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STPQGGARLGTRFGPYELHSVIGVGGMGEVYRAYDTARERMVAIKLLRPEMAADHSFQERFRRESRVAAR LQEPHVIPVHNFGEIDGVLYIDMRLVEGASLKEVLRSDGPLQPARAVSIIRQVAAALDDAHANGLVHRDI KPENVLLTGDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGERGGPASDIYSLACLLYESLT GRAPFEAADVRQVWSAHMFAAPPRPSIMRRGVSRAFDDVIARGMAKNPTERYATAGELARAAAAAASAAP VAEPVPPVTPPSTRQFSGVHPAMTPPPAPAPIAAARRPGRGQGALVAGIVVMFVAAAVLALVLVFTGGSD PQPPRIAAPPSSSSDTSTPPSTSAVEGVSGTDSQGFVGHTARCDSGDTPAALIRTSLSLAIICDRGDGDY YYRGERLRDGANREIDGARRSGDGFTVTGSDGARYDVQPDQLTISSGGSVDSAEPALEYGSAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5210 | - | - | 100% (484) | protein kinase |
| M. gilvum PYR-GCK | Mflv_2026 | - | 1e-95 | 43.53% (425) | protein kinase |
| M. gilvum PYR-GCK | Mflv_5237 | - | 1e-79 | 47.83% (345) | protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1772 | pknE | 6e-91 | 48.21% (390) | transmembrane serine/threonine-protein kinase E |
| M. tuberculosis H37Rv | Rv1743 | pknE | 1e-90 | 48.21% (390) | transmembrane serine/threonine-protein kinase E |
| M. leprae Br4923 | MLBr_00017 | pknA | 2e-56 | 36.32% (391) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_4435 | - | 1e-55 | 39.25% (372) | serine/threonine-protein kinase PknJ |
| M. marinum M | MMAR_2444 | - | 2e-87 | 47.12% (365) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_2158 | - | 1e-129 | 51.09% (505) | serine/threonine protein kinase |
| M. smegmatis MC2 155 | MSMEG_4366 | - | 1e-180 | 66.22% (518) | serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_4409 | - | 2e-87 | 79.17% (192) | PUTATIVE serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_3180 | pknE | 9e-85 | 42.17% (434) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_1066 | - | 0.0 | 86.21% (486) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1772|M.bovis_AF2122/97 -M--DGTAESREGTQFG---------PYRLRRLVGRGGMGDVYEAEDTVR
Rv1743|M.tuberculosis_H37Rv -M--DGTAESREGTQFG---------PYRLRRLVGRGGMGDVYEAEDTVR
MUL_3180|M.ulcerans_Agy99 MS--DATADSREGSQFG---------PYRLRRIVGRGAMGDVYEAEDTVR
Mflv_5210|M.gilvum_PYR-GCK MS--TPQGGARLGTRFG---------PYELHSVIGVGGMGEVYRAYDTAR
Mvan_1066|M.vanbaalenii_PYR-1 MS--TPKGGSRLGTRFG---------PYELQSVIGVGGMGEVYRAYDTAR
MSMEG_4366|M.smegmatis_MC2_155 MTPMASNGASRLGTRFG---------PYELRSLIGVGGMGEVYRAYDTVK
TH_4409|M.thermoresistible__bu MT--SSSGGSRVGTRFG---------PYELRSLIGVGGMGEVYRAYDTVR
MAV_2158|M.avium_104 MS--SSSRGSRLGTRLG---------PYELRSLIGTGTLGEVYRAYDTVK
MMAR_2444|M.marinum_M MS--DTVPTSRVGTQFG---------PYRLRRLLGRGGMGEVYEAHDTVK
MLBr_00017|M.leprae_Br4923 -------MSPRIGVMLSG--------RYRLHRLIATGGMGQVWEAVDSRL
MAB_4435|M.abscessus_ATCC_1997 MTSSDRSSPGPGGQQPGDLPPGTVVSGYQIERVLGRGGMGTVYLAANPNL
* . *.:. ::. * :* *: * :.
Mb1772|M.bovis_AF2122/97 ERIVALKLMSETLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFGEIDG-
Rv1743|M.tuberculosis_H37Rv ERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDG-
MUL_3180|M.ulcerans_Agy99 ERVVALKLMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDG-
Mflv_5210|M.gilvum_PYR-GCK ERMVAIKLLRPEMAADHSFQERFRRESRVAARLQEPHVIPVHNFGEIDG-
Mvan_1066|M.vanbaalenii_PYR-1 ERMVAIKLLRPEMAADHSFQERFRRESRVAARLQEPHVIPVHDFGEIDG-
MSMEG_4366|M.smegmatis_MC2_155 GREVAVKLLRAEFAADPRFQERFRRESRVAARLQEPHVIPVHDFGDIDG-
TH_4409|M.thermoresistible__bu GRMVALKLLRPELAADPNFQERFRRESRLAARLQEPHVIPVHDFGDIDG-
MAV_2158|M.avium_104 DRLVALKLLRGELDAG--FRQRLWRECRAVTRLQEPHVLPLHDFGEIDG-
MMAR_2444|M.marinum_M DRTVALKLMSQQFNSDSTFRRRMQREAHTAGRLQEPHIVPIHDFGEIDG-
MLBr_00017|M.leprae_Br4923 GRRVAVKVLKGEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHMD
MAB_4435|M.abscessus_ATCC_1997 QRSEALKILSAQSSRDPEFRARFMREASLAASLDHPNIVTVHNRGETPEG
* *:*:: . * *: *. . *:.* : .:*: *:
Mb1772|M.bovis_AF2122/97 ----QLYVDMRLIN-GVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA
Rv1743|M.tuberculosis_H37Rv ----QLYVDMRLIN-GVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA
MUL_3180|M.ulcerans_Agy99 ----QLYVDMRLID-GKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHA
Mflv_5210|M.gilvum_PYR-GCK ----VLYIDMRLVE-GASLKEVLRSDGPLQPARAVSIIRQVAAALDDAHA
Mvan_1066|M.vanbaalenii_PYR-1 ----VLYIDMRLVE-GASLKDVLRAEGALPPARAVSILRQVAAALDAAHA
MSMEG_4366|M.smegmatis_MC2_155 ----VLYIDMRLVE-GASLKDILRTDGPLDPRRTASIVAQVASALDAAHA
TH_4409|M.thermoresistible__bu ----VLYIDMRLVD-GASLKDILRSSGPLEPARAAAIIKQVAAALDAAHA
MAV_2158|M.avium_104 ----VPFIDMQLVDDGGSLKELLREQGGLEPSRAASITGQVARALDAAHA
MMAR_2444|M.marinum_M ----QLFIDMRFIE-GTDLGSVLKR-GALPAPRAVAIVSQVAEALDAAHR
MLBr_00017|M.leprae_Br4923 GEGRTAYLVMELVN-GEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHA
MAB_4435|M.abscessus_ATCC_1997 ----DLWIAMQYVQ--GSDAHSESASGRMSLTRAVHIISEVAKALDYLHA
:: *. :: * : :: : : . **: *
Mb1772|M.bovis_AF2122/97 AGATHRDVKPENILVSA-DDFAYLVDFGIASATTDE-KLTQLGNTVGTLY
Rv1743|M.tuberculosis_H37Rv AGATHRDVKPENILVSA-DDFAYLVDFGIASATTDE-KLTQLGNTVGTLY
MUL_3180|M.ulcerans_Agy99 AGVTHRDVKPENILVSH-DDFAYLVDFGIASATSDE-KLTQLGSTVGTLY
Mflv_5210|M.gilvum_PYR-GCK NGLVHRDIKPENVLLTG-DDFAYLVDFGIAHGGGEA-SVTSTGLVVGSSA
Mvan_1066|M.vanbaalenii_PYR-1 NGLVHRDIKPENVLLTP-DDFAYLVDFGIAHGGGEA-SVTSTGLVVGSSA
MSMEG_4366|M.smegmatis_MC2_155 DGLVHRDIKPENVLLTG-DDFAYLVDFGIAHVGGEA-SVTMTGMLIGSSA
TH_4409|M.thermoresistible__bu DGLIHRDIKPENVLLTA-DDFAYLVDFGIAHAGGDA-GVTRTGMLIGSSA
MAV_2158|M.avium_104 AGLMHLDVKPENILLTH-DHFTYLADFGLAQAAGDE-KLSRT--------
MMAR_2444|M.marinum_M GGVVHRDIKPENILITG-NDFAYLVDFGIAAAATDQ-HLTKTGTAVGSWS
MLBr_00017|M.leprae_Br4923 AGLVHRDVKPGNILITP-TGQVKITDFGIAKAVDAA-PVTQTGMVMGTAQ
MAB_4435|M.abscessus_ATCC_1997 RGLVHRDVKPANILLSAGDRRIMLGDFGLTRALDDSNSVTSAGNVTATIA
* * *:** *:*:: : ***:: ::
Mb1772|M.bovis_AF2122/97 YMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLS-VMGAHINQ
Rv1743|M.tuberculosis_H37Rv YMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLS-VMGAHINQ
MUL_3180|M.ulcerans_Agy99 YMAPERFSSGDVTYRADIYALACVLYECLTGSPPYRGDQLS-VIGAHLSQ
Mflv_5210|M.gilvum_PYR-GCK YMAPERFSGERGGPASDIYSLACLLYESLTGRAPFEAADVRQVWSAHMFA
Mvan_1066|M.vanbaalenii_PYR-1 YMAPERFSGERGGPASDVYSLACLLYESLTGRAPFEAADVRQVWSAHMFA
MSMEG_4366|M.smegmatis_MC2_155 YMAPERFSGETVGPPADIYALACLVYESLIGRPPYEAGDLRQLMSAHMFS
TH_4409|M.thermoresistible__bu YMAPERFANGRVX-------------------------------------
MAV_2158|M.avium_104 YMAPERFTTGSLGPQTDIYSLACVLYECLTGQPPFEGADPGELRSAHLLS
MMAR_2444|M.marinum_M YMAPERFGDDEVTYRSDIYALACVLYECLTGTPPYQTQNLSTLMGAHLMQ
MLBr_00017|M.leprae_Br4923 YIAPEQALGHDATPASDVYSLGVIGYEVVSGKRPFTGDGALTVAMKHIKE
MAB_4435|M.abscessus_ATCC_1997 YAAPEILSGTAVDGRADVYALGCTLFRMLTGQPPFGSGNSLPAIINAHLS
* ***
Mb1772|M.bovis_AF2122/97 AIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATAD
Rv1743|M.tuberculosis_H37Rv AIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATAD
MUL_3180|M.ulcerans_Agy99 PIPRPSAARPGIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPD
Mflv_5210|M.gilvum_PYR-GCK APPRPSIMRRGVSRAFDDVIARGMAKNPTERYATAGELARAAA-AAAS-A
Mvan_1066|M.vanbaalenii_PYR-1 PPPRPSIMRRGVSRTFDDVVARGMAKQPHDRYPTAGELARAAS-AAAE-G
MSMEG_4366|M.smegmatis_MC2_155 APPRPSIMRRGVPRAFDEVIATAMAKDPAARYATAGELARAVS-AAAAGE
TH_4409|M.thermoresistible__bu XSPR----------------------------------------------
MAV_2158|M.avium_104 PAPRPSIMRRGVGRAFDDIITRGMAKQRSARFASAGELARAASEAVFAAY
MMAR_2444|M.marinum_M PIPRPSRHRPDIPTAFDEVIARGMAKDPALRYPTAGELARAARQALSAGD
MLBr_00017|M.leprae_Br4923 PPPP---LPADLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHR
MAB_4435|M.abscessus_ATCC_1997 APPPRISQLAPVPESWDALIAKAMAKTPADRYQSAGELAMAAQQILTDPA
*
Mb1772|M.bovis_AF2122/97 QDRATDILRRSQVAKLPV--PSTHP--------------VSPGTRWPQP-
Rv1743|M.tuberculosis_H37Rv QDRATDILRRSQVAKLPV--PSTHP--------------VSPGTRWPQP-
MUL_3180|M.ulcerans_Agy99 QDRATDILQRSQVAQLPAGFASTSPGGFAPSSPAVPVPGSAPSTGWPAPS
Mflv_5210|M.gilvum_PYR-GCK APVAEPVP--PVTP------PSTRQ------------------FSGVHP-
Mvan_1066|M.vanbaalenii_PYR-1 APAAETVA--PVTP------PSTRQ------------------FSTVYP-
MSMEG_4366|M.smegmatis_MC2_155 APPSKPTP--PQVPGRPP--TPTRQ------------------FSELYPN
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 EPVSAAAG--LGGPRPLP--APPAQ------------------FDDPDD-
MMAR_2444|M.marinum_M QERAATLI--AGTHQLAA--PPSGP------------------MPWAPP-
MLBr_00017|M.leprae_Br4923 PPRP----------------------------------------------
MAB_4435|M.abscessus_ATCC_1997 QHRQTVTQPVPATTPAPIAAPEPVH------------------AMAPLAM
Mb1772|M.bovis_AF2122/97 -------------TPWAG------------GAPPWGPPSSPLPRSARQPW
Rv1743|M.tuberculosis_H37Rv -------------TPWAG------------GAPPWGPPSSPLPRSARQPW
MUL_3180|M.ulcerans_Agy99 VPGAPVAPSAPVPTPWAGVPGWGVGHTGTTGAPPWGQPP-PEPTVAAKTW
Mflv_5210|M.gilvum_PYR-GCK ---------------------------AMTP-PPAPAPIAA-------AR
Mvan_1066|M.vanbaalenii_PYR-1 ---------------------------TPPPMPPMPAVAPP-------AR
MSMEG_4366|M.smegmatis_MC2_155 -------PEHTGFTPYPPAYPSVPAPPRRTPTPPAPAAVAAPAVRTPGKK
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 -----------------------------TLGPPPVGERPP-------RG
MMAR_2444|M.marinum_M -----------------------------PWTSPARRTRTP------WLL
MLBr_00017|M.leprae_Br4923 ------------------------------NQTPSSGRASP--------T
MAB_4435|M.abscessus_ATCC_1997 ADTGQSMLKHKRIAAIIGVMVLVVASSVVAVLIWPRADEGTDPRTKASPS
Mb1772|M.bovis_AF2122/97 LWVGVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLN
Rv1743|M.tuberculosis_H37Rv LWVGVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLN
MUL_3180|M.ulcerans_Agy99 PWIAAAVAVVVVIAGVLGVVIAHPWRSPGPPTASAPPPPPPDAVQLRVLN
Mflv_5210|M.gilvum_PYR-GCK RPGRGQGALVAGIVVMFVAAAVLALVLVFTGGSDPQP-PRIAAP----PS
Mvan_1066|M.vanbaalenii_PYR-1 RFSRGQVGLVAATVVMFTAALVLAAVLVFSGGDTGSPSPRIAAP----PS
MSMEG_4366|M.smegmatis_MC2_155 RFTRTQMMLVVATVVLFGIAAVLATMLVGGDDNASTGNTGITPPEGATST
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 PAGRLPVVVTAVAVLMLIAGVVLSVKTVVGTHHNNSAPPPAPTTRALAPP
MMAR_2444|M.marinum_M AVAVLVVVIVVVGTGIFLARKEPASGPTGGVSTTAGAPSGITATAGPTVA
MLBr_00017|M.leprae_Br4923 TIPSSTQARAAVACGTKTPAPRRSRPSTSGNRPPPARNTFSSGQRALLWA
MAB_4435|M.abscessus_ATCC_1997 AAQVAPGASLAGQPNTVLDTLLPGQFDYPEGWEKNPSPTFRSGEFNPAVP
Mb1772|M.bovis_AF2122/97 DGVFVGSSVAPTTIDIFNEPICPPCG------------------------
Rv1743|M.tuberculosis_H37Rv DGVFVGSSVAPTTIDIFNEPICPPCG------------------------
MUL_3180|M.ulcerans_Agy99 DGVFIGSSAATTTIDIFNEPICPPCG------------------------
Mflv_5210|M.gilvum_PYR-GCK SSSDTSTPPSTSAVEGVSGTD-----------------------------
Mvan_1066|M.vanbaalenii_PYR-1 SSSEAPSTSSASAVEGVSGTD-----------------------------
MSMEG_4366|M.smegmatis_MC2_155 SESTTTTTSNRSATANVSGTD-----------------------------
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 PPTTPPPPLTPTLSRPVTGAD-----------------------------
MMAR_2444|M.marinum_M PTQLESFLLSPEQINTIVGTTGIVIDHNATEMTDPGPENSLSTEQCLGAL
MLBr_00017|M.leprae_Br4923 AGMLGALAIIIAVLIVIN--------------------------------
MAB_4435|M.abscessus_ATCC_1997 PGSATNIGGTPVGCNTIDPAWALRAK------------------------
Mb1772|M.bovis_AF2122/97 ---SFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASY
Rv1743|M.tuberculosis_H37Rv ---SFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASY
MUL_3180|M.ulcerans_Agy99 ---AFIRSYASDIDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRAVAASY
Mflv_5210|M.gilvum_PYR-GCK ---------SQGFVGHTARCD--SGDTP------AALIRTSLSLAI----
Mvan_1066|M.vanbaalenii_PYR-1 ---------SQGFVGHTARCD--SGSTP------AALIRTSLSLAI----
MSMEG_4366|M.smegmatis_MC2_155 ---------EQGFVGHTARCD--SDATP------AALIRTATSLAI----
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 ---------GLGFIGETARCD--PGNPP------AAVVRTAKSLAV----
MMAR_2444|M.marinum_M IGYQTRTYKSSGYTGMLAQLMQKPRSTPGYVVVQGAVIFASADQAVGFVA
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_4435|M.abscessus_ATCC_1997 ---GRETSTLYLRDRKKPEREILIRVVPAADALSTDGASDALKRCDAVAY
Mb1772|M.bovis_AF2122/97 CVAGQ----NDPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQTVG
Rv1743|M.tuberculosis_H37Rv CVAGQ----NDPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQTVG
MUL_3180|M.ulcerans_Agy99 CVAAQ----DDPKVYTDFYAALFASDFQPQEAAASDRTDAELAHLAQTVG
Mflv_5210|M.gilvum_PYR-GCK -------------ICDRGDGDYYYRGERLRDGANREIDGARRSGDGFTVT
Mvan_1066|M.vanbaalenii_PYR-1 -------------ICETSDGDYYYRGERLRDGANREIQGAQRSGDGFVVT
MSMEG_4366|M.smegmatis_MC2_155 -------------ICERDSGGYYYRGERLRDGANLKIDDAQRSGDGYVAV
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 -------------VCQNLSGSYYYRGERIRDGAHIELSNAERVEDGFDVT
MMAR_2444|M.marinum_M AQADQWRSCAGKDVTQVNNGKTSRWTFREVSGAPPKISLQRDLADSVVVC
MLBr_00017|M.leprae_Br4923 -------------SYAGNEQHQPPTPTVTDTGTPPATKTLSGFPAAYCEY
MAB_4435|M.abscessus_ATCC_1997 IIPGSSTTWRCSFEFDEPNPVQNGQKELTTTESCYMFPSGANSIRQHVSF
Mb1772|M.bovis_AF2122/97 AEPTAISCIKSGADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQ
Rv1743|M.tuberculosis_H37Rv AEPTAISCIKSGADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQ
MUL_3180|M.ulcerans_Agy99 ANGTATSCIKAGNDMGTARTKAAAADATLSELNAG---------------
Mflv_5210|M.gilvum_PYR-GCK G-SDGARYDVQPDQLTISSGGSVDSAEPALEYGSAQ--------------
Mvan_1066|M.vanbaalenii_PYR-1 G-SDGARYDVQPDQLTISSNGSVDSAEPALEYGSAQ--------------
MSMEG_4366|M.smegmatis_MC2_155 NPADGARYEVSPEGLTIMSNGHVDSSEPPEEYGSK---------------
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 NPVDGVVYEVRPNRLRIISFGHVDSSEPVLQYATAS--------------
MMAR_2444|M.marinum_M QHVLSAVSNIVLDVNVCAPNVTDQASEIADTMAAKVPT------------
MLBr_00017|M.leprae_Br4923 RVNWTNHKEISNSGLPKQAARAQLAGAIDISPVAGQT-------------
MAB_4435|M.abscessus_ATCC_1997 NVVRGLLVYILASGASNRNDAAGSLSATALSFATTMKILRYGR-------
Mb1772|M.bovis_AF2122/97 DPSWLARLIG
Rv1743|M.tuberculosis_H37Rv DPSWLARLIG
MUL_3180|M.ulcerans_Agy99 ----LRRC--
Mflv_5210|M.gilvum_PYR-GCK ----------
Mvan_1066|M.vanbaalenii_PYR-1 ----------
MSMEG_4366|M.smegmatis_MC2_155 ----------
TH_4409|M.thermoresistible__bu ----------
MAV_2158|M.avium_104 ----------
MMAR_2444|M.marinum_M ----------
MLBr_00017|M.leprae_Br4923 ----------
MAB_4435|M.abscessus_ATCC_1997 ----------