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MAADSPTVAQILRRQARCRPDHPFLVCDSDRISYAQADLRSAELARGLIALGIGKAAHVGLLYPNGSDFV IGMLAAARIGAVVIPISTFVTPRELHEQLVDSDTQILLSADTFRSHDYAGRLRQLLGDTGFDGEDRLFSR AIPQLRTAWVSYRRGAPRRTRSIECVYRLSQTIDPTMLRALEDDVDGSDVLAIVYTSGTTSAPKGVVHTH SALVRHQQNLNVIRGLGTDDKLFCNSPFCWIGGFAFGLLATLLAGSTLVCSNADAATTLDLLEREKPTMT NGFASTVARLANHPSFGRRDLSSMRRGNLYPIMAPEARPVDPELRHNMLGMTEAGSIVLISADESDQPES RRGSFGKPAPGFDTIIIEPGTGEVANVGQVGELCIRGPFVMQGYYKRSREECFDADGWFHTGDLVRADQD GYMYFTGRLSSLIKTAGANVSPAEVERAIAKLGMVAHVVGIPDPQRGQVVAAVLVVADGVGALDELALRE RLETELSAYKIPTRFATLPPSEIPLLSSGKVDTHQLKKCFDA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4026 | fadD35_1 | - | 100% (532) | fatty-acid-CoA ligase FadD35_1 |
| M. marinum M | MMAR_4027 | - | 3e-78 | 35.43% (525) | fatty-acid-CoA ligase |
| M. marinum M | MMAR_3852 | fadD35 | 1e-50 | 29.65% (516) | fatty-acid-CoA ligase FadD35 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 3e-50 | 29.77% (514) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4363 | - | 1e-174 | 59.33% (536) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 3e-50 | 29.77% (514) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01994 | fadD10 | 3e-24 | 23.06% (555) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 1e-53 | 29.98% (547) | AMP-binding domain protein |
| M. avium 104 | MAV_1579 | - | 0.0 | 68.28% (536) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2216 | - | 1e-167 | 56.21% (523) | AMP-binding enzyme |
| M. thermoresistible (build 8) | TH_3971 | - | 3e-91 | 38.05% (502) | PUTATIVE putative putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 3e-45 | 31.00% (542) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1981 | - | 1e-171 | 59.55% (534) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 MAAAEVVDPNRLSYDRGPSAPSLLE-----------------STIGANLA
Rv2505c|M.tuberculosis_H37Rv MAAAEVVDPNRLSYDRGPSAPSLLE-----------------STIGANLA
MAB_4377c|M.abscessus_ATCC_199 ----------MKAYDAGATLSPIIE-----------------ETIGENFE
MUL_4126|M.ulcerans_Agy99 --------------------MTSDP-----------------RTVPTALD
MMAR_4026|M.marinum_M -----------------------MAADS--------------PTVAQILR
MAV_1579|M.avium_104 -----------------------MPGDF--------------ATVGATLR
Mflv_4363|M.gilvum_PYR-GCK ------------------------MSDP--------------CTVAEVLR
Mvan_1981|M.vanbaalenii_PYR-1 -----------------------MTPDP--------------ATVADVLR
MSMEG_2216|M.smegmatis_MC2_155 -----------------------MAETL--------------VELLEGLR
TH_3971|M.thermoresistible__bu -----------------------MTSTPSATRVFRYEPLPYDAVLPAMLA
MLBr_01994|M.leprae_Br4923 --------------------MSHLP-----------------PTVLERIL
: :
Mb2533c|M.bovis_AF2122/97 ATAARYGHREALVDMVA---RRRFNYSELLTDVHRLATGLVRAGIGPGDR
Rv2505c|M.tuberculosis_H37Rv ATAARYGHREALVDMVA---RRRFNYSELLTDVHRLATGLVRAGIGPGDR
MAB_4377c|M.abscessus_ATCC_199 RIARAHPDVGALVDVSG---DRRWTYRELDAEINRVARGLMSLGVAAGDR
MUL_4126|M.ulcerans_Agy99 RLVRRLPNHDALVTD-----ERSFTVSELNDEVYRAAAALIELGVKPAAR
MMAR_4026|M.marinum_M RQARCRPDHPFLVCDS-----DRISYAQADLRSAELARGLIALGIGKAAH
MAV_1579|M.avium_104 HQARWRGDHPLLICDA-----ERISYAEADVRSAELARGLIALGAGKGTH
Mflv_4363|M.gilvum_PYR-GCK AQRRHG-DKPLLICDD-----ERLSYAEADERSAVLAARLTTLGVGKGSH
Mvan_1981|M.vanbaalenii_PYR-1 RQRLWA-DKPLLVCDR-----TRLSYGEADERSAVLAQRLVALGAGKGTH
MSMEG_2216|M.smegmatis_MC2_155 D----RGDHTLLVCDD-----ERLTYADAEHRSARLADALIALGAGKGTH
TH_3971|M.thermoresistible__bu AVTGAHSAGDLVVTVTGDGSVERITYGEAEDRSADMAARLLAAGVTKGVR
MLBr_01994|M.leprae_Br4923 KQAHERPEAIALRRSDG---TSELRYGQLVAEVNGLAAHLSAQSVSQRSR
: : * * . :
Mb2533c|M.bovis_AF2122/97 VGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVI
Rv2505c|M.tuberculosis_H37Rv VGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVI
MAB_4377c|M.abscessus_ATCC_199 VGIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVRTLI
MUL_4126|M.ulcerans_Agy99 VGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAPVLF
MMAR_4026|M.marinum_M VGLLYPNGSDFVIGMLAAARIGAVVIPISTFVTPRELHEQLVDSDTQILL
MAV_1579|M.avium_104 VGLLHPNGARFVVAMLAAARIGAVVVPFSTFVTVRELREQLLDSDVEILL
Mflv_4363|M.gilvum_PYR-GCK VGILYPNGAQWVVAMLAAARIGAVVVPFSTFSTAVELRRQLRDSDVGVLL
Mvan_1981|M.vanbaalenii_PYR-1 VGLLYPNSAEFVVAMLAATRIGAVVVPFSTFGTAPEVRRQLVDSDVSVLL
MSMEG_2216|M.smegmatis_MC2_155 VGVLYPNGADFVVAMLAVARVGAVVVPFSTFLTEAELRVQLLDSDVSIML
TH_3971|M.thermoresistible__bu VGILAPNGPDFVTAFLATARIGAVAVPINTFFQPPELEWVLRDADIHTLL
MLBr_01994|M.leprae_Br4923 VLVISDNGPETYLSVLACAKLGAIAVMVDGNLPPATISRFSEICDPSAVL
* : * * .:** : .. ::
Mb2533c|M.bovis_AF2122/97 AVASFKDADYAAMLAEVG-------------PRCPDLADVILLESDRWDA
Rv2505c|M.tuberculosis_H37Rv AVASFKDADYAAMLAEVG-------------PRCPDLADVILLESDRWDA
MAB_4377c|M.abscessus_ATCC_199 CAKAFKSSDYVAMASQVM-------------PDAPGLRDVVFIGTSDWTE
MUL_4126|M.ulcerans_Agy99 AMGHFLGSDRVAGLDRKA-------------LPALRHIVRIPIEEPDGTW
MMAR_4026|M.marinum_M SADTFRSHDYAGRLRQLLGDTGFDGEDRLFSRAIPQLR-TAWVSYRRGAP
MAV_1579|M.avium_104 SARSFRPHDYARRLSEAVSETDFDPGRRLFCTAAPQLRRVLFAPQTVGAP
Mflv_4363|M.gilvum_PYR-GCK ATRAFRTHDYVRALGEAVGVPLDDG--PLLSAEVPVLRHVVFD---AECG
Mvan_1981|M.vanbaalenii_PYR-1 AARSFRSHDYVQTLTDAVGARPTHG--PVFSTAAPVLRHVLFDDQDSDAR
MSMEG_2216|M.smegmatis_MC2_155 SARSFRSHDYVGQISRVR-------------ADAPCLRHVVFEIPAAGDP
TH_3971|M.thermoresistible__bu AVETLLGRDMFERIEAAAGEWQVVDG-QLRIERLPQLRNILPLGTARREW
MLBr_01994|M.leprae_Br4923 VARECRIDS----------------------SSLPEILHSIPAITVNTTA
.
Mb2533c|M.bovis_AF2122/97 LAG----------AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGVT
Rv2505c|M.tuberculosis_H37Rv LAG----------AEPDLPALQQTAARLDGSDPVNIQYTSGTTAYPKGVT
MAB_4377c|M.abscessus_ATCC_199 LVAG--------AERVTETALRARMSQLSNTDPINIQYTSGTTGYPKGAT
MUL_4126|M.ulcerans_Agy99 DEFI--------ETGTDTGAVTARAAAVSPDDVSDILFTSGTTGRSKGVL
MMAR_4026|M.marinum_M RRTRSIECVYRLSQTIDPTMLRALEDDVDGSDVLAIVYTSGTTSAPKGVV
MAV_1579|M.avium_104 ------------GGGIDPALLAAMEDDVQACDPLAIVYTSGSTSTPKGVV
Mflv_4363|M.gilvum_PYR-GCK -------------GAAD---VSALEGDVDGSDVLAIIYTSGSTSDPKGVV
Mvan_1981|M.vanbaalenii_PYR-1 -------------GRVDDALLRAMEDDVDGCDPLAVIYTSGSTSAPKGVV
MSMEG_2216|M.smegmatis_MC2_155 ------------------ERRAGLEADVEGSDVLAIIYTSGSTGAPKGVV
TH_3971|M.thermoresistible__bu P--------SSWPDPVPENFRKACEATVRSADDLLVIYTSGSTSTPKGII
MLBr_01994|M.leprae_Br4923 DATYS--------ACSLDIDYLAGNLNYGTDDPLAMTFTSGTTGEPKAVL
* : :***:*. .*.
Mb2533c|M.bovis_AF2122/97 LSHRNILNNGYLVG----ELLGYTAQDRICIPVPFYHCFGMVMGNLAATS
Rv2505c|M.tuberculosis_H37Rv LSHRNILNNGYLVG----ELLGYTAQDRICIPVPFYHCFGMVMGNLAATS
MAB_4377c|M.abscessus_ATCC_199 LSHRNVLNNGFFVA----ESIQLQAGDRLCIPVPFYHCFGMVMGNLGCTT
MUL_4126|M.ulcerans_Agy99 CAHRQSLSASASWA----ANGKITADDRHLCINPFFHNFGYKAGILACLQ
MMAR_4026|M.marinum_M HTHSALVRHQQNLN----VIRGLGTDDKLFCNSPFCWIGGFAFGLLATLL
MAV_1579|M.avium_104 HTHGALLEHQRNLN----GIRGLTADDRLFCNSPFFWIGGFAFGLLATLV
Mflv_4363|M.gilvum_PYR-GCK HTHTSLLAHQRGLN----EIRGLTAEDRLFCNSPFFWIGGFAFGLLATLV
Mvan_1981|M.vanbaalenii_PYR-1 HTHAALLAHQRSLN----EIRRLTADDRLFCNSPFFWIGGFAFGLLATLV
MSMEG_2216|M.smegmatis_MC2_155 HTHSSLLAHQRDLN----VLRGLTADDKLFCNSPFFWVGGLAFALLASMI
TH_3971|M.thermoresistible__bu HTHGTTITHSRFIA----TAHDWDHNDRIYVPMVFFWVAGLVFGFLGPMQ
MLBr_01994|M.leprae_Br4923 LPNRTFFAIPDILREKGLAWIDWVVNETTYSPLSATHIGGLWWILNCLMH
.: . : *
Mb2533c|M.bovis_AF2122/97 HGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPDFTDYEL
Rv2505c|M.tuberculosis_H37Rv HGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFIAELGLPDFTDYEL
MAB_4377c|M.abscessus_ATCC_199 HGATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLADPGFAHRDL
MUL_4126|M.ulcerans_Agy99 TGATLFPHLT-FDPLRTLQAIERHRITVLPGPPTIYQTLLDHPARDDYDL
MMAR_4026|M.marinum_M AG-STLVCSNA-DAATTLDLLEREKPTMTNGFASTVARLANHPSFGRRDL
MAV_1579|M.avium_104 AG-STLICSNATDAGATLDLLEAEKPTMTNGFSAGIAHLAEHPSFADRDL
Mflv_4363|M.gilvum_PYR-GCK AG-STLICSTASDAGRTLDLLEAEKPTMTNGFVAGITHLTRHPSFARRDL
Mvan_1981|M.vanbaalenii_PYR-1 AG-ATLICSNATDAADTLDLLEAEKPTVTNGFVAGITHLPRHPSFARRDL
MSMEG_2216|M.smegmatis_MC2_155 AG-ATLVCSNSTDAGATFDLLEAEKPTITNGFVAGIAHLTRHPSFPHRNL
TH_3971|M.thermoresistible__bu VG-AAILTEHKFDAGEVLRLLQSEKATYTTGFGHIGPALVNHPDFASTDL
MLBr_01994|M.leprae_Br4923 GGLCITGGEHTSSLTEVLNANKVATTCLVPTLLSKLVYELKFGDVVTPPL
* . .: : *
Mb2533c|M.bovis_AF2122/97 GSLRTGIMAGAACPVEVMRKV-ISRMHMPGVSICYGMTETSPVSTQTRAD
Rv2505c|M.tuberculosis_H37Rv GSLRTGIMAGAACPVEVMRKV-ISRMHMPGVSICYGMTETSPVSTQTRAD
MAB_4377c|M.abscessus_ATCC_199 STLRTGIMAGSVCPVEVMKRC-IDEMHMAGVAIAYGMTETSPVSCQTLFD
MUL_4126|M.ulcerans_Agy99 SSLRFAVTGAATVPVVLVERM-QSELDIDIVLTAYGLTEANGMGTMCRAD
MMAR_4026|M.marinum_M SSMRRGNLYPIMAPEARPVDP-ELRHNMLGMTEAGSIVLISAD-----ES
MAV_1579|M.avium_104 SSMRRGNLYPIMAVEARPADP-ELRHNMLGMTEAGGVVLIGDD-----EA
Mflv_4363|M.gilvum_PYR-GCK SSMRRGNLYSIMAPDVRPADP-ELRHNMLGMTEAGSVVLLSGD-----ES
Mvan_1981|M.vanbaalenii_PYR-1 SSMRRGNLYPIMAAGARPADA-ELRHNMLGMTETGSVVLLSGD-----DS
MSMEG_2216|M.smegmatis_MC2_155 SSIRRGNLYPLMAPDVRPADP-DLRHNMLGSTESGSVVLLDPD-----DT
TH_3971|M.thermoresistible__bu SSLREGYQQVLLPPERRTPDP-SLRVAQLGMTETCSSHTWWPP-----HE
MLBr_01994|M.leprae_Br4923 RLIVYGGSRVIAADVRFIEAAGVRTAQFYGLSETGCTALCLPTD----NG
: .
Mb2533c|M.bovis_AF2122/97 DSVDRRVGTVGRVGPHLEIKVVDPATG-----ETVPRGVVGEFCTRGYSV
Rv2505c|M.tuberculosis_H37Rv DSVDRRVGTVGRVGPHLEIKVVDPATG-----ETVPRGVVGEFCTRGYSV
MAB_4377c|M.abscessus_ATCC_199 DDLDRRTATVGRAHPHIEIKIVDPNSG-----ETVQRGQSGELCTRGYSV
MUL_4126|M.ulcerans_Agy99 DDALTVATTCGRPFADFELRIG-PDTG-----EVLLRGP---------NV
MMAR_4026|M.marinum_M DQPESRRGSFGKPAPGFDTIIIEPGTG-----EVANVGQVGELCIRGPFV
MAV_1579|M.avium_104 DQPEHRRGSFGKPAPGFEARILDPDTG-----AAVAVGEVGELCIRGPYL
Mflv_4363|M.gilvum_PYR-GCK DQPEARRGSYGFLAPGFDARVVDPDTG-----SDTDG-AVGELVLRGPHL
Mvan_1981|M.vanbaalenii_PYR-1 DQPESRRGSFGFLAPGFQARVVDPDTG-----CDVAVSTPGVLLLRGPFL
MSMEG_2216|M.smegmatis_MC2_155 DQPEHRRGSFGRPAPGFETKVLD----------------SGELCIRGPYL
TH_3971|M.thermoresistible__bu ELPEAKRGSLGVSAPGYEHKIVD-EAG-----NEVPNGVTGEICVRGTAM
MLBr_01994|M.leprae_Br4923 SISKIEAGAVGRPYPGVEVYLADPNGGGPTVADTASSASFGTLWIKSPAN
. : * . : :
Mb2533c|M.bovis_AF2122/97 MAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVRGGE
Rv2505c|M.tuberculosis_H37Rv MAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSGYVRIAGRIKDLVVRGGE
MAB_4377c|M.abscessus_ATCC_199 MLGYWNDEAHTREVLDTDGWMHTGDLAVMRDDGYCTIIGRLKDMVIRGGE
MUL_4126|M.ulcerans_Agy99 MLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGNLRITDRLKDMYICGGF
MMAR_4026|M.marinum_M MQGYYK--RSREECFDADGWFHTGDLVRADQDGYMYFTGRLSSLIKTAGA
MAV_1579|M.avium_104 MQRYHK--RSREECFDPDGWFHTGDLVRADADGYFYFAGRLGAMIKTAGA
Mflv_4363|M.gilvum_PYR-GCK MQRYYG--RSREECFDADGWFHTGDLVRRDDDGVFYFVGRAGSMIKTAGA
Mvan_1981|M.vanbaalenii_PYR-1 MQGYYG--RAREDCFDGDGWFDTGDLVRRDGDGVFYFIGRTGTMIKTAGA
MSMEG_2216|M.smegmatis_MC2_155 MQGYYG--RSREECFDTDGWFHTGDLVRVDDDGYFYFLGRAGAMIKTAGA
TH_3971|M.thermoresistible__bu MRAMVG--RHWFELVDRDGWLHTKDAGYRDDDGHLYFAGRLDEMIKTSGT
MLBr_01994|M.leprae_Br4923 MLGYWNNPERTREIL-VDGWVNTGDLVERREDGFFYIKGRSSEMIVSGGV
* . ***..* * * : .* : .*
Mb2533c|M.bovis_AF2122/97 NISPREIEELLHTHPD-----IVDGHVIGVPDAKYGEELMAVVKLRNDAP
Rv2505c|M.tuberculosis_H37Rv NISPREIEELLHTHPD-----IVDGHVIGVPDAKYGEELMAVVKLRNDAP
MAB_4377c|M.abscessus_ATCC_199 NIYPREIEEFLLTHPD-----IEDVHVVGVPDEKYGEELCAWVRMRPDRV
MUL_4126|M.ulcerans_Agy99 NVYPAEVEQVLARLDG-----VADVAVIGIPDHRLGEVGRAFIVARPG-F
MMAR_4026|M.marinum_M NVSPAEVERAIAKLG-------MVAHVVGIPDPQRGQVVAAVLVVADGVG
MAV_1579|M.avium_104 NVSAVEVEKAIAAVTG-----GATAYVVGIPDARRGQLVAAAVVWPDDRA
Mflv_4363|M.gilvum_PYR-GCK NVAPAEVEKALSAALQAV-DAGVAVHVVGLPDPERGQIVAAVIATDNG-T
Mvan_1981|M.vanbaalenii_PYR-1 NVAPGEVEKAIIAVIP---DPDVVVHVVGLPDAERGQLVAAVIASD---T
MSMEG_2216|M.smegmatis_MC2_155 NVTPDEVQKALQHVLEGRDMRDVTVQVVGLPDQERGQLVAAVVATADP-A
TH_3971|M.thermoresistible__bu NVAPMEVEAALGKIEAVR-----IAYVVGVPDPEKGAIVSAAVVLNEG-Y
MLBr_01994|M.leprae_Br4923 NIVPDEVDRIAESVSG-----VGEAACYEIPDAHFGALVGLAVIPSAELN
*: . *:: :** . * :
Mb2533c|M.bovis_AF2122/97 ELTIERLREYCMGRIAR-FKIPR---YLWIVDEFPMTVTGKVRKVEMRQQ
Rv2505c|M.tuberculosis_H37Rv ELTIERLREYCMGRIAR-FKIPR---YLWIVDEFPMTVTGKVRKVEMRQQ
MAB_4377c|M.abscessus_ATCC_199 VIDAVAIRAFASGRLAH-YKIPR---YVHVVESFPMTVTGKVRKIEMRQQ
MUL_4126|M.ulcerans_Agy99 NLDEKSVIDYTREHLAN-FKAPR---SVRFVDTLPRNAGGKVVKPQLREL
MMAR_4026|M.marinum_M ALDELALRERLETELSA-YKIPTRFATLPPSE-IPLLSSGKVDTHQLKKC
MAV_1579|M.avium_104 ALDPDALRERLKSELSA-YKIPRRFASLRRAD-VPLLSSGKVDLRQLRKL
Mflv_4363|M.gilvum_PYR-GCK VFDEPAVKEALSTQVSA-YKIPRRVLSLRHTE-IPTMSSGKIDLAALRRL
Mvan_1981|M.vanbaalenii_PYR-1 EVDVSGLQETLRSHLSA-YKIPRRVATVRHAD-IPMLSSGKVDLSALRRL
MSMEG_2216|M.smegmatis_MC2_155 AFDEAAVRAALRAQLSS-YKVPRRFAVIHSDE-LPVKSSGKIDVAALREL
TH_3971|M.thermoresistible__bu TATADDLVAECRSRLAA-YKVPKKWAILSDADRLPYTTTNKIDKVRLTQL
MLBr_01994|M.leprae_Br4923 ESTAIELKRRIAARYRRESESMARPSKIVIVADIPRTQSGKVIRATLAAA
: . : : .* .*: :
Mb2533c|M.bovis_AF2122/97 ALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv ALEYLRGQQ-------
MAB_4377c|M.abscessus_ATCC_199 TIQIFGLPEPGRTDEQ
MUL_4126|M.ulcerans_Agy99 A---------------
MMAR_4026|M.marinum_M FDA-------------
MAV_1579|M.avium_104 FDA-------------
Mflv_4363|M.gilvum_PYR-GCK FDD-------------
Mvan_1981|M.vanbaalenii_PYR-1 FGALR-----------
MSMEG_2216|M.smegmatis_MC2_155 FDD-------------
TH_3971|M.thermoresistible__bu MASGELC---------
MLBr_01994|M.leprae_Br4923 LNGEQLGMVVRD----