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TPDPATVADVLRRQRLWADKPLLVCDRTRLSYGEADERSAVLAQRLVALGAGKGTHVGLLYPNSAEFVVA MLAATRIGAVVVPFSTFGTAPEVRRQLVDSDVSVLLAARSFRSHDYVQTLTDAVGARPTHGPVFSTAAPV LRHVLFDDQDSDARGRVDDALLRAMEDDVDGCDPLAVIYTSGSTSAPKGVVHTHAALLAHQRSLNEIRRL TADDRLFCNSPFFWIGGFAFGLLATLVAGATLICSNATDAADTLDLLEAEKPTVTNGFVAGITHLPRHPS FARRDLSSMRRGNLYPIMAAGARPADAELRHNMLGMTETGSVVLLSGDDSDQPESRRGSFGFLAPGFQAR VVDPDTGCDVAVSTPGVLLLRGPFLMQGYYGRAREDCFDGDGWFDTGDLVRRDGDGVFYFIGRTGTMIKT AGANVAPGEVEKAIIAVIPDPDVVVHVVGLPDAERGQLVAAVIASDTEVDVSGLQETLRSHLSAYKIPRR VATVRHADIPMLSSGKVDLSALRRLFGALR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1981 | - | - | 100% (521) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_2960 | - | 4e-70 | 37.41% (532) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_1980 | - | 1e-69 | 36.40% (489) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 1e-49 | 31.50% (508) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4363 | - | 0.0 | 72.78% (518) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 1e-49 | 31.50% (508) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-26 | 23.49% (545) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 5e-51 | 31.30% (508) | AMP-binding domain protein |
| M. marinum M | MMAR_4026 | fadD35_1 | 1e-171 | 59.55% (534) | fatty-acid-CoA ligase FadD35_1 |
| M. avium 104 | MAV_1579 | - | 0.0 | 68.70% (524) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2216 | - | 1e-173 | 61.24% (516) | AMP-binding enzyme |
| M. thermoresistible (build 8) | TH_3971 | - | 2e-85 | 38.08% (499) | PUTATIVE putative putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 3e-42 | 30.24% (539) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 ---MAAAEVVDPNRLSYDRGPSAPSLLE-----------------STIGA
Rv2505c|M.tuberculosis_H37Rv ---MAAAEVVDPNRLSYDRGPSAPSLLE-----------------STIGA
MAB_4377c|M.abscessus_ATCC_199 -------------MKAYDAGATLSPIIE-----------------ETIGE
MUL_4126|M.ulcerans_Agy99 -----------------------MTSDP-----------------RTVPT
Mvan_1981|M.vanbaalenii_PYR-1 --------------------------MTPDP--------------ATVAD
Mflv_4363|M.gilvum_PYR-GCK ---------------------------MSDP--------------CTVAE
MMAR_4026|M.marinum_M --------------------------MAADS--------------PTVAQ
MAV_1579|M.avium_104 --------------------------MPGDF--------------ATVGA
MSMEG_2216|M.smegmatis_MC2_155 --------------------------MAETL--------------VELLE
TH_3971|M.thermoresistible__bu --------------------------MTSTPSATRVFRYEPLPYDAVLPA
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:
Mb2533c|M.bovis_AF2122/97 NLAATAARYGHREALVDMVA---RRRFNYSELLTDVHRLATGLVRAGIGP
Rv2505c|M.tuberculosis_H37Rv NLAATAARYGHREALVDMVA---RRRFNYSELLTDVHRLATGLVRAGIGP
MAB_4377c|M.abscessus_ATCC_199 NFERIARAHPDVGALVDVSG---DRRWTYRELDAEINRVARGLMSLGVAA
MUL_4126|M.ulcerans_Agy99 ALDRLVRRLPNHDALVTD-----ERSFTVSELNDEVYRAAAALIELGVKP
Mvan_1981|M.vanbaalenii_PYR-1 VLRRQRLWA-DKPLLVCDR-----TRLSYGEADERSAVLAQRLVALGAGK
Mflv_4363|M.gilvum_PYR-GCK VLRAQRRHG-DKPLLICDD-----ERLSYAEADERSAVLAARLTTLGVGK
MMAR_4026|M.marinum_M ILRRQARCRPDHPFLVCDS-----DRISYAQADLRSAELARGLIALGIGK
MAV_1579|M.avium_104 TLRHQARWRGDHPLLICDA-----ERISYAEADVRSAELARGLIALGAGK
MSMEG_2216|M.smegmatis_MC2_155 GLRD----RGDHTLLVCDD-----ERLTYADAEHRSARLADALIALGAGK
TH_3971|M.thermoresistible__bu MLAAVTGAHSAGDLVVTVTGDGSVERITYGEAEDRSADMAARLLAAGVTK
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEG-----TLTYKELDRAAHALANGLIAKGVRG
:: . : * * *
Mb2533c|M.bovis_AF2122/97 GDRVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVA
Rv2505c|M.tuberculosis_H37Rv GDRVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVA
MAB_4377c|M.abscessus_ATCC_199 GDRVGIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVR
MUL_4126|M.ulcerans_Agy99 AARVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAP
Mvan_1981|M.vanbaalenii_PYR-1 GTHVGLLYPNSAEFVVAMLAATRIGAVVVPFSTFGTAPEVRRQLVDSDVS
Mflv_4363|M.gilvum_PYR-GCK GSHVGILYPNGAQWVVAMLAAARIGAVVVPFSTFSTAVELRRQLRDSDVG
MMAR_4026|M.marinum_M AAHVGLLYPNGSDFVIGMLAAARIGAVVIPISTFVTPRELHEQLVDSDTQ
MAV_1579|M.avium_104 GTHVGLLHPNGARFVVAMLAAARIGAVVVPFSTFVTVRELREQLLDSDVE
MSMEG_2216|M.smegmatis_MC2_155 GTHVGVLYPNGADFVVAMLAVARVGAVVVPFSTFLTEAELRVQLLDSDVS
TH_3971|M.thermoresistible__bu GVRVGILAPNGPDFVTAFLATARIGAVAVPINTFFQPPELEWVLRDADIH
MLBr_02546|M.leprae_Br4923 GDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAK
. :.: * :* . .:** : :.. :
Mb2533c|M.bovis_AF2122/97 MVIAVASFKDADYAAMLAEVG-------------PRCPDLADVILLESDR
Rv2505c|M.tuberculosis_H37Rv MVIAVASFKDADYAAMLAEVG-------------PRCPDLADVILLESDR
MAB_4377c|M.abscessus_ATCC_199 TLICAKAFKSSDYVAMASQVM-------------PDAPGLRDVVFIGTSD
MUL_4126|M.ulcerans_Agy99 VLFAMGHFLGSDRVAGLDRKA-------------LPALRHIVRIPIEEPD
Mvan_1981|M.vanbaalenii_PYR-1 VLLAARSFRSHDYVQTLTDAVGARPTHG--PVFSTAAPVLRHVLFDDQDS
Mflv_4363|M.gilvum_PYR-GCK VLLATRAFRTHDYVRALGEAVGVPLDDG--PLLSAEVPVLRHVVFD---A
MMAR_4026|M.marinum_M ILLSADTFRSHDYAGRLRQLLGDTGFDGEDRLFSRAIPQLR-TAWVSYRR
MAV_1579|M.avium_104 ILLSARSFRPHDYARRLSEAVSETDFDPGRRLFCTAAPQLRRVLFAPQTV
MSMEG_2216|M.smegmatis_MC2_155 IMLSARSFRSHDYVGQISRVR-------------ADAPCLRHVVFEIPAA
TH_3971|M.thermoresistible__bu TLLAVETLLGRDMFERIEAAAGEWQVVDG-QLRIERLPQLRNILPLGTAR
MLBr_02546|M.leprae_Br4923 VIIYDDEYT--KVVSKAEPALG-------------KLRALGVNPDEEEPP
:: .
Mb2533c|M.bovis_AF2122/97 WDALAG----------AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPK
Rv2505c|M.tuberculosis_H37Rv WDALAG----------AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPK
MAB_4377c|M.abscessus_ATCC_199 WTELVAG--------AERVTETALRARMSQLSNTDPINIQYTSGTTGYPK
MUL_4126|M.ulcerans_Agy99 GTWDEFI--------ETGTDTGAVTARAAAVSPDDVSDILFTSGTTGRSK
Mvan_1981|M.vanbaalenii_PYR-1 DARG-------------RVDDALLRAMEDDVDGCDPLAVIYTSGSTSAPK
Mflv_4363|M.gilvum_PYR-GCK ECGG-------------AAD---VSALEGDVDGSDVLAIIYTSGSTSDPK
MMAR_4026|M.marinum_M GAPRRTRSIECVYRLSQTIDPTMLRALEDDVDGSDVLAIVYTSGTTSAPK
MAV_1579|M.avium_104 GAP------------GGGIDPALLAAMEDDVQACDPLAIVYTSGSTSTPK
MSMEG_2216|M.smegmatis_MC2_155 GDPE------------------RRAGLEADVEGSDVLAIIYTSGSTGAPK
TH_3971|M.thermoresistible__bu REWP--------SSWPDPVPENFRKACEATVRSADDLLVIYTSGSTSTPK
MLBr_02546|M.leprae_Br4923 GSTDET----------LAELIARSSSAPAPKVRKRASIIILTSGTTGTPK
: ***:*. .*
Mb2533c|M.bovis_AF2122/97 GVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSH
Rv2505c|M.tuberculosis_H37Rv GVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSH
MAB_4377c|M.abscessus_ATCC_199 GATLSHRNVLNNGFFVAESIQLQAGDRLCIPVPFYHCFGMVMGNLGCTTH
MUL_4126|M.ulcerans_Agy99 GVLCAHRQSLSASASWAANGKITADDRHLCINPFFHNFGYKAGILACLQT
Mvan_1981|M.vanbaalenii_PYR-1 GVVHTHAALLAHQRSLNEIRRLTADDRLFCNSPFFWIGGFAFGLLATLVA
Mflv_4363|M.gilvum_PYR-GCK GVVHTHTSLLAHQRGLNEIRGLTAEDRLFCNSPFFWIGGFAFGLLATLVA
MMAR_4026|M.marinum_M GVVHTHSALVRHQQNLNVIRGLGTDDKLFCNSPFCWIGGFAFGLLATLLA
MAV_1579|M.avium_104 GVVHTHGALLEHQRNLNGIRGLTADDRLFCNSPFFWIGGFAFGLLATLVA
MSMEG_2216|M.smegmatis_MC2_155 GVVHTHSSLLAHQRDLNVLRGLTADDKLFCNSPFFWVGGLAFALLASMIA
TH_3971|M.thermoresistible__bu GIIHTHGTTITHSRFIATAHDWDHNDRIYVPMVFFWVAGLVFGFLGPMQV
MLBr_02546|M.leprae_Br4923 GANRNTPASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLG
* : : : * . *.
Mb2533c|M.bovis_AF2122/97 GAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPD--FTDYE
Rv2505c|M.tuberculosis_H37Rv GAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPD--FTDYE
MAB_4377c|M.abscessus_ATCC_199 GATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLADPG--FAHRD
MUL_4126|M.ulcerans_Agy99 GATLFPHLT-FDPLRTLQAIERHRITVLPGPPTIYQTLLDHPA--RDDYD
Mvan_1981|M.vanbaalenii_PYR-1 G-ATLICSNATDAADTLDLLEAEKPTVTNGFVAGITHLPRHPS--FARRD
Mflv_4363|M.gilvum_PYR-GCK G-STLICSTASDAGRTLDLLEAEKPTMTNGFVAGITHLTRHPS--FARRD
MMAR_4026|M.marinum_M G-STLVCSNA-DAATTLDLLEREKPTMTNGFASTVARLANHPS--FGRRD
MAV_1579|M.avium_104 G-STLICSNATDAGATLDLLEAEKPTMTNGFSAGIAHLAEHPS--FADRD
MSMEG_2216|M.smegmatis_MC2_155 G-ATLVCSNSTDAGATFDLLEAEKPTITNGFVAGIAHLTRHPS--FPHRN
TH_3971|M.thermoresistible__bu G-AAILTEHKFDAGEVLRLLQSEKATYTTGFGHIGPALVNHPD--FASTD
MLBr_02546|M.leprae_Br4923 S--TLVLRRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSD
. . .. .: :: .: . :
Mb2533c|M.bovis_AF2122/97 LGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRAD
Rv2505c|M.tuberculosis_H37Rv LGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRAD
MAB_4377c|M.abscessus_ATCC_199 LSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETSPVSCQTLFD
MUL_4126|M.ulcerans_Agy99 LSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRAD
Mvan_1981|M.vanbaalenii_PYR-1 LSSMRRGNLYPIMAAGARPADAELRHNMLGMTETGSVVLLSGD-----DS
Mflv_4363|M.gilvum_PYR-GCK LSSMRRGNLYSIMAPDVRPADPELRHNMLGMTEAGSVVLLSGD-----ES
MMAR_4026|M.marinum_M LSSMRRGNLYPIMAPEARPVDPELRHNMLGMTEAGSIVLISAD-----ES
MAV_1579|M.avium_104 LSSMRRGNLYPIMAVEARPADPELRHNMLGMTEAGGVVLIGDD-----EA
MSMEG_2216|M.smegmatis_MC2_155 LSSIRRGNLYPLMAPDVRPADPDLRHNMLGSTESGSVVLLDPD-----DT
TH_3971|M.thermoresistible__bu LSSLREGYQQVLLPPERRTPDPSLRVAQLGMTETCSSHTWWPP-----HE
MLBr_02546|M.leprae_Br4923 LSSLRVVFVSGSQLGAELATRALEELGPVIYNMYGSTEIAFAT---IAGP
*.::* . .
Mb2533c|M.bovis_AF2122/97 DSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCTRGYSVMAGYW
Rv2505c|M.tuberculosis_H37Rv DSVDRRVGTVGRVGPHLEIKVVDPATGETVPRGVVGEFCTRGYSVMAGYW
MAB_4377c|M.abscessus_ATCC_199 DDLDRRTATVGRAHPHIEIKIVDPNSGETVQRGQSGELCTRGYSVMLGYW
MUL_4126|M.ulcerans_Agy99 DDALTVATTCGRPFADFELRIG-PDTGEVLLRGP---------NVMLGYL
Mvan_1981|M.vanbaalenii_PYR-1 DQPESRRGSFGFLAPGFQARVVDPDTGCDVAVSTPGVLLLRGPFLMQGYY
Mflv_4363|M.gilvum_PYR-GCK DQPEARRGSYGFLAPGFDARVVDPDTGSDTDG-AVGELVLRGPHLMQRYY
MMAR_4026|M.marinum_M DQPESRRGSFGKPAPGFDTIIIEPGTGEVANVGQVGELCIRGPFVMQGYY
MAV_1579|M.avium_104 DQPEHRRGSFGKPAPGFEARILDPDTGAAVAVGEVGELCIRGPYLMQRYH
MSMEG_2216|M.smegmatis_MC2_155 DQPEHRRGSFGRPAPGFETKVLD-----------SGELCIRGPYLMQGYY
TH_3971|M.thermoresistible__bu ELPEAKRGSLGVSAPGYEHKIVD-EAGNEVPNGVTGEICVRGTAMMRAMV
MLBr_02546|M.leprae_Br4923 KDLQINSATVGPVVKGVKVKILD-DSGKEVPRGQVGRIFVGNAFPFEGYT
. : * . : :
Mb2533c|M.bovis_AF2122/97 NDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVRGGENISPR
Rv2505c|M.tuberculosis_H37Rv NDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVRGGENISPR
MAB_4377c|M.abscessus_ATCC_199 NDEAHTREVLDTDGWMHTGDLAVMRDDGYCTIIGRLKDMVIRGGENIYPR
MUL_4126|M.ulcerans_Agy99 DDPRATAAAIDADGWLHTGDIGVLDEAGNLRITDRLKDMYICGGFNVYPA
Mvan_1981|M.vanbaalenii_PYR-1 G--RAREDCFDGDGWFDTGDLVRRDGDGVFYFIGRTGTMIKTAGANVAPG
Mflv_4363|M.gilvum_PYR-GCK G--RSREECFDADGWFHTGDLVRRDDDGVFYFVGRAGSMIKTAGANVAPA
MMAR_4026|M.marinum_M K--RSREECFDADGWFHTGDLVRADQDGYMYFTGRLSSLIKTAGANVSPA
MAV_1579|M.avium_104 K--RSREECFDPDGWFHTGDLVRADADGYFYFAGRLGAMIKTAGANVSAV
MSMEG_2216|M.smegmatis_MC2_155 G--RSREECFDTDGWFHTGDLVRVDDDGYFYFLGRAGAMIKTAGANVTPD
TH_3971|M.thermoresistible__bu G--RHWFELVDRDGWLHTKDAGYRDDDGHLYFAGRLDEMIKTSGTNVAPM
MLBr_02546|M.leprae_Br4923 G--GGGKQIID--GLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPA
.* * : : * . : .* : .* *: .
Mb2533c|M.bovis_AF2122/97 EIEELLHTHPD-----IVDGHVIGVPDAKYGEELMAVVKLRNDAPELTIE
Rv2505c|M.tuberculosis_H37Rv EIEELLHTHPD-----IVDGHVIGVPDAKYGEELMAVVKLRNDAPELTIE
MAB_4377c|M.abscessus_ATCC_199 EIEEFLLTHPD-----IEDVHVVGVPDEKYGEELCAWVRMRPDRVVIDAV
MUL_4126|M.ulcerans_Agy99 EVEQVLARLDG-----VADVAVIGIPDHRLGEVGRAFIVARPG-FNLDEK
Mvan_1981|M.vanbaalenii_PYR-1 EVEKAIIAVIP---DPDVVVHVVGLPDAERGQLVAAVIASD---TEVDVS
Mflv_4363|M.gilvum_PYR-GCK EVEKALSAALQAV-DAGVAVHVVGLPDPERGQIVAAVIATDNG-TVFDEP
MMAR_4026|M.marinum_M EVERAIAKLG-------MVAHVVGIPDPQRGQVVAAVLVVADGVGALDEL
MAV_1579|M.avium_104 EVEKAIAAVTG-----GATAYVVGIPDARRGQLVAAAVVWPDDRAALDPD
MSMEG_2216|M.smegmatis_MC2_155 EVQKALQHVLEGRDMRDVTVQVVGLPDQERGQLVAAVVATADP-AAFDEA
TH_3971|M.thermoresistible__bu EVEAALGKIEAVR-----IAYVVGVPDPEKGAIVSAAVVLNEG-YTATAD
MLBr_02546|M.leprae_Br4923 EVEDLISGHPE-----VVEATAIGVDDKEWGARLRAFVVKKQD-ATIDED
*:: : .:*: * . * * :
Mb2533c|M.bovis_AF2122/97 RLREYCMGRIARFKIPR---YLWIVDEFPMTVTGKVRKVEMRQQALEYLR
Rv2505c|M.tuberculosis_H37Rv RLREYCMGRIARFKIPR---YLWIVDEFPMTVTGKVRKVEMRQQALEYLR
MAB_4377c|M.abscessus_ATCC_199 AIRAFASGRLAHYKIPR---YVHVVESFPMTVTGKVRKIEMRQQTIQIFG
MUL_4126|M.ulcerans_Agy99 SVIDYTREHLANFKAPR---SVRFVDTLPRNAGGKVVKPQLRELA-----
Mvan_1981|M.vanbaalenii_PYR-1 GLQETLRSHLSAYKIPRRVATVRHAD-IPMLSSGKVDLSALRRLFGALR-
Mflv_4363|M.gilvum_PYR-GCK AVKEALSTQVSAYKIPRRVLSLRHTE-IPTMSSGKIDLAALRRLFDD---
MMAR_4026|M.marinum_M ALRERLETELSAYKIPTRFATLPPSE-IPLLSSGKVDTHQLKKCFDA---
MAV_1579|M.avium_104 ALRERLKSELSAYKIPRRFASLRRAD-VPLLSSGKVDLRQLRKLFDA---
MSMEG_2216|M.smegmatis_MC2_155 AVRAALRAQLSSYKVPRRFAVIHSDE-LPVKSSGKIDVAALRELFDD---
TH_3971|M.thermoresistible__bu DLVAECRSRLAAYKVPKKWAILSDADRLPYTTTNKIDKVRLTQLMASGEL
MLBr_02546|M.leprae_Br4923 AIKAYVRDHLARYKVPR---EVIFLEELPRNPTGKVLKRELRDFEVH---
: .:: :* * : : .* .*: :
Mb2533c|M.bovis_AF2122/97 GQQ-------
Rv2505c|M.tuberculosis_H37Rv GQQ-------
MAB_4377c|M.abscessus_ATCC_199 LPEPGRTDEQ
MUL_4126|M.ulcerans_Agy99 ----------
Mvan_1981|M.vanbaalenii_PYR-1 ----------
Mflv_4363|M.gilvum_PYR-GCK ----------
MMAR_4026|M.marinum_M ----------
MAV_1579|M.avium_104 ----------
MSMEG_2216|M.smegmatis_MC2_155 ----------
TH_3971|M.thermoresistible__bu C---------
MLBr_02546|M.leprae_Br4923 ----------