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VVLGAGPAGLGIARELKHRHGVDPLIVDRSDAPAASWRARYDGFRLNTCGFWSHLPGQRIPLSFGRWPTR DQMVEYFDDYVRRQGLRLRLGVRAERIDRDGAGWSITTDDEDVRASAVVVALGNHNTPGLPPWPGMDGFT GQLLHAADYRSAEPFGGQEVLVVGSGNSAVDIALQLSSAVAAKVWMSVRTPPQLVPRSTAGLPIDTLGPL LATLPVWLLDGAAAAMRRVWFGELAGVGLPPPRQGIYTALRAQAKVPTIADELVPRVKDGRIEIVSAVES FETNRVVLADGTALAPQVVIGATGYRRGLDALVGHLGVLTDDGHPVVNGPPAAAPGLWFAGYEEPLIGPL RAFRRHAPDVAEVVSHLAASSAASQTLSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3867 | - | - | 100% (380) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4373 | - | 3e-22 | 31.48% (324) | flavin-containing monooxygenase |
| M. gilvum PYR-GCK | Mflv_0126 | - | 4e-19 | 23.82% (340) | hypothetical protein Mflv_0126 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3075c | - | 3e-17 | 26.93% (349) | monooxygenase |
| M. tuberculosis H37Rv | Rv3049c | - | 3e-17 | 26.93% (349) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 7e-07 | 21.19% (387) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2607 | - | 4e-22 | 29.50% (322) | putative flavin-containing monooxygenase |
| M. marinum M | MMAR_0403 | - | 2e-19 | 25.34% (363) | monooxygenase |
| M. avium 104 | MAV_3915 | - | 9e-17 | 25.94% (347) | flavin-containing monooxygenase FMO |
| M. smegmatis MC2 155 | MSMEG_2202 | - | 8e-21 | 28.12% (320) | dimethylaniline monooxygenase |
| M. thermoresistible (build 8) | TH_4273 | - | 6e-84 | 46.53% (346) | PUTATIVE FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_1053 | - | 4e-19 | 25.07% (363) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1971 | - | 5e-22 | 29.50% (322) | dimethylaniline monooxygenase (N-oxide-forming) |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3075c|M.bovis_AF2122/97 -MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQG-VD-
Rv3049c|M.tuberculosis_H37Rv -MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQG-VD-
MAV_3915|M.avium_104 MTDVVTHTETAPTPAAKAAKPVHTRAVIIGTGFSGLGMAIALQKQG-VG-
MMAR_0403|M.marinum_M ----------MTSPLSVG---------IIGAGPGGLALGILLKNRG-FEN
MUL_1053|M.ulcerans_Agy99 ----------MTSPLSVG---------IIGAGPGGLALGILLKNRG-FEN
Mflv_3867|M.gilvum_PYR-GCK -------------------------MVVLGAGPAGLGIARELKHRH-GVD
TH_4273|M.thermoresistible__bu --------------------MNDHQVAVIGAGPSGVAAAVSLRDR--GIR
MSMEG_2202|M.smegmatis_MC2_155 ------------------MTPALPRTAIIGAGISGLTAGKMLKDY--RVP
Mvan_1971|M.vanbaalenii_PYR-1 ------------------MDQTHPRVAVIGAGISGLTAGKMLKDY--GVS
MAB_2607|M.abscessus_ATCC_1997 --------------------MTGPSTAIIGAGISGLTSVKMLSDY--GIP
MLBr_00065|M.leprae_Br4923 --------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKS
::*:* .*: * .
Mb3075c|M.bovis_AF2122/97 FVILEKADDVGGTWRDN-------TYPGCACDIPSHLYSFSFEPKADWKH
Rv3049c|M.tuberculosis_H37Rv FVILEKADDVGGTWRDN-------TYPGCACDIPSHLYSFSFEPKADWKH
MAV_3915|M.avium_104 FVILEKADDIGGTWRDN-------SYPGCACDIPSHLYSFSFEPKPDWKN
MMAR_0403|M.marinum_M FTIFDRESDVGGTWRIN-------TYPGLACDVKSHLYSYSFDLNPGWSR
MUL_1053|M.ulcerans_Agy99 FNIFDRESDVGGTWRIN-------TYPGLACDVKSHLYSYSFDLNPGWSG
Mflv_3867|M.gilvum_PYR-GCK PLIVDRSDAPAASWRAR--------YDGFRLNTCGFWSHLPGQRIPLSFG
TH_4273|M.thermoresistible__bu PLLIDRAEHVGASWRAR--------YDRLRLNTGRLTSHLPNRPYPAGTA
MSMEG_2202|M.smegmatis_MC2_155 YTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKHRLSFKDFPMPEHYP
Mvan_1971|M.vanbaalenii_PYR-1 YTTFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSKDRLSFKDFPMPEHYP
MAB_2607|M.abscessus_ATCC_1997 HTCFETSDRIGGNWAFGNPNGHSSAYRSLHIDTSRHQLSFRDFPMPDSYP
MLBr_00065|M.leprae_Br4923 YVILEKRAGMGGTWDLFR-------YPGIRSDSDMYTLGFRFRPWTKCQA
.: ...* * : .
Mb3075c|M.bovis_AF2122/97 LFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTA--
Rv3049c|M.tuberculosis_H37Rv LFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTA--
MAV_3915|M.avium_104 PFSYQPEIWDYLKGVTEKYGLRRYIEFNSLVDRAHWDDDEHRWHVFTT--
MMAR_0403|M.marinum_M LWSGQPEILAYFQRCADRYGLRPHLRLSTEIRSARWESQTRQWTLSTA--
MUL_1053|M.ulcerans_Agy99 LWSGQPEILAYFQRCADRYELRPHLRLGTEIRSARWESQTRQWTLSTA--
Mflv_3867|M.gilvum_PYR-GCK RWPTRDQMVEYFDDYVRRQGLRLRLGVRAERIDRD----GAGWSITTD--
TH_4273|M.thermoresistible__bu VFPTRDQVVAHLDRHAREDGIDLLLGTTVARVDRD----GEGWRLWTS--
MSMEG_2202|M.smegmatis_MC2_155 SFPHHTQIKEYLDAYADAFGLLDHIEFGNGVVHAERGA-HGGWVIEDQ--
Mvan_1971|M.vanbaalenii_PYR-1 SFPHHSQVKAYLDEYAEVFGLLEHIEFGNGVVHAAKDG-SGGWRILDQ--
MAB_2607|M.abscessus_ATCC_1997 HFPHHTLIKQYLEDYARAFDLKRNIEFQNGIVHAEHRP-GGGWELLTQ--
MLBr_00065|M.leprae_Br4923 IADGKP-ILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENN
: ::. . : : * :
Mb3075c|M.bovis_AF2122/97 -DGREYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQWDH---S
Rv3049c|M.tuberculosis_H37Rv -DGREYVAQFLISGAGALHIPS--FPEIAGRDEFAGPAFHSAQWDH---S
MAV_3915|M.avium_104 -DGREYVAQFLISGAGALHIPS--LPDIEGRDEFAGPAFHSAEWDH---T
MMAR_0403|M.marinum_M -DGEQHQFSVVVSAVGIFSRPA--YPDLVEQQRFTGTVMHSSRWDH---S
MUL_1053|M.ulcerans_Agy99 -DGEQHQFSVVVSVVGIFSRPA--YPDLVEQQRFTGTVMHSSRWDH---S
Mflv_3867|M.gilvum_PYR-GCK -DED-VRASAVVVALGNHNTPG--LPPWPGMDGFTGQLLHAADYRS---A
TH_4273|M.thermoresistible__bu -GGD-VCARHVVVATGYEHTPN--IPDWPGADGFTGRLLHSSAYRN---P
MSMEG_2202|M.smegmatis_MC2_155 -ASARRDFDLLVVANGHHWDPR--MPDFPG--EFTGEQIHSHHYIDPRTP
Mvan_1971|M.vanbaalenii_PYR-1 -AGAQRHFDLLVVANGHHWDPR--LPQFPG--SFAGESIHSHSYVDPSTP
MAB_2607|M.abscessus_ATCC_1997 -AGERRLFDLLVVANGHHWDPR--YPDFPG--TFTGTALHSHHYIDPRTP
MLBr_00065|M.leprae_Br4923 GTPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPE---D
:. * * *:* :*. :
Mb3075c|M.bovis_AF2122/97 IDLTGKRVAIVGTGASAIQIVPEIVG--QVAELQLYQRTPPWVVPRTNEE
Rv3049c|M.tuberculosis_H37Rv IDLTGKRVAIVGTGASAIQIVPEIVG--QVAELQLYQRTPPWVVPRTNEE
MAV_3915|M.avium_104 VDLTGKRVAVIGTGASAIQIVPEIVG--QVAELQLYQRTPPWVVPRSNPE
MMAR_0403|M.marinum_M VPLAGARIAVLGTGSTAAQLVPELAK--VADRVYSIQRSPTWILPKPDRP
MUL_1053|M.ulcerans_Agy99 VPLAGARIAVLGTGSTAAQLVPELAK--VADRVYSIQRSPTWILPKPDRP
Mflv_3867|M.gilvum_PYR-GCK EPFGGQEVLVVGSGNSAVDIALQLSS-AVAAKVWMSVRTPPQLVPRSTAG
TH_4273|M.thermoresistible__bu IPFSGLRVLVVGAGSSAMEIVHDVAT-GGAAQAWLAVRTPPNIMLRALPG
MSMEG_2202|M.smegmatis_MC2_155 LDLTGKRILVVGIGNSAADITVELSSRTLQNQVTLSTRSSAWIVPKYLAG
Mvan_1971|M.vanbaalenii_PYR-1 LDLSGKRILVVGIGNSAADITVELSSKALRNDVTLSTRSSAWIVPKYIAG
MAB_2607|M.abscessus_ATCC_1997 LDLMDKRILVVGLGNSAADIAVELSSRATGNTVTLSTRSGAWIVPKYVAG
MLBr_00065|M.leprae_Br4923 LDYAAKNIVVIGSGATAVTLVPALAN-SGAKHVTMLQRSPTYIVSQPAKD
.: ::* * :* :. : *: . :: :
Mb3075c|M.bovis_AF2122/97 LPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKY
Rv3049c|M.tuberculosis_H37Rv LPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKY
MAV_3915|M.avium_104 IPPAVRAAMENVPGLRALVRLAIYWGQEALAFGMTKRPNLLKVIEAYAKY
MMAR_0403|M.marinum_M YSRWERWVFAHVPFAARLYRTRLWLRSESNISVIEHGSPKTKEFTELALR
MUL_1053|M.ulcerans_Agy99 YSRWERWVFAHVPFAARLYRTRLWLRSESNISVIEHGSPKTKEFTELALR
Mflv_3867|M.gilvum_PYR-GCK -------------------LPIDTLGPLLATLPVWLLDGAAAAMRRVWFG
TH_4273|M.thermoresistible__bu G------------------FPSDYLATPLFDAPVGLVDRMARLAQRATIG
MSMEG_2202|M.smegmatis_MC2_155 -------------------QPGDKFFRTTPYLPLSWQRKAVQMIAPMLGT
Mvan_1971|M.vanbaalenii_PYR-1 -------------------RPGDTFWRTSPYLPLSWQRKAVQLVAPMLGT
MAB_2607|M.abscessus_ATCC_1997 -------------------QPADKYFRTSPHLPMSWQRKLFQMMQPLMSG
MLBr_00065|M.leprae_Br4923 KIAARLNRWLPDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVA
Mb3075c|M.bovis_AF2122/97 NIRRSVKDRELRRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRIDR
Rv3049c|M.tuberculosis_H37Rv NIRRSVKDRELRRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRIDR
MAV_3915|M.avium_104 NIRRSVKDKELRRKLTPHYRIGCKRILNSSTYYGAVADPKTELVTDHIAR
MMAR_0403|M.marinum_M MLENTVSDPQLRRQLTPDHPMGCKRLVFSSEFLTALARPNVELVTSPARY
MUL_1053|M.ulcerans_Agy99 MLENTVSDPQLRRQLTPDHPMGCKRLVFSSEFLTALTRPNVELVTSPARY
Mflv_3867|M.gilvum_PYR-GCK ELAGVGLPPPRQGIYTALRAQAKVPTIAD-ELVPRVKDGRIEIVSA-VES
TH_4273|M.thermoresistible__bu DLSEYGLPTPREGVFARGKRLGRAPVIVDREVVDAIRARRFEVVRT-IGR
MSMEG_2202|M.smegmatis_MC2_155 DPTAYGLPAPN-------HKLFEAHPTQSVELPLRLGSGDVTPKPN-VAR
Mvan_1971|M.vanbaalenii_PYR-1 DPTMYGLPPAD-------HKLFEAHPTQSVELPLRLGSGDVTPKPN-VAR
MAB_2607|M.abscessus_ATCC_1997 RPDQLGLPMPN-------HKFGEAHFTQSVELPLRLGSGDIVPKPD-ISR
MLBr_00065|M.leprae_Br4923 RRLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDR
. :
Mb3075c|M.bovis_AF2122/97 ITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVD
Rv3049c|M.tuberculosis_H37Rv ITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVD
MAV_3915|M.avium_104 ITPDGIVTADGT----HRPVDVIVYATGFHVTDSYTYVQIKGLHGEDLVD
MMAR_0403|M.marinum_M LRQRSLVTADGA----EYDVDVVVCATGYAAADYLGQLEVLGEDGAGLHE
MUL_1053|M.ulcerans_Agy99 LRQRSLVTADGA----EYDVDVVVCATGYAAADYLGQLEVLGEDGAGLHE
Mflv_3867|M.gilvum_PYR-GCK FETNRVVLADGT----ALAPQVVIGATGYRRGLDALVGHLGVLTDD----
TH_4273|M.thermoresistible__bu FDGGTVVLTDGR----RLQPDAVICATGYSRGLEPLVGHLGVLDDR----
MSMEG_2202|M.smegmatis_MC2_155 LSGDTVLFEDGT----SDVFDVIIYATGYNITFPFFDRDFISAPDN----
Mvan_1971|M.vanbaalenii_PYR-1 LDGHTVHFVDGT----SADFDVIIYATGYNITFPFFDPEFISAPDN----
MAB_2607|M.abscessus_ATCC_1997 FDGHTVHFEDGT----STDVDVIIFATGYNITFPFFDPEFLSAPDN----
MLBr_00065|M.leprae_Br4923 FTSTGIRLKSGN----ELRADIIVTATGLNLQLFGGAVATVDGQPVD---
: : .* : :: ***
Mb3075c|M.bovis_AF2122/97 RWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
Rv3049c|M.tuberculosis_H37Rv RWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADA
MAV_3915|M.avium_104 RWNREGIGAHRGITVADVPNLFFLLGPNTGLGHNSVVFMIESQIRYVADA
MMAR_0403|M.marinum_M VWR-DGAHAYLGMAVPGFPNFFMLYGPNTNVGSNSVIFMLEAQARYIVAA
MUL_1053|M.ulcerans_Agy99 VWR-DGAHAYLGMAVPGFPNFFMLCGPNTNVGSNSVIFMLEAQARYIVAA
Mflv_3867|M.gilvum_PYR-GCK -----GHPVVNGPPAAAPG-LWFAG---YEEPLIGPLRAFRRHAPDVAE-
TH_4273|M.thermoresistible__bu -----GLPRSAGEVAAALG-LWFIG---FQS-RPGLISFAAKQSQRIAKR
MSMEG_2202|M.smegmatis_MC2_155 -----QIRLYKRMFKPGIDDLVFIG---FAQAIPTLFPFVECQSRLLAAY
Mvan_1971|M.vanbaalenii_PYR-1 -----SIRLYKRMFKPGVDDLVFIG---FAQSVPTLFPFVECQSRLLAAY
MAB_2607|M.abscessus_ATCC_1997 -----RIDLYKRMFKPGLDDLIFVG---LAQAVPSLFPFVECQARLVGAY
MLBr_00065|M.leprae_Br4923 ---LAQTMSYKGMMLSGLPNMIYTVGYTNASWTLKADLVSEFFCRLLNYM
. : :
Mb3075c|M.bovis_AF2122/97 IAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGK
Rv3049c|M.tuberculosis_H37Rv IAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGK
MAV_3915|M.avium_104 IATCDKLGAQALAPTRAAQDRFNDELQRRLGPSVWNSGGCSSWYLDEHGK
MMAR_0403|M.marinum_M LAHLRRKSKTYIAVRPGVLAEFMAKVDRWMTGTVWTT-ECSNYFRAPNGR
MUL_1053|M.ulcerans_Agy99 LAHLRRKSKTYIAVRPGVLAEFIAKVDRWMTGTVWTT-ECSNYFRAPNGR
Mflv_3867|M.gilvum_PYR-GCK VVSHLAASSAASQTLSR---------------------------------
TH_4273|M.thermoresistible__bu IAAELVAAPAITPVADGG--------------------------------
MSMEG_2202|M.smegmatis_MC2_155 AVGRYALPSTDEMERVIDADQRLHAGHCTDRPRHTQQVDYFYYEHDIRAR
Mvan_1971|M.vanbaalenii_PYR-1 AVGRYALPSADEMERTIDADQQLHAGHCTDRPRHTQQVDYFVYEHDLLKR
MAB_2607|M.abscessus_ATCC_1997 AAGKYRLPPVDEMRAVIEAEHRKYTGHMLDRPRHTQQLDYFLYEHDMRTK
MLBr_00065|M.leprae_Br4923 NANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQ
.
Mb3075c|M.bovis_AF2122/97 NTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN------
Rv3049c|M.tuberculosis_H37Rv NTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN------
MAV_3915|M.avium_104 NTVLWGGYTWEYWRATRAVKPEEYQFYGIG-----SRAGV----------
MMAR_0403|M.marinum_M VVTQWPRSARSFWGMTRRFKPADFSFQPAAVFAADGGDRNAGQR------
MUL_1053|M.ulcerans_Agy99 VVTQWPRSARSFWGMTRRFKPADFSFQPAAVFAADGGDRNAGQRWPNPRP
Mflv_3867|M.gilvum_PYR-GCK --------------------------------------------------
TH_4273|M.thermoresistible__bu --------------------------------------------------
MSMEG_2202|M.smegmatis_MC2_155 EMPAGAKRAERRAAGTRTAIVGSVA-------------------------
Mvan_1971|M.vanbaalenii_PYR-1 EIPAGRKRAQRVAAVAR---------------------------------
MAB_2607|M.abscessus_ATCC_1997 ELPRGLARAGGVA-------------------------------------
MLBr_00065|M.leprae_Br4923 NYLRDIRLIRRGKVADEGLLFAKKTTPVTV--------------------
Mb3075c|M.bovis_AF2122/97 -----------------------
Rv3049c|M.tuberculosis_H37Rv -----------------------
MAV_3915|M.avium_104 -----------------------
MMAR_0403|M.marinum_M -----------------------
MUL_1053|M.ulcerans_Agy99 SIGWTPCCAPSRRRESTSPRSRS
Mflv_3867|M.gilvum_PYR-GCK -----------------------
TH_4273|M.thermoresistible__bu -----------------------
MSMEG_2202|M.smegmatis_MC2_155 -----------------------
Mvan_1971|M.vanbaalenii_PYR-1 -----------------------
MAB_2607|M.abscessus_ATCC_1997 -----------------------
MLBr_00065|M.leprae_Br4923 -----------------------