For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_2947 | - | - | 100% (267) | serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_4409 | - | 4e-62 | 64.64% (181) | PUTATIVE serine/threonine-protein kinase PknD |
| M. thermoresistible (build 8) | TH_2631 | - | 3e-42 | 43.69% (206) | PUTATIVE serine/threonine protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 5e-67 | 56.88% (218) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_5210 | - | 4e-71 | 61.90% (210) | protein kinase |
| M. tuberculosis H37Rv | Rv1266c | pknH | 5e-67 | 56.88% (218) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | MLBr_00016 | pknB | 1e-42 | 42.72% (206) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_4435 | - | 8e-43 | 43.40% (212) | serine/threonine-protein kinase PknJ |
| M. marinum M | MMAR_2444 | - | 1e-72 | 55.04% (258) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_1417 | - | 9e-66 | 57.75% (213) | serine/threonine-protein kinase PknE |
| M. smegmatis MC2 155 | MSMEG_4366 | - | 1e-75 | 60.34% (232) | serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_3180 | pknE | 2e-65 | 57.14% (210) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_1066 | - | 2e-72 | 62.86% (210) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5210|M.gilvum_PYR-GCK MS-----------TPQGGARLGTRFGPYELHSVIGVGGMGEVYRAYDTAR
Mvan_1066|M.vanbaalenii_PYR-1 MS-----------TPKGGSRLGTRFGPYELQSVIGVGGMGEVYRAYDTAR
MSMEG_4366|M.smegmatis_MC2_155 MTPM---------ASNGASRLGTRFGPYELRSLIGVGGMGEVYRAYDTVK
TH_2947|M.thermoresistible__bu MS-------------GPESRAGTRFGKYELTALLGRGGMGEVYEAFDTEK
Mb1297c|M.bovis_AF2122/97 MS-----------DAQ-DSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVK
Rv1266c|M.tuberculosis_H37Rv MS-----------DAQ-DSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVK
MAV_1417|M.avium_104 MS-----------DER-SSKVGSMFGPYHLKRLLGRGGMGEVYEAEHTVK
MMAR_2444|M.marinum_M MS-----------DTVPTSRVGTQFGPYRLRRLLGRGGMGEVYEAHDTVK
MUL_3180|M.ulcerans_Agy99 MS-----------DATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVR
MAB_4435|M.abscessus_ATCC_1997 MTSSDRSSPGPGGQQPGDLPPGTVVSGYQIERVLGRGGMGTVYLAANPNL
MLBr_00016|M.leprae_Br4923 -----------------MTTPPHLSDRYELGDILGFGGMSEVHLARDIRL
. *.: ::* *.*. *: * .
Mflv_5210|M.gilvum_PYR-GCK ERMVAIKLLRPEMAADHSFQERFRRESRVAARLQEPHVIPVHNFG-EIDG
Mvan_1066|M.vanbaalenii_PYR-1 ERMVAIKLLRPEMAADHSFQERFRRESRVAARLQEPHVIPVHDFG-EIDG
MSMEG_4366|M.smegmatis_MC2_155 GREVAVKLLRAEFAADPRFQERFRRESRVAARLQEPHVIPVHDFG-DIDG
TH_2947|M.thermoresistible__bu RRAVALKILRAEYARDDRFRTRFLRESHAAAILQEPHVIPIHDWG-EIDG
Mb1297c|M.bovis_AF2122/97 EWTVAVKLMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYG-EVDG
Rv1266c|M.tuberculosis_H37Rv EWTVAVKLMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYG-EVDG
MAV_1417|M.avium_104 EWTVAVKLLNESFSSDPVFRERMKREARTAGRLQEPHVVPVHDYG-EIDG
MMAR_2444|M.marinum_M DRTVALKLMSQQFNSDSTFRRRMQREAHTAGRLQEPHIVPIHDFG-EIDG
MUL_3180|M.ulcerans_Agy99 ERVVALKLMSQTLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYG-EIDG
MAB_4435|M.abscessus_ATCC_1997 QRSEALKILSAQSSRDPEFRARFMREASLAASLDHPNIVTVHNRGETPEG
MLBr_00016|M.leprae_Br4923 HRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPSIVAVYDTGEAETS
*:*:: * * *: **: *. *:.* ::.::: * .
Mflv_5210|M.gilvum_PYR-GCK V---LYIDMRLVEGASLKEVLRSDGPLQPARAVSIIRQVAAALDDAHANG
Mvan_1066|M.vanbaalenii_PYR-1 V---LYIDMRLVEGASLKDVLRAEGALPPARAVSILRQVAAALDAAHANG
MSMEG_4366|M.smegmatis_MC2_155 V---LYIDMRLVEGASLKDILRTDGPLDPRRTASIVAQVASALDAAHADG
TH_2947|M.thermoresistible__bu N---LFIDMRLVQGRTLHDLIT-DGPLGPDRAVEIVQQVADALDAAHAEG
Mb1297c|M.bovis_AF2122/97 Q---MFLEMRLVEGTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADG
Rv1266c|M.tuberculosis_H37Rv Q---MFLEMRLVEGTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADG
MAV_1417|M.avium_104 Q---MFLEMRLVEGTDLDSVLKRFGPLPPPRAVAIITQIASALDAAHAAG
MMAR_2444|M.marinum_M Q---LFIDMRFIEGTDLGSVLKR-GALPAPRAVAIVSQVAEALDAAHRGG
MUL_3180|M.ulcerans_Agy99 Q---LYVDMRLIDGKDLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAG
MAB_4435|M.abscessus_ATCC_1997 D---LWIAMQYVQGSDAHSESAS-GRMSLTRAVHIISEVAKALDYLHARG
MLBr_00016|M.leprae_Br4923 AGPLPYIVMEYVDGATLRDIVHTDGPMPPQQAIEIVADACQALNFSHQNG
:: *. ::* * : :: * : **: * *
Mflv_5210|M.gilvum_PYR-GCK LVHRDIKPENVLLTG-DDFAYLVDFGIAHGGGEA-SVTSTGLVVGSSAYM
Mvan_1066|M.vanbaalenii_PYR-1 LVHRDIKPENVLLTP-DDFAYLVDFGIAHGGGEA-SVTSTGLVVGSSAYM
MSMEG_4366|M.smegmatis_MC2_155 LVHRDIKPENVLLTG-DDFAYLVDFGIAHVGGEA-SVTMTGMLIGSSAYM
TH_2947|M.thermoresistible__bu LVHRDVKPHNILVTP-ADFAYLVDFGIAAMQGDS-RLTLAGTQIGSLAYM
Mb1297c|M.bovis_AF2122/97 VMHRDVKPQNILITR-DDFAYLVDFGIASATTDE-KLTQLGTAVGTWKYM
Rv1266c|M.tuberculosis_H37Rv VMHRDVKPQNILITR-DDFAYLVDFGIASATTDE-KLTQLGTAVGTWKYM
MAV_1417|M.avium_104 VMHRDVKPQNILVTR-DDFAYLVDFGIASATTDE-KLTQLGTAVGTWKYM
MMAR_2444|M.marinum_M VVHRDIKPENILITG-NDFAYLVDFGIAAAATDQ-HLTKTGTAVGSWSYM
MUL_3180|M.ulcerans_Agy99 VTHRDVKPENILVSH-DDFAYLVDFGIASATSDE-KLTQLGSTVGTLYYM
MAB_4435|M.abscessus_ATCC_1997 LVHRDVKPANILLSAGDRRIMLGDFGLTRALDDSNSVTSAGNVTATIAYA
MLBr_00016|M.leprae_Br4923 IIHRDVKPANIMISA-TNAVKVMDFGIARAIADSTSVTQTAAVIGTAQYL
: ***:** *:::: : ***:: : :* . .: *
Mflv_5210|M.gilvum_PYR-GCK APERFSGERGGPASDIYSLACLLYESLTGRAPFEAA-DVRQVWSAHMFAA
Mvan_1066|M.vanbaalenii_PYR-1 APERFSGERGGPASDVYSLACLLYESLTGRAPFEAA-DVRQVWSAHMFAP
MSMEG_4366|M.smegmatis_MC2_155 APERFSGETVGPPADIYALACLVYESLIGRPPYEAG-DLRQLMSAHMFSA
TH_2947|M.thermoresistible__bu APERFNDEPCTPATDIYALACVLYEALTGNTPFDTG-SHESLX------X
Mb1297c|M.bovis_AF2122/97 APERFSNDEVTYRADIYALACVLHECLTGAPPYRAD-SAGTLVSSHLMGP
Rv1266c|M.tuberculosis_H37Rv APERFSNDEVTYRADIYALACVLHECLTGAPPYRAD-SAGTLVSSHLMGP
MAV_1417|M.avium_104 APERFSDAEVTYRADIYALACVLFECLTGSAPYRAD-SAGVLVSAHVMDP
MMAR_2444|M.marinum_M APERFGDDEVTYRSDIYALACVLYECLTGTPPYQTQ-NLSTLMGAHLMQP
MUL_3180|M.ulcerans_Agy99 APERFSSGDVTYRADIYALACVLYECLTGSPPYRGD-QLS-VIGAHLSQP
MAB_4435|M.abscessus_ATCC_1997 APEILSGTAVDGRADVYALGCTLFRMLTGQPPFGSGNSLPAIINAHLSAP
MLBr_00016|M.leprae_Br4923 SPEQARGDSVDARSDVYSLGCVLYEILTGEPPFIGD-SPVSVAYQHVRED
:** . :*:*:*.* :.. * * .*: . :
Mflv_5210|M.gilvum_PYR-GCK PPRPSIMRRGVSRAFDDVIARGMAKNPTERYATAGELARAAAAAAS----
Mvan_1066|M.vanbaalenii_PYR-1 PPRPSIMRRGVSRTFDDVVARGMAKQPHDRYPTAGELARAASAAAE----
MSMEG_4366|M.smegmatis_MC2_155 PPRPSIMRRGVPRAFDEVIATAMAKDPAARYATAGELARAVSAAAAG---
TH_2947|M.thermoresistible__bu XPR--------------------------RHRTPRRVVGAEVDGAGD---
Mb1297c|M.bovis_AF2122/97 IPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQ
Rv1266c|M.tuberculosis_H37Rv IPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQ
MAV_1417|M.avium_104 IPAPSARRPGVPKAFDAVIARGMAKKPEDRYASAGDLALAAKEALSTPDQ
MMAR_2444|M.marinum_M IPRPSRHRPDIPTAFDEVIARGMAKDPALRYPTAGELARAARQALSAGDQ
MUL_3180|M.ulcerans_Agy99 IPRPSAARPGIPAGFDNVIARGMAKDPADRYATCGDLSAAAYSALATPDQ
MAB_4435|M.abscessus_ATCC_1997 PPRISQLAP-VPESWDALIAKAMAKTPADRYQSAGELAMAAQQILTDPAQ
MLBr_00016|M.leprae_Br4923 PIPPSQRHEGISVDLDAVVLKALAKNPENRYQTAAEMRADLIRVHSGQPP
*: : :
Mflv_5210|M.gilvum_PYR-GCK -----------------------------------AAPVAEPVPPVTP--
Mvan_1066|M.vanbaalenii_PYR-1 -----------------------------------GAPAAETVAPVTP--
MSMEG_4366|M.smegmatis_MC2_155 -----------------------------------EAPPSKPTPPQVPGR
TH_2947|M.thermoresistible__bu -----------------------------------QEPVRRRPGPVTG--
Mb1297c|M.bovis_AF2122/97 DHAADILRRSQESTLPG-----------TAAVTAQPPTMPTVTPPPIQAA
Rv1266c|M.tuberculosis_H37Rv DHAADILRRSQESTLPAPPKPVPPPTMPATAMAPRQPPAPPVTPPGVQPA
MAV_1417|M.avium_104 DRAATILRRSQEAALPAAGQR------DAGASTVLAPPPAVNTRQPGSAA
MMAR_2444|M.marinum_M ERAATLIAGTHQLAAPP------------------SGPMPWAPPPWTSPA
MUL_3180|M.ulcerans_Agy99 DRATDILQRSQVAQLPAG--------------FASTSPGGFAPSSPAVPV
MAB_4435|M.abscessus_ATCC_1997 HRQTVTQPVP------------------------ATTPAPIAAPEPVHAM
MLBr_00016|M.leprae_Br4923 EAPKVLTDADRSCLLSSG-----------------AGNFGVPRTDALSRQ
Mflv_5210|M.gilvum_PYR-GCK ---------------------PSTRQFSGVHP------------------
Mvan_1066|M.vanbaalenii_PYR-1 ---------------------PSTRQFSTVYP------------------
MSMEG_4366|M.smegmatis_MC2_155 PP-------------------TPTRQFSELYPNPEHTGFTPYPPAYPSVP
TH_2947|M.thermoresistible__bu --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 P-------------------TGQPSWAPNSGPMPASGPTPTPQYYQGG--
Rv1266c|M.tuberculosis_H37Rv PKPSYTPPAQPGPAGQRPGPTGQPSWAPNSGPMPASGPTPTPQYYQGG--
MAV_1417|M.avium_104 S-------------------QAGRGWTPESGPIPAAG-QPGPPYYQGGNA
MMAR_2444|M.marinum_M R-------------------RTRTPWLLAVAVLVVVIVVVGTGIFLARK-
MUL_3180|M.ulcerans_Agy99 PG-----------------SAPSTGWPAPSVPGAPVAPSAPVPTPWAGVP
MAB_4435|M.abscessus_ATCC_1997 AP----------------LAMADTGQSMLKHKRIAAIIGVMVLVVASSVV
MLBr_00016|M.leprae_Br4923 SLD-----------------ETESDGSIGRWVAVVAVLAVLTIAIVAAFN
Mflv_5210|M.gilvum_PYR-GCK ---AMTP-PPAPAPIAA---------------------------------
Mvan_1066|M.vanbaalenii_PYR-1 ---TPPPMPPMPAVAPP---------------------------------
MSMEG_4366|M.smegmatis_MC2_155 APPRRTPTPPAPAAVAAPAVR-----------------------------
TH_2947|M.thermoresistible__bu ----DVPD------------------------------------------
Mb1297c|M.bovis_AF2122/97 GWGAPPS--GGPSPWAQTPRK----TNPWPLVAGAAAVVLVLVLGAIGIW
Rv1266c|M.tuberculosis_H37Rv GWGAPPS--GGPSPWAQTPRK----TNPWPLVAGAAAVVLVLVLGAIGIW
MAV_1417|M.avium_104 NWAAAPAQFAGPPPWGRPPPK----RRVWPIVA-AVVAVLVVIAGGVGVW
MMAR_2444|M.marinum_M EPASGPT--GGVSTTAGAPS---------------------------GIT
MUL_3180|M.ulcerans_Agy99 GWGVGHTGTTGAPPWGQPPPEPTVAAKTWPWIAAAVAVVVVIAGVLGVVI
MAB_4435|M.abscessus_ATCC_1997 AVLIWPRADEGTDPRTKASPS----------------------------A
MLBr_00016|M.leprae_Br4923 TFGGNTRDVQVPDVRGQVSADAISALQNRGFKTRTLQKPDSTIPPDHVIS
Mflv_5210|M.gilvum_PYR-GCK ----------------ARRPGRGQGALVAGIVVMFVAAAVLALVLVFTGG
Mvan_1066|M.vanbaalenii_PYR-1 ----------------ARRFSRGQVGLVAATVVMFTAALVLAAVLVFSGG
MSMEG_4366|M.smegmatis_MC2_155 -------------TPGKKRFTRTQMMLVVATVVLFGIAAVLATMLVGGDD
TH_2947|M.thermoresistible__bu -----------------RRAAR----------------------------
Mb1297c|M.bovis_AF2122/97 IANRPKPVQP-PQPVAEERLSALLLNSSEVNAVMGSSSMQPGKPITSMDS
Rv1266c|M.tuberculosis_H37Rv IAIRPKPVQP-PQPVAEERLSALLLNSSEVNAVMGSSSMQPGKPITSMDS
MAV_1417|M.avium_104 LVIRPKPEPPQAAPLTSDRLGALLLSASEVNAVMGSSTMEPGKPITATDS
MMAR_2444|M.marinum_M ATAGP--------TVAPTQLESFLLSPEQINTIVGTTGIVIDHNATEMTD
MUL_3180|M.ulcerans_Agy99 AHPWRSPGPPTASAPPPPPPDAVQLRVLNDGVFIGSSAATTTIDIFNEPI
MAB_4435|M.abscessus_ATCC_1997 AQVAPGASLAGQPNTVLDTLLPGQFDYPEGWEKNPSPTFRSGEFNPAVPP
MLBr_00016|M.leprae_Br4923 TEPGANASVGAGDEITINVSTGPEQREVPDVSSLNYTDAVKKLTSSGFKS
Mflv_5210|M.gilvum_PYR-GCK SDPQP-PRIAAP----PSSSSDTSTPPSTSAVEGVSGTDSQGFVGHTARC
Mvan_1066|M.vanbaalenii_PYR-1 DTGSPSPRIAAP----PSSSSEAPSTSSASAVEGVSGTDSQGFVGHTARC
MSMEG_4366|M.smegmatis_MC2_155 NASTGNTGITPPEGATSTSESTTTTTSNRSATANVSGTDEQGFVGHTARC
TH_2947|M.thermoresistible__bu --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 S--PVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVNQ
Rv1266c|M.tuberculosis_H37Rv S--PVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVNQ
MAV_1417|M.avium_104 S--SVTVSVPDCQGALYTTQDPVYAGSGYSAVNGLVSSEPGDNYDHWVNQ
MMAR_2444|M.marinum_M PGPENSLSTEQCLGALIGYQTRTYKSSGYTGMLAQLMQKPRSTPGYVVVQ
MUL_3180|M.ulcerans_Agy99 CP-PCGAFIRSYASDIDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRAVA
MAB_4435|M.abscessus_ATCC_1997 GSATNIGGTPVGCNTIDPAWALRAKGRETSTLYLRDRKKPEREILIRVVP
MLBr_00016|M.leprae_Br4923 FKQANSPSTPELLGKVIGTNPSANQTSAITNVITIIVGSGPETKQIPDVT
Mflv_5210|M.gilvum_PYR-GCK DSGDTPAALIR-----TSLSLAIICDRGD--GDYYYRGERLRDGANREID
Mvan_1066|M.vanbaalenii_PYR-1 DSGSTPAALIR-----TSLSLAIICETSD--GDYYYRGERLRDGANREIQ
MSMEG_4366|M.smegmatis_MC2_155 DSDATPAALIR-----TATSLAIICERDS--GGYYYRGERLRDGANLKID
TH_2947|M.thermoresistible__bu --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 AVVAFPTADKA-----RAFVQTSADKWKN-CAGKTVTVTNKAKTYRWTFA
Rv1266c|M.tuberculosis_H37Rv AVVAFPTADKA-----RAFVQTSADKWKN-CAGKTVTVTNKAKTYRWTFA
MAV_1417|M.avium_104 AVVLFPSADKA-----KSFLQTSLQKWKG-CAGQTVTVTNKSKTYRWTFA
MMAR_2444|M.marinum_M GAVIFASADQA-----VGFVAAQADQWRS-CAGKDVTQVNNGKTSRWTFR
MUL_3180|M.ulcerans_Agy99 ASYCVAAQDDP-----KVYTDFYAALFASDFQPQEAAASDRTDAELAHLA
MAB_4435|M.abscessus_ATCC_1997 AADALSTDGAS-----DALKRCDAVAYIIPGSSTTWRCSFEFDEPNPVQN
MLBr_00016|M.leprae_Br4923 GQIVEIAQKNLNVYGFTKFSQASVDSPRPTGEVIGTNPPKDATVPVDSVI
Mflv_5210|M.gilvum_PYR-GCK GARRSGDGFTVTG-SDGARYDVQPDQLTIS-----SGGSVDSAEPALEYG
Mvan_1066|M.vanbaalenii_PYR-1 GAQRSGDGFVVTG-SDGARYDVQPDQLTIS-----SNGSVDSAEPALEYG
MSMEG_4366|M.smegmatis_MC2_155 DAQRSGDGYVAVNPADGARYEVSPEGLTIM-----SNGHVDSSEPPEEYG
TH_2947|M.thermoresistible__bu --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DVKGSPPTITVIDTQEGAEGWECQRAMSVA-----NNVVVDVNACGYQIT
Rv1266c|M.tuberculosis_H37Rv DVKGSPPTITVIDTQEGAEGWECQRAMSVA-----NNVVVDVNACGYRIT
MAV_1417|M.avium_104 QVQGAPPKITLMDTQEGADGWECQRALSVA-----NNVIVDINACGYRIT
MMAR_2444|M.marinum_M EVSGAPPKISLQRDLADSV-VVCQHVLSAV-----SNIVLDVNVCAPNVT
MUL_3180|M.ulcerans_Agy99 QTVGAN-GTATSCIKAGNDMGTARTKAAAA-----DATLSELNAGLRRC-
MAB_4435|M.abscessus_ATCC_1997 GQKELTTTESCYMFPSGANSIRQHVSFNVV-----RGLLVYILASGASNR
MLBr_00016|M.leprae_Br4923 ELQVSKGNQFVMPDLSGMFWADAEPRLRALGWTGVLDKGPDVDAGGSQHN
Mflv_5210|M.gilvum_PYR-GCK SAQ----------------------
Mvan_1066|M.vanbaalenii_PYR-1 SAQ----------------------
MSMEG_4366|M.smegmatis_MC2_155 SK-----------------------
TH_2947|M.thermoresistible__bu -------------------------
Mb1297c|M.bovis_AF2122/97 NQAGQIAAKIVDKVNKE--------
Rv1266c|M.tuberculosis_H37Rv NQAGQIAAKIVDKVNKE--------
MAV_1417|M.avium_104 DQGDQIADKIVAKIDNE--------
MMAR_2444|M.marinum_M DQASEIADTMAAKVPT---------
MUL_3180|M.ulcerans_Agy99 -------------------------
MAB_4435|M.abscessus_ATCC_1997 NDAAGSLSATALSFATTMKILRYGR
MLBr_00016|M.leprae_Br4923 RVAYQNPPAGAGVNRDGIITLKFGQ