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PGDFATVGATLRHQARWRGDHPLLICDAERISYAEADVRSAELARGLIALGAGKGTHVGLLHPNGARFVV AMLAAARIGAVVVPFSTFVTVRELREQLLDSDVEILLSARSFRPHDYARRLSEAVSETDFDPGRRLFCTA APQLRRVLFAPQTVGAPGGGIDPALLAAMEDDVQACDPLAIVYTSGSTSTPKGVVHTHGALLEHQRNLNG IRGLTADDRLFCNSPFFWIGGFAFGLLATLVAGSTLICSNATDAGATLDLLEAEKPTMTNGFSAGIAHLA EHPSFADRDLSSMRRGNLYPIMAVEARPADPELRHNMLGMTEAGGVVLIGDDEADQPEHRRGSFGKPAPG FEARILDPDTGAAVAVGEVGELCIRGPYLMQRYHKRSREECFDPDGWFHTGDLVRADADGYFYFAGRLGA MIKTAGANVSAVEVEKAIAAVTGGATAYVVGIPDARRGQLVAAAVVWPDDRAALDPDALRERLKSELSAY KIPRRFASLRRADVPLLSSGKVDLRQLRKLFDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1579 | - | - | 100% (524) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1577 | - | 2e-87 | 39.15% (516) | AMP-binding enzyme, putative |
| M. avium 104 | MAV_0600 | fadD | 4e-47 | 31.60% (538) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 9e-56 | 30.64% (532) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4363 | - | 0.0 | 66.79% (524) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 9e-56 | 30.64% (532) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-27 | 25.24% (515) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 2e-55 | 30.84% (535) | AMP-binding domain protein |
| M. marinum M | MMAR_4026 | fadD35_1 | 0.0 | 68.28% (536) | fatty-acid-CoA ligase FadD35_1 |
| M. smegmatis MC2 155 | MSMEG_2216 | - | 0.0 | 63.87% (512) | AMP-binding enzyme |
| M. thermoresistible (build 8) | TH_3577 | - | 4e-99 | 41.11% (540) | PUTATIVE putative putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 8e-47 | 30.93% (540) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1981 | - | 0.0 | 68.70% (524) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 ------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
Rv2505c|M.tuberculosis_H37Rv ------MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREA
MAB_4377c|M.abscessus_ATCC_199 ----------------MKAYDAGATLSPIIEETIGENFERIARAHPDVGA
MUL_4126|M.ulcerans_Agy99 --------------------------MTSDPRTVPTALDRLVRRLPNHDA
MAV_1579|M.avium_104 --------------------------MPGDFATVGATLRHQARWRGDHPL
MMAR_4026|M.marinum_M --------------------------MAADSPTVAQILRRQARCRPDHPF
Mflv_4363|M.gilvum_PYR-GCK ---------------------------MSDPCTVAEVLRAQ-RRHGDKPL
Mvan_1981|M.vanbaalenii_PYR-1 --------------------------MTPDPATVADVLRRQ-RLWADKPL
MSMEG_2216|M.smegmatis_MC2_155 -----------------------------MAETLVELLEGL-RDRGDHTL
TH_3577|M.thermoresistible__bu ------------------------MPFPTIEPTVPALLRWCGERFGSADF
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:
Mb2533c|M.bovis_AF2122/97 LVDMVA------------RRRFNYSELLTDVHRLATGLVRAGIGPGDRVG
Rv2505c|M.tuberculosis_H37Rv LVDMVA------------RRRFNYSELLTDVHRLATGLVRAGIGPGDRVG
MAB_4377c|M.abscessus_ATCC_199 LVDVSG------------DRRWTYRELDAEINRVARGLMSLGVAAGDRVG
MUL_4126|M.ulcerans_Agy99 LVTD--------------ERSFTVSELNDEVYRAAAALIELGVKPAARVG
MAV_1579|M.avium_104 LICD--------------AERISYAEADVRSAELARGLIALGAGKGTHVG
MMAR_4026|M.marinum_M LVCD--------------SDRISYAQADLRSAELARGLIALGIGKAAHVG
Mflv_4363|M.gilvum_PYR-GCK LICD--------------DERLSYAEADERSAVLAARLTTLGVGKGSHVG
Mvan_1981|M.vanbaalenii_PYR-1 LVCD--------------RTRLSYGEADERSAVLAQRLVALGAGKGTHVG
MSMEG_2216|M.smegmatis_MC2_155 LVCD--------------DERLTYADAEHRSARLADALIALGAGKGTHVG
TH_3577|M.thermoresistible__bu LIAG--------------GRTLSYADLNRRSARLGMSLLRHGVGKGDHVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
* . : . * * . :.
Mb2533c|M.bovis_AF2122/97 IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
Rv2505c|M.tuberculosis_H37Rv IWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAV
MAB_4377c|M.abscessus_ATCC_199 IWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLICA
MUL_4126|M.ulcerans_Agy99 IWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAM
MAV_1579|M.avium_104 LLHPNGARFVVAMLAAARIGAVVVPFSTFVTVRELREQLLDSDVEILLSA
MMAR_4026|M.marinum_M LLYPNGSDFVIGMLAAARIGAVVIPISTFVTPRELHEQLVDSDTQILLSA
Mflv_4363|M.gilvum_PYR-GCK ILYPNGAQWVVAMLAAARIGAVVVPFSTFSTAVELRRQLRDSDVGVLLAT
Mvan_1981|M.vanbaalenii_PYR-1 LLYPNSAEFVVAMLAATRIGAVVVPFSTFGTAPEVRRQLVDSDVSVLLAA
MSMEG_2216|M.smegmatis_MC2_155 VLYPNGADFVVAMLAVARVGAVVVPFSTFLTEAELRVQLLDSDVSIMLSA
TH_3577|M.thermoresistible__bu ILMPNSVDWAVAWFAVTRIGAVAVPINTFSKPRELAWTVRHADLRAVLAW
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: * :.: . .:** : :.. : ::
Mb2533c|M.bovis_AF2122/97 ASFKDADYAAMLAEVG-------------PRCPDLADVILLESDRWDALA
Rv2505c|M.tuberculosis_H37Rv ASFKDADYAAMLAEVG-------------PRCPDLADVILLESDRWDALA
MAB_4377c|M.abscessus_ATCC_199 KAFKSSDYVAMASQVM-------------PDAPGLRDVVFIGTSDWTELV
MUL_4126|M.ulcerans_Agy99 GHFLGSDRVAGLDRKA-------------LPALRHIVRIPIEEPDGTWDE
MAV_1579|M.avium_104 RSFRPHDYARRLSEAVSETDFDPGRRLFCTAAPQLRRVLFAP---QTVGA
MMAR_4026|M.marinum_M DTFRSHDYAGRLRQLLGDTGFDGEDRLFSRAIPQLR-TAWVS---YRRGA
Mflv_4363|M.gilvum_PYR-GCK RAFRTHDYVRALGEAVGVPLDDG--PLLSAEVPVLRHVVFD------AEC
Mvan_1981|M.vanbaalenii_PYR-1 RSFRSHDYVQTLTDAVGARPTHG--PVFSTAAPVLRHVLFDD---QDSDA
MSMEG_2216|M.smegmatis_MC2_155 RSFRSHDYVGQISRVR-------------ADAPCLRHVVFE------IPA
TH_3577|M.thermoresistible__bu ADFGTNDFLARLEEALPGLDRQRCGRIAVRGAPFLRTVAVWGSPDRRWAT
MLBr_02546|M.leprae_Br4923 DEYT--KVVSKAEPALG-------------KLRALGVNPDEEEPPGSTDE
: .
Mb2533c|M.bovis_AF2122/97 G-------------AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGV
Rv2505c|M.tuberculosis_H37Rv G-------------AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGV
MAB_4377c|M.abscessus_ATCC_199 AG-----------AERVTETALRARMSQLSNTDPINIQYTSGTTGYPKGA
MUL_4126|M.ulcerans_Agy99 FI-----------ETGTDTGAVTARAAAVSPDDVSDILFTSGTTGRSKGV
MAV_1579|M.avium_104 P------------GGGIDPALLAAMEDDVQACDPLAIVYTSGSTSTPKGV
MMAR_4026|M.marinum_M PRRTRSIECVYRLSQTIDPTMLRALEDDVDGSDVLAIVYTSGTTSAPKGV
Mflv_4363|M.gilvum_PYR-GCK GG-------------AAD---VSALEGDVDGSDVLAIIYTSGSTSDPKGV
Mvan_1981|M.vanbaalenii_PYR-1 RG-------------RVDDALLRAMEDDVDGCDPLAVIYTSGSTSAPKGV
MSMEG_2216|M.smegmatis_MC2_155 AG-------------DPER--RAGLEADVEGSDVLAIIYTSGSTGAPKGV
TH_3577|M.thermoresistible__bu PVADDALGDAPGDVPGVDAGHLTAVEACVTPADDVAVIYTSGSTGDPKGA
MLBr_02546|M.leprae_Br4923 TL-------------AELIARSSSAPAPKVRKRASIIILTSGTTGTPKGA
: ***:*. .**.
Mb2533c|M.bovis_AF2122/97 TLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGA
Rv2505c|M.tuberculosis_H37Rv TLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGA
MAB_4377c|M.abscessus_ATCC_199 TLSHRNVLNNGFFVAESIQLQAGDRLCIPVPFYHCFGMVMGNLGCTTHGA
MUL_4126|M.ulcerans_Agy99 LCAHRQSLSASASWAANGKITADDRHLCINPFFHNFGYKAGILACLQTGA
MAV_1579|M.avium_104 VHTHGALLEHQRNLNGIRGLTADDRLFCNSPFFWIGGFAFGLLATLVAG-
MMAR_4026|M.marinum_M VHTHSALVRHQQNLNVIRGLGTDDKLFCNSPFCWIGGFAFGLLATLLAG-
Mflv_4363|M.gilvum_PYR-GCK VHTHTSLLAHQRGLNEIRGLTAEDRLFCNSPFFWIGGFAFGLLATLVAG-
Mvan_1981|M.vanbaalenii_PYR-1 VHTHAALLAHQRSLNEIRRLTADDRLFCNSPFFWIGGFAFGLLATLVAG-
MSMEG_2216|M.smegmatis_MC2_155 VHTHSSLLAHQRDLNVLRGLTADDKLFCNSPFFWVGGLAFALLASMIAG-
TH_3577|M.thermoresistible__bu VHSHGALIRHSFNLTHVYVVRPGDVLFTSMPFFWVGGLITGLHAVVHHG-
MLBr_02546|M.leprae_Br4923 NRNTPASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGS-
: . : *: * . . .
Mb2533c|M.bovis_AF2122/97 AMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPD--FTDYELG
Rv2505c|M.tuberculosis_H37Rv AMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPD--FTDYELG
MAB_4377c|M.abscessus_ATCC_199 TIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLADPG--FAHRDLS
MUL_4126|M.ulcerans_Agy99 TLFPHLT-FDPLRTLQAIERHRITVLPGPPTIYQTLLDHPA--RDDYDLS
MAV_1579|M.avium_104 STLICSNATDAGATLDLLEAEKPTMTNGFSAGIAHLAEHPS--FADRDLS
MMAR_4026|M.marinum_M STLVCSNA-DAATTLDLLEREKPTMTNGFASTVARLANHPS--FGRRDLS
Mflv_4363|M.gilvum_PYR-GCK STLICSTASDAGRTLDLLEAEKPTMTNGFVAGITHLTRHPS--FARRDLS
Mvan_1981|M.vanbaalenii_PYR-1 ATLICSNATDAADTLDLLEAEKPTVTNGFVAGITHLPRHPS--FARRDLS
MSMEG_2216|M.smegmatis_MC2_155 ATLVCSNSTDAGATFDLLEAEKPTITNGFVAGIAHLTRHPS--FPHRNLS
TH_3577|M.thermoresistible__bu ATLVTQPAFDPADALRLIETHRATITLGWPQQGRTLSEHPD--FAIRDLS
MLBr_02546|M.leprae_Br4923 -TLVLRRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLS
. .. .: :: .: . :*.
Mb2533c|M.bovis_AF2122/97 SLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRADDS
Rv2505c|M.tuberculosis_H37Rv SLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRADDS
MAB_4377c|M.abscessus_ATCC_199 TLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETSPVSCQTLFDDD
MUL_4126|M.ulcerans_Agy99 SLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDD
MAV_1579|M.avium_104 SMRRGNLYPIMAVEARPADPELRHNMLGMTEAGGVVLIGDD-----EADQ
MMAR_4026|M.marinum_M SMRRGNLYPIMAPEARPVDPELRHNMLGMTEAGSIVLISAD-----ESDQ
Mflv_4363|M.gilvum_PYR-GCK SMRRGNLYSIMAPDVRPADPELRHNMLGMTEAGSVVLLSGD-----ESDQ
Mvan_1981|M.vanbaalenii_PYR-1 SMRRGNLYPIMAAGARPADAELRHNMLGMTETGSVVLLSGD-----DSDQ
MSMEG_2216|M.smegmatis_MC2_155 SIRRGNLYPLMAPDVRPADPDLRHNMLGSTESGSVVLLDPD-----DTDQ
TH_3577|M.thermoresistible__bu SVRRTSMPAMVPPDRRPVACDS----LGMTELCGNHLGADP-----YAEQ
MLBr_02546|M.leprae_Br4923 SLRVVFVSGSQLGAELATRALEELGPVIYNMYGSTEIAFAT---IAGPKD
::* . ..
Mb2533c|M.bovis_AF2122/97 VDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCTRGYSVMAGYWND
Rv2505c|M.tuberculosis_H37Rv VDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCTRGYSVMAGYWND
MAB_4377c|M.abscessus_ATCC_199 LDRRTATVGRAHPHIEIKIVDPNSGETVQRGQSGELCTRGYSVMLGYWND
MUL_4126|M.ulcerans_Agy99 ALTVATTCGRPFADFELRIG-PDTGEVLLRGP---------NVMLGYLDD
MAV_1579|M.avium_104 PEHRRGSFGKPAPGFEARILDPDTGAAVAVGEVGELCIRGPYLMQRYHK-
MMAR_4026|M.marinum_M PESRRGSFGKPAPGFDTIIIEPGTGEVANVGQVGELCIRGPFVMQGYYK-
Mflv_4363|M.gilvum_PYR-GCK PEARRGSYGFLAPGFDARVVDPDTGSDTDG-AVGELVLRGPHLMQRYYG-
Mvan_1981|M.vanbaalenii_PYR-1 PESRRGSFGFLAPGFQARVVDPDTGCDVAVSTPGVLLLRGPFLMQGYYG-
MSMEG_2216|M.smegmatis_MC2_155 PEHRRGSFGRPAPGFETKVLD-----------SGELCIRGPYLMQGYYG-
TH_3577|M.thermoresistible__bu PPHRRDTVGPSIDGLTHRIADPETGEPVPTGQTGEIWVRGYSLMQRLHK-
MLBr_02546|M.leprae_Br4923 LQINSATVGPVVKGVKVKILD-DSGKEVPRGQVGRIFVGNAFPFEGYTG-
: * . : :
Mb2533c|M.bovis_AF2122/97 PQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVR-GGENISPRE
Rv2505c|M.tuberculosis_H37Rv PQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVR-GGENISPRE
MAB_4377c|M.abscessus_ATCC_199 EAHTREVLDTDGWMHTGDLAVMRDDGYCTIIGRLKDMVIR-GGENIYPRE
MUL_4126|M.ulcerans_Agy99 PRATAAAIDADGWLHTGDIGVLDEAGNLRITDRLKDMYIC-GGFNVYPAE
MAV_1579|M.avium_104 -RSREECFDPDGWFHTGDLVRADADGYFYFAGRLGAMIKT-AGANVSAVE
MMAR_4026|M.marinum_M -RSREECFDADGWFHTGDLVRADQDGYMYFTGRLSSLIKT-AGANVSPAE
Mflv_4363|M.gilvum_PYR-GCK -RSREECFDADGWFHTGDLVRRDDDGVFYFVGRAGSMIKT-AGANVAPAE
Mvan_1981|M.vanbaalenii_PYR-1 -RAREDCFDGDGWFDTGDLVRRDGDGVFYFIGRTGTMIKT-AGANVAPGE
MSMEG_2216|M.smegmatis_MC2_155 -RSREECFDTDGWFHTGDLVRVDDDGYFYFLGRAGAMIKT-AGANVTPDE
TH_3577|M.thermoresistible__bu -REREDVFTEDGYYRTGDCGAADADGWIRFTGRLGDLIKTGSGTNVTPAE
MLBr_02546|M.leprae_Br4923 ---GGGKQIIDGLLSSGDVGYFDEHDLLYISGRDDEMIVS-GGENVFPAE
** :** . : .* : .* *: . *
Mb2533c|M.bovis_AF2122/97 IEELLHTHPD-----IVDGHVIGVPDAKYGEELMAVVKLRNDAPELTIER
Rv2505c|M.tuberculosis_H37Rv IEELLHTHPD-----IVDGHVIGVPDAKYGEELMAVVKLRNDAPELTIER
MAB_4377c|M.abscessus_ATCC_199 IEEFLLTHPD-----IEDVHVVGVPDEKYGEELCAWVRMRPDRVVIDAVA
MUL_4126|M.ulcerans_Agy99 VEQVLARLDG-----VADVAVIGIPDHRLGEVGRAFIVARPG-FNLDEKS
MAV_1579|M.avium_104 VEKAIAAVTG-----GATAYVVGIPDARRGQLVAAAVVWPDDRAALDPDA
MMAR_4026|M.marinum_M VERAIAKLG-------MVAHVVGIPDPQRGQVVAAVLVVADGVGALDELA
Mflv_4363|M.gilvum_PYR-GCK VEKALSAALQAV-DAGVAVHVVGLPDPERGQIVAAVIATDNG-TVFDEPA
Mvan_1981|M.vanbaalenii_PYR-1 VEKAIIAVIP---DPDVVVHVVGLPDAERGQLVAAVIASD---TEVDVSG
MSMEG_2216|M.smegmatis_MC2_155 VQKALQHVLEGRDMRDVTVQVVGLPDQERGQLVAAVVATADP-AAFDEAA
TH_3577|M.thermoresistible__bu VESALCELPG-----VLEAYVVGARDPHGATVVAAAAVPGRG-HELDAAA
MLBr_02546|M.leprae_Br4923 VEDLISGHPE-----VVEATAIGVDDKEWGARLRAFVVKKQD-ATIDEDA
:: : .:* * . . * .
Mb2533c|M.bovis_AF2122/97 LREYCMGRIARFKIPRYLWIVD--EFPMTVTGKVRKVEMRQQALEYLRGQ
Rv2505c|M.tuberculosis_H37Rv LREYCMGRIARFKIPRYLWIVD--EFPMTVTGKVRKVEMRQQALEYLRGQ
MAB_4377c|M.abscessus_ATCC_199 IRAFASGRLAHYKIPRYVHVVE--SFPMTVTGKVRKIEMRQQTIQIFGLP
MUL_4126|M.ulcerans_Agy99 VIDYTREHLANFKAPRSVRFVD--TLPRNAGGKVVKPQLRELA-------
MAV_1579|M.avium_104 LRERLKSELSAYKIPRRFASLRRADVPLLSSGKVDLRQLRKLFDA-----
MMAR_4026|M.marinum_M LRERLETELSAYKIPTRFATLPPSEIPLLSSGKVDTHQLKKCFDA-----
Mflv_4363|M.gilvum_PYR-GCK VKEALSTQVSAYKIPRRVLSLRHTEIPTMSSGKIDLAALRRLFDD-----
Mvan_1981|M.vanbaalenii_PYR-1 LQETLRSHLSAYKIPRRVATVRHADIPMLSSGKVDLSALRRLFGALR---
MSMEG_2216|M.smegmatis_MC2_155 VRAALRAQLSSYKVPRRFAVIHSDELPVKSSGKIDVAALRELFDD-----
TH_3577|M.thermoresistible__bu LRDGLRTMLSAYKIPRHIWVADKADLPFTDTGKIVRSELAEQLSARLRQQ
MLBr_02546|M.leprae_Br4923 IKAYVRDHLARYKVPREVIFLE--ELPRNPTGKVLKRELRDFEVH-----
: :: :* * . .* **: :
Mb2533c|M.bovis_AF2122/97 Q-------
Rv2505c|M.tuberculosis_H37Rv Q-------
MAB_4377c|M.abscessus_ATCC_199 EPGRTDEQ
MUL_4126|M.ulcerans_Agy99 --------
MAV_1579|M.avium_104 --------
MMAR_4026|M.marinum_M --------
Mflv_4363|M.gilvum_PYR-GCK --------
Mvan_1981|M.vanbaalenii_PYR-1 --------
MSMEG_2216|M.smegmatis_MC2_155 --------
TH_3577|M.thermoresistible__bu ATADL---
MLBr_02546|M.leprae_Br4923 --------