For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPDFRTRMQREARTAGR LQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDV KPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIYALTCVLYECLT GSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQ DRATDILRRSQVAKLPVPSTHPVSPGTRWPQPTPWAGGAPPWGPPSSPLPRSARQPWLWVGVAVAVVVAL AGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGVFVGSSVAPTTIDIFNEPICPPCGSFIRSYA SDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASYCVAGQNDPKLYASFYSALFGSDFQPQENAA SDRTDAELAHLAQTVGAEPTAISCIKSGADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSW LARLIG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1772 | pknE | - | 100% (566) | transmembrane serine/threonine-protein kinase E |
| M. bovis AF2122 / 97 | Mb1297c | pknH | e-124 | 53.42% (438) | transmembrane serine/threonine-protein kinase H |
| M. bovis AF2122 / 97 | Mb0955c | pknDa | 4e-98 | 65.30% (268) | serine/threonine protein kinase D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2026 | - | 1e-117 | 57.47% (388) | protein kinase |
| M. tuberculosis H37Rv | Rv1743 | pknE | 0.0 | 99.82% (566) | transmembrane serine/threonine-protein kinase E |
| M. leprae Br4923 | MLBr_00017 | pknA | 4e-49 | 34.21% (380) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_4435 | - | 2e-54 | 38.01% (371) | serine/threonine-protein kinase PknJ |
| M. marinum M | MMAR_2581 | pknE | 0.0 | 73.97% (607) | transmembrane serine/threonine-protein kinase E PknE |
| M. avium 104 | MAV_1417 | - | 1e-123 | 56.09% (419) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_4366 | - | 9e-86 | 49.71% (348) | serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_2947 | - | 2e-66 | 59.05% (210) | PUTATIVE serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_3180 | pknE | 0.0 | 74.01% (581) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_4693 | - | 1e-116 | 55.17% (406) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1772|M.bovis_AF2122/97 ---MDGTAESREGTQFG----------PYRLRRLVGRGGMGDVYEAEDTV
Rv1743|M.tuberculosis_H37Rv ---MDGTAESREGTQFG----------PYRLRRLVGRGGMGDVYEAEDTV
MMAR_2581|M.marinum_M --MSDATADSREGSQFG----------PYRLRRIVGRGAMGDVYEAEDTV
MUL_3180|M.ulcerans_Agy99 --MSDATADSREGSQFG----------PYRLRRIVGRGAMGDVYEAEDTV
MAV_1417|M.avium_104 ---MSDERSSKVGSMFG----------PYHLKRLLGRGGMGEVYEAEHTV
Mflv_2026|M.gilvum_PYR-GCK --MTDPQHGSRVGSQVG----------PYRLQRLLGKGGMGEVYEAYDTV
Mvan_4693|M.vanbaalenii_PYR-1 --MTDPQRGSRVGSQVG----------PYRLRRLLGKGGMGEVYEAEDTV
MSMEG_4366|M.smegmatis_MC2_155 MTPMASNGASRLGTRFG----------PYELRSLIGVGGMGEVYRAYDTV
TH_2947|M.thermoresistible__bu ----MSGPESRAGTRFG----------KYELTALLGRGGMGEVYEAFDTE
MLBr_00017|M.leprae_Br4923 -------MSPRIGVMLSG---------RYRLHRLIATGGMGQVWEAVDSR
MAB_4435|M.abscessus_ATCC_1997 -MTSSDRSSPGPGGQQPGDLPPGTVVSGYQIERVLGRGGMGTVYLAANPN
. * *.: ::. *.** *: * ..
Mb1772|M.bovis_AF2122/97 RERIVALKLMSETLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFGEIDG
Rv1743|M.tuberculosis_H37Rv RERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDG
MMAR_2581|M.marinum_M RERVVALKLMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDG
MUL_3180|M.ulcerans_Agy99 RERVVALKLMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDG
MAV_1417|M.avium_104 KEWTVAVKLLNESFSSDPVFRERMKREARTAGRLQEPHVVPVHDYGEIDG
Mflv_2026|M.gilvum_PYR-GCK KDRVVALKLLPESASHDPVFRKRLQREAHAAGRLQEPHVVPIHDYGEIDG
Mvan_4693|M.vanbaalenii_PYR-1 KDRVVALKLLPEAVSHDPVFRKRLQREAHAAGRLQEPHVVPIHDYGEVDG
MSMEG_4366|M.smegmatis_MC2_155 KGREVAVKLLRAEFAADPRFQERFRRESRVAARLQEPHVIPVHDFGDIDG
TH_2947|M.thermoresistible__bu KRRAVALKILRAEYARDDRFRTRFLRESHAAAILQEPHVIPIHDWGEIDG
MLBr_00017|M.leprae_Br4923 LGRRVAVKVLKGEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHM
MAB_4435|M.abscessus_ATCC_1997 LQRSEALKILSAQSSRDPEFRARFMREASLAASLDHPNIVTVHNRGETPE
*:*:: : * * *: *: :. *:.* : .:*: *:
Mb1772|M.bovis_AF2122/97 -----QLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA
Rv1743|M.tuberculosis_H37Rv -----QLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHA
MMAR_2581|M.marinum_M -----QLYVDMRLIDGKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHA
MUL_3180|M.ulcerans_Agy99 -----QLYVDMRLIDGKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHA
MAV_1417|M.avium_104 -----QMFLEMRLVEGTDLDSVLKRFGPLPPPRAVAIITQIASALDAAHA
Mflv_2026|M.gilvum_PYR-GCK -----LLFVDMRMIDGVDLRRILKEQGAMSPARATAIVRQIASALDAAHR
Mvan_4693|M.vanbaalenii_PYR-1 -----LLFVDMRLIDGTDLRKLLKEQGPMTPARATAIVAQVASALDAAHQ
MSMEG_4366|M.smegmatis_MC2_155 -----VLYIDMRLVEGASLKDILRTDGPLDPRRTASIVAQVASALDAAHA
TH_2947|M.thermoresistible__bu -----NLFIDMRLVQGRTLHDLI-TDGPLGPDRAVEIVQQVADALDAAHA
MLBr_00017|M.leprae_Br4923 DGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHA
MAB_4435|M.abscessus_ATCC_1997 G----DLWIAMQYVQGSDAHSES-ASGRMSLTRAVHIISEVAKALDYLHA
:: *. ::* * : :: : : . **: *
Mb1772|M.bovis_AF2122/97 AGATHRDVKPENILVSADD-FAYLVDFGIASATTDE-KLTQLGNTVGTLY
Rv1743|M.tuberculosis_H37Rv AGATHRDVKPENILVSADD-FAYLVDFGIASATTDE-KLTQLGNTVGTLY
MMAR_2581|M.marinum_M AGVTHRDVKPENILVSHDD-FAYLVDFGIASATSDE-KLTQLGSTVGTLY
MUL_3180|M.ulcerans_Agy99 AGVTHRDVKPENILVSHDD-FAYLVDFGIASATSDE-KLTQLGSTVGTLY
MAV_1417|M.avium_104 AGVMHRDVKPQNILVTRDD-FAYLVDFGIASATTDE-KLTQLGTAVGTWK
Mflv_2026|M.gilvum_PYR-GCK AGIMHRDVKPENILVTRDD-FAYLVDFGIANAATDE-SLTELGTAVGTYA
Mvan_4693|M.vanbaalenii_PYR-1 NGIMHRDVKPENILINRDD-FAYLVDFGIANAVTDE-ALTELGTAVGTYA
MSMEG_4366|M.smegmatis_MC2_155 DGLVHRDIKPENVLLTGDD-FAYLVDFGIAHVGGEA-SVTMTGMLIGSSA
TH_2947|M.thermoresistible__bu EGLVHRDVKPHNILVTPAD-FAYLVDFGIAAMQGDS-RLTLAGTQIGSLA
MLBr_00017|M.leprae_Br4923 AGLVHRDVKPGNILITPTG-QVKITDFGIAKAVDAA-PVTQTGMVMGTAQ
MAB_4435|M.abscessus_ATCC_1997 RGLVHRDVKPANILLSAGDRRIMLGDFGLTRALDDSNSVTSAGNVTATIA
* ***:** *:*:. . : ***:: :* * .:
Mb1772|M.bovis_AF2122/97 YMAPERFSESHATYRADIYALTCVLYECLTGSPPYQ-GDQLSVMG-AHIN
Rv1743|M.tuberculosis_H37Rv YMAPERFSESHATYRADIYALTCVLYECLTGSPPYQ-GDQLSVMG-AHIN
MMAR_2581|M.marinum_M YMAPERFSSGDVTYRADIYALACVLYECLTGSPPYR-GDQLSVMG-AHLS
MUL_3180|M.ulcerans_Agy99 YMAPERFSSGDVTYRADIYALACVLYECLTGSPPYR-GDQLSVIG-AHLS
MAV_1417|M.avium_104 YMAPERFSDAEVTYRADIYALACVLFECLTGSAPYR-ADSAGVLVSAHVM
Mflv_2026|M.gilvum_PYR-GCK YMAPERFAAGEVTHRADVYALTCVLHECLTGTQPFE-GDSVSVVITAHLN
Mvan_4693|M.vanbaalenii_PYR-1 YMAPERFTNGEVTHRADVYALTCVLHECLTGAQPFQ-GDSVSVVITAHLN
MSMEG_4366|M.smegmatis_MC2_155 YMAPERFSGETVGPPADIYALACLVYESLIGRPPYE-AGDLRQLMSAHMF
TH_2947|M.thermoresistible__bu YMAPERFNDEPCTPATDIYALACVLYEALTGNTPFD-TGSHESLX-----
MLBr_00017|M.leprae_Br4923 YIAPEQALGHDATPASDVYSLGVIGYEVVSGKRPFT-GDGALTVAMKHIK
MAB_4435|M.abscessus_ATCC_1997 YAAPEILSGTAVDGRADVYALGCTLFRMLTGQPPFGSGNSLPAIINAHLS
* *** :*:*:* .. : * *: . :
Mb1772|M.bovis_AF2122/97 QAIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATA
Rv1743|M.tuberculosis_H37Rv QAIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATA
MMAR_2581|M.marinum_M QPIPRPSAARPGIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATP
MUL_3180|M.ulcerans_Agy99 QPIPRPSAARPGIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATP
MAV_1417|M.avium_104 DPIPAPSARRPGVPKAFDAVIARGMAKKPEDRYASAGDLALAAKEALSTP
Mflv_2026|M.gilvum_PYR-GCK QPAPRPSSLRQGIPAGLDEVIARGMAKRPEDRFASAGELADAATDALTRA
Mvan_4693|M.vanbaalenii_PYR-1 DPAPRPSQSRPGIPAGLDDVISRGMAKRPEDRYASAGEMARAATAALTGA
MSMEG_4366|M.smegmatis_MC2_155 SAPPRPSIMRRGVPRAFDEVIATAMAKDPAARYATAGELARAVSAAAAGE
TH_2947|M.thermoresistible__bu XXPRRHRTPRR--------VVG--------------------AEVDGAGD
MLBr_00017|M.leprae_Br4923 EPPP---PLPADLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGH
MAB_4435|M.abscessus_ATCC_1997 APPPRISQLAP-VPESWDALIAKAMAKTPADRYQSAGELAMAAQQILTDP
:: . :
Mb1772|M.bovis_AF2122/97 DQDRATDILRRSQVAKLPV-------PSTHP--------------VSPGT
Rv1743|M.tuberculosis_H37Rv DQDRATDILRRSQVAKLPV-------PSTHP--------------VSPGT
MMAR_2581|M.marinum_M DQDRATDILQRSQVAQLPAGF-----ASTPPGGFAPSSPAVPVPGSAPST
MUL_3180|M.ulcerans_Agy99 DQDRATDILQRSQVAQLPAGF-----ASTSPGGFAPSSPAVPVPGSAPST
MAV_1417|M.avium_104 DQDRAATILRRSQEAALPAAGQRDAGASTVLAPPPAVNTRQPGSAASQAG
Mflv_2026|M.gilvum_PYR-GCK EQDQAASILQRSQAATMMAPL-----PPPPPPPPPPPP--------PQFA
Mvan_4693|M.vanbaalenii_PYR-1 QQDQADSILQRSQAATMMAPL-----PPPPPPPPPSTPGGPLPYGGSPVP
MSMEG_4366|M.smegmatis_MC2_155 APPSKPTPPQVPGRPPTPTRQFSELYPNPEHTGFTPYPPAYPSVPAPPRR
TH_2947|M.thermoresistible__bu QEPVRRRPGPVTG-------------------------------DVPDRR
MLBr_00017|M.leprae_Br4923 RPPRPNQTPSSGRASPTTIPS---------STQARAAVACGTKTPAPRRS
MAB_4435|M.abscessus_ATCC_1997 AQHRQTVTQPVPATTPAPIAAP----EPVHAMAPLAMADTGQSMLKHKRI
Mb1772|M.bovis_AF2122/97 RWPQP--------------TPWAG------------GAPPWGPPSSPLPR
Rv1743|M.tuberculosis_H37Rv RWPQP--------------TPWAG------------GAPPWGPPSSPLPR
MMAR_2581|M.marinum_M GWPAPSVPGAPVAPSAPVPTPWAGVPGWGVGHTGTTGAPPWGQPP-PQPT
MUL_3180|M.ulcerans_Agy99 GWPAPSVPGAPVAPSAPVPTPWAGVPGWGVGHTGTTGAPPWGQPP-PEPT
MAV_1417|M.avium_104 RGWTPESGPIPAAGQPGPPYYQGGNANWAAAPAQFAGPPPWGRPP-----
Mflv_2026|M.gilvum_PYR-GCK ATPPP----------GGAATYQGGYQPPPPPGWGPP---PVPPGRPGGSG
Mvan_4693|M.vanbaalenii_PYR-1 PPPPP----------PGQPTQASGFHTPPPPGGPPPGWPPQPPQSSGGGG
MSMEG_4366|M.smegmatis_MC2_155 TPTPP-------------------------------APAAVAAPAVRTPG
TH_2947|M.thermoresistible__bu AAR-----------------------------------------------
MLBr_00017|M.leprae_Br4923 RPSTS-------------------------------GNRPPPARNTFSSG
MAB_4435|M.abscessus_ATCC_1997 AAIIG----------VMVLVVASSVVAVLIWPRADEGTDPRTKASPSAAQ
Mb1772|M.bovis_AF2122/97 SARQPWLWVGVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAV
Rv1743|M.tuberculosis_H37Rv SARQPWLWVGVAVAVVVALAGGLGIALAHPWRSSGPRTSAPPPPPPADAV
MMAR_2581|M.marinum_M VAAKTWPWIAAAVAVVVVIAGVLGVVIAHPWRSPGPPTASAPPPPPPDAV
MUL_3180|M.ulcerans_Agy99 VAAKTWPWIAAAVAVVVVIAGVLGVVIAHPWRSPGPPTASAPPPPPPDAV
MAV_1417|M.avium_104 PKRRVWPIVAAVVAVLVVIAGGVGVWLVIRPK-PEPPQAAPLTSDRLGAL
Mflv_2026|M.gilvum_PYR-GCK GSKGPLIAVVAG-AVVLLVLAAVGIWLVTKSDDPGSTTASPTSSSAAP-T
Mvan_4693|M.vanbaalenii_PYR-1 GSKGPMIALLAGAAVIILVLAGLGIWLVVKPDSTSDPVASRTSTSAAPTT
MSMEG_4366|M.smegmatis_MC2_155 KKRFTRTQMMLVVATVVLFGIAAVLATMLVGGDDNASTGNTGITPPEGAT
TH_2947|M.thermoresistible__bu --------------------------------------------------
MLBr_00017|M.leprae_Br4923 QRALLWAAGMLGALAIIIAVLIVINSYAGNEQHQPPTPTVTDTGTPPATK
MAB_4435|M.abscessus_ATCC_1997 VAPGASLAGQPNTVLDTLLPGQFDYPEGWEKNPSPTFRSGEFNPAVPPGS
Mb1772|M.bovis_AF2122/97 ELRVLNDGVFVGSSVAPTTIDIFNEPICPPCGSFIRSYASDIDTAVADKQ
Rv1743|M.tuberculosis_H37Rv ELRVLNDGVFVGSSVAPTTIDIFNEPICPPCGSFIRSYASDIDTAVADKQ
MMAR_2581|M.marinum_M QLRVLNDGVFIGSSAATTTIDIFNEPICPPCGAFIRSYASDIDAAVANKK
MUL_3180|M.ulcerans_Agy99 QLRVLNDGVFIGSSAATTTIDIFNEPICPPCGAFIRSYASDIDAAVANKK
MAV_1417|M.avium_104 LLSASEVNAVMGSSTMEP-----GKPITATDSSSVTVSVPDCQGALYTTQ
Mflv_2026|M.gilvum_PYR-GCK TSREPTRRTRTTTSAPPATGSYDQQLMAMLSGGHDGSNCEPVSPPAQTAV
Mvan_4693|M.vanbaalenii_PYR-1 TSRGSTTRTRTSTSTPPPTESYDQQLMALLSGGHDSSNCEPVDPPAPTIL
MSMEG_4366|M.smegmatis_MC2_155 STSESTTTTTSNRSATANVSGTDEQGFVGHTARCDSDATPAALIRTATSL
TH_2947|M.thermoresistible__bu --------------------------------------------------
MLBr_00017|M.leprae_Br4923 TLSGFPAAYCEYRVNWTNHKEISNSGLPKQAARAQLAGAIDISPVAGQT-
MAB_4435|M.abscessus_ATCC_1997 ATNIGGTPVGCNTIDPAWALRAKGRETSTLYLRDRKKPEREILIRVVPAA
Mb1772|M.bovis_AF2122/97 LAVR----YHLLNFLDDQSHSKNYSTRAVAASYCVAGQNDPKLYASFYSA
Rv1743|M.tuberculosis_H37Rv LAVR----YHLLNFLDDQSHSKNYSTRAVAASYCVAGQNDPKLYASFYSA
MMAR_2581|M.marinum_M LAVR----YHLLNFLDEQSHTKTYSTRAVAASYCVAAQDDPKVYTDFYAA
MUL_3180|M.ulcerans_Agy99 LAVR----YHLLNFLDEQSHTKTYSTRAVAASYCVAAQDDPKVYTDFYAA
MAV_1417|M.avium_104 DPVYAGSGYSAVNGLVSSEPGDNYDHWVNQAVVLFPSADKAKSFLQTSLQ
Mflv_2026|M.gilvum_PYR-GCK ATVD-----CTQNTNPGGPAFTRYSLFADRGALDAAFDEAIRVNSELLEC
Mvan_4693|M.vanbaalenii_PYR-1 ATVD-----CTQALTPGGPAFTRYSLFEDRGALDAAFEEAIRVNSELVQC
MSMEG_4366|M.smegmatis_MC2_155 AIIC-----------ERDSGGYYYRGERLRDGANLKIDDAQRSGDGYVAV
TH_2947|M.thermoresistible__bu --------------------------------------------------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_4435|M.abscessus_ATCC_1997 DALSTDGASDALKRCDAVAYIIPGSSTTWRCSFEFDEPNPVQNGQKELTT
Mb1772|M.bovis_AF2122/97 LFGSDFQPQENAASDRTDAELAHLAQTVGAEP-TAISCIKSGADLGTAQT
Rv1743|M.tuberculosis_H37Rv LFGSDFQPQENAASDRTDAELAHLAQTVGAEP-TAISCIKSGADLGTAQT
MMAR_2581|M.marinum_M LFASDFQPQEAAASDRTDAELAHLAQTVGANG-TATSCIKAGNDMGTART
MUL_3180|M.ulcerans_Agy99 LFASDFQPQEAAASDRTDAELAHLAQTVGANG-TATSCIKAGNDMGTART
MAV_1417|M.avium_104 KWKG-CAGQTVTVTNKSKTYRWTFAQVQGAPPKITLMDTQEGADGWECQR
Mflv_2026|M.gilvum_PYR-GCK PGSGVDSPTTWHYTETPDQVVGQVACGTYNEN-PDIVWTND-----EKLL
Mvan_4693|M.vanbaalenii_PYR-1 PGSGVDSPTTWHYTETPDQVVGQIACGTYDGN-PDLVWTKD-----DDLL
MSMEG_4366|M.smegmatis_MC2_155 ------NPADGARYEVSPEGLTIMSNGHVDSSEPPEEYGSK---------
TH_2947|M.thermoresistible__bu --------------------------------------------------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_4435|M.abscessus_ATCC_1997 TESCYMFPSGANSIRQHVSFNVVRGLLVYILASGASNRNDAAGSLSATAL
Mb1772|M.bovis_AF2122/97 KATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG-
Rv1743|M.tuberculosis_H37Rv KATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG-
MMAR_2581|M.marinum_M KAAAADATLSELNASGTPFVWDGSKSIDLQNPSWLTKLIG-
MUL_3180|M.ulcerans_Agy99 KAAAADATLSELNAG-------------------LRRC---
MAV_1417|M.avium_104 ALSVANNVIVDINACGYRITDQGDQIAD----KIVAKIDNE
Mflv_2026|M.gilvum_PYR-GCK LADAQSPNLEDLHDWWLEFG---------------------
Mvan_4693|M.vanbaalenii_PYR-1 LADAQGPNLEELHNWWLEFG---------------------
MSMEG_4366|M.smegmatis_MC2_155 -----------------------------------------
TH_2947|M.thermoresistible__bu -----------------------------------------
MLBr_00017|M.leprae_Br4923 -----------------------------------------
MAB_4435|M.abscessus_ATCC_1997 SFATTMKILRYGR----------------------------