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aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_4409 | - | - | 100% (199) | serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_2947 | - | 2e-62 | 64.64% (181) | PUTATIVE serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_2631 | - | 8e-37 | 44.32% (176) | PUTATIVE serine/threonine protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1772 | pknE | 9e-65 | 62.09% (182) | transmembrane serine/threonine-protein kinase E |
| M. gilvum PYR-GCK | Mflv_5210 | - | 7e-88 | 79.17% (192) | protein kinase |
| M. tuberculosis H37Rv | Rv1743 | pknE | 3e-64 | 62.09% (182) | transmembrane serine/threonine-protein kinase E |
| M. leprae Br4923 | MLBr_00017 | pknA | 8e-39 | 44.32% (185) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_0034c | - | 2e-37 | 43.24% (185) | putative serine/threonine-protein kinase PknA |
| M. marinum M | MMAR_4156 | pknH | 3e-64 | 60.22% (186) | transmembrane serine/threonine-protein kinase H PknH |
| M. avium 104 | MAV_2158 | - | 9e-64 | 64.58% (192) | serine/threonine protein kinase |
| M. smegmatis MC2 155 | MSMEG_4366 | - | 2e-90 | 83.77% (191) | serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_3180 | pknE | 2e-63 | 57.51% (193) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_1066 | - | 5e-88 | 79.69% (192) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5210|M.gilvum_PYR-GCK -MS--TPQGGARLGTRFG-PYELHSVIGVGGMGEVYRAYDTARERMVAIK
Mvan_1066|M.vanbaalenii_PYR-1 -MS--TPKGGSRLGTRFG-PYELQSVIGVGGMGEVYRAYDTARERMVAIK
MSMEG_4366|M.smegmatis_MC2_155 -MTPMASNGASRLGTRFG-PYELRSLIGVGGMGEVYRAYDTVKGREVAVK
TH_4409|M.thermoresistible__bu -MT--SSSGGSRVGTRFG-PYELRSLIGVGGMGEVYRAYDTVRGRMVALK
MAV_2158|M.avium_104 -MS--SSSRGSRLGTRLG-PYELRSLIGTGTLGEVYRAYDTVKDRLVALK
Mb1772|M.bovis_AF2122/97 -MD---GTAESREGTQFG-PYRLRRLVGRGGMGDVYEAEDTVRERIVALK
Rv1743|M.tuberculosis_H37Rv -MD---GTAESREGTQFG-PYRLRRLVGRGGMGDVYEAEDTVRERIVALK
MUL_3180|M.ulcerans_Agy99 MSD---ATADSREGSQFG-PYRLRRIVGRGAMGDVYEAEDTVRERVVALK
MMAR_4156|M.marinum_M -MG---EAPDSRVGSMFG-PYHLKRLLGRGGMGEVYEAEHTVKEWTVAVK
MLBr_00017|M.leprae_Br4923 --------MSPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVK
MAB_0034c|M.abscessus_ATCC_199 --------MTVRVGETLSGRYRLQRLIATGGMGQVWEGTDSRLGRKVAVK
* * :. *.*: ::. * :*:*:.. .: **:*
Mflv_5210|M.gilvum_PYR-GCK LLRPEMAADHSFQERFRRESRVAARLQEPHVIPVHNFGEIDG-----VLY
Mvan_1066|M.vanbaalenii_PYR-1 LLRPEMAADHSFQERFRRESRVAARLQEPHVIPVHDFGEIDG-----VLY
MSMEG_4366|M.smegmatis_MC2_155 LLRAEFAADPRFQERFRRESRVAARLQEPHVIPVHDFGDIDG-----VLY
TH_4409|M.thermoresistible__bu LLRPELAADPNFQERFRRESRLAARLQEPHVIPVHDFGDIDG-----VLY
MAV_2158|M.avium_104 LLRGELDAG--FRQRLWRECRAVTRLQEPHVLPLHDFGEIDG-----VPF
Mb1772|M.bovis_AF2122/97 LMSETLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFGEIDG-----QLY
Rv1743|M.tuberculosis_H37Rv LMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDG-----QLY
MUL_3180|M.ulcerans_Agy99 LMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDG-----QLY
MMAR_4156|M.marinum_M LMTTEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEIDG-----QMF
MLBr_00017|M.leprae_Br4923 VLKGEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHMDGEGRTAY
MAB_0034c|M.abscessus_ATCC_199 VLKAEFSSDPEFIERFRAEARTVAMLNHPGIASVYDYGETDIDSEGRTAY
:: : . * *: *.* . *:.* : .::::*: . :
Mflv_5210|M.gilvum_PYR-GCK IDMRLVE-GASLKEVLRSDGPLQPARAVSIIRQVAAALDDAHANGLVHRD
Mvan_1066|M.vanbaalenii_PYR-1 IDMRLVE-GASLKDVLRAEGALPPARAVSILRQVAAALDAAHANGLVHRD
MSMEG_4366|M.smegmatis_MC2_155 IDMRLVE-GASLKDILRTDGPLDPRRTASIVAQVASALDAAHADGLVHRD
TH_4409|M.thermoresistible__bu IDMRLVD-GASLKDILRSSGPLEPARAAAIIKQVAAALDAAHADGLIHRD
MAV_2158|M.avium_104 IDMQLVDDGGSLKELLREQGGLEPSRAASITGQVARALDAAHAAGLMHLD
Mb1772|M.bovis_AF2122/97 VDMRLIN-GVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRD
Rv1743|M.tuberculosis_H37Rv VDMRLIN-GVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRD
MUL_3180|M.ulcerans_Agy99 VDMRLID-GKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRD
MMAR_4156|M.marinum_M LEMRLIE-GTDLDSILKRFGPLTPPRAVAIITQIASALDAAHADGVMHRD
MLBr_00017|M.leprae_Br4923 LVMELVN-GEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRD
MAB_0034c|M.abscessus_ATCC_199 LVMELIH-GEPLNSVLKRTGRLSLRHSLDMLEQTGRALQVAHAAGLVHRD
: *.*:. * * :*: * * :: : * . **: *** * * *
Mflv_5210|M.gilvum_PYR-GCK IKPENVLLTGDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSG
Mvan_1066|M.vanbaalenii_PYR-1 IKPENVLLTPDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSG
MSMEG_4366|M.smegmatis_MC2_155 IKPENVLLTGDDFAYLVDFGIAHVGGEASVTMTGMLIGSSAYMAPERFSG
TH_4409|M.thermoresistible__bu IKPENVLLTADDFAYLVDFGIAHAGGDAGVTRTGMLIGSSAYMAPERFAN
MAV_2158|M.avium_104 VKPENILLTHDHFTYLADFGLAQAAGDEKLSRT--------YMAPERFTT
Mb1772|M.bovis_AF2122/97 VKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSE
Rv1743|M.tuberculosis_H37Rv VKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSE
MUL_3180|M.ulcerans_Agy99 VKPENILVSHDDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSS
MMAR_4156|M.marinum_M VKPPNILITRDDFAYLVDFGIASATGDEKLTQLGTAVGTWKYMAPERFAN
MLBr_00017|M.leprae_Br4923 VKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG
MAB_0034c|M.abscessus_ATCC_199 VKPGNILITPTGQVKLTDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG
:** *:*:: . :.***:* :: *:***:
Mflv_5210|M.gilvum_PYR-GCK ERGGPASDIYSLACLLYESLTGRAPFEAADVRQVWSAHMFAAPPRPSIMR
Mvan_1066|M.vanbaalenii_PYR-1 ERGGPASDVYSLACLLYESLTGRAPFEAADVRQVWSAHMFAPPPRPSIMR
MSMEG_4366|M.smegmatis_MC2_155 ETVGPPADIYALACLVYESLIGRPPYEAGDLRQLMSAHMFSAPPRPSIMR
TH_4409|M.thermoresistible__bu GRVX-------------------------------------XSPR-----
MAV_2158|M.avium_104 GSLGPQTDIYSLACVLYECLTGQPPFEGADPGELRSAHLLSPAPRPSIMR
Mb1772|M.bovis_AF2122/97 SHATYRADIYALTCVLYECLTGSPPYQGD-QLSVMGAHINQAIPRPSTVR
Rv1743|M.tuberculosis_H37Rv SHATYRADIYALTCVLYECLTGSPPYQGD-QLSVMGAHINQAIPRPSTVR
MUL_3180|M.ulcerans_Agy99 GDVTYRADIYALACVLYECLTGSPPYRGD-QLSVIGAHLSQPIPRPSAAR
MMAR_4156|M.marinum_M EEVTYRADIYALACVLFECLTGSPPYRSDSAGTLVTAHLMDPVPQVSTVR
MLBr_00017|M.leprae_Br4923 HDATPASDVYSLGVIGYEVVSGKRPFTGDGALTVAMKHIKEPPPP---LP
MAB_0034c|M.abscessus_ATCC_199 HDATPASDVYSLGVVGYEAVSGKRPFSGDGALTVAMKHIKETPSP---LP
.
Mflv_5210|M.gilvum_PYR-GCK RGVSRAFDDVIARGMAKNPTERYATAGELARAAA-AAAS-AAPVAEPVP-
Mvan_1066|M.vanbaalenii_PYR-1 RGVSRTFDDVVARGMAKQPHDRYPTAGELARAAS-AAAE-GAPAAETVA-
MSMEG_4366|M.smegmatis_MC2_155 RGVPRAFDEVIATAMAKDPAARYATAGELARAVS-AAAAGEAPPSKPTP-
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 RGVGRAFDDIITRGMAKQRSARFASAGELARAASEAVFAAYEPVSAAAG-
Mb1772|M.bovis_AF2122/97 PGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILR
Rv1743|M.tuberculosis_H37Rv PGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILR
MUL_3180|M.ulcerans_Agy99 PGIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQ
MMAR_4156|M.marinum_M SGIPKAFDAVIARGMAKKPEERYASAGDLARAAHDALSNPDQDHAADILR
MLBr_00017|M.leprae_Br4923 ADLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPPRPNQTP-
MAB_0034c|M.abscessus_ATCC_199 ADLPPNVRELIEITLVKNPQNRYTSGGPFADAVAAVRAGRRPPRPNQAP-
Mflv_5210|M.gilvum_PYR-GCK -----------------------PVTP----PSTRQFSGVHP--------
Mvan_1066|M.vanbaalenii_PYR-1 -----------------------PVTP----PSTRQFSTVYP--------
MSMEG_4366|M.smegmatis_MC2_155 -----------------------PQVPGRPPTPTRQFSELYPNPEHTGFT
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 -----------------------LGGPRPLPAPPAQFDDPDD--------
Mb1772|M.bovis_AF2122/97 RSQVAKLPV--PSTHP--------------VSPGTRWPQP----------
Rv1743|M.tuberculosis_H37Rv RSQVAKLPV--PSTHP--------------VSPGTRWPQP----------
MUL_3180|M.ulcerans_Agy99 RSQVAQLPAGFASTSPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPS
MMAR_4156|M.marinum_M RSRESTLPG-TAAITP-----QPPTMPAVTPPPAMPYADPASSG------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5210|M.gilvum_PYR-GCK ---------------------AMTP-PPAPAPIAA-------ARRPGRGQ
Mvan_1066|M.vanbaalenii_PYR-1 ---------------------TPPPMPPMPAVAPP-------ARRFSRGQ
MSMEG_4366|M.smegmatis_MC2_155 PYPPAYPSVP--------APPRRTPTPPAPAAVAAPAVRTPGKKRFTRTQ
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 -----------------------TLGPPPVGERPP-------RGPAGRLP
Mb1772|M.bovis_AF2122/97 ----TPWAG------------GAPPWGPPSSPLPRS------ARQPWLWV
Rv1743|M.tuberculosis_H37Rv ----TPWAG------------GAPPWGPPSSPLPRS------ARQPWLWV
MUL_3180|M.ulcerans_Agy99 APVPTPWAGVPGWGVGHTGTTGAPPWGQPP-PEPTV------AAKTWPWI
MMAR_4156|M.marinum_M ---PLPQSAP----------TGQPGWAPASGPIPAAH---QPAQVPQYYQ
MLBr_00017|M.leprae_Br4923 -------------------------------------------SSGRASP
MAB_0034c|M.abscessus_ATCC_199 -------------------------------------------TISRATP
Mflv_5210|M.gilvum_PYR-GCK GALVAGIVVMFVAAAVLALVLVFTGGSDPQP-PRIAAP----PSSSSD--
Mvan_1066|M.vanbaalenii_PYR-1 VGLVAATVVMFTAALVLAAVLVFSGGDTGSPSPRIAAP----PSSSSE--
MSMEG_4366|M.smegmatis_MC2_155 MMLVVATVVLFGIAAVLATMLVGGDDNASTGNTGITPPEGATSTSEST--
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 VVVTAVAVLMLIAGVVLSVKTVVGTHHNNSAPPPAPTTRALAPPPPTT--
Mb1772|M.bovis_AF2122/97 GVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGV
Rv1743|M.tuberculosis_H37Rv GVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGV
MUL_3180|M.ulcerans_Agy99 AAAVAVVVVIAGVLGVVIAHPWRSPGPPTASAPPPPPPDAVQLRVLNDGV
MMAR_4156|M.marinum_M SGSWASTPPGTPPQQPVGPTPWNQPPPKRNPWPIVAGVAALVFVLIVGGI
MLBr_00017|M.leprae_Br4923 TTIPSSTQARAAVACGTKTPAPR-RSRPSTSGNRPPPARN-TFSSGQR--
MAB_0034c|M.abscessus_ATCC_199 AAIPPATQVRPAVGAPSRVAPPTSRTRQPTGSHRPPPPRRGTFSPGQK--
Mflv_5210|M.gilvum_PYR-GCK -----TSTPPSTSAVEGVSGTDSQGFVGHTARCDSGDTPAALIRTSLSLA
Mvan_1066|M.vanbaalenii_PYR-1 -----APSTSSASAVEGVSGTDSQGFVGHTARCDSGSTPAALIRTSLSLA
MSMEG_4366|M.smegmatis_MC2_155 -----TTTTSNRSATANVSGTDEQGFVGHTARCDSDATPAALIRTATSLA
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 -----PPPPLTPTLSRPVTGADGLGFIGETARCDPGNPPAAVVRTAKSLA
Mb1772|M.bovis_AF2122/97 FVGSSVAPTTIDIFNEPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLN
Rv1743|M.tuberculosis_H37Rv FVGSSVAPTTIDIFNEPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLN
MUL_3180|M.ulcerans_Agy99 FIGSSAATTTIDIFNEPICPPCGAFIRSYASDIDAAVANKKLAVRYHLLN
MMAR_4156|M.marinum_M GVWLVTNSDSTPKAGPGTTGSTTTTSPKPETTSPETTTTPAGDPQARLLS
MLBr_00017|M.leprae_Br4923 ----------ALLWAAGMLGALAIIIAVLIVINSYAGNEQHQPPTPTVTD
MAB_0034c|M.abscessus_ATCC_199 ----------ALMWAAAVLGIFAIIIAALILLQASEKKNQTPSIPATVSG
Mflv_5210|M.gilvum_PYR-GCK IICD------------------RGDGDYYYRGERLRDGANREIDGARRSG
Mvan_1066|M.vanbaalenii_PYR-1 IICE------------------TSDGDYYYRGERLRDGANREIQGAQRSG
MSMEG_4366|M.smegmatis_MC2_155 IICE------------------RDSGGYYYRGERLRDGANLKIDDAQRSG
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 VVCQ------------------NLSGSYYYRGERIRDGAHIELSNAERVE
Mb1772|M.bovis_AF2122/97 FLDD----------QSHSKNYSTRAVAASYCVAGQNDPKLYASFYSALFG
Rv1743|M.tuberculosis_H37Rv FLDD----------QSHSKNYSTRAVAASYCVAGQNDPKLYASFYSALFG
MUL_3180|M.ulcerans_Agy99 FLDE----------QSHTKTYSTRAVAASYCVAAQDDPKVYTDFYAALFA
MMAR_4156|M.marinum_M YLPSGYASGVCTATTPKPNSVWTGAVAMYNCGQNTNDGGPSRAVYG-LFP
MLBr_00017|M.leprae_Br4923 TGTP------------------PATKTLSGFPAAYCEYRVNWTNHKEISN
MAB_0034c|M.abscessus_ATCC_199 SETP------------------SSPGSAS---------------------
Mflv_5210|M.gilvum_PYR-GCK DGFTVTG-SDGARYDVQPDQLTISSG-----------GSVDSAEPALEYG
Mvan_1066|M.vanbaalenii_PYR-1 DGFVVTG-SDGARYDVQPDQLTISSN-----------GSVDSAEPALEYG
MSMEG_4366|M.smegmatis_MC2_155 DGYVAVNPADGARYEVSPEGLTIMSN-----------GHVDSSEPPEEYG
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 DGFDVTNPVDGVVYEVRPNRLRIISF-----------GHVDSSEPVLQYA
Mb1772|M.bovis_AF2122/97 SDFQPQENAASDRTDAELAHLAQTVGAEPTAISCIKSGADLGTAQTKATN
Rv1743|M.tuberculosis_H37Rv SDFQPQENAASDRTDAELAHLAQTVGAEPTAISCIKSGADLGTAQTKATN
MUL_3180|M.ulcerans_Agy99 SDFQPQEAAASDRTDAELAHLAQTVGANGTATSCIKAGNDMGTARTKAAA
MMAR_4156|M.marinum_M S-LEALKQAFND--DIAAVDLANCPGEGPSPDGWHYDRTPDVTAGMIACG
MLBr_00017|M.leprae_Br4923 SGLPKQAARAQLAGAIDISPVAGQT-------------------------
MAB_0034c|M.abscessus_ATCC_199 PGALAPANIVALLPDAEPDPIPGTKSP-----------------------
Mflv_5210|M.gilvum_PYR-GCK SAQ------------------------------------
Mvan_1066|M.vanbaalenii_PYR-1 SAQ------------------------------------
MSMEG_4366|M.smegmatis_MC2_155 SK-------------------------------------
TH_4409|M.thermoresistible__bu ---------------------------------------
MAV_2158|M.avium_104 TAS------------------------------------
Mb1772|M.bovis_AF2122/97 ASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG---
Rv1743|M.tuberculosis_H37Rv ASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG---
MUL_3180|M.ulcerans_Agy99 ADATLSELNAG-------------------LRRC-----
MMAR_4156|M.marinum_M TYKNHPNVIWSNDDKLMLSDAFGDPATLDELHTWWAKYG
MLBr_00017|M.leprae_Br4923 ---------------------------------------
MAB_0034c|M.abscessus_ATCC_199 ---------------------------------------