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VTPAPLTVPALLQRSVREFGDDTYLVTPTGRATYREIDNLSVRAARWLLGQGAGKGTRVGLFFANGIEWI TWWLAVSRIGAVAVPLSTLYTPAEIAKVLRLADVGILVAPPRVLNIDVGLRLREALPELAGQPSRAIAVR ATPFLRRIAITGETDLPCATRIDDTGVPQEILAAAESEVSPADLAVMVHTSGSTADPKGVLHTHGTLVRQ TSTWPAAIRAVTGSQGHARILCAMPFFWIGGLLAATGALHEPVTLAILPKLDAGAALDLAERERITGIVG WPAFTQRLREHPTFSVRDLSSAPMLRDGPLDIAMTDVPDGFPVHRTMTETAGGFAYTDMRIVDDNGVPAP DGTVGELHVRGIGVMAGYNKRERFETFDDDGWYHTGDKVYRRPGDPRVFYVGRTTDLIKAAGANVSPLEV EAVLAGFGEVAQCLVLGVDDAERGEEVCAVVVPSGTPGDTLDVALLAQRAREQLSAYKVPTRWVIACSDD IPTLPSGKFDRKALRRWIIDERLGVTAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3468 | - | - | 100% (518) | AMP-binding enzyme |
| M. smegmatis MC2 155 | MSMEG_2216 | - | 2e-64 | 36.45% (524) | AMP-binding enzyme |
| M. smegmatis MC2 155 | MSMEG_2215 | - | 9e-61 | 35.46% (533) | AMP-binding enzyme |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3591 | fadD3 | 1e-40 | 31.40% (535) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_3245 | - | 0.0 | 71.01% (514) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3561 | fadD3 | 7e-41 | 31.40% (535) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 3e-23 | 27.49% (513) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 2e-39 | 27.34% (545) | AMP-binding domain protein |
| M. marinum M | MMAR_4026 | fadD35_1 | 3e-74 | 36.19% (536) | fatty-acid-CoA ligase FadD35_1 |
| M. avium 104 | MAV_1579 | - | 2e-78 | 38.49% (530) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4072 | - | 0.0 | 69.33% (525) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 4e-41 | 30.54% (537) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2960 | - | 0.0 | 70.69% (505) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3591|M.bovis_AF2122/97 ---------------------MINDLRTVPAALDRLVRQLPDHTALIAE-
Rv3561|M.tuberculosis_H37Rv ---------------------MINDLRTVPAALDRLVRQLPDHTALIAE-
MUL_4126|M.ulcerans_Agy99 ---------------------MTSDPRTVPTALDRLVRRLPNHDALVTD-
MAB_4377c|M.abscessus_ATCC_199 -----------MKAYDAGATLSPIIEETIGENFERIARAHPDVGALVDVS
MSMEG_3468|M.smegmatis_MC2_155 ---------------------MTPAPLTVPALLQRSVREFGDDTYLVTP-
TH_4072|M.thermoresistible__bu ----------------VAGPVNRVTALTVPALLAGAAETFGDRTYVVTP-
Mflv_3245|M.gilvum_PYR-GCK ---------------------MDHTPLTVPALLTDAVRRFGERTYVVTPG
Mvan_2960|M.vanbaalenii_PYR-1 ---------------------MDS--LTIPALLSAAVRARGERIYLVTP-
MMAR_4026|M.marinum_M ---------------------MAADSPTVAQILRRQARCRPDHPFLVCD-
MAV_1579|M.avium_104 ---------------------MPGDFATVGATLRHQARWRGDHPLLICD-
MLBr_02661|M.leprae_Br4923 MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTD
:: . . . ::
Mb3591|M.bovis_AF2122/97 ---DRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLA
Rv3561|M.tuberculosis_H37Rv ---DRRFTSTELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLA
MUL_4126|M.ulcerans_Agy99 ---ERSFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTWHWVVACLA
MAB_4377c|M.abscessus_ATCC_199 G--DRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAEWVLVQYA
MSMEG_3468|M.smegmatis_MC2_155 ---TGRATYREIDNLSVRAARWLLGQGAGKGTRVGLFFANGIEWITWWLA
TH_4072|M.thermoresistible__bu ---AERLSYRQAADRSARLARWLLREGVGKGTRVGLFFPNGTDWIVWWLA
Mflv_3245|M.gilvum_PYR-GCK GTPDTRLTYADAEAQSADKARWLLANGAGKGTRVGLFFANDTEWVTWWLA
Mvan_2960|M.vanbaalenii_PYR-1 ---TERLTYAAAERRSAELARWLLGQGVGKGTRVGLFFPNGAEWVTWWLA
MMAR_4026|M.marinum_M ---SDRISYAQADLRSAELARGLIALGIGKAAHVGLLYPNGSDFVIGMLA
MAV_1579|M.avium_104 ---AERISYAEADVRSAELARGLIALGAGKGTHVGLLHPNGARFVVAMLA
MLBr_02661|M.leprae_Br4923 N--RIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIEFVVGLLA
: : * * . :*.: .. :: *
Mb3591|M.bovis_AF2122/97 IHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLG---ADRAAGL
Rv3561|M.tuberculosis_H37Rv IHHAGAAVVPLNTRYTATEATDILDRAGAPVLFAAGLFLG---ADRAAGL
MUL_4126|M.ulcerans_Agy99 IHHVGAAMVPLNTRYTADEAADILARTEAPVLFAMGHFLG---SDRVAGL
MAB_4377c|M.abscessus_ATCC_199 TAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKS---SDYVA-M
MSMEG_3468|M.smegmatis_MC2_155 VSRIGAVAVPLSTLYTPAEIAKVLRLADVGILVAPPRVLN---IDVGLRL
TH_4072|M.thermoresistible__bu VSRIGALAVPLSTLYQPAEIAKVVRLADIAVLIAPGTVLS---IDVPARF
Mflv_3245|M.gilvum_PYR-GCK VSRIGALAVPLSTLYRPAEIAKVLRLADIALLVAPNRVLD---IDVAQRL
Mvan_2960|M.vanbaalenii_PYR-1 VSRVGAVAVPLSTMYRPAEIAKVIRLADVALLIGPTRILD---IDVVSRF
MMAR_4026|M.marinum_M AARIGAVVIPISTFVTPRELHEQLVDSDTQILLSADTFRS---HDYAGRL
MAV_1579|M.avium_104 AARIGAVVVPFSTFVTVRELREQLLDSDVEILLSARSFRP---HDYARRL
MLBr_02661|M.leprae_Br4923 ASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVSDQRAATM
: * : :.. * : . : :
Mb3591|M.bovis_AF2122/97 DRAALPALRHVVRVPVEADDGTWD-----------------------EFI
Rv3561|M.tuberculosis_H37Rv DRAALPALRHVVRVPVEADDGTWD-----------------------EFI
MUL_4126|M.ulcerans_Agy99 DRKALPALRHIVRIPIEEPDGTWD-----------------------EFI
MAB_4377c|M.abscessus_ATCC_199 ASQVMPDAPGLRDVVFIGTSDWTE-----------------------LVA
MSMEG_3468|M.smegmatis_MC2_155 REALPELAGQPSRAIAVR---ATPFLR-RIAITGETDLPCATR------I
TH_4072|M.thermoresistible__bu EQAWPELAGQRAGQLALT---AAPYLR-TIVLTEPTDRPWAARW----KP
Mflv_3245|M.gilvum_PYR-GCK EAALPGLEGHRTPHLQIA---AAPYLR-SIAITGHSDAPWATA-----VD
Mvan_2960|M.vanbaalenii_PYR-1 EEALPELSGHDGPRLALT---EAPFLR-RIALTGPVAAPWATT-----ID
MMAR_4026|M.marinum_M RQLLGDTGFDGEDRLFSR---AIPQLR-TAWVSYRRGAPRRTRSIECVYR
MAV_1579|M.avium_104 SEAVSETDFDPGRRLFCT---AAPQLRRVLFAPQTVGAP-----------
MLBr_02661|M.leprae_Br4923 RYWPIAVSYGSVTGASEGS----------------------------LLV
Mb3591|M.bovis_AF2122/97 ATGAGALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASA
Rv3561|M.tuberculosis_H37Rv ATGAGALDAVAARAAAVAPQDVSDILFTSGTTGRSKGVLCAHRQSLSASA
MUL_4126|M.ulcerans_Agy99 ETGT-DTGAVTARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQSLSASA
MAB_4377c|M.abscessus_ATCC_199 GAERVTETALRARMSQLSNTDPINIQYTSGTTGYPKGATLSHRNVLNNGF
MSMEG_3468|M.smegmatis_MC2_155 DDTGVPQEILAAAESEVSPADLAVMVHTSGSTADPKGVLHTHGTLVRQTS
TH_4072|M.thermoresistible__bu DAATAAPELLSAVEAEVSPADLAVMVHTSGSTADPKGVLHTHGTLVRQTS
Mflv_3245|M.gilvum_PYR-GCK GAQTVSPDILLAAQEQVFPGDLAIMVHTSGSTADPKGVLHTHGTLVRQTS
Mvan_2960|M.vanbaalenii_PYR-1 DADSVPSRVQAAAEAEVSPADLAIMVHTSGSTADPKGVMHTHGTVVRQTS
MMAR_4026|M.marinum_M LSQTIDPTMLRALEDDVDGSDVLAIVYTSGTTSAPKGVVHTHSALVRHQQ
MAV_1579|M.avium_104 -GGGIDPALLAAMEDDVQACDPLAIVYTSGSTSTPKGVVHTHGALLEHQR
MLBr_02661|M.leprae_Br4923 HLDDTAALHPVTSTPDGLRHDDAMIMFTGGTTGLPKMVPWTDGNIAGSVH
: * : .*.*:*. .* . :.
Mb3591|M.bovis_AF2122/97 SWAANGKITS-------------------DDRYLCINPFFHNFGYKAGIL
Rv3561|M.tuberculosis_H37Rv SWAANGKITS-------------------DDRYLCINPFFHNFGYKAGIL
MUL_4126|M.ulcerans_Agy99 SWAANGKITA-------------------DDRHLCINPFFHNFGYKAGIL
MAB_4377c|M.abscessus_ATCC_199 FVAESIQLQA-------------------GDRLCIPVPFYHCFGMVMGNL
MSMEG_3468|M.smegmatis_MC2_155 TWPAAIRAVT---------------GSQGHARILCAMPFFWIGG-LLAAT
TH_4072|M.thermoresistible__bu TWPAAIWAVTRGSGTGSHTGAESGAGTADEPRILCAMPFFWIGG-LLAAT
Mflv_3245|M.gilvum_PYR-GCK TWPAAIRAVT---------------GSPADPVILSAMPFFWIGG-LLAAM
Mvan_2960|M.vanbaalenii_PYR-1 TWPAAVRAIT---------------GSDADPVILCAMPFFWIGG-VLAAT
MMAR_4026|M.marinum_M NLN-VIRGLG------------------TDDKLFCNSPFCWIGGFAFGLL
MAV_1579|M.avium_104 NLN-GIRGLT------------------ADDRLFCNSPFFWIGGFAFGLL
MLBr_02661|M.leprae_Br4923 AIITAYQLGP-------------------QDATVVVMPLYHGHGLIAALL
*: * .
Mb3591|M.bovis_AF2122/97 ACLQTG-ATLIPHVT-FDPLHALRAIERHRITVLPGPPTIYQSLLDHPAR
Rv3561|M.tuberculosis_H37Rv ACLQTG-ATLIPHVT-FDPLHALRAIERHRITVLPGPPTIYQSLLDHPAR
MUL_4126|M.ulcerans_Agy99 ACLQTG-ATLFPHLT-FDPLRTLQAIERHRITVLPGPPTIYQTLLDHPAR
MAB_4377c|M.abscessus_ATCC_199 GCTTHG-ATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLADPGF
MSMEG_3468|M.smegmatis_MC2_155 GALHEP-VTLA-ILPKLDAGAALDLAERERITGIVGWPAFTQRLREHPTF
TH_4072|M.thermoresistible__bu GALHDP-VTLL-VLPKLDAGTALDLIETERATGVVGWPAFTRRLRDHPTF
Mflv_3245|M.gilvum_PYR-GCK GALHES-ITLL-VMPRLDAATALDLVEAERATGIVGWPAFTQRMREHPSF
Mvan_2960|M.vanbaalenii_PYR-1 GALHEP-VTLL-VMPKLDAETALDLAENEKATGIVGWPAFTQRMREHPSF
MMAR_4026|M.marinum_M ATLLAG-STLV-CSNA-DAATTLDLLEREKPTMTNGFASTVARLANHPSF
MAV_1579|M.avium_104 ATLVAG-STLI-CSNATDAGATLDLLEAEKPTMTNGFSAGIAHLAEHPSF
MLBr_02661|M.leprae_Br4923 STLASGGVVLLPARARFSARTFWDDIDAVAATWYTAAPAIHRILLELAST
. .: .. : . . .: : .
Mb3591|M.bovis_AF2122/97 KDFDLSSLRFAVTGAATVPVVLVERMQSELDIDI-VLTAYGLTEANGMGT
Rv3561|M.tuberculosis_H37Rv KDFDLSSLRFAVTGAATVPVVLVERMQSELDIDI-VLTAYGLTEANGMGT
MUL_4126|M.ulcerans_Agy99 DDYDLSSLRFAVTGAATVPVVLVERMQSELDIDI-VLTAYGLTEANGMGT
MAB_4377c|M.abscessus_ATCC_199 AHRDLSTLRTGIMAGSVCPVEVMKRCIDEMHMAG-VAIAYGMTETSPVSC
MSMEG_3468|M.smegmatis_MC2_155 SVRDLSSA-----------------PMLRDGPLD-IAMT-----------
TH_4072|M.thermoresistible__bu DERDLGSA-----------------PMLRHGPLD-IAMT-----------
Mflv_3245|M.gilvum_PYR-GCK PRRDLSSV-----------------PMLRSGPLD-IAMT-----------
Mvan_2960|M.vanbaalenii_PYR-1 ADRDLSSA-----------------PMLRDGPLD-IAMT-----------
MMAR_4026|M.marinum_M GRRDLSSMRRGNLYPIMAPEARPVDPELRHNMLG-MTEAGSIVLIS----
MAV_1579|M.avium_104 ADRDLSSMRRGNLYPIMAVEARPADPELRHNMLG-MTEAGGVVLIG----
MLBr_02661|M.leprae_Br4923 QSFRSKRAKLRFIRSCSAPLTQETAQALREEFLAPVICAFGMTEATHQVT
. : :
Mb3591|M.bovis_AF2122/97 MCRPEDDAVTVATTCGRPFADFEL---RIADD-----------GEVLLRG
Rv3561|M.tuberculosis_H37Rv MCRPEDDAVTVATTCGRPFADFEL---RIADD-----------GEVLLRG
MUL_4126|M.ulcerans_Agy99 MCRADDDALTVATTCGRPFADFEL---RIGPDT----------GEVLLRG
MAB_4377c|M.abscessus_ATCC_199 QTLFDDDLDRRTATVGRAHPHIEI---KIVDPNSGETVQRGQSGELCTRG
MSMEG_3468|M.smegmatis_MC2_155 -DVPDGFPVHRTMTETAGGFAYTD---MRIVDDNGVPAPDGTVGELHVRG
TH_4072|M.thermoresistible__bu -DVPDGFPVHRTMSETAGGFAFTE---MRIVDGNGDPVPDGTVGELLVRG
Mflv_3245|M.gilvum_PYR-GCK -DVPDGFPVHRTMTETAGGFAYTE---MKIVDADGAPVDDGTVGELWVRG
Mvan_2960|M.vanbaalenii_PYR-1 -DVPDGFPVHRTMSETAGGFAHTE---MKIVDDAGMPVAAGVVGELLVRG
MMAR_4026|M.marinum_M -ADESDQPESRRGSFGKPAPGFDT---IIIEPGTGEVANVGQVGELCIRG
MAV_1579|M.avium_104 -DDEADQPEHRRGSFGKPAPGFEA---RILDPDTGAAVAVGEVGELCIRG
MLBr_02661|M.leprae_Br4923 TTNIKWFGQGENPTVTNGLVGQSTGVQIRIVGSDGQPLPPDTVGEVWLRG
: **: **
Mb3591|M.bovis_AF2122/97 PNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQ-AGNLRINDRLKDMYI
Rv3561|M.tuberculosis_H37Rv PNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQ-AGNLRITDRLKDMYI
MUL_4126|M.ulcerans_Agy99 PNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDE-AGNLRITDRLKDMYI
MAB_4377c|M.abscessus_ATCC_199 YSVMLGYWNDEAHTREVLDTDGWMHTGDLAVMRD-DGYCTIIGRLKDMVI
MSMEG_3468|M.smegmatis_MC2_155 IGVMAGYNK--RERFETFDDDGWYHTGDKVYRRPGDPRVFYVGRTTDLIK
TH_4072|M.thermoresistible__bu IGVMAGYNK--RERWEVFDADGWYHTGDRVYRKPGDPRLFYVGRTTELIK
Mflv_3245|M.gilvum_PYR-GCK VGVMAGYNK--RERSDTFDADGWYHTGDRVYRSAGDPRLFYVGRTTELIK
Mvan_2960|M.vanbaalenii_PYR-1 VGVMAGYNK--RERSDTFDADGWYHTGDRVYRRADDPRLFFVGRTGEMIK
MMAR_4026|M.marinum_M PFVMQGYYK--RSREECFDADGWFHTGD-LVRADQDGYMYFTGRLSSLIK
MAV_1579|M.avium_104 PYLMQRYHK--RSREECFDPDGWFHTGD-LVRADADGYFYFAGRLGAMIK
MLBr_02661|M.leprae_Br4923 STVVRGYLGDPAITAANFT-HGWLRTGDLGSLSV-TGDLRIRGRIKELIN
:: * : .** :*** .* :
Mb3591|M.bovis_AF2122/97 CGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLG-EVGRAFVVARPG-T
Rv3561|M.tuberculosis_H37Rv CGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLG-EVGRAFVVARPG-T
MUL_4126|M.ulcerans_Agy99 CGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLG-EVGRAFIVARPG-F
MAB_4377c|M.abscessus_ATCC_199 RGGENIYPREIEEFLLTHPDIEDVHVVGVPDEKYG-EELCAWVRMRPDRV
MSMEG_3468|M.smegmatis_MC2_155 AAGANVSPLEVEAVLAGFGEVAQCLVLGVDDAERGEEVCAVVVPSGTPGD
TH_4072|M.thermoresistible__bu SGGANVSPLEVEAVIEQSPAVAQCVVVGVDDPDRGEQVCAVVVPTHSGDH
Mflv_3245|M.gilvum_PYR-GCK TSGANVSPLEVEAVIESFDEVAQCVVVGIDHVERGEEVCAVLVPS---GD
Mvan_2960|M.vanbaalenii_PYR-1 TSGANVSPLEVEAVIETFDDIAQCVVVGVEHADRGEEVCAVLVPV---GN
MMAR_4026|M.marinum_M TAGANVSPAEVERAIAKLG--MVAHVVGIPDPQRGQVVAAVLVVA-DGVG
MAV_1579|M.avium_104 TAGANVSAVEVEKAIAAVTGGATAYVVGIPDARRGQLVAAAVVWP-DDRA
MLBr_02661|M.leprae_Br4923 RSGEKISPERVEGVLASHHNVMEVAVFGDPDKVYGETVTAVIVPR--EVI
.* :: . .:* : *.* . * . :
Mb3591|M.bovis_AF2122/97 GLDEASVIAYTREHLANFKTPR--SVRFVDVLPRNAAGKVSKPQLRELG-
Rv3561|M.tuberculosis_H37Rv GLDEASVIAYTREHLANFKTPR--SVRFVDVLPRNAAGKVSKPQLRELG-
MUL_4126|M.ulcerans_Agy99 NLDEKSVIDYTREHLANFKAPR--SVRFVDTLPRNAGGKVVKPQLRELA-
MAB_4377c|M.abscessus_ATCC_199 VIDAVAIRAFASGRLAHYKIPR--YVHVVESFPMTVTGKVRKIEMRQQTI
MSMEG_3468|M.smegmatis_MC2_155 TLDVALLAQRAREQLSAYKVPTRWVIACSDDIPTLPSGKFDRKALRRWII
TH_4072|M.thermoresistible__bu GLDVDSLAAQVGSQLSSYKVPTRWVVARADQIPTLPSGKFDRRTLRARVS
Mflv_3245|M.gilvum_PYR-GCK TVDTATLAERTRELLSPFKVPTRWITVDSARIPTLPSGKLNRKALREWVI
Mvan_2960|M.vanbaalenii_PYR-1 EVDVDSVARRTREALSSYKVPTRWVIASSEQIPTLPSGKLDRRAVRALIV
MMAR_4026|M.marinum_M ALDELALRERLETELSAYKIPTRFATLPPSEIPLLSSGKVDTHQLKKCFD
MAV_1579|M.avium_104 ALDPDALRERLKSELSAYKIPRRFASLRRADVPLLSSGKVDLRQLRKLFD
MLBr_02661|M.leprae_Br4923 APTPSELAVFCRDRLAAFEVPTR--FQEASALPHTAKGSLDRRAVAEQFA
: *: :: * .* *.. :
Mb3591|M.bovis_AF2122/97 ----------------
Rv3561|M.tuberculosis_H37Rv ----------------
MUL_4126|M.ulcerans_Agy99 ----------------
MAB_4377c|M.abscessus_ATCC_199 QIFGLPEPGRTDEQ--
MSMEG_3468|M.smegmatis_MC2_155 DERLGVTAR-------
TH_4072|M.thermoresistible__bu DGTLNAVQPVNADSRR
Mflv_3245|M.gilvum_PYR-GCK SSPAAGVR--------
Mvan_2960|M.vanbaalenii_PYR-1 SSGAAKAD--------
MMAR_4026|M.marinum_M A---------------
MAV_1579|M.avium_104 A---------------
MLBr_02661|M.leprae_Br4923 HRG-------------