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SPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKVLKGEFSSDPEFIERFRAEARTTAMLNHP GIASVHDYGESHMDGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRD VKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDATPASDVYSLGVIGYEVV SGKRPFTGDGALTVAMKHIKEPPPPLPADLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPP RPNQTPSSGRASPTTIPSSTQARAAVACGTKTPAPRRSRPSTSGNRPPPARNTFSSGQRALLWAAGMLGA LAIIIAVLIVINSYAGNEQHQPPTPTVTDTGTPPATKTLSGFPAAYCEYRVNWTNHKEISNSGLPKQAAR AQLAGAIDISPVAGQT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00017 | pknA | - | 100% (437) | putative serine/threonine protein kinase |
| M. leprae Br4923 | MLBr_00016 | pknB | 3e-58 | 35.99% (364) | putative serine/threonine protein kinase |
| M. leprae Br4923 | MLBr_00897 | - | 8e-52 | 41.63% (257) | serine-threonine protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0015c | pknA | 0.0 | 80.97% (431) | transmembrane serine/threonine-protein kinase A PKNA |
| M. gilvum PYR-GCK | Mflv_0811 | - | 1e-175 | 79.49% (390) | protein kinase |
| M. tuberculosis H37Rv | Rv0015c | pknA | 0.0 | 80.97% (431) | transmembrane serine/threonine-protein kinase A PKNA |
| M. abscessus ATCC 19977 | MAB_0034c | - | 1e-168 | 75.13% (398) | putative serine/threonine-protein kinase PknA |
| M. marinum M | MMAR_0017 | pknA | 0.0 | 83.13% (415) | serine/threonine-protein kinase a PknA |
| M. avium 104 | MAV_0019 | - | 0.0 | 82.62% (420) | serine/threonine protein kinases Drp72 |
| M. smegmatis MC2 155 | MSMEG_0030 | pknA | 0.0 | 80.15% (398) | serine/threonine protein kinase PknA |
| M. thermoresistible (build 8) | TH_2631 | - | 5e-62 | 37.77% (368) | PUTATIVE serine/threonine protein kinase |
| M. ulcerans Agy99 | MUL_0019 | pknA | 0.0 | 82.17% (415) | serine/threonine-protein kinase a PknA |
| M. vanbaalenii PYR-1 | Mvan_0024 | - | 1e-175 | 79.39% (393) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0811|M.gilvum_PYR-GCK MSPRVGVTLSGRYRLQRLIATGGMGQVWEGVDSRLGRRVAIKVLKAEYST
Mvan_0024|M.vanbaalenii_PYR-1 MSPRVGVTLSGRYRLQRLIATGGMGQVWEGVDSRLGRRVAIKVLKAEYST
MSMEG_0030|M.smegmatis_MC2_155 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDSRLGRRVAVKVLKAEFST
MAB_0034c|M.abscessus_ATCC_199 MTVRVGETLSGRYRLQRLIATGGMGQVWEGTDSRLGRKVAVKVLKAEFSS
MMAR_0017|M.marinum_M MSPRVGMTLSGRYRLQRLIATGGMGQVWEAVDSRLGRRVAVKVLKQEFSS
MUL_0019|M.ulcerans_Agy99 MSPIVGMTLSGRYRLQRLIATGGMGQVWEAVDSRLGRRVAVKVLKQEFSS
MAV_0019|M.avium_104 ------MTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKQEFSQ
Mb0015c|M.bovis_AF2122/97 MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSS
Rv0015c|M.tuberculosis_H37Rv MSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSS
MLBr_00017|M.leprae_Br4923 MSPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKVLKGEFSS
TH_2631|M.thermoresistible__bu --MTTPQHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLAR
**.**.* .::. ***.:* . * ** * **:***: : :
Mflv_0811|M.gilvum_PYR-GCK DSEFVERFRAEARTVAMLNHPGIAGVYDYGETDIDGEGRTAYLVMELVNG
Mvan_0024|M.vanbaalenii_PYR-1 DAEFVERFRAEARTVAMLNHPGIAGVYDYGETDIDGEGRTAYLVMELVNG
MSMEG_0030|M.smegmatis_MC2_155 DAEFVERFRAEARTVAMLNHPGIASVYDYGETELDGEGRTAYLVMELING
MAB_0034c|M.abscessus_ATCC_199 DPEFIERFRAEARTVAMLNHPGIASVYDYGETDIDSEGRTAYLVMELIHG
MMAR_0017|M.marinum_M DPEFIERFRAEARTTAMLNHPGIAAVHDYGESQMNGEGRTAYLVMELVNG
MUL_0019|M.ulcerans_Agy99 DPEFIERFRAEARTTAMLNHPGIAAVHDYGESQMNGEGRTAYLVMELVNG
MAV_0019|M.avium_104 DPEFIERFRAEARTTAMLNHPGIAAVHDYGESQLDGEGRTAYLVMELVNG
Mb0015c|M.bovis_AF2122/97 DPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNG
Rv0015c|M.tuberculosis_H37Rv DPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNG
MLBr_00017|M.leprae_Br4923 DPEFIERFRAEARTTAMLNHPGIASVHDYGESHMDGEGRTAYLVMELVNG
TH_2631|M.thermoresistible__bu DPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETP-TGPLPYIVMEYVDG
*..* *** **:..* ****.*..*:* **:. * .*:*** :.*
Mflv_0811|M.gilvum_PYR-GCK EPLNSVIKRTGRLSLRHALDMLEQTGRALQVAHSAGLVHRDVKPGNILIT
Mvan_0024|M.vanbaalenii_PYR-1 EPLNSVIKRTGRLSLRHALDMLEQTGRALQVAHSAGLVHRDVKPGNILIT
MSMEG_0030|M.smegmatis_MC2_155 EPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHTAGLVHRDVKPGNILIT
MAB_0034c|M.abscessus_ATCC_199 EPLNSVLKRTGRLSLRHSLDMLEQTGRALQVAHAAGLVHRDVKPGNILIT
MMAR_0017|M.marinum_M EPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHAAGLVHRDVKPGNILIT
MUL_0019|M.ulcerans_Agy99 EPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHAAGLVHRDVKPGNILIT
MAV_0019|M.avium_104 EPLNSVLKRTGRLSLRHALDMLEQTGRALQVAHAAGLVHRDVKPGNILIT
Mb0015c|M.bovis_AF2122/97 EPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILIT
Rv0015c|M.tuberculosis_H37Rv EPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILIT
MLBr_00017|M.leprae_Br4923 EPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILIT
TH_2631|M.thermoresistible__bu VTLRDIVHTDGPMEPKRAIEVIADACQALNFSHQHGIIHRDVKPANIMIS
.*..::: * :. ::::::: :: :**:.:* *::******.**:*:
Mflv_0811|M.gilvum_PYR-GCK PTGQVKLTDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGHDATAASD
Mvan_0024|M.vanbaalenii_PYR-1 PTGQVKLTDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGHDATAASD
MSMEG_0030|M.smegmatis_MC2_155 PTGQVKLTDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGHDATAASD
MAB_0034c|M.abscessus_ATCC_199 PTGQVKLTDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGHDATPASD
MMAR_0017|M.marinum_M PTGQVKITDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGQDASPSSD
MUL_0019|M.ulcerans_Agy99 PTGQVKITDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGQDASPSSD
MAV_0019|M.avium_104 PTGQVKITDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGHDATPASD
Mb0015c|M.bovis_AF2122/97 PTGQVKITDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGHDASPASD
Rv0015c|M.tuberculosis_H37Rv PTGQVKITDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGHDASPASD
MLBr_00017|M.leprae_Br4923 PTGQVKITDFGIAKAVDAAP-VTQTGMVMGTAQYIAPEQALGHDATPASD
TH_2631|M.thermoresistible__bu KTGAVKVMDFGIARAIADSNSVTQTAAVIGTAQYLSPEQARGETVDARSD
** **: *****:*: : ****. *:*****::**** *. . . **
Mflv_0811|M.gilvum_PYR-GCK VYSLGVVGYEAVSGKRPFTGDGALTVAMKHIKETPPPLP---ADLPPNVR
Mvan_0024|M.vanbaalenii_PYR-1 VYSLGVVGYEAVSGKRPFIGDGALTVAMKHIKETPPPLP---ADLPPNVR
MSMEG_0030|M.smegmatis_MC2_155 VYSLGVVGYESVSGKRPFTGDGALTVAMKHIKETPPPLP---ADLPPNVR
MAB_0034c|M.abscessus_ATCC_199 VYSLGVVGYEAVSGKRPFSGDGALTVAMKHIKETPSPLP---ADLPPNVR
MMAR_0017|M.marinum_M VYSLGVVGYEAVSGKRPFTGDGALTVAMKHIKEPPPPLP---AELPPNVR
MUL_0019|M.ulcerans_Agy99 VYSLGVVGYEAVSGKRPFTGDGALTVAMKHIKEPPPPLP---AELPPNVR
MAV_0019|M.avium_104 VYSLGVVGYEVVSGKRPFSGDGALTVAMKHIKEPPPPLP---AELPPNVR
Mb0015c|M.bovis_AF2122/97 VYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLP---PDLPPNVR
Rv0015c|M.tuberculosis_H37Rv VYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLP---PDLPPNVR
MLBr_00017|M.leprae_Br4923 VYSLGVIGYEVVSGKRPFTGDGALTVAMKHIKEPPPPLP---ADLPPNVR
TH_2631|M.thermoresistible__bu VYSLGCVLYEILTGEPPFVGDSPVAVAYQHVREDPVPPSRRNPAVSPELD
***** : ** ::*: ** **..::** :*::* * * . . :.*::
Mflv_0811|M.gilvum_PYR-GCK ELIEITLVKNPGMRYKSGGPFADAVAAVRAGRRPPRPNAAPSIGRAAPAA
Mvan_0024|M.vanbaalenii_PYR-1 ELIEITLVKNPGMRYKSGGPFADAVAAVRAGRRPPRPNAAPSIGRAAPTA
MSMEG_0030|M.smegmatis_MC2_155 ELIEITLVKNPGMRYKSGGPFADAVAAVRAGRRPPRPNQAPTLGRAAPAA
MAB_0034c|M.abscessus_ATCC_199 ELIEITLVKNPQNRYTSGGPFADAVAAVRAGRRPPRPNQAPTISRATPAA
MMAR_0017|M.marinum_M ELIEITLVKNPGLRYRSGGPFADAVAAVRAGRRPPRPSQSPPAGRAAPAA
MUL_0019|M.ulcerans_Agy99 ELIEITLVKNPGLRYRSGGPFADAVAAVRAGRRPPRPSQSPPAGRAAPAA
MAV_0019|M.avium_104 ELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQSPPPGRASPAA
Mb0015c|M.bovis_AF2122/97 ELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAPAA
Rv0015c|M.tuberculosis_H37Rv ELIEITLVKNPAMRYRSGGPFADAVAAVRAGRRPPRPSQTPPPGRAAPAA
MLBr_00017|M.leprae_Br4923 ELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPPRPNQTPSSGRASPTT
TH_2631|M.thermoresistible__bu AVVLKALAKNPDNRYQTAAEMRADLVRVHSGEQPEAPKVLTDAERTSLLA
:: :*.*** ** :.. : :. *::*.:* *. . *:: :
Mflv_0811|M.gilvum_PYR-GCK VPPAIQNRPPAEATGRAPAQTSRTRTTGSHHRSAPPARRTFSSGQRALLW
Mvan_0024|M.vanbaalenii_PYR-1 VPPAIASRPAADPTGRAPAPTSRTRATGSHHRSAPPPRGGFSSGQRALLW
MSMEG_0030|M.smegmatis_MC2_155 VPSAAQARASADLTGRAPVTAARARPTATAAHRTPPPRRTFSSGQRALLW
MAB_0034c|M.abscessus_ATCC_199 IPPATQVRPAVGAPSRVAPPTSRTRQPTGSHRPPPPRRGTFSPGQKALMW
MMAR_0017|M.marinum_M IPSSAPARIAPAPTTRTTTPR-RTRPATGGH-RPPPARRTFSSGQRALLW
MUL_0019|M.ulcerans_Agy99 IPSSAPARIAPAPTTRTTTPR-RTRPATGGH-RPPPSRRTFSSGQRALLW
MAV_0019|M.avium_104 IPSSPTTRAAAVSSGRTAAPR-RTRPATGGH-RPPPARRTFSSGQRALLW
Mb0015c|M.bovis_AF2122/97 IPSGTTARVAANSAGRTAASR-RSRPATGGH-RPP--RRTFSSGQRALLW
Rv0015c|M.tuberculosis_H37Rv IPSGTTARVAANSAGRTAASR-RSRPATGGH-RPP--RRTFSSGQRALLW
MLBr_00017|M.leprae_Br4923 IPSSTQARAAVACGTKTPAPR-RSRPSTSGN-RPPPARNTFSSGQRALLW
TH_2631|M.thermoresistible__bu SGPAHDRTQPTDAVIDPVIPRYTGSDRGGSVGRWVAAVAVLAVLTVVVTV
.. . :: .:
Mflv_0811|M.gilvum_PYR-GCK AAGVLG------------------ALAIVIAILIVLNHQDQQNSPNRTTN
Mvan_0024|M.vanbaalenii_PYR-1 AAGVLG------------------ALAIVIAILIVLNAQDRKDQPPPTT-
MSMEG_0030|M.smegmatis_MC2_155 AAGVLG------------------ALAIVIAILIVLNAQDRKDREQSPPP
MAB_0034c|M.abscessus_ATCC_199 AAAVLG------------------IFAIIIAALILLQASEKKNQTPSIPA
MMAR_0017|M.marinum_M AAGVLG------------------ALAIIIAVLIVINSRAD-SQQQPPPP
MUL_0019|M.ulcerans_Agy99 AAGVLG------------------ALAIIIAVLIVINSRAD-SQQQSPPP
MAV_0019|M.avium_104 AAGVLG------------------ALAIIIAVLIVINSRAD-QQQQ--PP
Mb0015c|M.bovis_AF2122/97 AAGVLG------------------ALAIIIAVLLVIKAPGDNSPQQAPTP
Rv0015c|M.tuberculosis_H37Rv AAGVLG------------------ALAIIIAVLLVIKAPGDNSPQQAPTP
MLBr_00017|M.leprae_Br4923 AAGMLG------------------ALAIIIAVLIVINSYAGNEQHQPPTP
TH_2631|M.thermoresistible__bu AINMIGGNPRNVQVPDVSGQASADAIAALQNRGFKTRTQQQPDNSVPPDR
* ::* :* : : . .
Mflv_0811|M.gilvum_PYR-GCK TVTETP----GSPPAAPGEGPAETPGAAAPVKPD-EP----GQNRVSGPV
Mvan_0024|M.vanbaalenii_PYR-1 -VTETP----TSQGAPP-----ETPGAAAPAFGDHEP----DRYWVLRPV
MSMEG_0030|M.smegmatis_MC2_155 TVTDTV----TETTPYE-----ETPAAMP------------DLMIMLRAA
MAB_0034c|M.abscessus_ATCC_199 TVSGSE----TPSSPGS-----ASPGALAP------------ANIVALLP
MMAR_0017|M.marinum_M TVTQTTTAHQTPTGQGPRLNWTEGKAIGNPGLQSNQPDLVDDAGRNRPIG
MUL_0019|M.ulcerans_Agy99 TVTQTTTAHQTPTGQGPRLNWTDGQSIGNPGLQSNQPDLVDDAGRNRPIG
MAV_0019|M.avium_104 TVTDTG----TPPASAPPPTKTPSGSGAHPGLRLDWP----DDGTIGASG
Mb0015c|M.bovis_AF2122/97 TVTTTG----NPPASN------TGGTDASP--RLNWT----ERGETRHSG
Rv0015c|M.tuberculosis_H37Rv TVTTTG----NPPASN------TGGTDASP--RLNWT----ERGETRHSG
MLBr_00017|M.leprae_Br4923 TVTDTG----TPPATKT----LSGFPAAYCEYRVNWT----NHKEISNSG
TH_2631|M.thermoresistible__bu VISTDPPADTSVSAGDEITVNVSTGPQQREIPDVSSLTYAEAVRRLSAAG
::
Mflv_0811|M.gilvum_PYR-GCK DT-------ASPSVMLHVSEQILR--------------------------
Mvan_0024|M.vanbaalenii_PYR-1 DN-------LSPLTTRHVSEQNLR--------------------------
MSMEG_0030|M.smegmatis_MC2_155 QP-------EPPP-----SEQIQR--------------------------
MAB_0034c|M.abscessus_ATCC_199 DA-------EPDPIPGTKSP------------------------------
MMAR_0017|M.marinum_M NR-GSATSWNVTVTPQHLAALARFEMQR----------------------
MUL_0019|M.ulcerans_Agy99 NR-DSATSWNVTVTPQHRAALARFEMQR----------------------
MAV_0019|M.avium_104 FRDGPARHWTSQ--------------------------------------
Mb0015c|M.bovis_AF2122/97 LQ-----SWVVPPTPHSRASLARYEIAQ----------------------
Rv0015c|M.tuberculosis_H37Rv LQ-----SWVVPPTPHSRASLARYEIAQ----------------------
MLBr_00017|M.leprae_Br4923 LP-----KQAARAQLAGAIDISPVAGQT----------------------
TH_2631|M.thermoresistible__bu FEKFRQSESPSTPELRGKVVATNPPANQTAAITNEITVVVGTGPATREVP
Mflv_0811|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0024|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0030|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0017|M.marinum_M --------------------------------------------------
MUL_0019|M.ulcerans_Agy99 --------------------------------------------------
MAV_0019|M.avium_104 --------------------------------------------------
Mb0015c|M.bovis_AF2122/97 --------------------------------------------------
Rv0015c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
TH_2631|M.thermoresistible__bu DITGQTVELAERNLSVYGFTKFTQSAVDSTAPAGQVVGTNPPAGTTVSLD
Mflv_0811|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0024|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0030|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_0017|M.marinum_M --------------------------------------------------
MUL_0019|M.ulcerans_Agy99 --------------------------------------------------
MAV_0019|M.avium_104 --------------------------------------------------
Mb0015c|M.bovis_AF2122/97 --------------------------------------------------
Rv0015c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
TH_2631|M.thermoresistible__bu SVIELEVSKGNQFVMPDLIGMFWTDAEPRLRALGWTGVLDKGADIPNSGQ
Mflv_0811|M.gilvum_PYR-GCK ----------------------------
Mvan_0024|M.vanbaalenii_PYR-1 ----------------------------
MSMEG_0030|M.smegmatis_MC2_155 ----------------------------
MAB_0034c|M.abscessus_ATCC_199 ----------------------------
MMAR_0017|M.marinum_M ----------------------------
MUL_0019|M.ulcerans_Agy99 ----------------------------
MAV_0019|M.avium_104 ----------------------------
Mb0015c|M.bovis_AF2122/97 ----------------------------
Rv0015c|M.tuberculosis_H37Rv ----------------------------
MLBr_00017|M.leprae_Br4923 ----------------------------
TH_2631|M.thermoresistible__bu RANAVVRQNPSPGAGVNYDARITLNFAS