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TPMASNGASRLGTRFGPYELRSLIGVGGMGEVYRAYDTVKGREVAVKLLRAEFAADPRFQERFRRESRVA ARLQEPHVIPVHDFGDIDGVLYIDMRLVEGASLKDILRTDGPLDPRRTASIVAQVASALDAAHADGLVHR DIKPENVLLTGDDFAYLVDFGIAHVGGEASVTMTGMLIGSSAYMAPERFSGETVGPPADIYALACLVYES LIGRPPYEAGDLRQLMSAHMFSAPPRPSIMRRGVPRAFDEVIATAMAKDPAARYATAGELARAVSAAAAG EAPPSKPTPPQVPGRPPTPTRQFSELYPNPEHTGFTPYPPAYPSVPAPPRRTPTPPAPAAVAAPAVRTPG KKRFTRTQMMLVVATVVLFGIAAVLATMLVGGDDNASTGNTGITPPEGATSTSESTTTTTSNRSATANVS GTDEQGFVGHTARCDSDATPAALIRTATSLAIICERDSGGYYYRGERLRDGANLKIDDAQRSGDGYVAVN PADGARYEVSPEGLTIMSNGHVDSSEPPEEYGSK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4366 | - | - | 100% (525) | serine/threonine-protein kinase PknD |
| M. smegmatis MC2 155 | MSMEG_1200 | - | 3e-79 | 55.97% (268) | serine/threonine-protein kinase PknD |
| M. smegmatis MC2 155 | MSMEG_0886 | - | 2e-56 | 38.74% (382) | serine/threonine-protein kinase PknD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 8e-90 | 41.76% (443) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_5210 | - | 1e-180 | 66.22% (518) | protein kinase |
| M. tuberculosis H37Rv | Rv1266c | pknH | 2e-91 | 49.15% (352) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | MLBr_00017 | pknA | 1e-57 | 34.79% (411) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_0034c | - | 1e-56 | 33.57% (414) | putative serine/threonine-protein kinase PknA |
| M. marinum M | MMAR_4156 | pknH | 6e-94 | 42.22% (450) | transmembrane serine/threonine-protein kinase H PknH |
| M. avium 104 | MAV_2158 | - | 1e-126 | 48.66% (522) | serine/threonine protein kinase |
| M. thermoresistible (build 8) | TH_4409 | - | 4e-90 | 83.77% (191) | PUTATIVE serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_3180 | pknE | 9e-88 | 49.42% (346) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_1066 | - | 0.0 | 66.22% (518) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5210|M.gilvum_PYR-GCK MS--TPQGGARLGTRFG-PYELHSVIGVGGMGEVYRAYDTARERMVAIKL
Mvan_1066|M.vanbaalenii_PYR-1 MS--TPKGGSRLGTRFG-PYELQSVIGVGGMGEVYRAYDTARERMVAIKL
MSMEG_4366|M.smegmatis_MC2_155 MTPMASNGASRLGTRFG-PYELRSLIGVGGMGEVYRAYDTVKGREVAVKL
TH_4409|M.thermoresistible__bu MT--SSSGGSRVGTRFG-PYELRSLIGVGGMGEVYRAYDTVRGRMVALKL
MAV_2158|M.avium_104 MS--SSSRGSRLGTRLG-PYELRSLIGTGTLGEVYRAYDTVKDRLVALKL
Mb1297c|M.bovis_AF2122/97 MS--DAQ-DSRVGSMFG-PYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKL
Rv1266c|M.tuberculosis_H37Rv MS--DAQ-DSRVGSMFG-PYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKL
MMAR_4156|M.marinum_M MG--EAP-DSRVGSMFG-PYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKL
MUL_3180|M.ulcerans_Agy99 MS--DATADSREGSQFG-PYRLRRIVGRGAMGDVYEAEDTVRERVVALKL
MLBr_00017|M.leprae_Br4923 MS-------PRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKV
MAB_0034c|M.abscessus_ATCC_199 MT-------VRVGETLSGRYRLQRLIATGGMGQVWEGTDSRLGRKVAVKV
* * * :. *.*: ::. * :*:*:.. .: **:*:
Mflv_5210|M.gilvum_PYR-GCK LRPEMAADHSFQERFRRESRVAARLQEPHVIPVHNFGEIDG-----VLYI
Mvan_1066|M.vanbaalenii_PYR-1 LRPEMAADHSFQERFRRESRVAARLQEPHVIPVHDFGEIDG-----VLYI
MSMEG_4366|M.smegmatis_MC2_155 LRAEFAADPRFQERFRRESRVAARLQEPHVIPVHDFGDIDG-----VLYI
TH_4409|M.thermoresistible__bu LRPELAADPNFQERFRRESRLAARLQEPHVIPVHDFGDIDG-----VLYI
MAV_2158|M.avium_104 LRGELDAG--FRQRLWRECRAVTRLQEPHVLPLHDFGEIDG-----VPFI
Mb1297c|M.bovis_AF2122/97 MTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDG-----QMFL
Rv1266c|M.tuberculosis_H37Rv MTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDG-----QMFL
MMAR_4156|M.marinum_M MTTEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEIDG-----QMFL
MUL_3180|M.ulcerans_Agy99 MSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDG-----QLYV
MLBr_00017|M.leprae_Br4923 LKGEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHMDGEGRTAYL
MAB_0034c|M.abscessus_ATCC_199 LKAEFSSDPEFIERFRAEARTVAMLNHPGIASVYDYGETDIDSEGRTAYL
: : . * *: *.* . *:.* : .::::*: . ::
Mflv_5210|M.gilvum_PYR-GCK DMRLVE-GASLKEVLRSDGPLQPARAVSIIRQVAAALDDAHANGLVHRDI
Mvan_1066|M.vanbaalenii_PYR-1 DMRLVE-GASLKDVLRAEGALPPARAVSILRQVAAALDAAHANGLVHRDI
MSMEG_4366|M.smegmatis_MC2_155 DMRLVE-GASLKDILRTDGPLDPRRTASIVAQVASALDAAHADGLVHRDI
TH_4409|M.thermoresistible__bu DMRLVD-GASLKDILRSSGPLEPARAAAIIKQVAAALDAAHADGLIHRDI
MAV_2158|M.avium_104 DMQLVDDGGSLKELLREQGGLEPSRAASITGQVARALDAAHAAGLMHLDV
Mb1297c|M.bovis_AF2122/97 EMRLVE-GTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDV
Rv1266c|M.tuberculosis_H37Rv EMRLVE-GTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDV
MMAR_4156|M.marinum_M EMRLIE-GTDLDSILKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDV
MUL_3180|M.ulcerans_Agy99 DMRLID-GKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDV
MLBr_00017|M.leprae_Br4923 VMELVN-GEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDV
MAB_0034c|M.abscessus_ATCC_199 VMELIH-GEPLNSVLKRTGRLSLRHSLDMLEQTGRALQVAHAAGLVHRDV
*.*:. * * :*: * * :: : * . **: *** *: * *:
Mflv_5210|M.gilvum_PYR-GCK KPENVLLTGDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGE
Mvan_1066|M.vanbaalenii_PYR-1 KPENVLLTPDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGE
MSMEG_4366|M.smegmatis_MC2_155 KPENVLLTGDDFAYLVDFGIAHVGGEASVTMTGMLIGSSAYMAPERFSGE
TH_4409|M.thermoresistible__bu KPENVLLTADDFAYLVDFGIAHAGGDAGVTRTGMLIGSSAYMAPERFANG
MAV_2158|M.avium_104 KPENILLTHDHFTYLADFGLAQAAGDEKLSRT--------YMAPERFTTG
Mb1297c|M.bovis_AF2122/97 KPQNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSND
Rv1266c|M.tuberculosis_H37Rv KPQNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSND
MMAR_4156|M.marinum_M KPPNILITRDDFAYLVDFGIASATGDEKLTQLGTAVGTWKYMAPERFANE
MUL_3180|M.ulcerans_Agy99 KPENILVSHDDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSG
MLBr_00017|M.leprae_Br4923 KPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGH
MAB_0034c|M.abscessus_ATCC_199 KPGNILITPTGQVKLTDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGH
** *:*:: . :.***:* :: *:***:
Mflv_5210|M.gilvum_PYR-GCK RGGPASDIYSLACLLYESLTGRAPFEAADVRQVWSAHMFAAPPRPSIMRR
Mvan_1066|M.vanbaalenii_PYR-1 RGGPASDVYSLACLLYESLTGRAPFEAADVRQVWSAHMFAPPPRPSIMRR
MSMEG_4366|M.smegmatis_MC2_155 TVGPPADIYALACLVYESLIGRPPYEAGDLRQLMSAHMFSAPPRPSIMRR
TH_4409|M.thermoresistible__bu RVX-------------------------------------XSPR------
MAV_2158|M.avium_104 SLGPQTDIYSLACVLYECLTGQPPFEGADPGELRSAHLLSPAPRPSIMRR
Mb1297c|M.bovis_AF2122/97 EVTYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRP
Rv1266c|M.tuberculosis_H37Rv EVTYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRP
MMAR_4156|M.marinum_M EVTYRADIYALACVLFECLTGSPPYRSDSAGTLVTAHLMDPVPQVSTVRS
MUL_3180|M.ulcerans_Agy99 DVTYRADIYALACVLYECLTGSPPYRGD-QLSVIGAHLSQPIPRPSAARP
MLBr_00017|M.leprae_Br4923 DATPASDVYSLGVIGYEVVSGKRPFTGDGALTVAMKHIKEPPPP---LPA
MAB_0034c|M.abscessus_ATCC_199 DATPASDVYSLGVVGYEAVSGKRPFSGDGALTVAMKHIKETPSP---LPA
.
Mflv_5210|M.gilvum_PYR-GCK GVSRAFDDVIARGMAKNPTERYATAGELARAAA-AAAS-AAPVAEPVP--
Mvan_1066|M.vanbaalenii_PYR-1 GVSRTFDDVVARGMAKQPHDRYPTAGELARAAS-AAAE-GAPAAETVA--
MSMEG_4366|M.smegmatis_MC2_155 GVPRAFDEVIATAMAKDPAARYATAGELARAVS-AAAAGEAPPSKPTP--
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 GVGRAFDDIITRGMAKQRSARFASAGELARAASEAVFAAYEPVSAAAG--
Mb1297c|M.bovis_AF2122/97 GIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRR
Rv1266c|M.tuberculosis_H37Rv GIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRR
MMAR_4156|M.marinum_M GIPKAFDAVIARGMAKKPEERYASAGDLARAAHDALSNPDQDHAADILRR
MUL_3180|M.ulcerans_Agy99 GIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQR
MLBr_00017|M.leprae_Br4923 DLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPPR-------
MAB_0034c|M.abscessus_ATCC_199 DLPPNVRELIEITLVKNPQNRYTSGGPFADAVAAVRAGRRPPR-------
Mflv_5210|M.gilvum_PYR-GCK ---------------------PVTP----PSTRQFSGVHP----------
Mvan_1066|M.vanbaalenii_PYR-1 ---------------------PVTP----PSTRQFSTVYP----------
MSMEG_4366|M.smegmatis_MC2_155 ---------------------PQVPGRPPTPTRQFSELYPNPEHTGFTPY
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 ---------------------LGGPRPLPAPPAQFDDPDD----------
Mb1297c|M.bovis_AF2122/97 SQESTLPG-----------TAAVTAQ--PPTMPTVTPPPIQAAP------
Rv1266c|M.tuberculosis_H37Rv SQESTLPAPPKPVPPPTMPATAMAPR--QPPAPPVTPPGVQPAPKPSYTP
MMAR_4156|M.marinum_M SRESTLPG-----------TAAITPQ--PPTMPAVTPPPAMPYADPASSG
MUL_3180|M.ulcerans_Agy99 SQVAQLPAG----------FASTSPGGFAPSSPAVPVPGSAPST------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5210|M.gilvum_PYR-GCK --------------AMTP-PPAPAPIAA----------------------
Mvan_1066|M.vanbaalenii_PYR-1 --------------TPPPMPPMPAVAPP----------------------
MSMEG_4366|M.smegmatis_MC2_155 PPA---YPSVPAPPRRTPTPPAPAAVAAPA--------------------
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 ----------------TLGPPPVGERPP----------------------
Mb1297c|M.bovis_AF2122/97 -------------TGQPSWAPNSGPMPASG-PTPTPQYYQGGGWGAPPSG
Rv1266c|M.tuberculosis_H37Rv PAQPGPAGQRPGPTGQPSWAPNSGPMPASG-PTPTPQYYQGGGWGAPPSG
MMAR_4156|M.marinum_M PLP------QSAPTGQPGWAPASGPIPAAHQPAQVPQYYQSGSWASTPPG
MUL_3180|M.ulcerans_Agy99 --------------GWPAPSVPGAPVAPSA-PVPTPWAGVPG-WGVGHTG
MLBr_00017|M.leprae_Br4923 ----------------PNQTPSSGRASP----------------------
MAB_0034c|M.abscessus_ATCC_199 ----------------PNQAPTISRATP----------------------
Mflv_5210|M.gilvum_PYR-GCK ------------ARRPGR-------GQGALVAGIVVMFVAAAVLALVLVF
Mvan_1066|M.vanbaalenii_PYR-1 ------------ARRFSR-------GQVGLVAATVVMFTAALVLAAVLVF
MSMEG_4366|M.smegmatis_MC2_155 -------VRTPGKKRFTR-------TQMMLVVATVVLFGIAAVLATMLVG
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 ------------RGPAGR-------LPVVVTAVAVLMLIAGVVLSVKTVV
Mb1297c|M.bovis_AF2122/97 -------GPSPWAQTPRK----TNPWPLVAGAAAVVLVLVLGAIGIWIAN
Rv1266c|M.tuberculosis_H37Rv -------GPSPWAQTPRK----TNPWPLVAGAAAVVLVLVLGAIGIWIAI
MMAR_4156|M.marinum_M TPPQQPVGPTPWNQPPPK----RNPWPIVAGVAALVFVLIVGGIGVWLVT
MUL_3180|M.ulcerans_Agy99 -----TTGAPPWGQPPPEPTVAAKTWPWIA-AAVAVVVVIAGVLGVVIAH
MLBr_00017|M.leprae_Br4923 --------------------------TTIPSSTQARAAVACGTKTPAPR-
MAB_0034c|M.abscessus_ATCC_199 --------------------------AAIPPATQVRPAVGAPSRVAPPTS
Mflv_5210|M.gilvum_PYR-GCK -----TGGSDPQP-PRIAAP----PSSSSDTSTPPSTSAVEGVSGTDSQG
Mvan_1066|M.vanbaalenii_PYR-1 -----SGGDTGSPSPRIAAP----PSSSSEAPSTSSASAVEGVSGTDSQG
MSMEG_4366|M.smegmatis_MC2_155 -----GDDNASTGNTGITPPEGATSTSESTTTTTSNRSATANVSGTDEQG
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 -----GTHHNNSAPPPAPTTRALAPPPPTTPPPPLTPTLSRPVTGADGLG
Mb1297c|M.bovis_AF2122/97 ------RPKPVQPPQPVAEERLSALLLNSSEVNAVMGSSSMQPG-KPITS
Rv1266c|M.tuberculosis_H37Rv ------RPKPVQPPQPVAEERLSALLLNSSEVNAVMGSSSMQPG-KPITS
MMAR_4156|M.marinum_M ------NSDSTPKAGPGTTG--STTTTSPKPETTSPETTTTPAG-DPQAR
MUL_3180|M.ulcerans_Agy99 PWRSPGPPTASAPPPPPPDAVQLRVLNDGVFIGSSAATTTIDIFNEPICP
MLBr_00017|M.leprae_Br4923 -----RSRPSTSGNRPPPARN-TFSSGQRALLWAAGMLGALAIIIAVLIV
MAB_0034c|M.abscessus_ATCC_199 -----RTRQPTGSHRPPPPRRGTFSPGQKALMWAAAVLGIFAIIIAALIL
Mflv_5210|M.gilvum_PYR-GCK FVGHTARCDSGDTPAALIRTS--------LSLAIICDRGDGDYYYRGERL
Mvan_1066|M.vanbaalenii_PYR-1 FVGHTARCDSGSTPAALIRTS--------LSLAIICETSDGDYYYRGERL
MSMEG_4366|M.smegmatis_MC2_155 FVGHTARCDSDATPAALIRTA--------TSLAIICERDSGGYYYRGERL
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 FIGETARCDPGNPPAAVVRTA--------KSLAVVCQNLSGSYYYRGERI
Mb1297c|M.bovis_AF2122/97 MDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVN
Rv1266c|M.tuberculosis_H37Rv MDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVN
MMAR_4156|M.marinum_M LLSYLPSGYASGVCTATTPKPNSVWTGAVAMYNCGQNTNDGGPSRAVYG-
MUL_3180|M.ulcerans_Agy99 PCGAFIRSYASDIDAAVANKKLAVR----YHLLNFLDEQSHTKTYSTRAV
MLBr_00017|M.leprae_Br4923 INSYAGNEQHQPPTPTVTDTG---------TPPATKTLSGFPAAYCEYRV
MAB_0034c|M.abscessus_ATCC_199 LQASEKKNQTPSIPATVSGSE---------TPSSPGSAS-----------
Mflv_5210|M.gilvum_PYR-GCK RDGANREIDGARRSGDGFTVTG-SDGARYDVQPDQ----LTISSGGSVDS
Mvan_1066|M.vanbaalenii_PYR-1 RDGANREIQGAQRSGDGFVVTG-SDGARYDVQPDQ----LTISSNGSVDS
MSMEG_4366|M.smegmatis_MC2_155 RDGANLKIDDAQRSGDGYVAVNPADGARYEVSPEG----LTIMSNGHVDS
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 RDGAHIELSNAERVEDGFDVTNPVDGVVYEVRPNR----LRIISFGHVDS
Mb1297c|M.bovis_AF2122/97 QAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKAKTYRWTFADVKGS
Rv1266c|M.tuberculosis_H37Rv QAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKAKTYRWTFADVKGS
MMAR_4156|M.marinum_M --LFPSLEALKQAFNDDIAAVDLANCPGEGPSPD------GWHYDRTPDV
MUL_3180|M.ulcerans_Agy99 AASYCVAAQDDPKVYTDFYAALFASDFQPQEAAAS-----DRTDAELAHL
MLBr_00017|M.leprae_Br4923 NWTNHKEISNSGLPKQAARAQLAGAIDISPVAGQT---------------
MAB_0034c|M.abscessus_ATCC_199 ----------PGALAPANIVALLPDAEPDPIPGTKSP-------------
Mflv_5210|M.gilvum_PYR-GCK AEPALEYGSAQ---------------------------------------
Mvan_1066|M.vanbaalenii_PYR-1 AEPALEYGSAQ---------------------------------------
MSMEG_4366|M.smegmatis_MC2_155 SEPPEEYGSK----------------------------------------
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 SEPVLQYATAS---------------------------------------
Mb1297c|M.bovis_AF2122/97 PPTITVIDTQEGAEGWECQRAMSVANNV-VVDVNACGYQITNQAGQIAAK
Rv1266c|M.tuberculosis_H37Rv PPTITVIDTQEGAEGWECQRAMSVANNV-VVDVNACGYRITNQAGQIAAK
MMAR_4156|M.marinum_M TAGMIACGTYKNHP-----NVIWSNDDK-LMLSDAFGDPATLDELHTWWA
MUL_3180|M.ulcerans_Agy99 AQTVGANGTAT--------SCIKAGNDMGTARTKAAAADATLSELNAGLR
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5210|M.gilvum_PYR-GCK --------
Mvan_1066|M.vanbaalenii_PYR-1 --------
MSMEG_4366|M.smegmatis_MC2_155 --------
TH_4409|M.thermoresistible__bu --------
MAV_2158|M.avium_104 --------
Mb1297c|M.bovis_AF2122/97 IVDKVNKE
Rv1266c|M.tuberculosis_H37Rv IVDKVNKE
MMAR_4156|M.marinum_M KYG-----
MUL_3180|M.ulcerans_Agy99 RC------
MLBr_00017|M.leprae_Br4923 --------
MAB_0034c|M.abscessus_ATCC_199 --------