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VSTPKGGSRLGTRFGPYELQSVIGVGGMGEVYRAYDTARERMVAIKLLRPEMAADHSFQERFRRESRVAA RLQEPHVIPVHDFGEIDGVLYIDMRLVEGASLKDVLRAEGALPPARAVSILRQVAAALDAAHANGLVHRD IKPENVLLTPDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGERGGPASDVYSLACLLYESL TGRAPFEAADVRQVWSAHMFAPPPRPSIMRRGVSRTFDDVVARGMAKQPHDRYPTAGELARAASAAAEGA PAAETVAPVTPPSTRQFSTVYPTPPPMPPMPAVAPPARRFSRGQVGLVAATVVMFTAALVLAAVLVFSGG DTGSPSPRIAAPPSSSSEAPSTSSASAVEGVSGTDSQGFVGHTARCDSGSTPAALIRTSLSLAIICETSD GDYYYRGERLRDGANREIQGAQRSGDGFVVTGSDGARYDVQPDQLTISSNGSVDSAEPALEYGSAQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1066 | - | - | 100% (486) | protein kinase |
| M. vanbaalenii PYR-1 | Mvan_4693 | - | 2e-91 | 43.71% (421) | protein kinase |
| M. vanbaalenii PYR-1 | Mvan_1033 | - | 6e-77 | 46.42% (349) | protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1772 | pknE | 5e-88 | 47.72% (373) | transmembrane serine/threonine-protein kinase E |
| M. gilvum PYR-GCK | Mflv_5210 | - | 0.0 | 86.21% (486) | protein kinase |
| M. tuberculosis H37Rv | Rv1743 | pknE | 9e-88 | 47.72% (373) | transmembrane serine/threonine-protein kinase E |
| M. leprae Br4923 | MLBr_00017 | pknA | 2e-57 | 34.51% (426) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_0034c | - | 3e-57 | 35.90% (390) | putative serine/threonine-protein kinase PknA |
| M. marinum M | MMAR_2444 | - | 2e-90 | 47.12% (382) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_2158 | - | 1e-129 | 50.40% (502) | serine/threonine protein kinase |
| M. smegmatis MC2 155 | MSMEG_4366 | - | 0.0 | 66.22% (518) | serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_4409 | - | 1e-87 | 79.69% (192) | PUTATIVE serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_3180 | pknE | 8e-83 | 48.16% (326) | transmembrane serine/threonine-protein kinase E PknE |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1772|M.bovis_AF2122/97 -M--DGTAESREGTQFG-PYRLRRLVGRGGMGDVYEAEDTVRERIVALKL
Rv1743|M.tuberculosis_H37Rv -M--DGTAESREGTQFG-PYRLRRLVGRGGMGDVYEAEDTVRERIVALKL
MUL_3180|M.ulcerans_Agy99 MS--DATADSREGSQFG-PYRLRRIVGRGAMGDVYEAEDTVRERVVALKL
Mvan_1066|M.vanbaalenii_PYR-1 MS--TPKGGSRLGTRFG-PYELQSVIGVGGMGEVYRAYDTARERMVAIKL
Mflv_5210|M.gilvum_PYR-GCK MS--TPQGGARLGTRFG-PYELHSVIGVGGMGEVYRAYDTARERMVAIKL
MSMEG_4366|M.smegmatis_MC2_155 MTPMASNGASRLGTRFG-PYELRSLIGVGGMGEVYRAYDTVKGREVAVKL
TH_4409|M.thermoresistible__bu MT--SSSGGSRVGTRFG-PYELRSLIGVGGMGEVYRAYDTVRGRMVALKL
MAV_2158|M.avium_104 MS--SSSRGSRLGTRLG-PYELRSLIGTGTLGEVYRAYDTVKDRLVALKL
MMAR_2444|M.marinum_M MS--DTVPTSRVGTQFG-PYRLRRLLGRGGMGEVYEAHDTVKDRTVALKL
MLBr_00017|M.leprae_Br4923 -------MSPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKV
MAB_0034c|M.abscessus_ATCC_199 -------MTVRVGETLSGRYRLQRLIATGGMGQVWEGTDSRLGRKVAVKV
* * :. *.*: ::. * :*:*:.. *: * **:*:
Mb1772|M.bovis_AF2122/97 MSETLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFGEIDG-----QLYV
Rv1743|M.tuberculosis_H37Rv MSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDG-----QLYV
MUL_3180|M.ulcerans_Agy99 MSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDG-----QLYV
Mvan_1066|M.vanbaalenii_PYR-1 LRPEMAADHSFQERFRRESRVAARLQEPHVIPVHDFGEIDG-----VLYI
Mflv_5210|M.gilvum_PYR-GCK LRPEMAADHSFQERFRRESRVAARLQEPHVIPVHNFGEIDG-----VLYI
MSMEG_4366|M.smegmatis_MC2_155 LRAEFAADPRFQERFRRESRVAARLQEPHVIPVHDFGDIDG-----VLYI
TH_4409|M.thermoresistible__bu LRPELAADPNFQERFRRESRLAARLQEPHVIPVHDFGDIDG-----VLYI
MAV_2158|M.avium_104 LRGELDAG--FRQRLWRECRAVTRLQEPHVLPLHDFGEIDG-----VPFI
MMAR_2444|M.marinum_M MSQQFNSDSTFRRRMQREAHTAGRLQEPHIVPIHDFGEIDG-----QLFI
MLBr_00017|M.leprae_Br4923 LKGEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHMDGEGRTAYL
MAB_0034c|M.abscessus_ATCC_199 LKAEFSSDPEFIERFRAEARTVAMLNHPGIASVYDYGETDIDSEGRTAYL
: : . * *: *.: . *:.* : .::::*: . ::
Mb1772|M.bovis_AF2122/97 DMRLIN-GVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDV
Rv1743|M.tuberculosis_H37Rv DMRLIN-GVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDV
MUL_3180|M.ulcerans_Agy99 DMRLID-GKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDV
Mvan_1066|M.vanbaalenii_PYR-1 DMRLVE-GASLKDVLRAEGALPPARAVSILRQVAAALDAAHANGLVHRDI
Mflv_5210|M.gilvum_PYR-GCK DMRLVE-GASLKEVLRSDGPLQPARAVSIIRQVAAALDDAHANGLVHRDI
MSMEG_4366|M.smegmatis_MC2_155 DMRLVE-GASLKDILRTDGPLDPRRTASIVAQVASALDAAHADGLVHRDI
TH_4409|M.thermoresistible__bu DMRLVD-GASLKDILRSSGPLEPARAAAIIKQVAAALDAAHADGLIHRDI
MAV_2158|M.avium_104 DMQLVDDGGSLKELLREQGGLEPSRAASITGQVARALDAAHAAGLMHLDV
MMAR_2444|M.marinum_M DMRFIE-GTDLGSVLKR-GALPAPRAVAIVSQVAEALDAAHRGGVVHRDI
MLBr_00017|M.leprae_Br4923 VMELVN-GEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDV
MAB_0034c|M.abscessus_ATCC_199 VMELIH-GEPLNSVLKRTGRLSLRHSLDMLEQTGRALQVAHAAGLVHRDV
*.::. * * :*: * * :: : * . **: ** * * *:
Mb1772|M.bovis_AF2122/97 KPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSES
Rv1743|M.tuberculosis_H37Rv KPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSES
MUL_3180|M.ulcerans_Agy99 KPENILVSHDDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSG
Mvan_1066|M.vanbaalenii_PYR-1 KPENVLLTPDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGE
Mflv_5210|M.gilvum_PYR-GCK KPENVLLTGDDFAYLVDFGIAHGGGEASVTSTGLVVGSSAYMAPERFSGE
MSMEG_4366|M.smegmatis_MC2_155 KPENVLLTGDDFAYLVDFGIAHVGGEASVTMTGMLIGSSAYMAPERFSGE
TH_4409|M.thermoresistible__bu KPENVLLTADDFAYLVDFGIAHAGGDAGVTRTGMLIGSSAYMAPERFANG
MAV_2158|M.avium_104 KPENILLTHDHFTYLADFGLAQAAGDEKLSRT--------YMAPERFTTG
MMAR_2444|M.marinum_M KPENILITGNDFAYLVDFGIAAAATDQHLTKTGTAVGSWSYMAPERFGDD
MLBr_00017|M.leprae_Br4923 KPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGH
MAB_0034c|M.abscessus_ATCC_199 KPGNILITPTGQVKLTDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGH
** *:*:: . :.***:* :: *:***:
Mb1772|M.bovis_AF2122/97 HATYRADIYALTCVLYECLTGSPPYQGDQLS-VMGAHINQAIPRPSTVRP
Rv1743|M.tuberculosis_H37Rv HATYRADIYALTCVLYECLTGSPPYQGDQLS-VMGAHINQAIPRPSTVRP
MUL_3180|M.ulcerans_Agy99 DVTYRADIYALACVLYECLTGSPPYRGDQLS-VIGAHLSQPIPRPSAARP
Mvan_1066|M.vanbaalenii_PYR-1 RGGPASDVYSLACLLYESLTGRAPFEAADVRQVWSAHMFAPPPRPSIMRR
Mflv_5210|M.gilvum_PYR-GCK RGGPASDIYSLACLLYESLTGRAPFEAADVRQVWSAHMFAAPPRPSIMRR
MSMEG_4366|M.smegmatis_MC2_155 TVGPPADIYALACLVYESLIGRPPYEAGDLRQLMSAHMFSAPPRPSIMRR
TH_4409|M.thermoresistible__bu RVX-------------------------------------XSPR------
MAV_2158|M.avium_104 SLGPQTDIYSLACVLYECLTGQPPFEGADPGELRSAHLLSPAPRPSIMRR
MMAR_2444|M.marinum_M EVTYRSDIYALACVLYECLTGTPPYQTQNLSTLMGAHLMQPIPRPSRHRP
MLBr_00017|M.leprae_Br4923 DATPASDVYSLGVIGYEVVSGKRPFTGDGALTVAMKHIKEPPPP---LPA
MAB_0034c|M.abscessus_ATCC_199 DATPASDVYSLGVVGYEAVSGKRPFSGDGALTVAMKHIKETPSP---LPA
.
Mb1772|M.bovis_AF2122/97 GIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRR
Rv1743|M.tuberculosis_H37Rv GIPVAFDAVIARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRR
MUL_3180|M.ulcerans_Agy99 GIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQR
Mvan_1066|M.vanbaalenii_PYR-1 GVSRTFDDVVARGMAKQPHDRYPTAGELARAAS-AAAE-GAPAAETVA--
Mflv_5210|M.gilvum_PYR-GCK GVSRAFDDVIARGMAKNPTERYATAGELARAAA-AAAS-AAPVAEPVP--
MSMEG_4366|M.smegmatis_MC2_155 GVPRAFDEVIATAMAKDPAARYATAGELARAVS-AAAAGEAPPSKPTP--
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 GVGRAFDDIITRGMAKQRSARFASAGELARAASEAVFAAYEPVSAAAG--
MMAR_2444|M.marinum_M DIPTAFDEVIARGMAKDPALRYPTAGELARAARQALSAGDQERAATLI--
MLBr_00017|M.leprae_Br4923 DLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPPRP------
MAB_0034c|M.abscessus_ATCC_199 DLPPNVRELIEITLVKNPQNRYTSGGPFADAVAAVRAGRRPPRP------
Mb1772|M.bovis_AF2122/97 SQVAKLPV--PSTHP--------------VSPGTRWPQP-----------
Rv1743|M.tuberculosis_H37Rv SQVAKLPV--PSTHP--------------VSPGTRWPQP-----------
MUL_3180|M.ulcerans_Agy99 SQVAQLPAGFASTSPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPSA
Mvan_1066|M.vanbaalenii_PYR-1 PVTP------PSTRQ------------------FSTVYP-----------
Mflv_5210|M.gilvum_PYR-GCK PVTP------PSTRQ------------------FSGVHP-----------
MSMEG_4366|M.smegmatis_MC2_155 PQVPGRPP--TPTRQ------------------FSELYPN-------PEH
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 LGGPRPLP--APPAQ------------------FDDPDD-----------
MMAR_2444|M.marinum_M AGTHQLAA--PPSGP------------------MPWAPP-----------
MLBr_00017|M.leprae_Br4923 --------------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 ---TPWAG------------GAPPWGPPSSPLPRSARQPWLWVGVAVAVV
Rv1743|M.tuberculosis_H37Rv ---TPWAG------------GAPPWGPPSSPLPRSARQPWLWVGVAVAVV
MUL_3180|M.ulcerans_Agy99 PVPTPWAGVPGWGVGHTGTTGAPPWGQPP-PEPTVAAKTWPWIAAAVAVV
Mvan_1066|M.vanbaalenii_PYR-1 -----------------TPPPMPPMPAVAPP-------ARRFSRGQVGLV
Mflv_5210|M.gilvum_PYR-GCK -----------------AMTP-PPAPAPIAA-------ARRPGRGQGALV
MSMEG_4366|M.smegmatis_MC2_155 TGFTPYPPAYPSVPAPPRRTPTPPAPAAVAAPAVRTPGKKRFTRTQMMLV
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 -------------------TLGPPPVGERPP-------RGPAGRLPVVVT
MMAR_2444|M.marinum_M -------------------PWTSPARRTRTP------WLLAVAVLVVVIV
MLBr_00017|M.leprae_Br4923 --------------------NQTPSSGRASP-----------TTIPSSTQ
MAB_0034c|M.abscessus_ATCC_199 --------------------NQAPTISRATP-----------AAIPPATQ
Mb1772|M.bovis_AF2122/97 VALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGVFVGSSVA
Rv1743|M.tuberculosis_H37Rv VALAGGLGIALAHPWRSSGPRTSAPPPPPPADAVELRVLNDGVFVGSSVA
MUL_3180|M.ulcerans_Agy99 VVIAGVLGVVIAHPWRSPGPPTASAPPPPPPDAVQLRVLNDGVFIGSSAA
Mvan_1066|M.vanbaalenii_PYR-1 AATVVMFTAALVLAAVLVFSGGDTGSPSPRIAAP----PSSSSEAPSTSS
Mflv_5210|M.gilvum_PYR-GCK AGIVVMFVAAAVLALVLVFTGGSDPQP-PRIAAP----PSSSSDTSTPPS
MSMEG_4366|M.smegmatis_MC2_155 VATVVLFGIAAVLATMLVGGDDNASTGNTGITPPEGATSTSESTTTTTSN
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 AVAVLMLIAGVVLSVKTVVGTHHNNSAPPPAPTTRALAPPPPTTPPPPLT
MMAR_2444|M.marinum_M VVGTGIFLARKEPASGPTGGVSTTAGAPSGITATAGPTVAPTQLESFLLS
MLBr_00017|M.leprae_Br4923 ARAAVACGTKTPAPR-RSRPSTSGNRPPPARN-TFSSGQRALLWAAGMLG
MAB_0034c|M.abscessus_ATCC_199 VRPAVGAPSRVAPPTSRTRQPTGSHRPPPPRRGTFSPGQKALMWAAAVLG
Mb1772|M.bovis_AF2122/97 PTTIDIFNEPICPPCG---------------------------SFIRSYA
Rv1743|M.tuberculosis_H37Rv PTTIDIFNEPICPPCG---------------------------SFIRSYA
MUL_3180|M.ulcerans_Agy99 TTTIDIFNEPICPPCG---------------------------AFIRSYA
Mvan_1066|M.vanbaalenii_PYR-1 ASAVEGVSGTD--------------------------------------S
Mflv_5210|M.gilvum_PYR-GCK TSAVEGVSGTD--------------------------------------S
MSMEG_4366|M.smegmatis_MC2_155 RSATANVSGTD--------------------------------------E
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 PTLSRPVTGAD--------------------------------------G
MMAR_2444|M.marinum_M PEQINTIVGTTGIVIDHNATEMTDPGPENSLSTEQCLGALIGYQTRTYKS
MLBr_00017|M.leprae_Br4923 ALAIIIA-------------------------------------------
MAB_0034c|M.abscessus_ATCC_199 IFAIIIA-------------------------------------------
Mb1772|M.bovis_AF2122/97 SDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASYCVAGQ----N
Rv1743|M.tuberculosis_H37Rv SDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRAVAASYCVAGQ----N
MUL_3180|M.ulcerans_Agy99 SDIDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRAVAASYCVAAQ----D
Mvan_1066|M.vanbaalenii_PYR-1 QGFVGHTARCD--SGSTP------AALIRTSLSLAI--------------
Mflv_5210|M.gilvum_PYR-GCK QGFVGHTARCD--SGDTP------AALIRTSLSLAI--------------
MSMEG_4366|M.smegmatis_MC2_155 QGFVGHTARCD--SDATP------AALIRTATSLAI--------------
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 LGFIGETARCD--PGNPP------AAVVRTAKSLAV--------------
MMAR_2444|M.marinum_M SGYTGMLAQLMQKPRSTPGYVVVQGAVIFASADQAVGFVAAQADQWRSCA
MLBr_00017|M.leprae_Br4923 -------------------------VLIVINSYAGN--------------
MAB_0034c|M.abscessus_ATCC_199 -------------------------ALILLQASEKK--------------
Mb1772|M.bovis_AF2122/97 DPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQTVGAEPTAISCIK
Rv1743|M.tuberculosis_H37Rv DPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQTVGAEPTAISCIK
MUL_3180|M.ulcerans_Agy99 DPKVYTDFYAALFASDFQPQEAAASDRTDAELAHLAQTVGANGTATSCIK
Mvan_1066|M.vanbaalenii_PYR-1 ---ICETSDGDYYYRGERLRDGANREIQGAQRSGDGFVVTG-SDGARYDV
Mflv_5210|M.gilvum_PYR-GCK ---ICDRGDGDYYYRGERLRDGANREIDGARRSGDGFTVTG-SDGARYDV
MSMEG_4366|M.smegmatis_MC2_155 ---ICERDSGGYYYRGERLRDGANLKIDDAQRSGDGYVAVNPADGARYEV
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 ---VCQNLSGSYYYRGERIRDGAHIELSNAERVEDGFDVTNPVDGVVYEV
MMAR_2444|M.marinum_M GKDVTQVNNGKTSRWTFREVSGAPPKISLQRDLADSVVVCQHVLSAVSNI
MLBr_00017|M.leprae_Br4923 ----EQHQPPTPTVTDTGTPPATKTLSGFPAAYCEYRVNWTNHKEISNSG
MAB_0034c|M.abscessus_ATCC_199 ----NQTPSIPATVSGSETPSSPGSAS---------------------PG
Mb1772|M.bovis_AF2122/97 SGADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG
Rv1743|M.tuberculosis_H37Rv SGADLGTAQTKATNASETLAGFNASGTPFVWDGSMVVNYQDPSWLARLIG
MUL_3180|M.ulcerans_Agy99 AGNDMGTARTKAAAADATLSELNAG-------------------LRRC--
Mvan_1066|M.vanbaalenii_PYR-1 QPDQLTISSNGSVDSAEPALEYGSAQ------------------------
Mflv_5210|M.gilvum_PYR-GCK QPDQLTISSGGSVDSAEPALEYGSAQ------------------------
MSMEG_4366|M.smegmatis_MC2_155 SPEGLTIMSNGHVDSSEPPEEYGSK-------------------------
TH_4409|M.thermoresistible__bu --------------------------------------------------
MAV_2158|M.avium_104 RPNRLRIISFGHVDSSEPVLQYATAS------------------------
MMAR_2444|M.marinum_M VLDVNVCAPNVTDQASEIADTMAAKVPT----------------------
MLBr_00017|M.leprae_Br4923 LPKQAARAQLAGAIDISPVAGQT---------------------------
MAB_0034c|M.abscessus_ATCC_199 ALAPANIVALLPDAEPDPIPGTKSP-------------------------