For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MGLREFLLTWWRQPHEFDWTARYFRARGLLRLHQVFIGCFSLLYGLTALLTVVWAYYDGGSVAARVLVIS IAASSCVLGVIWVFGPWPTERQSVAFAVYADVAVVAVMACYQDAFTAMPGLALLAANGIYIVVVHGPRAL VLHLAFTAAVFAVTYWLAIAQATAPVSVITVRLLVLLPTVIGVPVIVQSYLLALRMGADDALHDPLTRLY NRRGLDVHLAELVAPGGVQVGVLALDIDKFKAINDRHGHDAGDRVLVAVAEAARTAVTDLGVRSVTARTG GEEFVVVVEGGTQTVRRLATLLHDAVARCDAATVPTVSIGAAAARVDGDLGGAVRTMIELADAAMYRAKH AGGNQTVIVGDAVAAGD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0679 | - | - | 100% (367) | diguanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_0796 | - | 5e-45 | 35.65% (359) | diguanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_1665 | - | 2e-37 | 30.90% (356) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 2e-17 | 38.41% (164) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_0112 | - | 4e-46 | 34.70% (366) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 3e-17 | 38.41% (164) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 9e-17 | 37.21% (172) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_3940c | - | 2e-46 | 34.68% (372) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1995 | - | 4e-35 | 32.41% (361) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 5e-18 | 36.69% (169) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_3406 | - | 2e-19 | 23.81% (357) | PUTATIVE diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1995|M.avium_104 -----------MKWLAAWWGQPDHFDWLTGYLQDHGFGTATRRAMAVVGA
MAB_3940c|M.abscessus_ATCC_199 MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYAL
Mflv_0112|M.gilvum_PYR-GCK -----MVDGTVRTLLRQWWNQRDDYQWRIDFLRTRGLLPVLRYIIAGIGG
Mvan_0679|M.vanbaalenii_PYR-1 --------MGLREFLLTWWRQPHEFDWTARYFRARGLLRLHQVFIGCFSL
Mb1389c|M.bovis_AF2122/97 -----------------------MCNDTATPQLEELVTTVANQLMTVDAA
Rv1354c|M.tuberculosis_H37Rv -----------------------MCNDTATPQLEELVTTVANQLMTVDAA
MLBr_01750|M.leprae_Br4923 ----------------------------MTRSLDELVTRVASKLMAATAA
MSMEG_2196|M.smegmatis_MC2_155 ----------------------------MSESLDVLVTSVATQLMAVEAA
TH_3406|M.thermoresistible__bu ----------MLKALRRTWRKPDHYYWFTSFLAARRARTSTCRFIASITL
:
MAV_1995|M.avium_104 SLVLVPAN-VLWGATPFFPGLTLTVSVLAGMVGLGMAVLWLHG-WPTRRQ
MAB_3940c|M.abscessus_ATCC_199 IFAAICIA-VQFSDTGPRSMIGRVIVGLCAVGSLGWALRWAVGPWPSLRE
Mflv_0112|M.gilvum_PYR-GCK SLGVLSVY-NAFVPPGADGVLIRTGWAILAVGSLGWAARWALGSWPTVRE
Mvan_0679|M.vanbaalenii_PYR-1 LYGLTALLTVVWAYYDGGSVAARVLVISIAASSCVLGVIWVFGPWPTERQ
Mb1389c|M.bovis_AF2122/97 TSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPD
Rv1354c|M.tuberculosis_H37Rv TSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPD
MLBr_01750|M.leprae_Br4923 TAVTISEGVLAILVEHFGVDVSFLRHNNHDIHETKLIVEWPPRDYVPDPD
MSMEG_2196|M.smegmatis_MC2_155 TSVSVSQQVLAELVSFFDVDVSFLRHNDHRAHATRLVAEWPPRPVDAATD
TH_3406|M.thermoresistible__bu ILGLMPMV-MLAGPAGPQSMPGRLIAVAVTVTALVITLIWLRDRWPSRNQ
* . :
MAV_1995|M.avium_104 SVVFALTGSVAIGAGCLWQTEPLVGLMACSALSVTGGYNAFFHTAKFMGL
MAB_3940c|M.abscessus_ATCC_199 AVAFVAFADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFFLANRLLVA
Mflv_0112|M.gilvum_PYR-GCK SAALVVFVDVMMTVSALLFGDPTLAMSGIPILLCAGGYVVFFHGPRLHLV
Mvan_0679|M.vanbaalenii_PYR-1 SVAFAVYADVAVVAVMACYQDAFTAMPGLALLAANGIYIVVVHGPRALVL
Mb1389c|M.bovis_AF2122/97 PLRLIYFADADPVFALCEHAKEPLVFR---PEPATEDYQRLIEEARGVPV
Rv1354c|M.tuberculosis_H37Rv PLRLIYFADADPVFALCEHAKEPLVFR---PEPATEDYQRLIEEARGVPV
MLBr_01750|M.leprae_Br4923 PIGVVYFADADPVFAMAEYLKEPAVLR---PEPANADYQRRIEEGASVPA
MSMEG_2196|M.smegmatis_MC2_155 PIAVVHFADADPVFAMAEHLKEPAVFR---PEPLYDDYQRTIEAGRHIPA
TH_3406|M.thermoresistible__bu SRVVSLAAGLAIAVFAFTLPDPSAGLVWTAAFAVLAGYVALFHSARYATF
. . . . : * .
MAV_1995|M.avium_104 NFGLAGAIGALQAARLAAS---GQAMLAFTGYFLVLELNVIVPLSIQIVV
MAB_3940c|M.abscessus_ATCC_199 HVAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVLIPAVIQFGI
Mflv_0112|M.gilvum_PYR-GCK HIAWCTASVVGIAIWLAVSDPVFGPQLAVSRAIIALAVTVCVLPALQFGF
Mvan_0679|M.vanbaalenii_PYR-1 HLAFT-AAVFAVTYWLAIAQATAPVSVITVRLLVLLPTVIGVPVIVQSYL
Mb1389c|M.bovis_AF2122/97 TSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQARV
Rv1354c|M.tuberculosis_H37Rv TSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQARV
MLBr_01750|M.leprae_Br4923 VSLACVPLLSGEITTGVLGFVKYGDREWHDDELRALQAIATLFAQLQARI
MSMEG_2196|M.smegmatis_MC2_155 TSMACVPLLSGDVTTGVLGFVKFGDREWLPAELNALKAIASLFAQVQARI
TH_3406|M.thermoresistible__bu TVLFAAITAGVLSFELAKT---AGVAAAVCGFVFITVVTFAVVCACNLLV
: : .
MAV_1995|M.avium_104 RALWLDLLRANRDPLTGLLNRR---ACNRAIIGRMLTG---ASHMFLAVA
MAB_3940c|M.abscessus_ATCC_199 AVVRWDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPLDGDQVTAAA
Mflv_0112|M.gilvum_PYR-GCK WLLQDSSMQSLTDPLTELTNRRGLAVSVKRLNTDARAD------ATLCAL
Mvan_0679|M.vanbaalenii_PYR-1 LALRMGADDALHDPLTRLYNRRGLDVHLAELVAPGGVQ--------VGVL
Mb1389c|M.bovis_AF2122/97 AAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPG-------PVAAL
Rv1354c|M.tuberculosis_H37Rv AAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPG-------PVAAL
MLBr_01750|M.leprae_Br4923 VAEEQLRYLAEHDDLTGLLNRRALIAHLDERLADGQRG-------PVTLL
MSMEG_2196|M.smegmatis_MC2_155 EAEERLRYLADHDHLTGLYNRRALMAHLEARLAPGQPG-------PVAVM
TH_3406|M.thermoresistible__bu GLLDVDVLDADIEPLTGLLNRDAFYRSAGHLISRSRDD-----DRQLVIA
: : ** * **
MAV_1995|M.avium_104 MVDLDRFKALNDTHGHAAGDEALIAVAGALTAACGDT---TVVGRVGGEE
MAB_3940c|M.abscessus_ATCC_199 IVDIDRFKSINDRYGHGTGDRVLIDVAHALTCGTTGT---SVVGRSGGEE
Mflv_0112|M.gilvum_PYR-GCK LIDVDRFKSVNDTFGHAVGDDVLIRTARRIRASVPED---AVVVRWGGEE
Mvan_0679|M.vanbaalenii_PYR-1 ALDIDKFKAINDRHGHDAGDRVLVAVAEAARTAVTDLGVRSVTARTGGEE
Mb1389c|M.bovis_AF2122/97 FLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGE---SLIARLGGDE
Rv1354c|M.tuberculosis_H37Rv FLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGE---SLIARLGGDE
MLBr_01750|M.leprae_Br4923 FLGLDRLKAVNDYLGHNAGDRLIEVFADRLREAAESL---TVIARFGGDE
MSMEG_2196|M.smegmatis_MC2_155 FFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAP---KLIARLGGDE
TH_3406|M.thermoresistible__bu LINIDNLRLLRDTQGQAAADRARVAIGQTLRENTRHN---AFVAHLGQDE
..:*.:: :.* *: ..* . . : * :*
MAV_1995|M.avium_104 FLVADIVTT--EQLPGWGQQLCEAVAALDPP---VTASVGTATLPLRDLV
MAB_3940c|M.abscessus_ATCC_199 FLVVTVCPA--SAVAEFATRLRQAVTASMPAGIAVTASVGVAAQAVSRVV
Mflv_0112|M.gilvum_PYR-GCK FLVVDRIPG--NQAETVAERIRAAVAEPAEP---------TVTVSIGLAT
Mvan_0679|M.vanbaalenii_PYR-1 FVVVVEGGT--QTVRRLATLLHDAVARCDAAT-----VPTVSIGAAAARV
Mb1389c|M.bovis_AF2122/97 FVLIPASPMSADAAQPLAERLRDQLKDHVAIGG----EVLTRTVSIGVAS
Rv1354c|M.tuberculosis_H37Rv FVLIPASPMSADAAQPLAERLRDQLKDHVAIGG----EVLTRTVSIGVAS
MLBr_01750|M.leprae_Br4923 FVVVPAESVSVDVAESFAHRLQTRLQKQVVIDG----EILTRTVSIGVAT
MSMEG_2196|M.smegmatis_MC2_155 FVVVPDDPMSLDEATALAYRLQSVLRERVTVDG----EMLTRTVSIGIAQ
TH_3406|M.thermoresistible__bu FLIADTFSS--TDSFPLVERVRGAIATTPPRLT---ASIGVVSTPMRGLA
*:: : : . .
MAV_1995|M.avium_104 SEYAEHAFHQLVAQADSAMYEAKRCGGNQTRHRPAQVST-----------
MAB_3940c|M.abscessus_ATCC_199 SATSQEAIEVLTACADRAMYEAKHDGGDQSRILHADDDSEGRYLWRSGA-
Mflv_0112|M.gilvum_PYR-GCK CERADIDLIDVISAADAAMYEAKADGGNKVVITAEAA-------------
Mvan_0679|M.vanbaalenii_PYR-1 DGDLGGAVRTMIELADAAMYRAKHAGGNQTVIVGDAVAAGD---------
Mb1389c|M.bovis_AF2122/97 GTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGELRNDIELH
Rv1354c|M.tuberculosis_H37Rv GTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGELRNDIELH
MLBr_01750|M.leprae_Br4923 GLPGRDTTSDLLRWADHAALSAK-SDGSKVVVLDHGISAQHTLRTEVELH
MSMEG_2196|M.smegmatis_MC2_155 GIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAMAMEIDFRNDIELH
TH_3406|M.thermoresistible__bu VCPPETLLDELIAVASATMYEARRAGGNQARYRKYPNPTAVTEAHYPEQA
: *. : *: .*.
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 LRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPV
Rv1354c|M.tuberculosis_H37Rv LRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPV
MLBr_01750|M.leprae_Br4923 LAGMIDT-DLVLHYLPEVDMSTGKVLGTEALVRWQHPTRGLLFPDSFIPV
MSMEG_2196|M.smegmatis_MC2_155 LQSVIEGGALVLHYLPEIDMRTGEVLAAEALVRWEHPTRGLLSPDSFIGV
TH_3406|M.thermoresistible__bu ADDF----------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 AESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGF
Rv1354c|M.tuberculosis_H37Rv AESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGF
MLBr_01750|M.leprae_Br4923 AESINLAGKLGRMVMHSACAEFSRWRSAGVGLDALLRINVSPVQLVAEGF
MSMEG_2196|M.smegmatis_MC2_155 AESINLAGELGRWVLRTACAEFSRWRANGVGRNIVLRINVSPVQLVTDGF
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 VDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAI
Rv1354c|M.tuberculosis_H37Rv VDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAI
MLBr_01750|M.leprae_Br4923 VDNVAGTLDEFGLDGSMVCLEITENVVVQNIDATRKTLAGLKEVGVHLAI
MSMEG_2196|M.smegmatis_MC2_155 VESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTLTGLHNVGVQVAI
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 DDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEG
Rv1354c|M.tuberculosis_H37Rv DDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEG
MLBr_01750|M.leprae_Br4923 DDFGTGYSVLTHLKSLPVDTIKIDKSFVAELGSNASDLAIVRAIMALAKE
MSMEG_2196|M.smegmatis_MC2_155 DDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDLPIVRAVIALAGA
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_1995|M.avium_104 --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 FQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRL
Rv1354c|M.tuberculosis_H37Rv FQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRL
MLBr_01750|M.leprae_Br4923 FELEVVAEGVETAVAAQVLLELGCNRAQGFLLSRPVDGAAMESLLAKGVI
MSMEG_2196|M.smegmatis_MC2_155 FGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRV
TH_3406|M.thermoresistible__bu --------------------------------------------------
MAV_1995|M.avium_104 --------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------
Mflv_0112|M.gilvum_PYR-GCK --------------------
Mvan_0679|M.vanbaalenii_PYR-1 --------------------
Mb1389c|M.bovis_AF2122/97 PPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv PPTCIPATDPALS-------
MLBr_01750|M.leprae_Br4923 PMALGTCQSPEPSEHQIHRS
MSMEG_2196|M.smegmatis_MC2_155 PVHFSAAPRM----------
TH_3406|M.thermoresistible__bu --------------------