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ISEHFDAVIVGAGFAGIGAAIQFKRMGIENFVILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPN WSRLFSTGAEIKQYADDVADKYDVRRHIRFGVTVGGARWDDDAQLWRVNLADGETVDARYLVTATGFLSQ PHMPDIPGIAEFDGRVIHTTAWDDSYDPTGEKIGIIGTGATAVQLIPELAEKAADLTVYQRTPIWVVPKI DFRFSERAKQLFARIPLTQRLIRVITDTIYELMVWVAVLHNRQTRGRFNIAAGDLAKMHRFATIRDKELR AKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQDSGIARIESDGIVGNDGTKTPIDTLVLATGFDLWEANF PAIEVIGRDGRNLGKWWRETRFQAYQGVSMPHFPNFLSLASPFAFLGLNFFNTVEYQMRHMDRLFGELRR RGATTFEITEEANARYLARMTALLGDSLFTNGSCATARSYYFNPSGEPTLLRPTSTRAAIREATDFPIDD YRIV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0721 | - | - | 100% (495) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3104 | - | 0.0 | 65.09% (487) | cyclohexanone monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_3109 | - | 0.0 | 63.41% (492) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1428c | - | 1e-107 | 41.05% (497) | monoxygenase |
| M. gilvum PYR-GCK | Mflv_0184 | - | 0.0 | 85.16% (492) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1393c | - | 1e-107 | 41.05% (497) | monoxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 2e-30 | 29.11% (371) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_2477c | - | 1e-180 | 60.65% (493) | monooxygenase |
| M. marinum M | MMAR_2207 | - | 1e-111 | 41.81% (507) | monoxygenase |
| M. avium 104 | MAV_2172 | - | 0.0 | 69.23% (494) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_0816 | - | 0.0 | 75.93% (486) | flavin-binding monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 4e-84 | 37.26% (467) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1793 | - | 1e-108 | 41.80% (500) | monoxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1428c|M.bovis_AF2122/97 ------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDY
Rv1393c|M.tuberculosis_H37Rv ------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDY
MMAR_2207|M.marinum_M ----------------MSIEPDYQIVIVGAGFSGIGAAISLD-KAGFGDY
MUL_1793|M.ulcerans_Agy99 -------------------------MIVGAGFSGIGAAISLD-KAGFGDY
Mvan_0721|M.vanbaalenii_PYR-1 -----------------MISEHFDAVIVGAGFAGIGAAIQFK-RMGIENF
Mflv_0184|M.gilvum_PYR-GCK -----------------MNSEQFDAVIVGAGFAGIGTAIQLK-RSGIENF
MSMEG_0816|M.smegmatis_MC2_155 -----------------MRPVVHDAVIVGAGFAGLGAAIQLK-KMSFDDF
MAV_2172|M.avium_104 -----------------MVTDRFDAIIVGAGFGGIGAAIQLK-RLGFDNI
MAB_2477c|M.abscessus_ATCC_199 ------------------MTTQFDAVIVGAGFGGMGAAIQLK-ELGLTNL
TH_4080|M.thermoresistible__bu MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQ-RRGID-F
MLBr_00065|M.leprae_Br4923 -------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSY
:***:*:.*:. * :. .
Mb1428c|M.bovis_AF2122/97 LVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHEL
Rv1393c|M.tuberculosis_H37Rv LVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHEL
MMAR_2207|M.marinum_M LVIEAGDGVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGREL
MUL_1793|M.ulcerans_Agy99 LVIEAGDAVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGREL
Mvan_0721|M.vanbaalenii_PYR-1 VILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPNWSRLFSTGAEI
Mflv_0184|M.gilvum_PYR-GCK VILDREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPNWSRLFSTGDEI
MSMEG_0816|M.smegmatis_MC2_155 VILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPSWSRLFSTGREI
MAV_2172|M.avium_104 VILDREDDLGGTWHVNHYPGIAVDIPSTTYSYWFEPNPGWSRLFAPGGEV
MAB_2477c|M.abscessus_ATCC_199 AILDREDDLGGTWHVNHYPGLAVDIPSATYSYSFEPNPYWSRLFAPGSEL
TH_4080|M.thermoresistible__bu LMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFSYQDEI
MLBr_00065|M.leprae_Br4923 VILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIAD-GKPI
::: :**** *** * : *. :
Mb1428c|M.bovis_AF2122/97 KAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE---ITA
Rv1393c|M.tuberculosis_H37Rv KAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGE---ITA
MMAR_2207|M.marinum_M RAYAEHCADKYGIRPRIRFNTKVLGAEFDDERSLWRLQTDPGGE---LTT
MUL_1793|M.ulcerans_Agy99 RAYAEHCADKYGIRPRIRFNTKVLGAELDDERSLWRLQTDPGGD---LIT
Mvan_0721|M.vanbaalenii_PYR-1 KQYADDVADKYDVRRHIRFGVTVGGARWDDDAQLWRVNLADGET---VDA
Mflv_0184|M.gilvum_PYR-GCK KQYADHVADKYDVRRHIRFGVTVEGARWDEDATLWRVSLADGTT---LSS
MSMEG_0816|M.smegmatis_MC2_155 KRYADDVADKYDVRRHIRFGTTVTGARWDEDDNVWQVSLTDGEQ---LQA
MAV_2172|M.avium_104 KQYAADVADKYDVRRHMRFNTTVEGAQWDEDAEVWRVALAGGES---LTT
MAB_2477c|M.abscessus_ATCC_199 KQYASHVADKHDLRKYMRFNTPVSGARWDEEHQHWVVATESGDT---VTG
TH_4080|M.thermoresistible__bu QEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFTADGRE---YIA
MLBr_00065|M.leprae_Br4923 LEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISC
* . :.: :::. * * .. * : .
Mb1428c|M.bovis_AF2122/97 RFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGII
Rv1393c|M.tuberculosis_H37Rv RFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGII
MMAR_2207|M.marinum_M RFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGII
MUL_1793|M.ulcerans_Agy99 RFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGII
Mvan_0721|M.vanbaalenii_PYR-1 RYLVTATGFLSQPH--MPDIPGIAEFDGRVIHTTAWDDSYDPTGEKIGII
Mflv_0184|M.gilvum_PYR-GCK RYLLTATGFLSQPH--MPDIPGITEFEGRVIHTTAWDDSYDPSGEKIAVI
MSMEG_0816|M.smegmatis_MC2_155 RFLITATGFLSQPH--TPDIPGITEFDGKVIHTTDWDDGCSLYGRRAAVV
MAV_2172|M.avium_104 RFLITATGFLSQPH--TPDIPGIGSFGGKVVHTTAWDHDYRYQGRRIAVI
MAB_2477c|M.abscessus_ATCC_199 KYLLTATGYLSQPK--MPDIEGIESFAGKVIHTTKWDNSYRAAGHRIGLI
TH_4080|M.thermoresistible__bu QFLISCAGALHIPS--IPDFPGRDQFAGPAFHSAQWDHSVDLTGKRVAVI
MLBr_00065|M.leprae_Br4923 SFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVI
::. . * * : * .* * .*. * . ... ::
Mb1428c|M.bovis_AF2122/97 GTGASAVQVIPEMAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVR-WAMRI
Rv1393c|M.tuberculosis_H37Rv GTGASAVQVIPEMAPI-VSHLTVFQRTPIWCFPKFDVPLPTAVR-WAMRI
MMAR_2207|M.marinum_M GTGASAVQVIPEIAPI-VKHLTVFQRTPIWCFPKFDFPLPAALR-WAMRI
MUL_1793|M.ulcerans_Agy99 GTGASAVQVIPEIAPI-VKHLTVFQRTPIWCFPKFDFPLPAALR-WAMRI
Mvan_0721|M.vanbaalenii_PYR-1 GTGATAVQLIPELAEK-AADLTVYQRTPIWVVPKIDFRFSERAKQLFARI
Mflv_0184|M.gilvum_PYR-GCK GTGATAVQLIPELAKK-AADLTVYQRTPIWVVPKVDFRFSERAKRLFARV
MSMEG_0816|M.smegmatis_MC2_155 GTGATAVQLIPELAER-VAELTVYQRTPIWVVPKVDVRFPPAVRALFARV
MAV_2172|M.avium_104 GTGASAVQVVPELAKE-AEELTVYQRTATHVLPKVDFEFDPAVRRLFARV
MAB_2477c|M.abscessus_ATCC_199 GTGATAVQLIPELAKD-AQHLTVYQRTPIWVVPKADAKVPGVVKKLFAKV
TH_4080|M.thermoresistible__bu GTGASAIQIVPEIIDR-VAQLQLYQRTPAWVVPRTNDELPAWLRRALENI
MLBr_00065|M.leprae_Br4923 GSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPD
*:**:*: ::* : . .: : **:. ..:
Mb1428c|M.bovis_AF2122/97 PGGKAVHRLLSQAFVEATFPIAAHYFAVFP--LAKHMESAGRRYLRQQVH
Rv1393c|M.tuberculosis_H37Rv PGGKAVHRLLSQAFVEATFPIAAHYFAVFP--LAKHMESAGRRYLRQQVH
MMAR_2207|M.marinum_M PGGKALQRLLSQAYVEATFPISAHYFTVFP--LARWSAVLGRRYLRQRVN
MUL_1793|M.ulcerans_Agy99 PGGKALQRLLSQAYVEATFPISAHYFTVFP--LARWSAVLGRRYLRQRVD
Mvan_0721|M.vanbaalenii_PYR-1 PLTQRLIRVITDTIYELMVWVAVLHNRQTRGRFNIAAGDLAKMHRFATIR
Mflv_0184|M.gilvum_PYR-GCK PQTQRVLRWLTDSIYEVMVSVAVRHYGMFRGRFNISAADLAKIHRFVTIR
MSMEG_0816|M.smegmatis_MC2_155 PLTQRVVRAITDAIYAFMVDTAVLKHRYFR-RLNIAAADLGRLHLAASIR
MAV_2172|M.avium_104 PAAQRALRWVTDVLLEIIMIVGALHFKESRGRGNISASDLAKINRFRWIR
MAB_2477c|M.abscessus_ATCC_199 PRTQKIARTVGSAILEVIMVGGVLHFRQFR-QANHGASLLAKAHLFAQVR
TH_4080|M.thermoresistible__bu PGLRLALRGGIYALQEALAVGMTKYPGMLR-----IGHLLGKWNINRSVK
MLBr_00065|M.leprae_Br4923 KYAYTAVRWKNILRQSALYGACQKWPQRMR---NILLGHVARRLPKGYDV
* .:
Mb1428c|M.bovis_AF2122/97 DPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVA
Rv1393c|M.tuberculosis_H37Rv DPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVA
MMAR_2207|M.marinum_M DPVVRDQLTPRYAVGCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTAVA
MUL_1793|M.ulcerans_Agy99 DPVVRDQLTPRYAVDCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTSVA
Mvan_0721|M.vanbaalenii_PYR-1 DKELRAKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQDSGIARIESDGIV
Mflv_0184|M.gilvum_PYR-GCK DKDLRRRLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQDTGIARVESDGIV
MSMEG_0816|M.smegmatis_MC2_155 DPDLRSKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQADGIDHVEPDGIV
MAV_2172|M.avium_104 DKELRAKLTPDYDCGCKRPTFSNSFYRVLTQPNVHLETNPIERIEPDGIV
MAB_2477c|M.abscessus_ATCC_199 DRELRRKLTPDYDFGCKRPTFSNTYFRAFTKKNVSLETASIARIEADGIV
TH_4080|M.thermoresistible__bu DPQLRAKLTPDYRLGCKRILNSSTYYPAVADPRTEVITESIDRITTDGIV
MLBr_00065|M.leprae_Br4923 QKHFGPHYNPWEQRLCLVP--DGDLFRAIRKGTVDMVTDAIDRFTSTGIR
: . : .* * . .. . : * :. . .:
Mb1428c|M.bovis_AF2122/97 TTDGASHEIDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQA
Rv1393c|M.tuberculosis_H37Rv TTDGASHEIDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQA
MMAR_2207|M.marinum_M TDDGTDHEIDVLILATGFKVLDTDDVLTYPVIGRAGRSLSQFWEEHRAQA
MUL_1793|M.ulcerans_Agy99 TDDGTDHEIDVLILATGFKVLDTDDVLTYPVIGRAGRSLSQFWEEHRAQA
Mvan_0721|M.vanbaalenii_PYR-1 GNDGTKTPIDTLVLATGFDLWEAN-FPAIEVIGRDGRNLGKWWRETRFQA
Mflv_0184|M.gilvum_PYR-GCK AGDGTKTVIDTLVLATGFDLWEAN-FPAIEVIGRDGRNLGKWWRETRFQA
MSMEG_0816|M.smegmatis_MC2_155 NADGSKTVIDTLVLATGFDLWEAN-FPAIEVIGRQGRDLGKWWRETRFQA
MAV_2172|M.avium_104 TADGRKNVIDTLVLATGFDLWEAN-FPAIEVIGRKGRNLGKWWRETRFQA
MAB_2477c|M.abscessus_ATCC_199 TADGRKTVIDTLVLATGFNLWEST-FPAFEVIGREDYNLGKFWRDNRFQA
TH_4080|M.thermoresistible__bu TSDGTERAVDVIVYATGFHVSDSY--KYVQIKGLNGEDIVDRFNREGPMA
MLBr_00065|M.leprae_Br4923 LKSGNELRADIIVTATGLNLQLFG--------GAVATVDGQPVDLAQTMS
.* . * :: ***:.: * :
Mb1428c|M.bovis_AF2122/97 YEGVSVPGYPNFFTVFGPYGYVGSS-YFALIETQAHHIIRCLKRARRTGA
Rv1393c|M.tuberculosis_H37Rv YEGVSVPGYPNFFTVFGPYGYVGSS-YFALIETQAHHIIRCLKRARRTGA
MMAR_2207|M.marinum_M YQGVSVPGYPNFFAVFGPYGYVGSS-YFALIETQTHHILRCLKRARRDGA
MUL_1793|M.ulcerans_Agy99 YQGVSVPGYRNFFAVFGPYGYVGSS-YFALIETQTHHILRCLKRARRDGA
Mvan_0721|M.vanbaalenii_PYR-1 YQGVSMPHFPNFLSLASPFAFLGLN-FFNTVEYQMRHMDRLFGELRRRGA
Mflv_0184|M.gilvum_PYR-GCK YQGVSIPYFPNYLSLASPYAFIGLN-FFNTMEYQMRLMDRLFGELRRRGA
MSMEG_0816|M.smegmatis_MC2_155 YQGVSMPYFPNYLSLAGPYAFLGLN-FFNTMEYQMRLMERLLGEVARRDA
MAV_2172|M.avium_104 YQGVSMPYFPNYLSLASPFAFSGLS-FFHTIEYQMRHMDRLLGEVKRRGA
MAB_2477c|M.abscessus_ATCC_199 FEGIAVPKFPNLLTLNGPYSYSGLS-YFDTIESQMRHIKRLFAEMARTGT
TH_4080|M.thermoresistible__bu HRGTAVADLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEAIKAVDKAGA
MLBr_00065|M.leprae_Br4923 YKGMMLSGLPNMIYTVG-YTNASWTLKADLVSEFFCRLLNYMNANDFDTV
..* :. * . . . :. : . : .
Mb1428c|M.bovis_AF2122/97 TRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGD-VPLRP
Rv1393c|M.tuberculosis_H37Rv TRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGD-VPLRP
MMAR_2207|M.marinum_M TRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGD-VPLRP
MUL_1793|M.ulcerans_Agy99 TRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGD-VPLRP
Mvan_0721|M.vanbaalenii_PYR-1 TTFEITEEANARYLARMTALLGDSLFTNGSCATARSYYFNPSGEPTLLRP
Mflv_0184|M.gilvum_PYR-GCK TTFEVTEEANAEFLDRMTDLLGESLFTIGNCASARSYYFNPAGEPTLLRP
MSMEG_0816|M.smegmatis_MC2_155 RTFEVTEEANRRYLDRMTDALGDSLFTLGNCASARSYYFNPSGEATLLRP
MAV_2172|M.avium_104 TTFEVTEEANDRFMERMTKLLDNSVFYAGNCATSRSYYFSPSGEASLLRP
MAB_2477c|M.abscessus_ATCC_199 EVFEVTDEANTEFLDRMTRNLDNSVFYLGSCQTSRSYYFNQHGEAALLRP
TH_4080|M.thermoresistible__bu QALAPTREAQDRYNAELQARLGRSVWNTGGCR---SWYLDEHGNNRVLWG
MLBr_00065|M.leprae_Br4923 AVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRL
:.: . . : : . :
Mb1428c|M.bovis_AF2122/97 TTTVEAYWRSRRFDLGDYRISS
Rv1393c|M.tuberculosis_H37Rv TTTVEAYWRSRRFDLGDYRISS
MMAR_2207|M.marinum_M TTTVEAYWRGRHFDLDNYRFGR
MUL_1793|M.ulcerans_Agy99 TTTVEAYWRGRHFDLDDYRFGR
Mvan_0721|M.vanbaalenii_PYR-1 TSTRAAIREATDFPIDDYRIV-
Mflv_0184|M.gilvum_PYR-GCK TSTETAIREATEFPVTDYSFG-
MSMEG_0816|M.smegmatis_MC2_155 MTTRRAVAEASRFPLSDYTFA-
MAV_2172|M.avium_104 TSTLNSIREASSFPLSDYVIA-
MAB_2477c|M.abscessus_ATCC_199 TSTASAYKEQESFPLEAYQLA-
TH_4080|M.thermoresistible__bu GFTWQYRLATRTLDPAEYRFWG
MLBr_00065|M.leprae_Br4923 IRRGKVADEGLLFAKKTTPVTV
: .