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AQDFAFQKGLVPLGGGAHVFLSGDEGFGLANAGLVVSDDESLVVDTLYDVRHAREMLDEFGRHTATAPVR YVFNTHTDGDHFFGNQVFADDVEIITTEAARALMVQEHADLTAELLGGSSDPASNMHVLAPLAKPFHFNE VRVRPADTTFSGERALRVGKLDVELHELGPAHTVGDAVAFLPEHRVLFSGDLLTRGIVKVVWSGSIPNWI VALERIRAFGAKIVVPGHGPLLVDAEVDAAIDRGIAFWSDLHEQANRLYDQGVPAQDATALIDIAKYPEA MVTLPIIVTAIYHERNPEIPFQSLTQALESISGQLAKAAAGPK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2020c | - | - | 100% (324) | bifunctional HHDD isomerase/cyclase/dehydrase |
| M. abscessus ATCC 19977 | MAB_4805 | - | 1e-05 | 24.43% (221) | hypothetical protein MAB_4805 |
| M. abscessus ATCC 19977 | MAB_0414 | - | 4e-05 | 31.94% (72) | beta-lactamase-like hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0964 | - | 8e-41 | 33.33% (306) | bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate |
| M. gilvum PYR-GCK | Mflv_3131 | - | 8e-07 | 28.05% (221) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv0939 | - | 8e-41 | 33.33% (306) | bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4572 | - | 8e-43 | 36.07% (305) | bifunctional enzyme: 2-hydroxyhepta-2,4-diene- 1,7-dioate |
| M. avium 104 | MAV_1057 | - | 3e-40 | 33.33% (315) | fumarylacetoacetate hydrolase family protein, putative |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_0259 | - | 2e-41 | 34.56% (298) | POSSIBLE BIFUNCTIONAL ENZYME: |
| M. ulcerans Agy99 | MUL_4251 | - | 1e-06 | 36.62% (71) | hypothetical protein MUL_4251 |
| M. vanbaalenii PYR-1 | Mvan_3402 | - | 5e-09 | 27.60% (221) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAV
Rv0939|M.tuberculosis_H37Rv MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAV
MMAR_4572|M.marinum_M MKWVTYRSADGERVGVLSDGSIYAMAPGVALLDLIKRGADGLREAGENVL
MAV_1057|M.avium_104 MKWVTYQGDDGERVGVLRDDTIYAMGSGVTLLDLIARGAEGLRHAGEEAQ
TH_0259|M.thermoresistible__bu ------------------------MPPGTELIDLVALGADGLRDAGERAL
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4251|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 RSPAAVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDT
Rv0939|M.tuberculosis_H37Rv RSPAAVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDT
MMAR_4572|M.marinum_M RSPSEVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAVGGGRVLMDT
MAV_1057|M.avium_104 RSPAATVPAARARLLAPIPRPPSIRDSLCFLDHMRNCQAALGAGRVLADT
TH_0259|M.thermoresistible__bu RDPSEVVPLSDVVLRAPIPRPPAIRDCLCFLDHMRNCQEALGGGRVLKDA
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4251|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 WYRIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTV
Rv0939|M.tuberculosis_H37Rv WYRIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTV
MMAR_4572|M.marinum_M WYRIPAFYFACPATVLGPYDDAPMAPGSAWQDFELEIAAVIGTGGQDLSV
MAV_1057|M.avium_104 WYRVPAFYFACPATVLGPYDDAPTAPGSAWQDFELEIAAVIGTGGKDLSV
TH_0259|M.thermoresistible__bu WYRIPAFYFANPSAVFGPYDDVPTAPGSAWQDFELEIAAVIGTGGADLTV
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4251|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 EQAERSIIGYTIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPD
Rv0939|M.tuberculosis_H37Rv EQAERSIIGYTIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPD
MMAR_4572|M.marinum_M EQAEQSIIGYTIFNDWSARDLQQLEGQLRIGQAKGKDSGVTLGPYLVTAD
MAV_1057|M.avium_104 EQAEQAIIGYTIFNDWSARDLQQLDSQLGIGQAKGKDSGVTLGPYLVTPD
TH_0259|M.thermoresistible__bu AEAEQAIIGYTIFNDWSARDLQSLESQLGIGQAKGKDSGITLGPYLVTPD
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4251|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 ELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVIAYASRGVTLT
Rv0939|M.tuberculosis_H37Rv ELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVIAYASRGVTLT
MMAR_4572|M.marinum_M ELQAYRRDGKLSLQVSALVNDTVIGSGSTATMDWTFGEVISYVSRGVMLA
MAV_1057|M.avium_104 ELEPYRRNGKLDLRVTASVNDTVIGSGSTAQMDWTFGEVISYASRGVTLV
TH_0259|M.thermoresistible__bu ELDEFRTDGRLDLTVTALVNGEVIGSGSTAAMDWTFAEVISYASRGVFLH
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4251|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 PGDVFGSGTVPTCTLVEHLRPP--ESFPGWLHDGDVVTLQVEGLGETRQT
Rv0939|M.tuberculosis_H37Rv PGDVFGSGTVPTCTLVEHLRPP--ESFPGWLHDGDVVTLQVEGLGETRQT
MMAR_4572|M.marinum_M PGDVIGSGTVPTCTLVEHLTNP--DSFPGWLRDGDVVTLEVEGLGQTRQR
MAV_1057|M.avium_104 PGDVIGSGTVPTCTLVEHLDPAALESFPGWLHDGDVVTLRVEGLGETRQT
TH_0259|M.thermoresistible__bu PGEVFGSGTVPTCTLVEHLDMTDLAGFRGWLSDGDEVTLQVQGLGETRQT
MAB_2020c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_4251|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3131|M.gilvum_PYR-GCK ----------------------------MSELVWER----LTRHVMRCRL
Mvan_3402|M.vanbaalenii_PYR-1 -------------------------MVAGPSLEWER----ITAQVMRCRL
Mb0964|M.bovis_AF2122/97 VRTSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVADRVWAWTL
Rv0939|M.tuberculosis_H37Rv VRTSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVADRVWAWTL
MMAR_4572|M.marinum_M VCATPPPQPLAPRVDPNAAPEAARVNPAPPLVPYTRGLHQVADRVWAWTL
MAV_1057|M.avium_104 VRASGAPHPLAARPNPDAPPAAPRVNRAAARVPYTRGLHQVGDRVWAWTL
TH_0259|M.thermoresistible__bu VRHRPAPTLLPPRPNPDAAPAPARVNPAPAKVPYRRGLHQVGENVWAWTL
MAB_2020c|M.abscessus_ATCC_199 ---------------------------MAQDFAFQKGLVPLGGGAHVFLS
MUL_4251|M.ulcerans_Agy99 ----------------------------------------MSETAGSLTH
: .
Mflv_3131|M.gilvum_PYR-GCK P---FCDVTVGVVHSDGAAVVIDCGTTLTEARAVAADVSELTG-CAVTHL
Mvan_3402|M.vanbaalenii_PYR-1 P---FCDVTVGVVHAGGEALVVDTGTTLAEARAVVRDVAALTD-CVVRHV
Mb0964|M.bovis_AF2122/97 PDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDA
Rv0939|M.tuberculosis_H37Rv PDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDA
MMAR_4572|M.marinum_M PDGGFGWSNAGLVAGDGASLLVDTLFDLALTREMLDAMRPITDAAPITDA
MAV_1057|M.avium_104 PDGGYGWSNAGLIAGDGASLLVDTLFDLALTREMLTAMRPITASAPITDA
TH_0259|M.thermoresistible__bu PDGGYGWSNAGLVAGEGASLLVDTLFDLTLTREMLDAMQSITQRAPITDM
MAB_2020c|M.abscessus_ATCC_199 GDEGFGLANAGLVVSDDESLVVDTLYDVRHAREMLDEFGRHTATAPVRYV
MUL_4251|M.ulcerans_Agy99 P--AYGRLRP---VTDLASVLVADNPGLLTLEGTNTWVLRGPRSDELVVV
: :::: : . . . :
Mflv_3131|M.gilvum_PYR-GCK VLTHHHFDHVLGHPVFDGAQTFCSPEVTAALHER-EWLRSDALRYGADPQ
Mvan_3402|M.vanbaalenii_PYR-1 VVTHNHFDHVLGHSAFGGAQTFCSAEVVATMADAGESLRADAIRHGADPC
Mb0964|M.bovis_AF2122/97 LITHSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLG
Rv0939|M.tuberculosis_H37Rv LITHSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLG
MMAR_4572|M.marinum_M LITHSNGDHTHGNQLLSPSVRIIAAKGTAEEIAEDTGPTLLTAMQTIDLG
MAV_1057|M.avium_104 VITHSNGDHTHGNQLLDPAVRIIAAHGTAEEIAHGMAPEMLAMAQTANLG
TH_0259|M.thermoresistible__bu VITHCNGDHTHGNQLLDPSVRIIAAKETKDEIDHEMAPSMLALAQTGDLG
MAB_2020c|M.abscessus_ATCC_199 FNTHTDGDHFFGNQVFADDVEIITTEAARALMVQEHADLTAELLGGSSDP
MUL_4251|M.ulcerans_Agy99 DPGPADDEHIARIAALG---RIALVLISHRHGDHTDGIDKLFERTGAPVR
. :* : :
Mflv_3131|M.gilvum_PYR-GCK EVDDALTAAVP-----------PAVAVPYG--TVELAGVVVRISHPGRGH
Mvan_3402|M.vanbaalenii_PYR-1 EVDDALAALRP-----------PVGAVCDG--VVELGDVVVTIAHPGRGH
Mb0964|M.bovis_AF2122/97 PVATRYLRDRFGHFDFSGIKLRNADLTFDRDLAIELGGRRVDLLNLGPAH
Rv0939|M.tuberculosis_H37Rv PVATRYLRDRFGHFDFSGIKLRNADLTFDRDLAIELGGRRVDLLNLGPAH
MMAR_4572|M.marinum_M PVATRFMRDRFGHFDFSGIRLRNADQTFDHELTIDVGGRRVDLINLGPAH
MAV_1057|M.avium_104 PVATRYTRERFGHFDFSNITLRNADETFDRSLAVEVGGRRVDVLNLGPAH
TH_0259|M.thermoresistible__bu PIATTYARDRFGHFDFSGITIRNADHTFDKRLDLEVGGRQVTLLNLGPAH
MAB_2020c|M.abscessus_ATCC_199 ASNMHVLAPLAKPFHFNEVRVRPADTTFSGERALRVGKLDVELHELGPAH
MUL_4251|M.ulcerans_Agy99 AADPQFLRGDP--------------VALSDGEVIDAGGLKITVLAT-PGH
. : . : : .*
Mflv_3131|M.gilvum_PYR-GCK TGHDLIAVVTDGQDTVVFCGDLVEESGEPCVDDQSDPAAWPATLQRVVDA
Mvan_3402|M.vanbaalenii_PYR-1 TAHDLIVVVEGGPRTVVFCGDLVEESGDPCIDAQSDLDAWPGTLRRVLAA
Mb0964|M.bovis_AF2122/97 TTADSVVHVADAG--VLFAGDLLFIGCTPIVWAGP-IANWVAACDAMIAL
Rv0939|M.tuberculosis_H37Rv TTADSVVHVADAG--VLFAGDLLFIGCTPIVWAGP-IANWVAACDAMIAL
MMAR_4572|M.marinum_M TAADSVVHVPDAG--VLFAGDLLFIGCTPIVWNGP-IANWIAACDAMIAL
MAV_1057|M.avium_104 TAADSVVHVPDAG--VLFGGDLLFIGCTPIVWAGP-IANWVAACDAMIAL
TH_0259|M.thermoresistible__bu TAADTVIHIPDAG--VLFGGDLLFIGCTPIVWGGP-IANWIAACDTMLAL
MAB_2020c|M.abscessus_ATCC_199 TVGDAVAFLPEHR--VLFSGDLLTRGIVKVVWSGS-IPNWIVALERIRAF
MUL_4251|M.ulcerans_Agy99 TADSLSFVLEDAV---LTADSVLGRGTTVLDKQDGSLSEYLESLHRLRGL
* . : : ..:: . : : :
Mflv_3131|M.gilvum_PYR-GCK GGESGIYVPGHGAVVEAAFVRRQAQ-------WLA----GR---------
Mvan_3402|M.vanbaalenii_PYR-1 GGESAVYVPGHGALVDASFLRRQAD-------WLATAASGRGQVGC----
Mb0964|M.bovis_AF2122/97 DAP--TVVPGHGPVTGPDGIRAVRG----YLAHIAEQAEAAYRKGLSLPE
Rv0939|M.tuberculosis_H37Rv DAP--TVVPGHGPVTGPDGIRAVRG----YLAHIAEQAEAAYRKGLSLPE
MMAR_4572|M.marinum_M DAP--IVVPGHGPVTDPDGIRAVRG----YFEHVNEQAEAAYRKGLSLAE
MAV_1057|M.avium_104 DAP--TVVPGHGPVTDPDGIRAVRG----YLVHIAEQAEAAYRKGLSWPE
TH_0259|M.thermoresistible__bu DAP--TVVPGHGPITGPEGIHAVRD----YFEYITEQADDAHRRGLSFIE
MAB_2020c|M.abscessus_ATCC_199 GAK--IVVPGHGPLLVDAEVDAAIDRGIAFWSDLHEQANRLYDQGVPAQD
MUL_4251|M.ulcerans_Agy99 GPR--MVLPGHGPDLADIRIVAQGY--------LAHRQERLEQVRS----
. :****. : :
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0964|M.bovis_AF2122/97 AVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEWA
Rv0939|M.tuberculosis_H37Rv AVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEWA
MMAR_4572|M.marinum_M AIETVELGDYAAWLDSERIVVNIYQRYRELDPHTPEVERLALLVMQAEWA
MAV_1057|M.avium_104 AADTIDLGEYATWLDAERVVVNVYQRYRELDPHTPQLEVMALLVMQAEWL
TH_0259|M.thermoresistible__bu AADTIDLGPYANWLDAERVVVNVYQRYRELDPDTPQLGVITLLTMQAEWH
MAB_2020c|M.abscessus_ATCC_199 ATALIDIAKYPEAMVT--LPIIVTAIYHERNPEIPFQSLTQALESISGQL
MUL_4251|M.ulcerans_Agy99 -----ALRELGEQASARQIVEHVYVDVDEKLWDAAEWSVQVQLNHLHQAG
Mflv_3131|M.gilvum_PYR-GCK --------
Mvan_3402|M.vanbaalenii_PYR-1 --------
Mb0964|M.bovis_AF2122/97 ARHCT---
Rv0939|M.tuberculosis_H37Rv ARHCT---
MMAR_4572|M.marinum_M AKRV----
MAV_1057|M.avium_104 AKRS----
TH_0259|M.thermoresistible__bu AKRGAR--
MAB_2020c|M.abscessus_ATCC_199 AKAAAGPK
MUL_4251|M.ulcerans_Agy99 SQS-----