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MSSGHAEVVGGGIGGLTAATALALRGWTVRLHERDTRIRTVGAGIYVWDNGLEALDTIGAAAEGLDDAYE APAITVRASDGRPLYRIDVNQPGGARCVTLLRDRLIGALHVAAEHAGVEVCTGSAAVSATADGTVEFSTG TSTRADLVVAADGVHSLLRDRLGISYRRIRMRQGAARVMVSGERPFIPGMDVDQHHEFLGGRRRLLYTPC TATQTYLAFVADNDDTATVGPELDLAAWARAFPLLVPVFDAARGRALIRWDNFELIRLSTWSHGRVAVLG DAAHAQPPYVGQGGGTAMNSAVGLAAAVSESADVEDGLNRWEQALRPPIEKAQTTSYRMRLIGSVPEVLR GPLLGALGRSRSSATSQLIKKRSAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0302 | - | - | 100% (375) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_3330 | - | 7e-22 | 28.45% (355) | putative salicylate hydroxylase |
| M. abscessus ATCC 19977 | MAB_1601c | - | 4e-20 | 27.63% (380) | putative monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 9e-12 | 26.65% (349) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 2e-25 | 30.77% (364) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 2e-14 | 26.23% (324) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4944 | - | 5e-22 | 29.45% (326) | oxidoreductase |
| M. avium 104 | MAV_4429 | - | 2e-17 | 23.83% (386) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4641 | - | 2e-22 | 27.58% (388) | salicylate hydroxylase |
| M. thermoresistible (build 8) | TH_0968 | - | 7e-07 | 25.78% (322) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_4482 | - | 4e-12 | 25.31% (324) | hypothetical protein MUL_4482 |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 3e-22 | 29.04% (365) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1260|M.tuberculosis_H37Rv ------MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAID
MUL_4482|M.ulcerans_Agy99 ---MVGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLRPGGQAID
Mb0590c|M.bovis_AF2122/97 -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTGAG-SGIS
Mvan_3960|M.vanbaalenii_PYR-1 -----MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLTSG-AGIS
MSMEG_4641|M.smegmatis_MC2_155 -----MAASFLVVGAGITGLATAAALQRRGHDVCVAEARADTASG-AGIS
MAB_0302|M.abscessus_ATCC_1997 ----MSSGHAEVVGGGIGGLTAATALALRGWTVRLHERDTRIRTVGAGIY
MMAR_4944|M.marinum_M -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
TH_0968|M.thermoresistible__bu ---MTERVDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTLIDYPRGVG
: *.. * : * * * : * :
Rv1260|M.tuberculosis_H37Rv VRGPALDVLERMGL---LAAAQEHKTRIRGASFVDRDGNELFRDTESTPT
MUL_4482|M.ulcerans_Agy99 VRGPALTVLDRMGI---LDAARDRKTGIRGASVVDRDGNELSRDTESTPT
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRRMV
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLG---DSVRDAGGRVTAGAIRWRDGTWVRRPSVRRIV
Mvan_3960|M.vanbaalenii_PYR-1 IWPNALAALDQIGLG---DNVRQAGGRVTAGAIRWRDGTWLRRPSAQRIV
MSMEG_4641|M.smegmatis_MC2_155 IWPNALAALDAIGLG---DPVRAAGGRVTAGALRWHDGTWLRHPAAERIT
MAB_0302|M.abscessus_ATCC_1997 VWDNGLEALDTIGAA---AEGLDDAYEAPAITVRASDG----RPLYRIDV
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLE---QQTARLGGIVETMSYAEAHSGETMCRISMQPL
MAV_4429|M.avium_104 VWSNGETVLRQLGVE------MDGAGRQLSSVGAVTSTGRPLATLDVTAM
TH_0968|M.thermoresistible__bu LDDEALRTFQSIGLVDRILPHTVPNQILRFFDAKRRLLAEMAPPDARFGW
. . :*
Rv1260|M.tuberculosis_H37Rv GGPVNSPDIELLRDDLVELL-YGATQPSVEYLFDDSISTLQDDGDSVRVT
MUL_4482|M.ulcerans_Agy99 GGPIDSPNIELLRDDLIELL-DGTIQSTTEFIFDDSIATLQDDGAAVEVT
Mb0590c|M.bovis_AF2122/97 GDDFTS----LPRGDLAAAI-YTTIEDQVETIFDDSIATIDEHRDGVRLT
Mflv_2621|M.gilvum_PYR-GCK D-ALGEPLVVVRRSRLTDIL-REALPAG-TVRTGLAATRVSVGASSVRIT
Mvan_3960|M.vanbaalenii_PYR-1 H-ALGEPLVVVRRSALTEIL-LDALPPD-TVQTGLSATALSIAAATARVT
MSMEG_4641|M.smegmatis_MC2_155 R-ALGEPLVVIRRRVLTEIL-SGALAPG-TVVHGLEAHTVETCASGIRVT
MAB_0302|M.abscessus_ATCC_1997 NQPGGARCVTLLRDRLIGAL-HVAAEHAGVEVCTGSAAVSATADG--TVE
MMAR_4944|M.marinum_M IEQVGQRPYPIARAELQQML-MEAYGID-EIHFGMKMVEVANRDGAATAT
MAV_4429|M.avium_104 ARRLGAPVRMVPRRVLLERL-LDGFPTG-RIHCDRRAVALATSRDGVSVE
TH_0968|M.thermoresistible__bu PKRNGFVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEASDAGEDGVTVE
:
Rv1260|M.tuberculosis_H37Rv FERAA-AREFDLVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNF
MUL_4482|M.ulcerans_Agy99 FVRSG-TRTFDFLIGADGLHSNVRRKVFGPEEQFIKRLGTYAAIFTVPNF
Mb0590c|M.bovis_AF2122/97 FERTA-PRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGY
Mflv_2621|M.gilvum_PYR-GCK LSDGE-VRESDAVVGADGVNSVLARTLNGP-------LRTRYVGYTAWRG
Mvan_3960|M.vanbaalenii_PYR-1 LSDGR-TREADAVVGADGVNSMVARALNGP-------LPSRYVGYTAWRG
MSMEG_4641|M.smegmatis_MC2_155 FSDGS-VREASAVVGADGVDSVVARHLNGP-------LRRRYAGYTAWRG
MAB_0302|M.abscessus_ATCC_1997 FSTGT-STRADLVVAADGVHSLLRDRLGISYRRIRMRQGAARVMVSGERP
MMAR_4944|M.marinum_M FADGT-IASADILIGADGANSITREYVLGG---PVTRRYAGYVNYNGLVE
MAV_4429|M.avium_104 FTDGT-VAEGDVLIGADGLHSMVREWVGAR-----HAKATGWCSWQGLVS
TH_0968|M.thermoresistible__bu FADGHPPVRASYVVGCDGGRSTTRRLMGVS--------FDGTTSSTRWLV
: . ::..** * :
Rv1260|M.tuberculosis_H37Rv LELDYWQTWHYGDSTMAGVYSARNNTEARAALAFMDTELRIDYRDT-EAQ
MUL_4482|M.ulcerans_Agy99 LELDYWQKWHYGDNTMAGVYSARDNSEARAALGFMDTELQIDYRDT-EAQ
Mb0590c|M.bovis_AF2122/97 RPRDERSYVLY--NTVDRQLARFALRGDRTMFLFV---FRAEHDNPGVAP
Mflv_2621|M.gilvum_PYR-GCK IAAHPLDPELGGETLGPGTQVGHVPLGPDHTYWFATERTAEGGSAP-GGE
Mvan_3960|M.vanbaalenii_PYR-1 VAAYRLDPALAGETMSAGTEVGHVPLGPDHTYWFATERTREGSRSA-GGE
MSMEG_4641|M.smegmatis_MC2_155 IAAHPLDPELSGETMGAGVEVGHVPLGADHTYWFATERASQGQRSP-DGE
MAB_0302|M.abscessus_ATCC_1997 FIPG-MDVDQHHEFLGGRRRLLYTPCTATQTYLAFVADNDDTATVG----
MMAR_4944|M.marinum_M VDEAISPANEWTMYVGDGKRVSAMPVADDRFYFFFDVVEPEGLPFEKGTA
MAV_4429|M.avium_104 -LPEIAESDAALMMIGGSGNLGLWPAGGAEVQWWFDLPWSTGFVRP-QHP
TH_0968|M.thermoresistible__bu VDVANDPLGHPNSEVGADPARPYVSISIAHGIRRFEFMIHPHETDAEVDD
Rv1260|M.tuberculosis_H37Rv FAELQRRMAEDGWVRAQLLHYMRSAP---DFYFDEMSQILMDRWSRGRVA
MUL_4482|M.ulcerans_Agy99 FAELERRMIEDGWVRAQLLHYMRSAP---DFYFDEMAQIVMDSWAKGRVA
Mb0590c|M.bovis_AF2122/97 KDELRDQFGDVGWESRDILAALDDVE---DLYFDVVSQIRMDRWSRGRVL
Mflv_2621|M.gilvum_PYR-GCK HAYLTAKVADWADPIPRLVATTDPGD---LLRNDLYDRARAARWSDGRAV
Mvan_3960|M.vanbaalenii_PYR-1 HAYLTAKLAGWADPIPALLASTDPAD---VLRNDLYDRAQPRDWSRGPAV
MSMEG_4641|M.smegmatis_MC2_155 LTHLRRLFGSWAEPIPQLLAATDPAD---VLRNDLYDREPARCWARGPVV
MAB_0302|M.abscessus_ATCC_1997 ---PELDLAAWARAFPLLVPVFDAARGRALIRWDNFELIRLSTWSHGRVA
MMAR_4944|M.marinum_M REVLREQFAGWAPGVQALIDKLDPTT---TNRVEILDLDPFHTWVKGRVA
MAV_4429|M.avium_104 IETIRSHFAGWSEPVDRVLAILTDED--LAASPFPHFRHPIPPPGRGRVT
TH_0968|M.thermoresistible__bu PAFVRRMLGRRIPYPERVDMIR--------YRVYTHHSRIAGSFRKGRLL
. : *
Rv1260|M.tuberculosis_H37Rv LVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAG--DDYQLGFANYHAE
MUL_4482|M.ulcerans_Agy99 LVGDAAYCCSPLSGQGTSVAVLGAYILAGELAAAG--NDYQRGFANYHAE
Mb0590c|M.bovis_AF2122/97 LIGDAAGCISLLGGEGTGLAITEAYVLAGELARAG--GDHRRAFDAYEKR
Mflv_2621|M.gilvum_PYR-GCK LIGDAAHPMRPHLGQGGCQGIEDAAILARFLELA---DDVPTAFERFEAF
Mvan_3960|M.vanbaalenii_PYR-1 IVGDAAHPMRPHLGQGGCQGLEDAAILARFVGLS---PDLPAAFDRFGAF
MSMEG_4641|M.smegmatis_MC2_155 LAGDAAHPMRPHLGQGGCQGLEDAATLAALVARE---PDLPTAFARFATL
MAB_0302|M.abscessus_ATCC_1997 VLGDAAHAQPPYVGQGGGTAMNSAVGLAAAVSES---ADVEDGLNRWEQA
MMAR_4944|M.marinum_M VLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNP--TDVAAALAAYQAS
MAV_4429|M.avium_104 LLGDAAHTMPPTLAQGTNQALLDTMVLCQALADFG--RGTPGGQADVANA
TH_0968|M.thermoresistible__bu LAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVNGHAHDALLDTYDLE
: ***. .:* .: : * :
Rv1260|M.tuberculosis_H37Rv FHGFVERNQ-------WLVSDNIPGGAPIPQ--EEFERIVHSITIKDY--
MUL_4482|M.ulcerans_Agy99 FSGFGERNQ-------WLVTDNIPGGEPIPE--EAFERIVNSLELEDYRQ
Mb0590c|M.bovis_AF2122/97 LRPFIEGKQASAAKFIWFFRHPNPIRPVVSQRCDAHDELRPAGDAVRRQR
Mflv_2621|M.gilvum_PYR-GCK RKPRVGMLVREAQTLGRIVNVRPAVLSGLAGRATALIPERMVTAHLAWIA
Mvan_3960|M.vanbaalenii_PYR-1 RRRRVRPLVRESAAIGRIVNLRPAFLSGVASRASALIPEWAVASHLASIA
MSMEG_4641|M.smegmatis_MC2_155 RRRRVTRMVRTSRMIGRIVNLRPAVLSAAASRATVLVPEAVLTRQLASIA
MAB_0302|M.abscessus_ATCC_1997 LRPPIEKAQTTSYRMRLIGSVPEVLRGPLLGALGRSRSSATSQLIKKRSA
MMAR_4944|M.marinum_M RTERAGDLVLRARKRCDVIHAKDPDTTAAWYEELRNEDGTNIIRGLVANI
MAV_4429|M.avium_104 LRWYEKTRRRRVRAVSWVASLPVSHGEAVLRPAALVSDRLQAAALTMFLR
TH_0968|M.thermoresistible__bu RREHARAMIDLSTMVGRVISPTNRRVAALRDRLIHAASVVPTLKRYVLEM
.
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4482|M.ulcerans_Agy99 G-------------------------------------------------
Mb0590c|M.bovis_AF2122/97 A-------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK AGSAFVLPTAADLAR-----------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 AGSAFILPTAGDVGG-----------------------------------
MSMEG_4641|M.smegmatis_MC2_155 ARSAFTPVD-----------------------------------------
MAB_0302|M.abscessus_ATCC_1997 A-------------------------------------------------
MMAR_4944|M.marinum_M MGGPLTPLS-----------------------------------------
MAV_4429|M.avium_104 WTSHRRMSDHINRSVGEAINRSLGEAPKIPSRR-----------------
TH_0968|M.thermoresistible__bu RFKPMPRYLQGAVYHGGPRSKSSPTGTLFIQPRVDTRDAENVLLDDVLGP
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4482|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0302|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_0968|M.thermoresistible__bu GFAVLCWSNNLRAVLGEDAFSHWKSLGATFVEARPITQLHWPGHDDPDVV
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4482|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0302|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_0968|M.thermoresistible__bu VVGDRTGALKGWFDVHTDSVLFLRPDRCIAAACIAQRAPETSAALSEVMC
Rv1260|M.tuberculosis_H37Rv -------------------------------
MUL_4482|M.ulcerans_Agy99 -------------------------------
Mb0590c|M.bovis_AF2122/97 -------------------------------
Mflv_2621|M.gilvum_PYR-GCK -------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 -------------------------------
MSMEG_4641|M.smegmatis_MC2_155 -------------------------------
MAB_0302|M.abscessus_ATCC_1997 -------------------------------
MMAR_4944|M.marinum_M -------------------------------
MAV_4429|M.avium_104 -------------------------------
TH_0968|M.thermoresistible__bu LTQGGGNGAASPVLHVAQSAAEPSGTATRST