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VDGTVRTLLRQWWNQRDDYQWRIDFLRTRGLLPVLRYIIAGIGGSLGVLSVYNAFVPPGADGVLIRTGWA ILAVGSLGWAARWALGSWPTVRESAALVVFVDVMMTVSALLFGDPTLAMSGIPILLCAGGYVVFFHGPRL HLVHIAWCTASVVGIAIWLAVSDPVFGPQLAVSRAIIALAVTVCVLPALQFGFWLLQDSSMQSLTDPLTE LTNRRGLAVSVKRLNTDARADATLCALLIDVDRFKSVNDTFGHAVGDDVLIRTARRIRASVPEDAVVVRW GGEEFLVVDRIPGNQAETVAERIRAAVAEPAEPTVTVSIGLATCERADIDLIDVISAADAAMYEAKADGG NKVVITAEAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0112 | - | - | 100% (361) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_1453 | - | 4e-46 | 34.27% (356) | diguanylate cyclase |
| M. gilvum PYR-GCK | Mflv_3822 | - | 1e-44 | 35.64% (362) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 5e-15 | 33.12% (157) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 5e-15 | 33.12% (157) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01419 | - | 8e-18 | 36.31% (157) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 5e-56 | 35.65% (359) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 2e-35 | 32.01% (353) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 5e-15 | 31.68% (161) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_3406 | - | 1e-26 | 26.91% (353) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0796 | - | 1e-158 | 77.25% (356) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_01419|M.leprae_Br4923 MLETVRSVMVHSGECSAESTADKEHRHHDLVAQRYQRLVDHSPNMTCVHE
Mflv_0112|M.gilvum_PYR-GCK -----------------MVDGTVRTLLRQWWNQRDDYQWRIDFLRTR---
Mvan_0796|M.vanbaalenii_PYR-1 -----------------MGDGAVGDLLLQWWRQRDEYQWRIGFLRSR---
MAV_1995|M.avium_104 -----------------------MKWLAAWWGQPDHFDWLTGYLQDH---
MAB_3940c|M.abscessus_ATCC_199 ------------MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHAR---
Mb1389c|M.bovis_AF2122/97 ----------------------------------MCNDTATPQLEEL---
Rv1354c|M.tuberculosis_H37Rv ----------------------------------MCNDTATPQLEEL---
MSMEG_2196|M.smegmatis_MC2_155 ---------------------------------------MSESLDVL---
TH_3406|M.thermoresistible__bu ----------------------MLKALRRTWRKPDHYYWFTSFLAAR---
MLBr_01419|M.leprae_Br4923 SGRVTYLNPVGVKWMAAQSPEQIIGHPLIEFVHPDSMPAMMSRIAPLREV
:
Mflv_0112|M.gilvum_PYR-GCK --GLLPVLRYIIAGIGGSLGVLSVYNAFVPPG------------------
Mvan_0796|M.vanbaalenii_PYR-1 --GLLPVLRWLIAGIGATMGVLSAVNVVLPPG------------------
MAV_1995|M.avium_104 --GFGTATRRAMAVVGASLVLVPANVLWGATP------------------
MAB_3940c|M.abscessus_ATCC_199 --KLDRTVRNLIGGYALIFAAICIAVQFSDTG------------------
Mb1389c|M.bovis_AF2122/97 --VTTVANQLMTVDAATSAEVSQRVLAYLVEQ------------------
Rv1354c|M.tuberculosis_H37Rv --VTTVANQLMTVDAATSAEVSQRVLAYLVEQ------------------
MSMEG_2196|M.smegmatis_MC2_155 --VTSVATQLMAVEAATSVSVSQQVLAELVSF------------------
TH_3406|M.thermoresistible__bu --RARTSTCRFIASITLILGLMPMVMLAGPAG------------------
MLBr_01419|M.leprae_Br4923 GDASQPSEAVLLRLDGTTLEVEAVSVLTVWEGKPAYQVIFRDLTTQKAAE
Mflv_0112|M.gilvum_PYR-GCK -----ADGVLIRTGWAILAVGSLGWAARWALGSWPTVRESAALVVFVDVM
Mvan_0796|M.vanbaalenii_PYR-1 -----ADDTVFRLGWAVVAVGSLAWAARWAFLPWPTARESAVLVGCVDVL
MAV_1995|M.avium_104 -----FFPGLTLTVSVLAGMVGLGMAVLWLHG-WPTRRQSVVFALTGSVA
MAB_3940c|M.abscessus_ATCC_199 -----PRSMIGRVIVGLCAVGSLGWALRWAVGPWPSLREAVAFVAFADIG
Mb1389c|M.bovis_AF2122/97 -----LGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADAD
Rv1354c|M.tuberculosis_H37Rv -----LGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADAD
MSMEG_2196|M.smegmatis_MC2_155 -----FDVDVSFLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADAD
TH_3406|M.thermoresistible__bu -----PQSMPGRLIAVAVTVTALVITLIWLRDRWPSRNQSRVVSLAAGLA
MLBr_01419|M.leprae_Br4923 ETLRFQAALVNHVSDAIIATTSTGMVTSWNPAAEAIYRRSASDVLGMPIG
. . * .
Mflv_0112|M.gilvum_PYR-GCK MTVSALLFG------------------------DPTLAMSGIPILLCAGG
Mvan_0796|M.vanbaalenii_PYR-1 MTLSALLFG------------------------DPNLAMSGIPILLCAGG
MAV_1995|M.avium_104 IGAGCLWQT------------------------EPLVGLMACSALSVTGG
MAB_3940c|M.abscessus_ATCC_199 IAVACWQDS------------------------DPLAGLVGTVLFTPVGA
Mb1389c|M.bovis_AF2122/97 PVFALCEHA------------------------KEPLVFR---PEPATED
Rv1354c|M.tuberculosis_H37Rv PVFALCEHA------------------------KEPLVFR---PEPATED
MSMEG_2196|M.smegmatis_MC2_155 PVFAMAEHL------------------------KEPAVFR---PEPLYDD
TH_3406|M.thermoresistible__bu IAVFAFTLP------------------------DPSAGLVWTAAFAVLAG
MLBr_01419|M.leprae_Br4923 EAVGAPLDPGAIITEGGVLSTTQYASDGMALAVRVSAAVMENGFVLVCSD
.
Mflv_0112|M.gilvum_PYR-GCK YVVFFHGPRLHLVHIAWCTASVVGIAIWLAVSDPVFGPQLAVSR------
Mvan_0796|M.vanbaalenii_PYR-1 YVVFFHGPRLHLAHIAWCTVSVVGIAVWLAASTPDYGVQVAVSR------
MAV_1995|M.avium_104 YNAFFHTAKFMGLNFGLAGAIGALQAARLAAS---GQAMLAFTG------
MAB_3940c|M.abscessus_ATCC_199 YVSFFLANRLLVAHVAWCAPMIIALSSRLFAEGTVGAAMTALVK------
Mb1389c|M.bovis_AF2122/97 YQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEA------
Rv1354c|M.tuberculosis_H37Rv YQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEA------
MSMEG_2196|M.smegmatis_MC2_155 YQRTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDREWLPA------
TH_3406|M.thermoresistible__bu YVALFHSARYATFTVLFAAITAGVLSFELAKT---AGVAAAVCG------
MLBr_01419|M.leprae_Br4923 YTALLRVERRFQTVVALLEEGVIVLDGDGYVESVNPAALRILGVSDRSAL
* : :
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_01419|M.leprae_Br4923 DDPVRRAATLPMYDAQGRLLDHGRGAVREFLRTGTPKTGFIVGIDRPSDG
Mflv_0112|M.gilvum_PYR-GCK --------------AIIALAVTVCVLPALQFGFWLLQDSSMQSLTDPLTE
Mvan_0796|M.vanbaalenii_PYR-1 --------------AVIALLVTVCILPALQFGFWLLQGSSKQSLTDPLTE
MAV_1995|M.avium_104 --------------YFLVLELNVIVPLSIQIVVRALWLDLLRANRDPLTG
MAB_3940c|M.abscessus_ATCC_199 --------------VTSMLLVVVLIPAVIQFGIAVVRWDALAAQRDPLTG
Mb1389c|M.bovis_AF2122/97 --------------ELNALMTIATLFAQVQARVAAEARLRYLADHDDLTG
Rv1354c|M.tuberculosis_H37Rv --------------ELNALMTIATLFAQVQARVAAEARLRYLADHDDLTG
MSMEG_2196|M.smegmatis_MC2_155 --------------ELNALKAIASLFAQVQARIEAEERLRYLADHDHLTG
TH_3406|M.thermoresistible__bu --------------FVFITVVTFAVVCACNLLVGLLDVDVLDADIEPLTG
MLBr_01419|M.leprae_Br4923 TRVWLSVNSRSLNPVDPEDATLLISFTDVTAERQASQYLAHQAAHDTLTG
: : **
Mflv_0112|M.gilvum_PYR-GCK LTNRRGLAVSVKRLNTDARAD------ATLCALLIDVDRFKSVNDTFGHA
Mvan_0796|M.vanbaalenii_PYR-1 LTNRRGLAVSMQRLNEAAPTG------ADLCALLIDVDGFKRVNDTLGHA
MAV_1995|M.avium_104 LLNRR---ACNRAIIGRMLTG---ASHMFLAVAMVDLDRFKALNDTHGHA
MAB_3940c|M.abscessus_ATCC_199 LLNRRGIYAEWQRLYGELRREQPLDGDQVTAAAIVDIDRFKSINDRYGHG
Mb1389c|M.bovis_AF2122/97 LHNRRALLQHLDQRLAPGQPG-------PVAALFLDLDRLKAINDYLGHA
Rv1354c|M.tuberculosis_H37Rv LHNRRALLQHLDQRLAPGQPG-------PVAALFLDLDRLKAINDYLGHA
MSMEG_2196|M.smegmatis_MC2_155 LYNRRALMAHLEARLAPGQPG-------PVAVMFFDLDRLKAINDYLGHT
TH_3406|M.thermoresistible__bu LLNRDAFYRSAGHLISRSRDD-----DRQLVIALINIDNLRLLRDTQGQA
MLBr_01419|M.leprae_Br4923 LPNRTSILARIDEQRYCGAPD-----QLLTAVLFIDLDNFKGINDSLGHD
* ** :.::* :: :.* *:
Mflv_0112|M.gilvum_PYR-GCK VGDDVLIRTARRIRASVPEDAVVVRWGGEEFLVVDRIPG--NQAETVAER
Mvan_0796|M.vanbaalenii_PYR-1 VGDEVLIRTARRIRQSVRGDAVVVRWGGEEFLVVDRIPA--QQAGKVAER
MAV_1995|M.avium_104 AGDEALIAVAGALTAACGDTTVVGRVGGEEFLVADIVTT--EQLPGWGQQ
MAB_3940c|M.abscessus_ATCC_199 TGDRVLIDVAHALTCGTTGTSVVGRSGGEEFLVVTVCPA--SAVAEFATR
Mb1389c|M.bovis_AF2122/97 AGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAER
Rv1354c|M.tuberculosis_H37Rv AGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAER
MSMEG_2196|M.smegmatis_MC2_155 AGDAFISILAQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYR
TH_3406|M.thermoresistible__bu AADRARVAIGQTLRENTRHNAFVAHLGQDEFLIADTFSS--TDSFPLVER
MLBr_01419|M.leprae_Br4923 VGDVVLQTAAQRLRAGLRSRDVVGRFGGDEFVALILGKITHTELSKVVDR
..* . : .: : * :**: :
Mflv_0112|M.gilvum_PYR-GCK IRAAVAEPAEP-----TVTVSIGLATCER-------ADIDLIDVISAADA
Mvan_0796|M.vanbaalenii_PYR-1 IRAAVSAPAQP-----PVTVSIGLATCTR-------PDLDLIDVITAADA
MAV_1995|M.avium_104 LCEAVAALDPP------VTASVGTATLPLRDLVSEYAEHAFHQLVAQADS
MAB_3940c|M.abscessus_ATCC_199 LRQAVTASMPAG---IAVTASVGVAAQAVSRVVSATSQEAIEVLTACADR
Mb1389c|M.bovis_AF2122/97 LRDQLKDHVAIGGEVLTRTVSIGVASGTP-------GQHTPSDLLRRADQ
Rv1354c|M.tuberculosis_H37Rv LRDQLKDHVAIGGEVLTRTVSIGVASGTP-------GQHTPSDLLRRADQ
MSMEG_2196|M.smegmatis_MC2_155 LQSVLRERVTVDGEMLTRTVSIGIAQGIP-------GKDSTSDVLNRADH
TH_3406|M.thermoresistible__bu VRGAIATTPPR------LTASIGVVSTPMRGLAVCPPETLLDELIAVASA
MLBr_01419|M.leprae_Br4923 MHAALSEPTYVADAVLHLRASIGVVAIKGD------DPRNIGQILRDADT
: : .*:* . : *.
Mflv_0112|M.gilvum_PYR-GCK AMYEAKADGGNKVVITAEAA------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 AMYEAKARGGDRVVVTAGVR------------------------------
MAV_1995|M.avium_104 AMYEAKRCGGNQTRHRPAQVST----------------------------
MAB_3940c|M.abscessus_ATCC_199 AMYEAKHDGGDQSRILHADDDSEGRYLWRSGA------------------
Mb1389c|M.bovis_AF2122/97 AALAAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPE
Rv1354c|M.tuberculosis_H37Rv AALAAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPE
MSMEG_2196|M.smegmatis_MC2_155 AVLTAKGSGGNRVAVFSDAMAMEIDFRNDIELHLQSVIEGGALVLHYLPE
TH_3406|M.thermoresistible__bu TMYEARRAGGNQARYRKYPNPTAVTEAHYPEQAADDF-------------
MLBr_01419|M.leprae_Br4923 AMYRAKLSGEGTSYYTDTFNQQPS--------------------------
: *: * .
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 VDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRR
Rv1354c|M.tuberculosis_H37Rv VDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRR
MSMEG_2196|M.smegmatis_MC2_155 IDMRTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRT
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 ACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASS
Rv1354c|M.tuberculosis_H37Rv ACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASS
MSMEG_2196|M.smegmatis_MC2_155 ACAEFSRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGS
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 VCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLP
Rv1354c|M.tuberculosis_H37Rv VCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLP
MSMEG_2196|M.smegmatis_MC2_155 VCLEITESVVVQDIETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLP
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 IDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAAR
Rv1354c|M.tuberculosis_H37Rv IDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAAR
MSMEG_2196|M.smegmatis_MC2_155 VDTLKIDRSFVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAAL
TH_3406|M.thermoresistible__bu --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK ----------------------------------------------
Mvan_0796|M.vanbaalenii_PYR-1 ----------------------------------------------
MAV_1995|M.avium_104 ----------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 ----------------------------------------------
Mb1389c|M.bovis_AF2122/97 ILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
Rv1354c|M.tuberculosis_H37Rv ILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS
MSMEG_2196|M.smegmatis_MC2_155 TLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM---
TH_3406|M.thermoresistible__bu ----------------------------------------------
MLBr_01419|M.leprae_Br4923 ----------------------------------------------