For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVCIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFAKNP NWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDGRWVLRTDSGTESTVDFLISATGVLHHP RIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGSTGVQLVCGLAGVAGKVTMFQRTAQWVLPWPN PRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAVCRASLRRVRDPRLRRALTPDY EPMCKRLVMSGGFYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGR DGIRIDDVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEP KSAATEAYNTVLRAAMPNTVWTTGCDSWYLNKDGIPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATS RPQSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0916 | - | - | 100% (495) | monooxygenase |
| M. bovis AF2122 / 97 | Mb3075c | - | 6e-91 | 38.00% (479) | monooxygenase |
| M. bovis AF2122 / 97 | Mb1428c | - | 8e-78 | 36.64% (464) | monoxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4605 | - | 6e-94 | 39.18% (490) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0892 | - | 0.0 | 100.00% (495) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 2e-28 | 27.80% (428) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_0522c | - | 1e-143 | 50.11% (471) | monooxygenase |
| M. marinum M | MMAR_4641 | - | 0.0 | 72.13% (488) | monooxygenase |
| M. avium 104 | MAV_1795 | - | 8e-93 | 37.84% (473) | flavin-binding monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4451 | - | 4e-92 | 39.04% (479) | monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 1e-91 | 40.29% (479) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0256 | - | 0.0 | 71.11% (488) | monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_3427 | - | 1e-142 | 50.73% (479) | putative monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0916|M.bovis_AF2122/97 --MTG---------------RCPTVAVVGAGMSGMCVAITLLSAG-ITDV
Rv0892|M.tuberculosis_H37Rv --MTG---------------RCPTVAVVGAGMSGMCVAITLLSAG-ITDV
MMAR_4641|M.marinum_M --MTR---------------RDPSVAIVGAGMAGICMAITLLNSG-ITDV
MUL_0256|M.ulcerans_Agy99 --MTR---------------RDPSVAIVGAAMAGICMAITLLNSG-ITDV
MAB_0522c|M.abscessus_ATCC_199 --MSNG----AYTAVEKTRSRDIRVVVIGAGMSGLCMASTLRHRG-ITNF
Mvan_3427|M.vanbaalenii_PYR-1 --MG------------------IRVAIIGAGMSGLCMAAKLQDAG-IEDF
MSMEG_4451|M.smegmatis_MC2_155 --MSAP-----ASSTPTLP-ASVHTLVVGAGFAGLAAAAAVLREDPRADL
TH_4080|M.thermoresistible__bu MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQRRG--IDF
MAV_1795|M.avium_104 ----------------MARDHAHAALIIGAGFTGLGAAIRLAEAG-VDDI
Mflv_4605|M.gilvum_PYR-GCK ---MKP---VKREPTQDNPPGNPSIVIIGAGFAGITLALRLKRAG-FDRV
MLBr_00065|M.leprae_Br4923 -------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSY
::*:.::*: * :
Mb0916|M.bovis_AF2122/97 CIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEI
Rv0892|M.tuberculosis_H37Rv CIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEI
MMAR_4641|M.marinum_M TIYEKADEVGGTWRENTYPGLVCDVPSRLYQYSFAKNPDWSNLFSPGGEI
MUL_0256|M.ulcerans_Agy99 TIYEKADEVGGTWRENTYPGLVCDVPSRLYHYSFAKNPDWSNLFSPGGEI
MAB_0522c|M.abscessus_ATCC_199 TVYEKADEVGGTWRDNTYPGLQCDVPSRYYSYSFAPNPRWSKGFSPGSEI
Mvan_3427|M.vanbaalenii_PYR-1 TVFEKADEVGGTWRDNTYPGLACDVPSRYYAYSFRPNPEWSHMMPPGPEV
MSMEG_4451|M.smegmatis_MC2_155 LIIERADEVGGTWRDNTYPGCACDVPTSLYSFSFAPSAKWSHTFARQPEI
TH_4080|M.thermoresistible__bu LMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFSYQDEI
MAV_1795|M.avium_104 VILERADRVGGTWRDTTYPGASCDVPSLLYSYSFVKNPTWSRTYSPAPEI
Mflv_4605|M.gilvum_PYR-GCK LIVEKGDGVGGVWRENTYPGAACDVPSQLYSISSAPNPRWGRRYAEQGDI
MLBr_00065|M.leprae_Br4923 VILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKC-QAIADGKPI
: *: :**.* *** .* . . . :
Mb0916|M.bovis_AF2122/97 QDYLRGIAERYGLRHRIRFGATVVSARFDD----GRWVLRT---DSGTES
Rv0892|M.tuberculosis_H37Rv QDYLRGIAERYGLRHRIRFGATVVSARFDD----GRWVLRT---DSGTES
MMAR_4641|M.marinum_M QSYFCGIADRYRLRDRIRFGTEIVSARFED----DHWSVVT---DSGEET
MUL_0256|M.ulcerans_Agy99 QSYFCGIADRYRLRDRIRFGTEIVSARFED----DHWSVVT---DSGEET
MAB_0522c|M.abscessus_ATCC_199 HQYFVRFTDQQDLRRNIRFGTAVTRAEWVDEPGQSHWELEL---SDGGRD
Mvan_3427|M.vanbaalenii_PYR-1 FRYFRQFATERGIRRHIRFGADVTAARFRD----GKWWLTS---PAGD-E
MSMEG_4451|M.smegmatis_MC2_155 HRYLTSVADQTGLRHHLVTGCELLGAAWDDD--EQRWRVRT---SLG-MV
TH_4080|M.thermoresistible__bu QEYLQGVTAKYGLRRYIHFDSLVDRAHWDDT--EHRWHVFT---ADGREY
MAV_1795|M.avium_104 YRHLEDMADRFDIRRRIRFGHEVSGLAFDED--AGVWTATT---KNRKKF
Mflv_4605|M.gilvum_PYR-GCK LAYLRRVADESGLLSLLRTKTEIAKAAFDER--TNTWRLTT---TTSQEL
MLBr_00065|M.leprae_Br4923 LEYIKSTAVMHGIDKYIRLNHKVTGADWSS--IENRWTVQVENNGTPRMI
:: : : : : : . *
Mb0916|M.bovis_AF2122/97 TVDFLISATGVLHHPR--IPPIAGLDDFRGTVFHSARWDHTVPLLGRRIA
Rv0892|M.tuberculosis_H37Rv TVDFLISATGVLHHPR--IPPIAGLDDFRGTVFHSARWDHTVPLLGRRIA
MMAR_4641|M.marinum_M AVDFLIVATGLLHHPR--VPAIAGLDDFGGSAFHSARWDHRVAVQGQRVA
MUL_0256|M.ulcerans_Agy99 AVDFLIVATGLLHHPR--VPAIAGLDDFGGSAFHSARWDQRVAVQGRRVA
MAB_0522c|M.abscessus_ATCC_199 IADVVVGATGVLHLPR--LPEIEGLQSFAGPCFHSARWDHSVPYIGKRVG
Mvan_3427|M.vanbaalenii_PYR-1 EFDVLVTATGFLRVPR--YPDILGLDTFTGPMFHSSRWDHSVSLSDKRIG
MSMEG_4451|M.smegmatis_MC2_155 TATVLVAATGALSTPK--LPDVPGLDRFGGTVFHSATWNHDHDLTDERVA
TH_4080|M.thermoresistible__bu IAQFLISCAGALHIPS--IPDFPGRDQFAGPAFHSAQWDHSVDLTGKRVA
MAV_1795|M.avium_104 RARTVVLASGPLSDVS--FPDIRGLDSYRGHKIHSARWDHDYDFAGKRVA
Mflv_4605|M.gilvum_PYR-GCK ECDVVISAVGQLSRPS--VPDIPGISGFAGPSFHSANWDHDLNLSGKRLA
MLBr_00065|M.leprae_Br4923 SCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIV
:. . * * . * . : * :*. * . ..:
Mb0916|M.bovis_AF2122/97 VIGTGSTGVQLVCGLAGV-AGKVTMFQRTAQWVLPWPNPRYSKLARVFHR
Rv0892|M.tuberculosis_H37Rv VIGTGSTGVQLVCGLAGV-AGKVTMFQRTAQWVLPWPNPRYSKLARVFHR
MMAR_4641|M.marinum_M VIGSGSTGVQLVSALAGV-AAKVTMFQRTPQWILPWPNRQYSKVSRACYR
MUL_0256|M.ulcerans_Agy99 VIGSGSTGVQLVSALAGV-AAKVTMFQRTRQWILLWPNRQYSKVSRACYR
MAB_0522c|M.abscessus_ATCC_199 LIGTGSSGVQIIGALAEQ-VQHLSVFQRSAQWVAPVPNFTYSALSKSIWS
Mvan_3427|M.vanbaalenii_PYR-1 LIGTGSTGVQITSALGGN-VRHLKVFQRTPQWICPWPNLRVSEHTKAAMR
MSMEG_4451|M.smegmatis_MC2_155 VVGTGASAVQFVPEIADR-TAHLTVFQRTPAWVLPRLDRTLGRLERALYR
TH_4080|M.thermoresistible__bu VIGTGASAIQIVPEIIDR-VAQLQLYQRTPAWVVPRTNDELPAWLRRALE
MAV_1795|M.avium_104 VIGTGASAIQIIPELVKQ-AGFVKVFQRTPCWVLPRLDVATPPAVQALFA
Mflv_4605|M.gilvum_PYR-GCK VVGTGASSVQFVPVVAAG-AEHLDVFQRSAPWVLPKFDRQYGGRHHQLLR
MLBr_00065|M.leprae_Br4923 VIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQP--AKDKIAARLNR
::*:*::.: : : . : : **: ::
Mb0916|M.bovis_AF2122/97 AFPCLGSLAYKAYSLSFET-FAVALSNPGLHRKLVGAVCRASLRR-VRDP
Rv0892|M.tuberculosis_H37Rv AFPCLGSLAYKAYSLSFET-FAVALSNPGLHRKLVGAVCRASLRR-VRDP
MMAR_4641|M.marinum_M GAPWLESLAYKIWGRAFEQ-FTAALTRPGWHRRVTGMTCRASLRL-VRDP
MUL_0256|M.ulcerans_Agy99 GAPWLESLAYKIWGRAFEQ-FTAALTRPGWHRRVTGMTCRASLRL-VRDP
MAB_0522c|M.abscessus_ATCC_199 RIPVLNRISYLLWRFYFERGVGGSVVIPGARRKLIQGFVRASHRLLIRDA
Mvan_3427|M.vanbaalenii_PYR-1 RWTWLNSFGYWFWGGFVRSIFGVAPVRPGWQRWLYQTQCHWNLRLSVRDK
MSMEG_4451|M.smegmatis_MC2_155 RIPLSQRLVRGMVYIYREG-YLALLAHLTWLLPLLEIIAKTQLRRQVPDP
TH_4080|M.thermoresistible__bu NIPGLRLALRGGIYALQEA-LAVGMTKYPGMLRIGHLLGKWNINRSVKDP
MAV_1795|M.avium_104 KVPAAQELARQALYWGHEA-SATALVWDTPLTSLVARLGKAHLRAQVKDP
Mflv_4605|M.gilvum_PYR-GCK KLPILRLSERLMIWTIFEF-LALALVDAKPVARVLGVIALRHLGRQVSDA
MLBr_00065|M.leprae_Br4923 WLPDKYAYTAVRWKNILRQ-SALYGACQKWPQRMRNILLGHVARRLPKGY
. . : .
Mb0916|M.bovis_AF2122/97 RLRRALTPDYEPMCKRLVMS--GGFYRAIQRDDVELVTAGIDHVEHRGIV
Rv0892|M.tuberculosis_H37Rv RLRRALTPDYEPMCKRLVMS--GGFYRAIQRDDVELVTAGIDHVEHRGIV
MMAR_4641|M.marinum_M HLRQALTPDYQPMCKRLVMS--SGFYRAIQRDDVELVTTGIDRIENAGIV
MUL_0256|M.ulcerans_Agy99 HLRQALTPDYQPMCKRLVMS--SGFYRAIQRDDVELVTTGIDRIENAGIV
MAB_0522c|M.abscessus_ATCC_199 TLREKLHPDYEPLCRRLVMS--VPFFKAVQRPNVSVLTGGIDRVVPQGVI
Mvan_3427|M.vanbaalenii_PYR-1 ELKKKLTPPDQPMCKRMIFA--GHYYRTVQRPDVEIVTDPIVEVQPRGVV
MSMEG_4451|M.smegmatis_MC2_155 ALRRALTPDFRIGCKRILLT--NDWLPTLARDDVEVVTTALTEVTETGVR
TH_4080|M.thermoresistible__bu QLRAKLTPDYRLGCKRILNS--STYYPAVADPRTEVITESIDRITTDGIV
MAV_1795|M.avium_104 WLRRQLTPDFRPGCKRMLVS--SDYYPALQRDNCKLIDWPIATLSPAGIR
Mflv_4605|M.gilvum_PYR-GCK RLRSHLTPDYAPGCKRILFS--SDYYPALARPNVLLVTDDIQAVEPGGIR
MLBr_00065|M.leprae_Br4923 DVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTGIR
:: : * :*: :: :: : . *:
Mb0916|M.bovis_AF2122/97 TDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRIDDVWQD-GPHAHQ
Rv0892|M.tuberculosis_H37Rv TDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRIDDVWQD-GPHAHQ
MMAR_4641|M.marinum_M TDDGVLREVDVIVLATGFDSHAFFRPMKLIGRDGVEIDELWRG-GPYAYQ
MUL_0256|M.ulcerans_Agy99 TDDGVLREVDVIVLATGFDSHAFFRPMKLIGRDGVEIDELWRG-GPYAYQ
MAB_0522c|M.abscessus_ATCC_199 TNDGVLHELDILVCATGFDAHSYLRPMEVLGRDGIKLSDAWSD-GPRAYR
Mvan_3427|M.vanbaalenii_PYR-1 TADGTLHEVDLLALATGFDFHAYVRPLTITGEHGRTLDDAWAD-GPTAYR
MSMEG_4451|M.smegmatis_MC2_155 DGTGRLHDVDTIIFATGFTPTEPPVAHQLTGVTGTTLAAHWAG-SPSAHL
TH_4080|M.thermoresistible__bu TSDGTERAVDVIVYATGFHVSDSYKYVQIKGLNGEDIVDRFNREGPMAHR
MAV_1795|M.avium_104 TSDGIEHHLDCIVFATGYDVHLTGPPFPVTGLGGRSLAAEWAG-GAQAYK
Mflv_4605|M.gilvum_PYR-GCK TVNGDFHAADVIIYGTGFSATEFLSPMEVYGRSDRKLSDVWAD-GAHAYY
MLBr_00065|M.leprae_Br4923 LKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSY------K
* * : .** . :
Mb0916|M.bovis_AF2122/97 TVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDT
Rv0892|M.tuberculosis_H37Rv TVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDT
MMAR_4641|M.marinum_M TVAMPGFPNFFMMLGPHSPVGNYPLTGIAESQADHILRWIQRWRSSEFDT
MUL_0256|M.ulcerans_Agy99 TVAMPGFPNFFMMLDPHSPVGNYPLTGIAESQADHILRWIQRWRSSEFDT
MAB_0522c|M.abscessus_ATCC_199 AVGLAGFPNFFLLIGPNSPIGNNSLISIAETQVKFAMHWIDEIRSGRMQS
Mvan_3427|M.vanbaalenii_PYR-1 AVAVPGFPNMFMLMGPHAPVGNNSLVPVAEDQADYVMWWIDQLRSGRIVS
MSMEG_4451|M.smegmatis_MC2_155 GITVPGFPNLFLMYGPNTNLGHSSIVYMLESQAAYLAAALRVMRAEGLAS
TH_4080|M.thermoresistible__bu GTAVADLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEAIKAVDKAGAQA
MAV_1795|M.avium_104 SINVHGYPNLFVMTGPNSGPGHNSLLVYIEGQLDYAVRGITTILNDDLRY
Mflv_4605|M.gilvum_PYR-GCK GLSVPEFPNFLMMYGPNTNVGSGSIVYMLESQARHIVRLMKVLRAHPGSV
MLBr_00065|M.leprae_Br4923 GMMLSGLPNMIYTVG----YTNASWTLKADLVSEFFCRLLNYMNANDFDT
: ** . . : . :
Mb0916|M.bovis_AF2122/97 MEPKSAATEAYNTVLRAAMPNTVWTTG-CDSWYLNKDG-IPEVWPFAPAK
Rv0892|M.tuberculosis_H37Rv MEPKSAATEAYNTVLRAAMPNTVWTTG-CDSWYLNKDG-IPEVWPFAPAK
MMAR_4641|M.marinum_M VEPTSWATDEFNAKLRAAMPKTVWTTG-CSSWYLNDDG-VPEVWPFAPAE
MUL_0256|M.ulcerans_Agy99 VEPTSWATDEFNAKLRAAMPKTVWTTG-CSSWYLNDDW-VPEVWPFAPAE
MAB_0522c|M.abscessus_ATCC_199 VAPTAHAAETFNTQMRRAMPNTVWSTG-CDSWYLGADG-VPELWPWPPVD
Mvan_3427|M.vanbaalenii_PYR-1 AAPTEAATKQYNDAMKAAMPRTVWTTG-CRSWYLGKDG-LPELFPWEASR
MSMEG_4451|M.smegmatis_MC2_155 IDVRPDAERTYNEWINDALTNTVWNSGGCSSWYLDSRGRNSVMWPTFTFR
TH_4080|M.thermoresistible__bu LAPTREAQDRYNAELQARLGRSVWNTGGCRSWYLDEHGNNRVLWGGFTWQ
MAV_1795|M.avium_104 LDVREEVQRRHNEAIQRRLTKTTWMSG-CRSWYLTKDGFNGSMYPGFATQ
Mflv_4605|M.gilvum_PYR-GCK IEVRADVEKRFNDRLSRRLDRSVWT--MCTSWYRSARGSISTNWPSPTFL
MLBr_00065|M.leprae_Br4923 VAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIR
: : . . .
Mb0916|M.bovis_AF2122/97 HRAMLANLHPEEYDLRRYAAVRATSRPQSA--------------------
Rv0892|M.tuberculosis_H37Rv HRAMLANLHPEEYDLRRYAAVRATSRPQSA--------------------
MMAR_4641|M.marinum_M HRAMLANPDLDRYHLRRRPEVLAW--------------------------
MUL_0256|M.ulcerans_Agy99 HRAMLANPDLDQYHLRRRPEVLAW--------------------------
MAB_0522c|M.abscessus_ATCC_199 YRRTLTSPIRGDFAIT----------------------------------
Mvan_3427|M.vanbaalenii_PYR-1 YAELLRSPQVSDFDVRTAAV------------------------------
MSMEG_4451|M.smegmatis_MC2_155 FRARTRSFDVINYDTLRTRQQIRGVEQRCESQLADADREILAGQIRLAGE
TH_4080|M.thermoresistible__bu YRLATRTLDPAEYRFWG---------------------------------
MAV_1795|M.avium_104 YLRQMSDFRYQDYQAVARRARTPAASSA----------------------
Mflv_4605|M.gilvum_PYR-GCK YRLRARRPKRRAYVLSRPAPANSSRRGTPEPAN-----THLADMPYAPSG
MLBr_00065|M.leprae_Br4923 LIRRGKVADEGLLFAKKTTPVTV---------------------------
Mb0916|M.bovis_AF2122/97 -----------------------------------------
Rv0892|M.tuberculosis_H37Rv -----------------------------------------
MMAR_4641|M.marinum_M -----------------------------------------
MUL_0256|M.ulcerans_Agy99 -----------------------------------------
MAB_0522c|M.abscessus_ATCC_199 -----------------------------------------
Mvan_3427|M.vanbaalenii_PYR-1 -----------------------------------------
MSMEG_4451|M.smegmatis_MC2_155 DESVTPSTLRTVRRDQRYMTRGRIHAEVADLLDRTVAMNGE
TH_4080|M.thermoresistible__bu -----------------------------------------
MAV_1795|M.avium_104 -----------------------------------------
Mflv_4605|M.gilvum_PYR-GCK ADSVD------------------------------------
MLBr_00065|M.leprae_Br4923 -----------------------------------------