For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3577 | - | - | 100% (548) | putative putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3971 | - | 2e-92 | 39.69% (509) | PUTATIVE putative putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4072 | - | 5e-87 | 38.81% (554) | PUTATIVE AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 6e-61 | 30.80% (552) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4363 | - | 2e-85 | 39.28% (527) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 6e-61 | 30.80% (552) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-29 | 27.12% (520) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 1e-56 | 31.05% (525) | AMP-binding domain protein |
| M. marinum M | MMAR_4026 | fadD35_1 | 5e-88 | 38.88% (535) | fatty-acid-CoA ligase FadD35_1 |
| M. avium 104 | MAV_1579 | - | 5e-99 | 41.11% (540) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3468 | - | 3e-77 | 36.96% (533) | AMP-binding enzyme |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 1e-43 | 30.61% (539) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1981 | - | 2e-82 | 39.00% (518) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 ----------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAAT-----
Rv2505c|M.tuberculosis_H37Rv ----------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAAT-----
MAB_4377c|M.abscessus_ATCC_199 --------------------MKAYDAGATLSPIIEETIGENFERI-----
Mflv_4363|M.gilvum_PYR-GCK -------------------------------MSDPCTVAEVLRAQ-----
Mvan_1981|M.vanbaalenii_PYR-1 ------------------------------MTPDPATVADVLRRQ-----
MMAR_4026|M.marinum_M ------------------------------MAADSPTVAQILRRQ-----
MAV_1579|M.avium_104 ------------------------------MPGDFATVGATLRHQ-----
TH_3577|M.thermoresistible__bu ----------------------------MPFPTIEPTVPALLRWC-----
MSMEG_3468|M.smegmatis_MC2_155 ------------------------------MTPAPLTVPALLQRS-----
MUL_4126|M.ulcerans_Agy99 ------------------------------MTSDPRTVPTALDRL-----
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:: :
Mb2533c|M.bovis_AF2122/97 -----AARYGHREALVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDR
Rv2505c|M.tuberculosis_H37Rv -----AARYGHREALVDMVARRRFNYSELLTDVHRLATGLVRAGIGPGDR
MAB_4377c|M.abscessus_ATCC_199 -----ARAHPDVGALVDVSGDRRWTYRELDAEINRVARGLMSLGVAAGDR
Mflv_4363|M.gilvum_PYR-GCK -----RRHG-DKPLLICD--DERLSYAEADERSAVLAARLTTLGVGKGSH
Mvan_1981|M.vanbaalenii_PYR-1 -----RLWA-DKPLLVCD--RTRLSYGEADERSAVLAQRLVALGAGKGTH
MMAR_4026|M.marinum_M -----ARCRPDHPFLVCD--SDRISYAQADLRSAELARGLIALGIGKAAH
MAV_1579|M.avium_104 -----ARWRGDHPLLICD--AERISYAEADVRSAELARGLIALGAGKGTH
TH_3577|M.thermoresistible__bu -----GERFGSADFLIAG--GRTLSYADLNRRSARLGMSLLRHGVGKGDH
MSMEG_3468|M.smegmatis_MC2_155 -----VREFGDDTYLVTP--TGRATYREIDNLSVRAARWLLGQGAGKGTR
MUL_4126|M.ulcerans_Agy99 -----VRRLPNHDALVTD--ERSFTVSELNDEVYRAAAALIELGVKPAAR
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDE--EGTLTYKELDRAAHALANGLIAKGVRGGDG
*: . : . * * .
Mb2533c|M.bovis_AF2122/97 VGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVI
Rv2505c|M.tuberculosis_H37Rv VGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVI
MAB_4377c|M.abscessus_ATCC_199 VGIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLI
Mflv_4363|M.gilvum_PYR-GCK VGILYPNGAQWVVAMLAAARIGAVVVPFSTFSTAVELRRQLRDSDVGVLL
Mvan_1981|M.vanbaalenii_PYR-1 VGLLYPNSAEFVVAMLAATRIGAVVVPFSTFGTAPEVRRQLVDSDVSVLL
MMAR_4026|M.marinum_M VGLLYPNGSDFVIGMLAAARIGAVVIPISTFVTPRELHEQLVDSDTQILL
MAV_1579|M.avium_104 VGLLHPNGARFVVAMLAAARIGAVVVPFSTFVTVRELREQLLDSDVEILL
TH_3577|M.thermoresistible__bu VGILMPNSVDWAVAWFAVTRIGAVAVPINTFSKPRELAWTVRHADLRAVL
MSMEG_3468|M.smegmatis_MC2_155 VGLFFANGIEWITWWLAVSRIGAVAVPLSTLYTPAEIAKVLRLADVGILV
MUL_4126|M.ulcerans_Agy99 VGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLF
MLBr_02546|M.leprae_Br4923 IAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVII
:.: * : . .:** : :.. : :.
Mb2533c|M.bovis_AF2122/97 AVASFKDADYAAMLAEVGPRCPDLADVILLESDRWDALAG----------
Rv2505c|M.tuberculosis_H37Rv AVASFKDADYAAMLAEVGPRCPDLADVILLESDRWDALAG----------
MAB_4377c|M.abscessus_ATCC_199 CAKAFKSSDYVAMASQVMPDAPGLRDVVFIGTSDWTELVAGA--------
Mflv_4363|M.gilvum_PYR-GCK ATRAFRTHDYVRALGEAVGVPLDDG--PLLSAEVPVLRHVVFD------A
Mvan_1981|M.vanbaalenii_PYR-1 AARSFRSHDYVQTLTDAVGARPTHG--PVFSTAAPVLRHVLFDD---QDS
MMAR_4026|M.marinum_M SADTFRSHDYAGRLRQLLGDTGFDGEDRLFSRAIPQLR-TAWVS---YRR
MAV_1579|M.avium_104 SARSFRPHDYARRLSEAVSETDFDPGRRLFCTAAPQLRRVLFAP---QTV
TH_3577|M.thermoresistible__bu AWADFGTNDFLARLEEALPGLDRQRCGRIAVRGAPFLRTVAVWGSPDRRW
MSMEG_3468|M.smegmatis_MC2_155 APPRVLNIDVGLRLREALPELAGQPSRAIAVRATPFLRRIAITGETDLPC
MUL_4126|M.ulcerans_Agy99 AMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETG------
MLBr_02546|M.leprae_Br4923 YDDEYT--KVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAEL------
.
Mb2533c|M.bovis_AF2122/97 ----------------AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPK
Rv2505c|M.tuberculosis_H37Rv ----------------AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPK
MAB_4377c|M.abscessus_ATCC_199 ----------------ERVTETALRARMSQLSNTDPINIQYTSGTTGYPK
Mflv_4363|M.gilvum_PYR-GCK ECGG-------------AAD---VSALEGDVDGSDVLAIIYTSGSTSDPK
Mvan_1981|M.vanbaalenii_PYR-1 DARG-------------RVDDALLRAMEDDVDGCDPLAVIYTSGSTSAPK
MMAR_4026|M.marinum_M GAPRRTRSIECVYRLSQTIDPTMLRALEDDVDGSDVLAIVYTSGTTSAPK
MAV_1579|M.avium_104 GAP------------GGGIDPALLAAMEDDVQACDPLAIVYTSGSTSTPK
TH_3577|M.thermoresistible__bu ATPVADDALGDAPGDVPGVDAGHLTAVEACVTPADDVAVIYTSGSTGDPK
MSMEG_3468|M.smegmatis_MC2_155 ATRIDD----------TGVPQEILAAAESEVSPADLAVMVHTSGSTADPK
MUL_4126|M.ulcerans_Agy99 ------------------TDTGAVTARAAAVSPDDVSDILFTSGTTGRSK
MLBr_02546|M.leprae_Br4923 --------------------IARSSSAPAPKVRKRASIIILTSGTTGTPK
: ***:*. .*
Mb2533c|M.bovis_AF2122/97 GVTLSHRNILNNGY----LVGELLGYTAQDRICIPVPFYHCFGMVMGNLA
Rv2505c|M.tuberculosis_H37Rv GVTLSHRNILNNGY----LVGELLGYTAQDRICIPVPFYHCFGMVMGNLA
MAB_4377c|M.abscessus_ATCC_199 GATLSHRNVLNNGF----FVAESIQLQAGDRLCIPVPFYHCFGMVMGNLG
Mflv_4363|M.gilvum_PYR-GCK GVVHTHTSLLAHQR----GLNEIRGLTAEDRLFCNSPFFWIGGFAFGLLA
Mvan_1981|M.vanbaalenii_PYR-1 GVVHTHAALLAHQR----SLNEIRRLTADDRLFCNSPFFWIGGFAFGLLA
MMAR_4026|M.marinum_M GVVHTHSALVRHQQ----NLNVIRGLGTDDKLFCNSPFCWIGGFAFGLLA
MAV_1579|M.avium_104 GVVHTHGALLEHQR----NLNGIRGLTADDRLFCNSPFFWIGGFAFGLLA
TH_3577|M.thermoresistible__bu GAVHSHGALIRHSF----NLTHVYVVRPGDVLFTSMPFFWVGGLITGLHA
MSMEG_3468|M.smegmatis_MC2_155 GVLHTHGTLVRQTSTWPAAIRAVTGSQGHARILCAMPFFWIGGLLA-ATG
MUL_4126|M.ulcerans_Agy99 GVLCAHRQSLSASA----SWAANGKITADDRHLCINPFFHNFGYKAGILA
MLBr_02546|M.leprae_Br4923 GANRNTPASLAPLG----GILSKVPFRAHEVTLLPAPMFHALGYLHATLA
*. : *: * .
Mb2533c|M.bovis_AF2122/97 ATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPD--F
Rv2505c|M.tuberculosis_H37Rv ATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPD--F
MAB_4377c|M.abscessus_ATCC_199 CTTHGATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLADPG--F
Mflv_4363|M.gilvum_PYR-GCK TLVAGSTLIC-STASDAGRTLDLLEAEKPTMTNGFVAGITHLTRHPS--F
Mvan_1981|M.vanbaalenii_PYR-1 TLVAGATLIC-SNATDAADTLDLLEAEKPTVTNGFVAGITHLPRHPS--F
MMAR_4026|M.marinum_M TLLAGSTLVC-SNA-DAATTLDLLEREKPTMTNGFASTVARLANHPS--F
MAV_1579|M.avium_104 TLVAGSTLIC-SNATDAGATLDLLEAEKPTMTNGFSAGIAHLAEHPS--F
TH_3577|M.thermoresistible__bu VVHHGATLVT-QPAFDPADALRLIETHRATITLGWPQQGRTLSEHPD--F
MSMEG_3468|M.smegmatis_MC2_155 ALHEPVTLAI-LPKLDAGAALDLAERERITGIVGWPAFTQRLREHPT--F
MUL_4126|M.ulcerans_Agy99 CLQTGATLFP-HLTFDPLRTLQAIERHRITVLPGPPTIYQTLLDHPA--R
MLBr_02546|M.leprae_Br4923 MFLGSTLVLR--RRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLE
: .. .* : .: .
Mb2533c|M.bovis_AF2122/97 TDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETS-PVST
Rv2505c|M.tuberculosis_H37Rv TDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETS-PVST
MAB_4377c|M.abscessus_ATCC_199 AHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETS-PVSC
Mflv_4363|M.gilvum_PYR-GCK ARRDLSSMRRGNL------YSIMAPDVRPADPELRHNMLGMTEAGSVVLL
Mvan_1981|M.vanbaalenii_PYR-1 ARRDLSSMRRGNL------YPIMAAGARPADAELRHNMLGMTETGSVVLL
MMAR_4026|M.marinum_M GRRDLSSMRRGNL------YPIMAPEARPVDPELRHNMLGMTEAGSIVLI
MAV_1579|M.avium_104 ADRDLSSMRRGNL------YPIMAVEARPADPELRHNMLGMTEAGGVVLI
TH_3577|M.thermoresistible__bu AIRDLSSVRRTSM------PAMVPPDRRPVACDS----LGMTELCGNHLG
MSMEG_3468|M.smegmatis_MC2_155 SVRDLSSAP-------------MLRDG-PLD-------IAMTDVPDGFPV
MUL_4126|M.ulcerans_Agy99 DDYDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTM
MLBr_02546|M.leprae_Br4923 TKSDLSSLRVVFVSG----SQLGAELATRALEELGPVIYNMYGSTEIAFA
:*.: :
Mb2533c|M.bovis_AF2122/97 QTRADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCTRGYSV
Rv2505c|M.tuberculosis_H37Rv QTRADDSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCTRGYSV
MAB_4377c|M.abscessus_ATCC_199 QTLFDDDLDRRTATVGRAHPHIEIKIVDPNSGETVQRGQSGELCTRGYSV
Mflv_4363|M.gilvum_PYR-GCK SGDESDQPEARRGSYGFLAPGFDARVVDPDTGSDTDG-AVGELVLRGPHL
Mvan_1981|M.vanbaalenii_PYR-1 SGDDSDQPESRRGSFGFLAPGFQARVVDPDTGCDVAVSTPGVLLLRGPFL
MMAR_4026|M.marinum_M SADESDQPESRRGSFGKPAPGFDTIIIEPGTGEVANVGQVGELCIRGPFV
MAV_1579|M.avium_104 GDDEADQPEHRRGSFGKPAPGFEARILDPDTGAAVAVGEVGELCIRGPYL
TH_3577|M.thermoresistible__bu ADPYAEQPPHRRDTVGPSIDGLTHRIADPETGEPVPTGQTGEIWVRGYSL
MSMEG_3468|M.smegmatis_MC2_155 HRTMTETAG------GFAYT--DMRIVD-DNGVPAPDGTVGELHVRGIGV
MUL_4126|M.ulcerans_Agy99 CR-ADDDALTVATTCGRPFADFELRIGP----------DTGEVLLRGPNV
MLBr_02546|M.leprae_Br4923 TIAGPKDLQINSATVGPVVKGVKVKILD-DSGKEVPRGQVGRIFVGNAFP
. * : * . .
Mb2533c|M.bovis_AF2122/97 MAGYWNDPQKTAEVIDADGWMHTGDLAEM-DPSGYVRIAGRIKDLVVR-G
Rv2505c|M.tuberculosis_H37Rv MAGYWNDPQKTAEVIDADGWMHTGDLAEM-DPSGYVRIAGRIKDLVVR-G
MAB_4377c|M.abscessus_ATCC_199 MLGYWNDEAHTREVLDTDGWMHTGDLAVM-RDDGYCTIIGRLKDMVIR-G
Mflv_4363|M.gilvum_PYR-GCK MQRYYG--RSREECFDADGWFHTGDLVRR-DDDGVFYFVGRAGSMIKT-A
Mvan_1981|M.vanbaalenii_PYR-1 MQGYYG--RAREDCFDGDGWFDTGDLVRR-DGDGVFYFIGRTGTMIKT-A
MMAR_4026|M.marinum_M MQGYYK--RSREECFDADGWFHTGDLVRA-DQDGYMYFTGRLSSLIKT-A
MAV_1579|M.avium_104 MQRYHK--RSREECFDPDGWFHTGDLVRA-DADGYFYFAGRLGAMIKT-A
TH_3577|M.thermoresistible__bu MQRLHK--REREDVFTEDGYYRTGDCGAA-DADGWIRFTGRLGDLIKTGS
MSMEG_3468|M.smegmatis_MC2_155 MAGYNK--RERFETFDDDGWYHTGDKVYRRPGDPRVFYVGRTTDLIKA-A
MUL_4126|M.ulcerans_Agy99 MLGYLDDPRATAAAIDADGWLHTGDIGVL-DEAGNLRITDRLKDMYIC-G
MLBr_02546|M.leprae_Br4923 FEGYTG----GGGKQIIDGLLSSGDVGYF-DEHDLLYISGRDDEMIVS-G
: ** :** .* : .
Mb2533c|M.bovis_AF2122/97 GENISPREIEELLHTHPD----IVDGHVIGVPDAKYGEELMAVVKLRNDA
Rv2505c|M.tuberculosis_H37Rv GENISPREIEELLHTHPD----IVDGHVIGVPDAKYGEELMAVVKLRNDA
MAB_4377c|M.abscessus_ATCC_199 GENIYPREIEEFLLTHPD----IEDVHVVGVPDEKYGEELCAWVRMRPDR
Mflv_4363|M.gilvum_PYR-GCK GANVAPAEVEKALSAALQAVDAGVAVHVVGLPDPERGQIVAAVIATDNG-
Mvan_1981|M.vanbaalenii_PYR-1 GANVAPGEVEKAIIAVIP--DPDVVVHVVGLPDAERGQLVAAVIASD---
MMAR_4026|M.marinum_M GANVSPAEVERAIAKLG------MVAHVVGIPDPQRGQVVAAVLVVADGV
MAV_1579|M.avium_104 GANVSAVEVEKAIAAVTG----GATAYVVGIPDARRGQLVAAAVVWPDDR
TH_3577|M.thermoresistible__bu GTNVTPAEVESALCELPG----VLEAYVVGARDPHGATVVAAAAVPGRG-
MSMEG_3468|M.smegmatis_MC2_155 GANVSPLEVEAVLAGFGE----VAQCLVLGVDDAERGEEVCAVVVPSGTP
MUL_4126|M.ulcerans_Agy99 GFNVYPAEVEQVLARLDG----VADVAVIGIPDHRLGEVGRAFIVARPG-
MLBr_02546|M.leprae_Br4923 GENVFPAEVEDLISGHPE----VVEATAIGVDDKEWGARLRAFVVKKQD-
* *: . *:* : .:* * . . *
Mb2533c|M.bovis_AF2122/97 -PELTIERLREYCMGRIARFKIPRYLWIVDE--FPMTVTGKVRKVEMRQQ
Rv2505c|M.tuberculosis_H37Rv -PELTIERLREYCMGRIARFKIPRYLWIVDE--FPMTVTGKVRKVEMRQQ
MAB_4377c|M.abscessus_ATCC_199 -VVIDAVAIRAFASGRLAHYKIPRYVHVVES--FPMTVTGKVRKIEMRQQ
Mflv_4363|M.gilvum_PYR-GCK -TVFDEPAVKEALSTQVSAYKIPRRVLSLRHTEIPTMSSGKIDLAALRRL
Mvan_1981|M.vanbaalenii_PYR-1 -TEVDVSGLQETLRSHLSAYKIPRRVATVRHADIPMLSSGKVDLSALRRL
MMAR_4026|M.marinum_M -GALDELALRERLETELSAYKIPTRFATLPPSEIPLLSSGKVDTHQLKKC
MAV_1579|M.avium_104 -AALDPDALRERLKSELSAYKIPRRFASLRRADVPLLSSGKVDLRQLRKL
TH_3577|M.thermoresistible__bu -HELDAAALRDGLRTMLSAYKIPRHIWVADKADLPFTDTGKIVRSELAEQ
MSMEG_3468|M.smegmatis_MC2_155 GDTLDVALLAQRAREQLSAYKVPTRWVIACSDDIPTLPSGKFDRKALRRW
MUL_4126|M.ulcerans_Agy99 -FNLDEKSVIDYTREHLANFKAPRSVRFVDT--LPRNAGGKVVKPQLREL
MLBr_02546|M.leprae_Br4923 -ATIDEDAIKAYVRDHLARYKVPREVIFLEE--LPRNPTGKVLKRELRDF
. : :: :* * .* **. :
Mb2533c|M.bovis_AF2122/97 ALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv ALEYLRGQQ-------
MAB_4377c|M.abscessus_ATCC_199 TIQIFGLPEPGRTDEQ
Mflv_4363|M.gilvum_PYR-GCK FDD-------------
Mvan_1981|M.vanbaalenii_PYR-1 FGALR-----------
MMAR_4026|M.marinum_M FDA-------------
MAV_1579|M.avium_104 FDA-------------
TH_3577|M.thermoresistible__bu LSARLRQQATADL---
MSMEG_3468|M.smegmatis_MC2_155 IIDERLGVTAR-----
MUL_4126|M.ulcerans_Agy99 A---------------
MLBr_02546|M.leprae_Br4923 EVH-------------