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VSSSSRGSRLGTRLGPYELRSLIGTGTLGEVYRAYDTVKDRLVALKLLRGELDAGFRQRLWRECRAVTRL QEPHVLPLHDFGEIDGVPFIDMQLVDDGGSLKELLREQGGLEPSRAASITGQVARALDAAHAAGLMHLDV KPENILLTHDHFTYLADFGLAQAAGDEKLSRTYMAPERFTTGSLGPQTDIYSLACVLYECLTGQPPFEGA DPGELRSAHLLSPAPRPSIMRRGVGRAFDDIITRGMAKQRSARFASAGELARAASEAVFAAYEPVSAAAG LGGPRPLPAPPAQFDDPDDTLGPPPVGERPPRGPAGRLPVVVTAVAVLMLIAGVVLSVKTVVGTHHNNSA PPPAPTTRALAPPPPTTPPPPLTPTLSRPVTGADGLGFIGETARCDPGNPPAAVVRTAKSLAVVCQNLSG SYYYRGERIRDGAHIELSNAERVEDGFDVTNPVDGVVYEVRPNRLRIISFGHVDSSEPVLQYATAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2158 | - | - | 100% (486) | serine/threonine protein kinase |
| M. avium 104 | MAV_1417 | - | 3e-78 | 38.83% (497) | serine/threonine-protein kinase PknE |
| M. avium 104 | MAV_3463 | - | 2e-64 | 42.16% (370) | protein kinase/peptidyl-prolyl cis-trans isomerase, |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 1e-76 | 46.67% (330) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_5210 | - | 1e-129 | 51.09% (505) | protein kinase |
| M. tuberculosis H37Rv | Rv1266c | pknH | 4e-78 | 43.93% (387) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | MLBr_00897 | - | 1e-39 | 36.58% (257) | serine-threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_1988c | - | 5e-44 | 38.82% (255) | serine/threonine protein kinase |
| M. marinum M | MMAR_1982 | pknH_2 | 3e-83 | 45.84% (397) | transmembrane serine/threonine-protein kinase H PknH_2 |
| M. smegmatis MC2 155 | MSMEG_4366 | - | 1e-126 | 48.66% (522) | serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_4409 | - | 2e-63 | 64.58% (192) | PUTATIVE serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_3180 | pknE | 4e-82 | 43.06% (432) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_1066 | - | 1e-129 | 50.40% (502) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5210|M.gilvum_PYR-GCK ----MS--TPQGGARLGTRFGPYELHSVIGVGGMGEVYRAYDTARERMVA
Mvan_1066|M.vanbaalenii_PYR-1 ----MS--TPKGGSRLGTRFGPYELQSVIGVGGMGEVYRAYDTARERMVA
MSMEG_4366|M.smegmatis_MC2_155 ----MTPMASNGASRLGTRFGPYELRSLIGVGGMGEVYRAYDTVKGREVA
TH_4409|M.thermoresistible__bu ----MT--SSSGGSRVGTRFGPYELRSLIGVGGMGEVYRAYDTVRGRMVA
MAV_2158|M.avium_104 ----MS--SSSRGSRLGTRLGPYELRSLIGTGTLGEVYRAYDTVKDRLVA
Mb1297c|M.bovis_AF2122/97 ----MS--DAQ-DSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVA
Rv1266c|M.tuberculosis_H37Rv ----MS--DAQ-DSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVA
MUL_3180|M.ulcerans_Agy99 ----MS--DATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVRERVVA
MMAR_1982|M.marinum_M ----MS--ASARRSRVGTRFGPYYLKRQLGTGGMGEVYEAVDTVRQRVVA
MLBr_00897|M.leprae_Br4923 -----------------MLDGRYLLKAKIGNGGTATVYRGVDIRLDRPVA
MAB_1988c|M.abscessus_ATCC_199 MTSPKSPTGRLDPMIGAVLDGRYRIEAPIATGGMSTVYRGLDTRLDRPVA
* * :. :. * . **.. . **
Mflv_5210|M.gilvum_PYR-GCK IKLLRPEMAADHSFQERFRRESRVAARLQEPHVIPVHNFGEIDGVLYIDM
Mvan_1066|M.vanbaalenii_PYR-1 IKLLRPEMAADHSFQERFRRESRVAARLQEPHVIPVHDFGEIDGVLYIDM
MSMEG_4366|M.smegmatis_MC2_155 VKLLRAEFAADPRFQERFRRESRVAARLQEPHVIPVHDFGDIDGVLYIDM
TH_4409|M.thermoresistible__bu LKLLRPELAADPNFQERFRRESRLAARLQEPHVIPVHDFGDIDGVLYIDM
MAV_2158|M.avium_104 LKLLRGELDAG--FRQRLWRECRAVTRLQEPHVLPLHDFGEIDGVPFIDM
Mb1297c|M.bovis_AF2122/97 VKLMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEM
Rv1266c|M.tuberculosis_H37Rv VKLMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEM
MUL_3180|M.ulcerans_Agy99 LKLMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQLYVDM
MMAR_1982|M.marinum_M LKLMSESLSHDPVFRMRMQREARNAGRLQEPHVVPIHDYGEIDGQLYLDM
MLBr_00897|M.leprae_Br4923 VKVMDSRYTGDEQLLTRFQLEARSVARLKDPGLVAVYDQGIDARHPFLVM
MAB_1988c|M.abscessus_ATCC_199 VKVMDSRYASDSGFLARFRLEARAVARLRHPGLVAVFDQGMDGRHPFLVM
:*:: . : *: *.* . **:.* ::.:.: * :: *
Mflv_5210|M.gilvum_PYR-GCK RLVE-GASLKEVLRSDGPLQPARAVSIIRQVAAALDDAHANGLVHRDIKP
Mvan_1066|M.vanbaalenii_PYR-1 RLVE-GASLKDVLRAEGALPPARAVSILRQVAAALDAAHANGLVHRDIKP
MSMEG_4366|M.smegmatis_MC2_155 RLVE-GASLKDILRTDGPLDPRRTASIVAQVASALDAAHADGLVHRDIKP
TH_4409|M.thermoresistible__bu RLVD-GASLKDILRSSGPLEPARAAAIIKQVAAALDAAHADGLIHRDIKP
MAV_2158|M.avium_104 QLVDDGGSLKELLREQGGLEPSRAASITGQVARALDAAHAAGLMHLDVKP
Mb1297c|M.bovis_AF2122/97 RLVE-GTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKP
Rv1266c|M.tuberculosis_H37Rv RLVE-GTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKP
MUL_3180|M.ulcerans_Agy99 RLID-GKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDVKP
MMAR_1982|M.marinum_M RLIE-GTHLALLLERFGPVTPPWAVALVHQVASALDAAHAAGVMHRDVKP
MLBr_00897|M.leprae_Br4923 ELIE-GGTLRELLAERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKP
MAB_1988c|M.abscessus_ATCC_199 ELID-GGTLRELLRERGPMPPHAVAAVFNPLLGGLAVAHRSGLVHRDVKP
.*:: * * :* * : * ..:: : .* ** *: * *:**
Mflv_5210|M.gilvum_PYR-GCK ENVLLTGDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGERG
Mvan_1066|M.vanbaalenii_PYR-1 ENVLLTPDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGERG
MSMEG_4366|M.smegmatis_MC2_155 ENVLLTGDDFAYLVDFGIAHVGGEASVTMTGMLIGSSAYMAPERFSGETV
TH_4409|M.thermoresistible__bu ENVLLTADDFAYLVDFGIAHAGGDAGVTRTGMLIGSSAYMAPERFANGRV
MAV_2158|M.avium_104 ENILLTHDHFTYLADFGLAQAAGDEKLSRT--------YMAPERFTTGSL
Mb1297c|M.bovis_AF2122/97 QNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEV
Rv1266c|M.tuberculosis_H37Rv QNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEV
MUL_3180|M.ulcerans_Agy99 ENILVSHDDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSGDV
MMAR_1982|M.marinum_M ENILVTQDDFVYLVDFGIASAATDEKLTQIGSAVGTWRYMAPERFSDAEV
MLBr_00897|M.leprae_Br4923 ENILISDDGDVKIADFGLVRAVAAAGITSTSVILGTVAYLSPEQVRDGDA
MAB_1988c|M.abscessus_ATCC_199 ENVLISDDGEVKLADFGLVRAVAEAGITSTSVILGTAAYLSPEQVRTGSA
:*:*:: * . :.***:. :: *::**:.
Mflv_5210|M.gilvum_PYR-GCK GPASDIYSLACLLYESLTGRAPFEAADVRQVWSAHMFAAPPRPSIMRRGV
Mvan_1066|M.vanbaalenii_PYR-1 GPASDVYSLACLLYESLTGRAPFEAADVRQVWSAHMFAPPPRPSIMRRGV
MSMEG_4366|M.smegmatis_MC2_155 GPPADIYALACLVYESLIGRPPYEAGDLRQLMSAHMFSAPPRPSIMRRGV
TH_4409|M.thermoresistible__bu X-------------------------------------XSPR--------
MAV_2158|M.avium_104 GPQTDIYSLACVLYECLTGQPPFEGADPGELRSAHLLSPAPRPSIMRRGV
Mb1297c|M.bovis_AF2122/97 TYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGI
Rv1266c|M.tuberculosis_H37Rv TYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGI
MUL_3180|M.ulcerans_Agy99 TYRADIYALACVLYECLTGSPPYRGDQL-SVIGAHLSQPIPRPSAARPGI
MMAR_1982|M.marinum_M NQRADIYSLTCVLHECLTGTPPYRADSAGMLITAHLMAPIPRPSQLRPGI
MLBr_00897|M.leprae_Br4923 SPRSDVYSAGIMTYELLTGHTPFTGDSALSIAYQRLEIDVPRASTVITGV
MAB_1988c|M.abscessus_ATCC_199 GPRSDVYSAGILMYELLTGSTPFTGDTPLALAYQRIDRDVQAPSEAIDGV
Mflv_5210|M.gilvum_PYR-GCK SRAFDDVIARGMAKNPTERYATAGELARAAA-AAAS-AAPVAEPVP----
Mvan_1066|M.vanbaalenii_PYR-1 SRTFDDVVARGMAKQPHDRYPTAGELARAAS-AAAE-GAPAAETVA----
MSMEG_4366|M.smegmatis_MC2_155 PRAFDEVIATAMAKDPAARYATAGELARAVS-AAAAGEAPPSKPTP----
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 GRAFDDIITRGMAKQRSARFASAGELARAASEAVFAAYEPVSAAAG----
Mb1297c|M.bovis_AF2122/97 PKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQ
Rv1266c|M.tuberculosis_H37Rv PKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQ
MUL_3180|M.ulcerans_Agy99 PAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQRSQ
MMAR_1982|M.marinum_M PATFDAVIARGMAKRPEDRFASAGELAAAAHQALSAPHQAQEFRILKRSE
MLBr_00897|M.leprae_Br4923 PQQFDELVARATVRDPSGRYADAIEMAAQVDSIAEELALPP---------
MAB_1988c|M.abscessus_ATCC_199 PEEFDELVLRATSRDPDARYADAAQFGAELDAISSELRLPP---------
Mflv_5210|M.gilvum_PYR-GCK --------------------------PVTP----PSTRQFS---------
Mvan_1066|M.vanbaalenii_PYR-1 --------------------------PVTP----PSTRQFS---------
MSMEG_4366|M.smegmatis_MC2_155 --------------------------PQVPGRPPTPTRQFS---------
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 --------------------------LGGPRPLPAPPAQFD---------
Mb1297c|M.bovis_AF2122/97 ES-TLPG-----------TAAVTAQPPTMPTVTPPPIQAAP---------
Rv1266c|M.tuberculosis_H37Rv ES-TLPAPPKPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQ
MUL_3180|M.ulcerans_Agy99 VA-QLPAG--------FASTSPGGFAPSSPAVPVPGSAPST---------
MMAR_1982|M.marinum_M EAGGLHTD----------AAAEAGITFASPSTASPSAPTPVAS-------
MLBr_00897|M.leprae_Br4923 -------------------------------FRVPAPRNTA---------
MAB_1988c|M.abscessus_ATCC_199 -------------------------------FRVPAPRDSK---------
Mflv_5210|M.gilvum_PYR-GCK ------------------------GVHP---------------------A
Mvan_1066|M.vanbaalenii_PYR-1 ------------------------TVYP---------------------T
MSMEG_4366|M.smegmatis_MC2_155 ------------------------ELYPNPEHTGFTPYPPAYPSVPAPPR
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 ------------------------DPDD----------------------
Mb1297c|M.bovis_AF2122/97 ----------TGQPSWAPN---SGPMPASGPTPTPQY-YQGGGWG----A
Rv1266c|M.tuberculosis_H37Rv PGPAGQRPGPTGQPSWAPN---SGPMPASGPTPTPQY-YQGGGWG----A
MUL_3180|M.ulcerans_Agy99 -----------GWPAPSVP---GAPVAPSAPVPTPWAGVPGWGVG----H
MMAR_1982|M.marinum_M ----------TSQPDLRISGPLSIPSFPTSEANVPLFDASTSSWGDLTAA
MLBr_00897|M.leprae_Br4923 --------------------------------------------------
MAB_1988c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5210|M.gilvum_PYR-GCK MTP-PPAPAPIAA-------ARRPGRGQGALVAGIVVMFVAAAVLALVLV
Mvan_1066|M.vanbaalenii_PYR-1 PPPMPPMPAVAPP-------ARRFSRGQVGLVAATVVMFTAALVLAAVLV
MSMEG_4366|M.smegmatis_MC2_155 RTPTPPAPAAVAAPAVRTPGKKRFTRTQMMLVVATVVLFGIAAVLATMLV
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 -TLGPPPVGERPP-------RGPAGRLPVVVTAVAVLMLIAGVVLSVKTV
Mb1297c|M.bovis_AF2122/97 PPSGGPSPWAQTPR----KTNPWPLVAGAAAVVLVLVLGAIGIWIANRPK
Rv1266c|M.tuberculosis_H37Rv PPSGGPSPWAQTPR----KTNPWPLVAGAAAVVLVLVLGAIGIWIAIRPK
MUL_3180|M.ulcerans_Agy99 TGTTGAPPWGQPPPEPTVAAKTWPWIA-AAVAVVVVIAGVLGVVIAHPWR
MMAR_1982|M.marinum_M PPPQAPPAPPTPPTPPVPPTPPQPPKQTSDTSPSGPGPHSLAARLRNPWM
MLBr_00897|M.leprae_Br4923 -------------------------QYRSAALHRGHMVER---PVEQQVQ
MAB_1988c|M.abscessus_ATCC_199 -------------------------QHVAEQLYRSRLIDSGGNTTGNLSA
Mflv_5210|M.gilvum_PYR-GCK FTGGSDPQP-PRIAAP-------------PSSSSDTSTPPSTSAVEG---
Mvan_1066|M.vanbaalenii_PYR-1 FSGGDTGSPSPRIAAP-------------PSSSSEAPSTSSASAVEG---
MSMEG_4366|M.smegmatis_MC2_155 GGDDNASTGNTGITPPEGAT---------STSESTTTTTSNRSATAN---
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 VGTHHNNSAPPPAPTTRALA---------PPPPTTPPPPLTPTLSRP---
Mb1297c|M.bovis_AF2122/97 PVQPPQPVAEER--LSALLLNSSEVNAVMGSSSMQPGKPITSMDSSP-VT
Rv1266c|M.tuberculosis_H37Rv PVQPPQPVAEER--LSALLLNSSEVNAVMGSSSMQPGKPITSMDSSP-VT
MUL_3180|M.ulcerans_Agy99 SPGPPTASAPPPPPPDAVQLRVLNDGVFIGSSAATTTIDIFNEPICPPCG
MMAR_1982|M.marinum_M LLGAAALVALIVFAAQGIWLSFRPK----SESASTSPSTASPSAPSPASA
MLBr_00897|M.leprae_Br4923 P----VVNAPMP--------------------------------------
MAB_1988c|M.abscessus_ATCC_199 PGQADAADAASA--------------------------------------
Mflv_5210|M.gilvum_PYR-GCK ----------------------VSGTDSQGFVGHTARCDSGDTPAALIRT
Mvan_1066|M.vanbaalenii_PYR-1 ----------------------VSGTDSQGFVGHTARCDSGSTPAALIRT
MSMEG_4366|M.smegmatis_MC2_155 ----------------------VSGTDEQGFVGHTARCDSDATPAALIRT
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 ----------------------VTGADGLGFIGETARCDPGNPPAAVVRT
Mb1297c|M.bovis_AF2122/97 VSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVNQAVVAFP
Rv1266c|M.tuberculosis_H37Rv VSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVNQAVVAFP
MUL_3180|M.ulcerans_Agy99 AFIRSYASDIDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRAVAASYCVA
MMAR_1982|M.marinum_M DALARLLSTLPLGYAPGTCRAFLPAKDSLARVTCDKNVDPGG-PSRGVYT
MLBr_00897|M.leprae_Br4923 -----------------------HSTRQFTRRLRDCSAPRRP-------A
MAB_1988c|M.abscessus_ATCC_199 -----------------------AAALGVSARPSTPPRPRVPNPTRMMDP
Mflv_5210|M.gilvum_PYR-GCK SLSLAIICDRGDGDYYYRGERLRDGANREIDGARRSGDGFTVTG-SDGAR
Mvan_1066|M.vanbaalenii_PYR-1 SLSLAIICETSDGDYYYRGERLRDGANREIQGAQRSGDGFVVTG-SDGAR
MSMEG_4366|M.smegmatis_MC2_155 ATSLAIICERDSGGYYYRGERLRDGANLKIDDAQRSGDGYVAVNPADGAR
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 AKSLAVVCQNLSGSYYYRGERIRDGAHIELSNAERVEDGFDVTNPVDGVV
Mb1297c|M.bovis_AF2122/97 TADKARAFVQTSADKWKN-CAGKTVTVTNKAKTYRWTFADVKGSPPTITV
Rv1266c|M.tuberculosis_H37Rv TADKARAFVQTSADKWKN-CAGKTVTVTNKAKTYRWTFADVKGSPPTITV
MUL_3180|M.ulcerans_Agy99 AQDDPKVYTDFYAALFASDFQPQEAAASDRTDAELAHLAQTVGANGTATS
MMAR_1982|M.marinum_M LFGETATLRQYFDGLLRTDIMVDCPGEKKSPTAWHHPDSPQVGG---MIF
MLBr_00897|M.leprae_Br4923 RPDIDSPEEYEYEPVPDR---FAGIAISEFIWARQHARRMVLIWVGVVVA
MAB_1988c|M.abscessus_ATCC_199 VPAYDAGYDEEFDGEPDESAFFADIDDSDYRYERQQSRRAIFIWLVIVLI
Mflv_5210|M.gilvum_PYR-GCK YDVQPDQLTISSGGSVDSAEPALEYGSAQ---------------------
Mvan_1066|M.vanbaalenii_PYR-1 YDVQPDQLTISSNGSVDSAEPALEYGSAQ---------------------
MSMEG_4366|M.smegmatis_MC2_155 YEVSPEGLTIMSNGHVDSSEPPEEYGSK----------------------
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 YEVRPNRLRIISFGHVDSSEPVLQYATAS---------------------
Mb1297c|M.bovis_AF2122/97 IDTQEGAEGWECQRAMSVANNVVVDVNACGYQITNQAGQIAAKIVDKVNK
Rv1266c|M.tuberculosis_H37Rv IDTQEGAEGWECQRAMSVANNVVVDVNACGYRITNQAGQIAAKIVDKVNK
MUL_3180|M.ulcerans_Agy99 C-IKAGNDMGTARTKAAAADATLSELNAGLRRC-----------------
MMAR_1982|M.marinum_M CAIQEGSPSVVWTNEAQLMISVVQGDPRGPNLEELYSWWKKHS-------
MLBr_00897|M.leprae_Br4923 IAGLVATVAWTIGSHLSGLL------------------------------
MAB_1988c|M.abscessus_ATCC_199 LTSSVAAGCWSLGANITNLL------------------------------
Mflv_5210|M.gilvum_PYR-GCK -
Mvan_1066|M.vanbaalenii_PYR-1 -
MSMEG_4366|M.smegmatis_MC2_155 -
TH_4409|M.thermoresistible__bu -
MAV_2158|M.avium_104 -
Mb1297c|M.bovis_AF2122/97 E
Rv1266c|M.tuberculosis_H37Rv E
MUL_3180|M.ulcerans_Agy99 -
MMAR_1982|M.marinum_M -
MLBr_00897|M.leprae_Br4923 -
MAB_1988c|M.abscessus_ATCC_199 -