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HLAWERLTGSVHRCRLPFCDVTVGLICGRSGTLLVDTGTTLTEAAAIDADVHRLARRPVSHIALTHKHFD HVLGSSLFTGAEVYCAPEVVEYLGAATDQIRDDALRHGADAAEVDAAIAALRPGQHGIRDARIDLGDRTV TITHLGAGHTASDLAVIVPAARDGEPTVVFTGDLVEESGDPAIDADSDVTAWPATLDRLLALGGPGARYV PGHGRVVDAAFVRRQRDWLRARAATR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2782 | - | - | 100% (237) | metallo-beta-lactamase |
| M. avium 104 | MAV_1057 | - | 7e-13 | 30.18% (222) | fumarylacetoacetate hydrolase family protein, putative |
| M. avium 104 | MAV_3461 | - | 9e-06 | 26.98% (215) | metallo-beta-lactamase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1948 | - | 1e-98 | 73.31% (236) | hypothetical protein Mb1948 |
| M. gilvum PYR-GCK | Mflv_3131 | - | 6e-64 | 52.81% (231) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv1913 | - | 1e-98 | 73.31% (236) | hypothetical protein Rv1913 |
| M. leprae Br4923 | MLBr_01391 | - | 1e-05 | 28.42% (190) | hypothetical protein MLBr_01391 |
| M. abscessus ATCC 19977 | MAB_2020c | - | 6e-07 | 25.33% (225) | bifunctional HHDD isomerase/cyclase/dehydrase |
| M. marinum M | MMAR_2819 | - | 2e-94 | 71.19% (236) | hypothetical protein MMAR_2819 |
| M. smegmatis MC2 155 | MSMEG_3925 | - | 6e-05 | 28.57% (147) | AttM/AiiB family protein |
| M. thermoresistible (build 8) | TH_2173 | - | 4e-73 | 59.66% (233) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1621 | - | 5e-08 | 29.35% (201) | hypothetical protein MUL_1621 |
| M. vanbaalenii PYR-1 | Mvan_3402 | - | 5e-72 | 57.45% (235) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01391|M.leprae_Br4923 ---------MT-------ASIDPVNDYTGHVDPGTAARRALPGATILKV-
MUL_1621|M.ulcerans_Agy99 ---------MT-------VVDD---NYTGHVDPGTVARRTLPGATILKA-
Mflv_3131|M.gilvum_PYR-GCK ---MSELVWER-------LTRHVMRCRLPFCDVTVGVVHSDGAAVVIDC-
Mvan_3402|M.vanbaalenii_PYR-1 MVAGPSLEWER-------ITAQVMRCRLPFCDVTVGVVHAGGEALVVDT-
Mb1948|M.bovis_AF2122/97 ----MHFDWER-------LTDSVHRCRLPFCDVTVGLVRGRTGILLVDT-
Rv1913|M.tuberculosis_H37Rv ----MHFDWER-------LTDSVHRCRLPFCDVTVGLVRGRTGILLVDT-
MAV_2782|M.avium_104 ----MHLAWER-------LTGSVHRCRLPFCDVTVGLICGRSGTLLVDT-
MMAR_2819|M.marinum_M ----MNYDWEQ-------LPGSVYRCRLPFCDVTVGLVIGRDDALLVDS-
TH_2173|M.thermoresistible__bu ----VNFTWER-------LADKVFRTRLPFLDVTVGVVCGSTGTLLVDT-
MAB_2020c|M.abscessus_ATCC_199 --MAQDFAFQKGLVPLGGGAHVFLSGDEGFGLANAGLVVSDDESLVVDT-
MSMEG_3925|M.smegmatis_MC2_155 --MTSAHPFRR-------NTPELSRRDAIRRAGLLGIGASGLAALLAACG
:
MLBr_01391|M.leprae_Br4923 -SVGPMDNNAYLVTCS-ATGETLLIDAANDAEVLIDLVQRYAPKL-SLIV
MUL_1621|M.ulcerans_Agy99 -SVGPVDNNAYLVTCS-ATGQTLLIDAANDAEVLIDLIRRYAPKI-ALIV
Mflv_3131|M.gilvum_PYR-GCK -GTTLTEARAVAADVS-ELTGCAVTHLVLTHHHFDHVLGHPVFDG-AQTF
Mvan_3402|M.vanbaalenii_PYR-1 -GTTLAEARAVVRDVA-ALTDCVVRHVVVTHNHFDHVLGHSAFGG-AQTF
Mb1948|M.bovis_AF2122/97 -GTTLGEATAIAADVK-QIAGCQVTHVVLTHKHFDHVLGSSVFDQ-AEVF
Rv1913|M.tuberculosis_H37Rv -GTTLGEATAIAADVK-QIAGCQVTHVVLTHKHFDHVLGSSVFDQ-AEVF
MAV_2782|M.avium_104 -GTTLTEAAAIDADVH-RLARRPVSHIALTHKHFDHVLGSSLFTG-AEVY
MMAR_2819|M.marinum_M -GSTLREAAAIQADIR-QLADRRVAHIALTHKHFDHVLGSSAFVG-AEIY
TH_2173|M.thermoresistible__bu -GTTLGEAAAIVADVG-ELAATPITHILLTHNDFDHILGIGGHPG-AEVF
MAB_2020c|M.abscessus_ATCC_199 -LYDVRHAREMLDEFGRHTATAPVRYVFNTHTDGDHFFGNQVFADDVEII
MSMEG_3925|M.smegmatis_MC2_155 LGRDDTDPPATTAPAGGHTRQIFADRMYVLDGGTAHVTDISQWSPGVNEG
. ..
MLBr_01391|M.leprae_Br4923 TSHQHFDHWQALEAVVAATGAPTAVH--ELDAEPLPVRPDRLL-------
MUL_1621|M.ulcerans_Agy99 TSHQHFDHWQALQAVAEATGAPTAAH--EIDAEPLPVKPDRLL-------
Mflv_3131|M.gilvum_PYR-GCK CSPEVTAALHER-EWLRSDALRYGADPQEVDDALTAAVPPAVA-------
Mvan_3402|M.vanbaalenii_PYR-1 CSAEVVATMADAGESLRADAIRHGADPCEVDDALAALRPPVGA-------
Mb1948|M.bovis_AF2122/97 CAPEVVEYLRSATDRLREDALSYGADTAEVDRAIAALKPPQHG-------
Rv1913|M.tuberculosis_H37Rv CAPEVVEYLRSATDRLREDALSYGADTAEVDRAIAALKPPQHG-------
MAV_2782|M.avium_104 CAPEVVEYLGAATDQIRDDALRHGADAAEVDAAIAALRPGQHG-------
MMAR_2819|M.marinum_M CAPEVAEYLSSASHQLREDALHHGADAGEIDTAIAALRPPRHP-------
TH_2173|M.thermoresistible__bu STDRVVATLLHESAQLRDEALSYDADPQEIDAAIAARRIPDHA-------
MAB_2020c|M.abscessus_ATCC_199 TTEAARALMVQEHADLTAELLGGSSDPASNMHVLAPLAKPFHFNEVRVRP
MSMEG_3925|M.smegmatis_MC2_155 QSATFSNNVYLIEHGDEWMVWDTGLDENLIDVPGGEVVAHDVRG------
: .
MLBr_01391|M.leprae_Br4923 -----TNGDCVQIGELTFDVIHLR-GHTPGSIALALDGATSGPKTG---R
MUL_1621|M.ulcerans_Agy99 -----ANGDRVQIGELSFDVIHLR-GHTPGSIALALDGAATG-------G
Mflv_3131|M.gilvum_PYR-GCK -----VPYGTVELAGVVVRISHPGRGHTGHDLIAVVT----DGQ------
Mvan_3402|M.vanbaalenii_PYR-1 -----VCDGVVELGDVVVTIAHPGRGHTAHDLIVVVE----GGP------
Mb1948|M.bovis_AF2122/97 -----IYDAAVDLGDRTVTITHPGSGHTTADLVVVAPATGHADG------
Rv1913|M.tuberculosis_H37Rv -----IYDAAVDLGDRTVTITHPGSGHTTADLVVVAPATGHADG------
MAV_2782|M.avium_104 -----IRDARIDLGDRTVTITHLGAGHTASDLAVIVPAARDGE-------
MMAR_2819|M.marinum_M -----ILDADVHLGDRRVRITHLGRGHTSADLVVVATPPAAQTG------
TH_2173|M.thermoresistible__bu -----VRQAVVGLGDRTVSIVHPGRGHTDHDLIAVVR----GAE------
MAB_2020c|M.abscessus_ATCC_199 ADTTFSGERALRVGKLDVELHELGPAHTVGDAVAFLP------------E
MSMEG_3925|M.smegmatis_MC2_155 VVTRRLSDQFSELGVDPAAVNHIAFSHAHFDHVGNSRMFPSATWYVQRDE
:. : . .*: .
MLBr_01391|M.leprae_Br4923 VTQLFTGDCLFPGGVGKTW-QRSDFTQLLDDVTTRVFDVYADTTAIYPGH
MUL_1621|M.ulcerans_Agy99 VTQLFTGDCLFPGGVGKTW-QPGDFTQLVEDVSSRVFNVYPDSTVVYPGH
Mflv_3131|M.gilvum_PYR-GCK DTVVFCGDLVEESGEPCVD-DQSDPAAWPATLQ-RVVDAGGESGIYVPGH
Mvan_3402|M.vanbaalenii_PYR-1 RTVVFCGDLVEESGDPCID-AQSDLDAWPGTLR-RVLAAGGESAVYVPGH
Mb1948|M.bovis_AF2122/97 PTVVFTGDLVEESADPDID-ADSDLAAWPATLD-RVLAIGGPDASYVPGH
Rv1913|M.tuberculosis_H37Rv PTVVFTGDLVEESADPDID-ADSDLAAWPATLD-RVLAIGGPDASYVPGH
MAV_2782|M.avium_104 PTVVFTGDLVEESGDPAID-ADSDVTAWPATLD-RLLALGGPGARYVPGH
MMAR_2819|M.marinum_M PVVVFTGDLVEESADPAID-ADSDVAAWPATLE-RLLAIGGPDAIYVPGH
TH_2173|M.thermoresistible__bu RPVVFCGDLVEESGEPSVE-ADSDPGSWPATLD-RLLRIGGPDAVYVPGH
MAB_2020c|M.abscessus_ATCC_199 HRVLFSGDLLTRGIVKVVW-SGS-IPNWIVALE-RIRAFG--AKIVVPGH
MSMEG_3925|M.smegmatis_MC2_155 HAAMFGDSFADYGFIPDLYATMADNPTVLLDGDHDVFGDGTVVVLDTAGH
:* .. . . : .**
MLBr_01391|M.leprae_Br4923 G----------DDTVLGAERPSLAEWRERGW-------------------
MUL_1621|M.ulcerans_Agy99 G----------DDTALGFERPHLDEWRERGW-------------------
Mflv_3131|M.gilvum_PYR-GCK G----------AVVEAAFVRRQAQWLA----GR-----------------
Mvan_3402|M.vanbaalenii_PYR-1 G----------ALVDASFLRRQADWLATAASGRGQVGC------------
Mb1948|M.bovis_AF2122/97 G----------KVVDAQFVRRQRAWLRTRASRQPRETPATLPCKR-----
Rv1913|M.tuberculosis_H37Rv G----------KVVDAQFVRRQRAWLRTRASRQPRETPATLPCKR-----
MAV_2782|M.avium_104 G----------RVVDAAFVRRQRDWLRARAATR-----------------
MMAR_2819|M.marinum_M G----------SVVDADFIRGQRDWLKQRAHPGLR---------------
TH_2173|M.thermoresistible__bu G----------ATVDAAFVQRQRQWLAERV--------------------
MAB_2020c|M.abscessus_ATCC_199 GP-----LLVDAEVDAAIDRGIAFWSDLHEQANRLYDQGVPAQDATALID
MSMEG_3925|M.smegmatis_MC2_155 TPGHQSLLVHLRGAGTLLLSGDVAHFCDNFRHRRVPTFNADHDRSRASMD
.
MLBr_01391|M.leprae_Br4923 --------------------------------------------------
MUL_1621|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1948|M.bovis_AF2122/97 --------------------------------------------------
Rv1913|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2782|M.avium_104 --------------------------------------------------
MMAR_2819|M.marinum_M --------------------------------------------------
TH_2173|M.thermoresistible__bu --------------------------------------------------
MAB_2020c|M.abscessus_ATCC_199 IAKYPEAMVTLPIIVTAIYHERNPEIPFQSLTQALESISGQLAKAAAGPK
MSMEG_3925|M.smegmatis_MC2_155 RVDELIRTENATLLINHDARQNALIRQAPHAIE-----------------