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M. thermoresistible (build 8) TH_2173 ()

annotation: CONSERVED HYPOTHETICAL PROTEIN
coordinates: 4261596 - 4262291
length: 232

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2173-100% (232)CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_0259-9e-0626.73% (202) POSSIBLE BIFUNCTIONAL ENZYME:

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1948-2e-7359.40% (234) hypothetical protein Mb1948
M. gilvum PYR-GCKMflv_3131-2e-6656.19% (226) beta-lactamase domain-containing protein
M. tuberculosis H37RvRv1913-2e-7359.40% (234) hypothetical protein Rv1913
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2020c-3e-1129.58% (213) bifunctional HHDD isomerase/cyclase/dehydrase
M. marinum MMMAR_2819-8e-6754.70% (234) hypothetical protein MMAR_2819
M. avium 104MAV_2782-5e-7359.66% (233) metallo-beta-lactamase
M. smegmatis MC2 155-----
M. ulcerans Agy99MUL_2742-8e-0726.09% (115) hypothetical protein MUL_2742
M. vanbaalenii PYR-1Mvan_3402-1e-6756.25% (224) beta-lactamase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3131|M.gilvum_PYR-GCK          ---MSELVWER-------LTRHVMRCRLPFCDVTVGVVHSDGAAVVIDCG
Mvan_3402|M.vanbaalenii_PYR-1       MVAGPSLEWER-------ITAQVMRCRLPFCDVTVGVVHAGGEALVVDTG
MMAR_2819|M.marinum_M               ----MNYDWEQ-------LPGSVYRCRLPFCDVTVGLVIGRDDALLVDSG
MAV_2782|M.avium_104                ----MHLAWER-------LTGSVHRCRLPFCDVTVGLICGRSGTLLVDTG
Mb1948|M.bovis_AF2122/97            ----MHFDWER-------LTDSVHRCRLPFCDVTVGLVRGRTGILLVDTG
Rv1913|M.tuberculosis_H37Rv         ----MHFDWER-------LTDSVHRCRLPFCDVTVGLVRGRTGILLVDTG
TH_2173|M.thermoresistible__bu      ----VNFTWER-------LADKVFRTRLPFLDVTVGVVCGSTGTLLVDTG
MAB_2020c|M.abscessus_ATCC_199      --MAQDFAFQKGLVPLGGGAHVFLSGDEGFGLANAGLVVSDDESLVVDTL
MUL_2742|M.ulcerans_Agy99           ----MKVHHHNCG--TMNSPGAALLCHVLLVEAGNGLVLVDTGFGVQDCL
                                             ..        .         :  .  *::       : *  

Mflv_3131|M.gilvum_PYR-GCK          --------------TTLTEARAVAADVS-ELTGCAVTHLVLTHHHFDHVL
Mvan_3402|M.vanbaalenii_PYR-1       --------------TTLAEARAVVRDVA-ALTDCVVRHVVVTHNHFDHVL
MMAR_2819|M.marinum_M               --------------STLREAAAIQADIR-QLADRRVAHIALTHKHFDHVL
MAV_2782|M.avium_104                --------------TTLTEAAAIDADVH-RLARRPVSHIALTHKHFDHVL
Mb1948|M.bovis_AF2122/97            --------------TTLGEATAIAADVK-QIAGCQVTHVVLTHKHFDHVL
Rv1913|M.tuberculosis_H37Rv         --------------TTLGEATAIAADVK-QIAGCQVTHVVLTHKHFDHVL
TH_2173|M.thermoresistible__bu      --------------TTLGEAAAIVADVG-ELAATPITHILLTHNDFDHIL
MAB_2020c|M.abscessus_ATCC_199      --------------YDVRHAREMLDEFGRHTATAPVRYVFNTHTDGDHFF
MUL_2742|M.ulcerans_Agy99           DQRRLGAFRHFLRPALLQNETAVHQIERLGYRPSDVRHIVLTHFDSDHIG
                                                    : .   :            : ::  ** . **. 

Mflv_3131|M.gilvum_PYR-GCK          GHPVFDG-AQTFCSPEVTAALHER---EWLRSDALRYGADPQEVDDALTA
Mvan_3402|M.vanbaalenii_PYR-1       GHSAFGG-AQTFCSAEVVATMADAG--ESLRADAIRHGADPCEVDDALAA
MMAR_2819|M.marinum_M               GSSAFVG-AEIYCAPEVAEYLSSAS--HQLREDALHHGADAGEIDTAIAA
MAV_2782|M.avium_104                GSSLFTG-AEVYCAPEVVEYLGAAT--DQIRDDALRHGADAAEVDAAIAA
Mb1948|M.bovis_AF2122/97            GSSVFDQ-AEVFCAPEVVEYLRSAT--DRLREDALSYGADTAEVDRAIAA
Rv1913|M.tuberculosis_H37Rv         GSSVFDQ-AEVFCAPEVVEYLRSAT--DRLREDALSYGADTAEVDRAIAA
TH_2173|M.thermoresistible__bu      GIGGHPG-AEVFSTDRVVATLLHES--AQLRDEALSYDADPQEIDAAIAA
MAB_2020c|M.abscessus_ATCC_199      GNQVFADDVEIITTEAARALMVQEH--ADLTAELLGGSSDPASNMHVLAP
MUL_2742|M.ulcerans_Agy99           GLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGPKLVEHGHDG
                                    *   .        :  .   :        :    :    ..         

Mflv_3131|M.gilvum_PYR-GCK          AVPPAVA------------VPYGTVELAGVVVRISHPGRGHTGHDLIAVV
Mvan_3402|M.vanbaalenii_PYR-1       LRPPVGA------------VCDGVVELGDVVVTIAHPGRGHTAHDLIVVV
MMAR_2819|M.marinum_M               LRPPRHP------------ILDADVHLGDRRVRITHLGRGHTSADLVVVA
MAV_2782|M.avium_104                LRPGQHG------------IRDARIDLGDRTVTITHLGAGHTASDLAVIV
Mb1948|M.bovis_AF2122/97            LKPPQHG------------IYDAAVDLGDRTVTITHPGSGHTTADLVVVA
Rv1913|M.tuberculosis_H37Rv         LKPPQHG------------IYDAAVDLGDRTVTITHPGSGHTTADLVVVA
TH_2173|M.thermoresistible__bu      RRIPDHA------------VRQAVVGLGDRTVSIVHPGRGHTDHDLIAVV
MAB_2020c|M.abscessus_ATCC_199      LAKPFHFNEVRVRPADTTFSGERALRVGKLDVELHELGPAHTVGDAVAFL
MUL_2742|M.ulcerans_Agy99           ESSPGFA------------AAKTLDAIADGVVLVPMPG--HTRGHAAVAV
                                                              :.   * :   *  **  .  .  

Mflv_3131|M.gilvum_PYR-GCK          T-----DGQDTVVFCGDLVEESGEPCVDDQSDPAAWPATLQRVVDAGGES
Mvan_3402|M.vanbaalenii_PYR-1       E-----GGPRTVVFCGDLVEESGDPCIDAQSDLDAWPGTLRRVLAAGGES
MMAR_2819|M.marinum_M               TPPAAQTG-PVVVFTGDLVEESADPAIDADSDVAAWPATLERLLAIGGPD
MAV_2782|M.avium_104                --PAARDGEPTVVFTGDLVEESGDPAIDADSDVTAWPATLDRLLALGGPG
Mb1948|M.bovis_AF2122/97            PATGHADG-PTVVFTGDLVEESADPDIDADSDLAAWPATLDRVLAIGGPD
Rv1913|M.tuberculosis_H37Rv         PATGHADG-PTVVFTGDLVEESADPDIDADSDLAAWPATLDRVLAIGGPD
TH_2173|M.thermoresistible__bu      R--GAERP---VVFCGDLVEESGEPSVEADSDPGSWPATLDRLLRIGGPD
MAB_2020c|M.abscessus_ATCC_199      P-------EHRVLFSGDLLTR-GIVKVVWSGSIPNWIVALERIRAFG--A
MUL_2742|M.ulcerans_Agy99           D-----AGDRWILHCGDAFYHVGTLDGQSK-----VPFVLRSQEELFSFD
                                               ::. ** . . .      .        .*          

Mflv_3131|M.gilvum_PYR-GCK          GIYVPGHG-----AVVEAAFVRRQAQWLA----GR---------------
Mvan_3402|M.vanbaalenii_PYR-1       AVYVPGHG-----ALVDASFLRRQADWLATAASGRGQVGC----------
MMAR_2819|M.marinum_M               AIYVPGHG-----SVVDADFIRGQRDWLKQRAHPGLR-------------
MAV_2782|M.avium_104                ARYVPGHG-----RVVDAAFVRRQRDWLRARAATR---------------
Mb1948|M.bovis_AF2122/97            ASYVPGHG-----KVVDAQFVRRQRAWLRTRASRQPRETPATLPCKR---
Rv1913|M.tuberculosis_H37Rv         ASYVPGHG-----KVVDAQFVRRQRAWLRTRASRQPRETPATLPCKR---
TH_2173|M.thermoresistible__bu      AVYVPGHG-----ATVDAAFVQRQRQWLAERV------------------
MAB_2020c|M.abscessus_ATCC_199      KIVVPGHGPLLVDAEVDAAIDRGIAFWSDLHEQANRLYDQGVPAQDATAL
MUL_2742|M.ulcerans_Agy99           RRQLRDNQ-----ARLAELQRRQDPGLLIICAHDPSLYAVAKDLS-----
                                       : .:        :     :                            

Mflv_3131|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_2819|M.marinum_M               --------------------------------------------------
MAV_2782|M.avium_104                --------------------------------------------------
Mb1948|M.bovis_AF2122/97            --------------------------------------------------
Rv1913|M.tuberculosis_H37Rv         --------------------------------------------------
TH_2173|M.thermoresistible__bu      --------------------------------------------------
MAB_2020c|M.abscessus_ATCC_199      IDIAKYPEAMVTLPIIVTAIYHERNPEIPFQSLTQALESISGQLAKAAAG
MUL_2742|M.ulcerans_Agy99           --------------------------------------------------
                                                                                      

Mflv_3131|M.gilvum_PYR-GCK          --
Mvan_3402|M.vanbaalenii_PYR-1       --
MMAR_2819|M.marinum_M               --
MAV_2782|M.avium_104                --
Mb1948|M.bovis_AF2122/97            --
Rv1913|M.tuberculosis_H37Rv         --
TH_2173|M.thermoresistible__bu      --
MAB_2020c|M.abscessus_ATCC_199      PK
MUL_2742|M.ulcerans_Agy99           --