflv_0126|M.gilvum_PYR-GCK LGAVHGDDPDPRSWAEKKAAEDAELGRTIQPYVLVIGGGQGGIALGARLR
* ::* . .*: .
Mb0916|M.bovis_AF2122/97 SAGITDVCIYEKADDVGGTWRDN------------TYPGLTCDVPSRLYQ
Rv0892|M.tuberculosis_H37Rv SAGITDVCIYEKADDVGGTWRDN------------TYPGLTCDVPSRLYQ
MUL_0256|M.ulcerans_Agy99 NSGITDVTIYEKADEVGGTWREN------------TYPGLVCDVPSRLYH
MMAR_2622|M.marinum_M QAGLP-FVIIEKQAGVGGTWRAN------------RYPGCRVDIANHYYA
MSMEG_1682|M.smegmatis_MC2_155 LQGVPHVVVER--DRIAERWRSW------------RWDSLVANGPAWHDR
Mvan_1222|M.vanbaalenii_PYR-1 RAGIEHVVLEA--ATPVHAWADS------------RWDNFTLVTPNWHCR
MAV_3029|M.avium_104 DAGIEYQIIERN-DEVGGTWYTT------------RYPGIGVDTPSAYYS
MAB_0958c|M.abscessus_ATCC_199 RRGLEPLSRRQPADAPGHRFVILDHSPGPGGAWQFRWPTLTLDNTNRIYQ
TH_4273|M.thermoresistible__bu DRGIRPLLIDR-AEHVGASWRAR-------------YDRLRLNTGRLTSH
Mflv_0126|M.gilvum_PYR-GCK QLGVPAIVVDK-HERPGDQWRKR-------------YKSLCLHDPVWYDH
*: : :
Mb0916|M.bovis_AF2122/97 YS-FAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDD
Rv0892|M.tuberculosis_H37Rv YS-FAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDD
MUL_0256|M.ulcerans_Agy99 YS-FAKNPDWSNLFSPGGEIQSYFCGIADRYRLRDRIRFGTEIVSARFED
MMAR_2622|M.marinum_M YS-FEPNDHWSHSYSEQPEILNYLNDVAQRYEITPHVRFNTEVVSAAWQD
MSMEG_1682|M.smegmatis_MC2_155 FPGMEFN-IDPDAFADKEQVADYLVSYAEKIDAPIRTGVEVRSVRK-IHG
Mvan_1222|M.vanbaalenii_PYR-1 LPGYAYDGPDPDGFMTRDEVVDWLSGWLDTFDAPVRTHTRVTRLRNGTDG
MAV_3029|M.avium_104 LS-RDINGDWSSYYPQGAEYQAYLVSVADKNDLRKHTRFGTEVEALWWQE
MAB_0958c|M.abscessus_ATCC_199 LP--GLPFDEMGTIRASTAMPRYFGEYEDRYALDVRRPVHVRAVRPARRG
TH_4273|M.thermoresistible__bu LP-NRPYPAGTAVFPTRDQVVAHLDRHAREDGIDLLLGTTVARVDRDGEG
Mflv_0126|M.gilvum_PYR-GCK LP-YLPFPPNWPVFAPKDKIGDWLEFYTRVMEVPYWS--KTTCLSATFDE
. : .
Mb0916|M.bovis_AF2122/97 --GRWVLRT----DSGTESTVDFLISATGVLHHPRIPPIAGLDDFRGTVF
Rv0892|M.tuberculosis_H37Rv --GRWVLRT----DSGTESTVDFLISATGVLHHPRIPPIAGLDDFRGTVF
MUL_0256|M.ulcerans_Agy99 --DHWSVVT----DSGEETAVDFLIVATGLLHHPRVPAIAGLDDFGGSAF
MMAR_2622|M.marinum_M ESDSWAVRIRDHDGSAEVLSARAVICAVGQFSNPVIPDIKGGKDFAGPSF
MSMEG_1682|M.smegmatis_MC2_155 R-PGFHAET---SAG--TIDARYVVAATGAFQKPVIPRLIPDHAG-IHQI
Mvan_1222|M.vanbaalenii_PYR-1 G-FELTLRT---DAGEETLSCAHAVVATGGYPIPVLPSFAGALAPSVTQI
MAV_3029|M.avium_104 RRRQWQIHSVGPDGTRDVSYANVVIPAAGYLNRPRWPELAGRETFSGISI
MAB_0958c|M.abscessus_ATCC_199 ----FTIDT-----SVGEFPVDGLINATGTWDKPFVPFVPGAGTFRGRQL
TH_4273|M.thermoresistible__bu ----WRLWT-----SGGDVCARHVVVATGYEHTPNIPDWPGADGFTGRLL
Mflv_0126|M.gilvum_PYR-GCK AADQWTVEVD-RDGERLTLHPTQLVLATGMSGKPRVPTLPGQDVFRGDQH
: *.* * *
Mb0916|M.bovis_AF2122/97 HSARWDHTVPLLGRRIAVIGTGSTGVQLVCGLAGV-AGKVTMFQRTAQWV
Rv0892|M.tuberculosis_H37Rv HSARWDHTVPLLGRRIAVIGTGSTGVQLVCGLAGV-AGKVTMFQRTAQWV
MUL_0256|M.ulcerans_Agy99 HSARWDQRVAVQGRRVAVIGSGSTGVQLVSALAGV-AAKVTMFQRTRQWI
MMAR_2622|M.marinum_M HTADWDERVELAGKRVAVIGAGASGFQLVPAIADM-TERVDVYQRTAQWM
MSMEG_1682|M.smegmatis_MC2_155 HSSSYHNPDQLPAGAVLVVGAGSSGVQIADELQQS-GHRVYLSVGPHDRP
Mvan_1222|M.vanbaalenii_PYR-1 HSEQYRNAGQLPDGAVLVVGTGQSGAQIAEDLHLA-GRQVHLAVGNAPRV
MAV_3029|M.avium_104 HSAHWDLELDLTGKRVAIIGAGCTAVQIVDACVDQ-VAHLTVFQRQPHWV
MAB_0958c|M.abscessus_ATCC_199 HTHDYQRPEEFTGQHVLVVGGGISAVQLLMEISGI-ASVTTSWVTRRE--
TH_4273|M.thermoresistible__bu HSSAYRNPIPFSGLRVLVVGAGSSAMEIVHDVATGGAAQAWLAVRTPPNI
Mflv_0126|M.gilvum_PYR-GCK HSSAHPGPDAYAGKKAVVIGSNNSAHDICKALCEN-GVDVTMVQRSSTHI
*: ::* . :. ::
Mb0916|M.bovis_AF2122/97 LPWP--NPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHR
Rv0892|M.tuberculosis_H37Rv LPWP--NPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHR
MUL_0256|M.ulcerans_Agy99 LLWP--NRQYSKVSRACYRGAPWLESLAYKIWGRAFEQFTAALTRPGWHR
MMAR_2622|M.marinum_M APNINYHAAVSDPAKWAVRHLPYYGRWLRFVTWWPIADGAAHLTVIDPDW
MSMEG_1682|M.smegmatis_MC2_155 PRRYR--------GRDFCWWLGVLGKWD--MAAPPRG---AEHVTIAVSG
Mvan_1222|M.vanbaalenii_PYR-1 ARFYR--------GRDCMTWLADMGLYDRPAAEYPGGKAAIEKTNHYVTG
MAV_3029|M.avium_104 APRRRASDDVPAYQRWLGTRLPYYANWIRLKSYWGTADTNYPVILHDPQW
MAB_0958c|M.abscessus_ATCC_199 ---------------------------PVFVTDLTVERLRAAVAGVDERS
TH_4273|M.thermoresistible__bu MLR-----------ALPGGFPSDYLATPLFDAPVGLVDRMARLAQRATIG
Mflv_0126|M.gilvum_PYR-GCK VKSDT----------LMDIGLGDLYSERALASGMTTEKADLTFASLPYRI
Mb0916|M.bovis_AF2122/97 KLVGAVCRASLRRVR-------------DPRLRRALTPDYEPMCKRLVMS
Rv0892|M.tuberculosis_H37Rv KLVGAVCRASLRRVR-------------DPRLRRALTPDYEPMCKRLVMS
MUL_0256|M.ulcerans_Agy99 RVTGMTCRASLRLVR-------------DPHLRQALTPDYQPMCKRLVMS
MMAR_2622|M.marinum_M ENGGLSVSAANHQVRELFIAWMRAFT-DDEQLLAKVTPNYPPMGKRTLQD
MSMEG_1682|M.smegmatis_MC2_155 AHGGH-----------------------TVDFRSLAASGITLLGRADRFE
Mvan_1222|M.vanbaalenii_PYR-1 RDGGR-----------------------DIDLRRFAAEGMRLYGTLVGGH
MAV_3029|M.avium_104 AAEHLSVSPANDVLLRMCLDYIDRVFGAGSELARKVTPDFAPYGKRIIRD
MAB_0958c|M.abscessus_ATCC_199 RRGEP--------------------------QRSVVSATGLPWTAETAEA
TH_4273|M.thermoresistible__bu DLSEYG----------------------LPTPREGVFARGKRLGRAPVIV
Mflv_0126|M.gilvum_PYR-GCK MHEFQIP------------------------LYDQMRERDKEFYDRLEAA
Mb0916|M.bovis_AF2122/97 GG-FYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFD--
Rv0892|M.tuberculosis_H37Rv GG-FYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFD--
MUL_0256|M.ulcerans_Agy99 SG-FYRAIQRDDVELVTTGIDRIENAGIVTDDGVLREVDVIVLATGFD--
MMAR_2622|M.marinum_M NGTWLKTLQRDDVELIREGVAEITAHGVITRDGVYRPADVLIWATGFD--
MSMEG_1682|M.smegmatis_MC2_155 NG----------EMRFAPDLRTNIENGDANYLSMLDEADAYIARNGLD--
Mvan_1222|M.vanbaalenii_PYR-1 DT----------AVQFAPTLRRALDHADVVYNSICADIDAYIERTGAA--
MAV_3029|M.avium_104 PGGYYAALAREHVDVEASEPARVNQAGIVTADGRQIDLDVIIYATGY---
MAB_0958c|M.abscessus_ATCC_199 SR--------RGVLTRRPMFSRITPTGVTWPDGSSLEVDVILWCTGFRH-
TH_4273|M.thermoresistible__bu DR-EVVDAIRARRFEVVRTIGRFDGGTVVLTDGRRLQPDAVICATGYSRG
Mflv_0126|M.gilvum_PYR-GCK GF----------ELDWGADGSGLFMKYLRRGSGYYIDVGACDMVADGR--
. .. .
Mb0916|M.bovis_AF2122/97 SHAFFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFMMLGP-HSP
Rv0892|M.tuberculosis_H37Rv SHAFFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFMMLGP-HSP
MUL_0256|M.ulcerans_Agy99 SHAFFRPMKLIGRDGVEIDELWRGGPYAYQTVAMPGFPNFFMMLDP-HSP
MMAR_2622|M.marinum_M VNHQLGPIRVRGLDGVELNDLWGDAAYAYLGISVPGFPNFYCMYGPGTNA
MSMEG_1682|M.smegmatis_MC2_155 LPEEPGARIFGPDPDCVTNPIL------ELDLATAGITSVIWAVGF----
Mvan_1222|M.vanbaalenii_PYR-1 AGP-PGR--YTPVWEPETEPT-------ALDLAAEGVTAIVWAIGY----
MAV_3029|M.avium_104 YLDFLSTVDIRGRDGKKLTDEWGDAPRAYRGGMVPGFPNMFISSAPNYSP
MAB_0958c|M.abscessus_ATCC_199 ALDHLAPLHLRNGRG---------------GITMTGRLLTQVAGQP----
TH_4273|M.thermoresistible__bu LEPLVGHLGVLDDRGLPRSAG--------EVAAALGLWFIGFQSRP----
Mflv_0126|M.gilvum_PYR-GCK IKLAHGQVARLTEDSVVLADG---------TVLPADVVVYATGYGS----
.
Mb0916|M.bovis_AF2122/97 VGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAM
Rv0892|M.tuberculosis_H37Rv VGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAM
MUL_0256|M.ulcerans_Agy99 VGNYPLTGIAESQADHILRWIQRWRSSEFDTVEPTSWATDEFNAKLRAAM
MMAR_2622|M.marinum_M VNGASIIYNSECQMRYILGCIDMVLSEGARYAVLRDGVCSDYNQRSQRQL
MSMEG_1682|M.smegmatis_MC2_155 --------------ASDYGWLQVDAFDDAGKPIHQRGVSSEPGVYFLGLP
Mvan_1222|M.vanbaalenii_PYR-1 --------------RPDYRWIEASAFDGGGRPMQNRGVTTVPGLSFIGLP
MAV_3029|M.avium_104 GHGAGHNFGVEVMVHYVMECLQLMALRRATTVEVTQRAYEEYVADIDALM
MAB_0958c|M.abscessus_ATCC_199 -------------------AIHLLGYGSSASTIGANRASRAAVVELMNYL
TH_4273|M.thermoresistible__bu -------------------GLISFAAKQSQRIAKRIAAELVAAPAITPVA
Mflv_0126|M.gilvum_PYR-GCK ------------MNGWAADLIGQDVADKVGKVWGLGSDTPKDPGPWEGEQ
:
Mb0916|M.bovis_AF2122/97 PNTVWTT--GCDSWYLNKD-GIPEVWPFAPAKHRAMLANLHPEEYDLRRY
Rv0892|M.tuberculosis_H37Rv PNTVWTT--GCDSWYLNKD-GIPEVWPFAPAKHRAMLANLHPEEYDLRRY
MUL_0256|M.ulcerans_Agy99 PKTVWTT--GCSSWYLNDD-WVPEVWPFAPAEHRAMLANPDLDQYHLRRR
MMAR_2622|M.marinum_M ETMVYTHPAVCSSYYKNAAGDVPTLFAWRILDYWNWTNRPDRNHYEFRR-
MSMEG_1682|M.smegmatis_MC2_155 WQSRRGS-----SFLWGVWHDAKYIADHIA-IQRSYLTYHATHEKKGR--
Mvan_1222|M.vanbaalenii_PYR-1 WMHTWGS-----GRFLGVDSDARHIAETIIGAHRDSAPASPLRLAVGG--
MAV_3029|M.avium_104 AGTVWCHTPSAHTYYRSGGGRIVTAFPYRLVDFWRDHRAPSEEDLELR--
MAB_0958c|M.abscessus_ATCC_199 EGRTA---------------------------------------------
TH_4273|M.thermoresistible__bu DGG-----------------------------------------------
Mflv_0126|M.gilvum_PYR-GCK RNMWKPT-------------------------------------------
Mb0916|M.bovis_AF2122/97 AAVRATSRPQSA
Rv0892|M.tuberculosis_H37Rv AAVRATSRPQSA
MUL_0256|M.ulcerans_Agy99 PEVLAW------
MMAR_2622|M.marinum_M ------------
MSMEG_1682|M.smegmatis_MC2_155 ------------
Mvan_1222|M.vanbaalenii_PYR-1 ------------
MAV_3029|M.avium_104 ------------
MAB_0958c|M.abscessus_ATCC_199 ------------
TH_4273|M.thermoresistible__bu ------------
Mflv_0126|M.gilvum_PYR-GCK ------------