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VSELVWERLTRHVMRCRLPFCDVTVGVVHSDGAAVVIDCGTTLTEARAVAADVSELTGCAVTHLVLTHHH FDHVLGHPVFDGAQTFCSPEVTAALHEREWLRSDALRYGADPQEVDDALTAAVPPAVAVPYGTVELAGVV VRISHPGRGHTGHDLIAVVTDGQDTVVFCGDLVEESGEPCVDDQSDPAAWPATLQRVVDAGGESGIYVPG HGAVVEAAFVRRQAQWLAGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3131 | - | - | 100% (230) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1948 | - | 4e-67 | 56.71% (231) | hypothetical protein Mb1948 |
| M. tuberculosis H37Rv | Rv1913 | - | 4e-67 | 56.71% (231) | hypothetical protein Rv1913 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2020c | - | 4e-07 | 28.05% (221) | bifunctional HHDD isomerase/cyclase/dehydrase |
| M. marinum M | MMAR_2819 | - | 1e-59 | 50.87% (230) | hypothetical protein MMAR_2819 |
| M. avium 104 | MAV_2782 | - | 5e-64 | 52.81% (231) | metallo-beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3427 | - | 9e-05 | 27.22% (180) | metal dependent hydrolase |
| M. thermoresistible (build 8) | TH_2173 | - | 2e-66 | 56.19% (226) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_2742 | - | 7e-06 | 32.31% (130) | hypothetical protein MUL_2742 |
| M. vanbaalenii PYR-1 | Mvan_3402 | - | 6e-88 | 68.58% (226) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3131|M.gilvum_PYR-GCK --------------------------------------------MSELVW
Mvan_3402|M.vanbaalenii_PYR-1 -----------------------------------------MVAGPSLEW
MMAR_2819|M.marinum_M ---------------------------------------------MNYDW
MAV_2782|M.avium_104 ---------------------------------------------MHLAW
Mb1948|M.bovis_AF2122/97 ---------------------------------------------MHFDW
Rv1913|M.tuberculosis_H37Rv ---------------------------------------------MHFDW
TH_2173|M.thermoresistible__bu ---------------------------------------------VNFTW
MAB_2020c|M.abscessus_ATCC_199 -------------------------------------------MAQDFAF
MUL_2742|M.ulcerans_Agy99 ---------------------------------------------MKVHH
MSMEG_3427|M.smegmatis_MC2_155 MTTTDNTAHAGTQTIDELVPSRYAVQVGDIEVLVISDGVLPITASTMATN
Mflv_3131|M.gilvum_PYR-GCK ER-------LTRHVMRCRLPFCDVTVGVVHSDGAAVVIDCG---------
Mvan_3402|M.vanbaalenii_PYR-1 ER-------ITAQVMRCRLPFCDVTVGVVHAGGEALVVDTG---------
MMAR_2819|M.marinum_M EQ-------LPGSVYRCRLPFCDVTVGLVIGRDDALLVDSG---------
MAV_2782|M.avium_104 ER-------LTGSVHRCRLPFCDVTVGLICGRSGTLLVDTG---------
Mb1948|M.bovis_AF2122/97 ER-------LTDSVHRCRLPFCDVTVGLVRGRTGILLVDTG---------
Rv1913|M.tuberculosis_H37Rv ER-------LTDSVHRCRLPFCDVTVGLVRGRTGILLVDTG---------
TH_2173|M.thermoresistible__bu ER-------LADKVFRTRLPFLDVTVGVVCGSTGTLLVDTG---------
MAB_2020c|M.abscessus_ATCC_199 QKGLVPLGGGAHVFLSGDEGFGLANAGLVVSDDESLVVDTL---------
MUL_2742|M.ulcerans_Agy99 HNCG--TMNSPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLDQRRLGAFR
MSMEG_3427|M.smegmatis_MC2_155 ADSDTYRTWLSDRFLPQDILDWPLNVVVVRSGDRTILVDAG--------L
. :: : *
Mflv_3131|M.gilvum_PYR-GCK -----TTLTEARAVAADVS-ELTGCAVTHLVLTHHHFDHVLGHPVFDG-A
Mvan_3402|M.vanbaalenii_PYR-1 -----TTLAEARAVVRDVA-ALTDCVVRHVVVTHNHFDHVLGHSAFGG-A
MMAR_2819|M.marinum_M -----STLREAAAIQADIR-QLADRRVAHIALTHKHFDHVLGSSAFVG-A
MAV_2782|M.avium_104 -----TTLTEAAAIDADVH-RLARRPVSHIALTHKHFDHVLGSSLFTG-A
Mb1948|M.bovis_AF2122/97 -----TTLGEATAIAADVK-QIAGCQVTHVVLTHKHFDHVLGSSVFDQ-A
Rv1913|M.tuberculosis_H37Rv -----TTLGEATAIAADVK-QIAGCQVTHVVLTHKHFDHVLGSSVFDQ-A
TH_2173|M.thermoresistible__bu -----TTLGEAAAIVADVG-ELAATPITHILLTHNDFDHILGIGGHPG-A
MAB_2020c|M.abscessus_ATCC_199 -----YDVRHAREMLDEFGRHTATAPVRYVFNTHTDGDHFFGNQVFADDV
MUL_2742|M.ulcerans_Agy99 HFLRPALLQNETAVHQIERLGYRPSDVRHIVLTHFDSDHIGGLADFPDAQ
MSMEG_3427|M.smegmatis_MC2_155 GVEFPDFPRAGRTVARLEAAGIDPSAVTDVVLTHLHMDHIGGLLSHGLKE
: : : ** . **. * .
Mflv_3131|M.gilvum_PYR-GCK QTFCSPEVTAALHER---EWLRSDALRYGADPQEVDDALTAAVPPAVA--
Mvan_3402|M.vanbaalenii_PYR-1 QTFCSAEVVATMADAG--ESLRADAIRHGADPCEVDDALAALRPPVGA--
MMAR_2819|M.marinum_M EIYCAPEVAEYLSSAS--HQLREDALHHGADAGEIDTAIAALRPPRHP--
MAV_2782|M.avium_104 EVYCAPEVVEYLGAAT--DQIRDDALRHGADAAEVDAAIAALRPGQHG--
Mb1948|M.bovis_AF2122/97 EVFCAPEVVEYLRSAT--DRLREDALSYGADTAEVDRAIAALKPPQHG--
Rv1913|M.tuberculosis_H37Rv EVFCAPEVVEYLRSAT--DRLREDALSYGADTAEVDRAIAALKPPQHG--
TH_2173|M.thermoresistible__bu EVFSTDRVVATLLHES--AQLRDEALSYDADPQEIDAAIAARRIPDHA--
MAB_2020c|M.abscessus_ATCC_199 EIITTEAARALMVQEH--ADLTAELLGGSSDPASNMHVLAPLAKPFHFNE
MUL_2742|M.ulcerans_Agy99 VHVTSAEARGAIHAPSFRERVRYRSVQWAHGPKLVEHGHDGESSPGFA--
MSMEG_3427|M.smegmatis_MC2_155 RLRPDLRIHVASAEANFWESPDFSHTEMPAPVPPALRAIAGRFLDEYRG-
Mflv_3131|M.gilvum_PYR-GCK ----------VPYGTVELAGVVVRISHPGRGHTGHDLIAVVT-----DGQ
Mvan_3402|M.vanbaalenii_PYR-1 ----------VCDGVVELGDVVVTIAHPGRGHTAHDLIVVVE-----GGP
MMAR_2819|M.marinum_M ----------ILDADVHLGDRRVRITHLGRGHTSADLVVVATPPAAQTG-
MAV_2782|M.avium_104 ----------IRDARIDLGDRTVTITHLGAGHTASDLAVIV--PAARDGE
Mb1948|M.bovis_AF2122/97 ----------IYDAAVDLGDRTVTITHPGSGHTTADLVVVAPATGHADG-
Rv1913|M.tuberculosis_H37Rv ----------IYDAAVDLGDRTVTITHPGSGHTTADLVVVAPATGHADG-
TH_2173|M.thermoresistible__bu ----------VRQAVVGLGDRTVSIVHPGRGHTDHDLIAVVR--GAERP-
MAB_2020c|M.abscessus_ATCC_199 VRVRPADTTFSGERALRVGKLDVELHELGPAHTVGDAVAFLP-------E
MUL_2742|M.ulcerans_Agy99 ----------AAKTLDAIADGVVLVPMPG--HTRGHAAVAVD-----AGD
MSMEG_3427|M.smegmatis_MC2_155 -------QIQTFDSEYDITPG-VHVARTG-GHTPGHSVVRLA-----SGE
: * : * ** . .
Mflv_3131|M.gilvum_PYR-GCK DTVVFCGDLVEESGEPCVDDQSDPAAWPATLQRVVDAGGESGIYVPGHG-
Mvan_3402|M.vanbaalenii_PYR-1 RTVVFCGDLVEESGDPCIDAQSDLDAWPGTLRRVLAAGGESAVYVPGHG-
MMAR_2819|M.marinum_M PVVVFTGDLVEESADPAIDADSDVAAWPATLERLLAIGGPDAIYVPGHG-
MAV_2782|M.avium_104 PTVVFTGDLVEESGDPAIDADSDVTAWPATLDRLLALGGPGARYVPGHG-
Mb1948|M.bovis_AF2122/97 PTVVFTGDLVEESADPDIDADSDLAAWPATLDRVLAIGGPDASYVPGHG-
Rv1913|M.tuberculosis_H37Rv PTVVFTGDLVEESADPDIDADSDLAAWPATLDRVLAIGGPDASYVPGHG-
TH_2173|M.thermoresistible__bu --VVFCGDLVEESGEPSVEADSDPGSWPATLDRLLRIGGPDAVYVPGHG-
MAB_2020c|M.abscessus_ATCC_199 HRVLFSGDLLTR-GIVKVVWSGSIPNWIVALERIRAFG--AKIVVPGHGP
MUL_2742|M.ulcerans_Agy99 RWILHCGDAFYHVGTLDGQSK-----VPFVLRSQEELFSFDRRQLRDNQ-
MSMEG_3427|M.smegmatis_MC2_155 DRLTFAGDAVFAPGFDNPQWHN---GFEHDPEESVRVRVELLRELAATG-
: . ** . . :
Mflv_3131|M.gilvum_PYR-GCK ----AVVEAAFVRRQAQWLA----GR------------------------
Mvan_3402|M.vanbaalenii_PYR-1 ----ALVDASFLRRQADWLATAASGRGQVGC-------------------
MMAR_2819|M.marinum_M ----SVVDADFIRGQRDWLKQRAHPGLR----------------------
MAV_2782|M.avium_104 ----RVVDAAFVRRQRDWLRARAATR------------------------
Mb1948|M.bovis_AF2122/97 ----KVVDAQFVRRQRAWLRTRASRQPRETPATLPCKR------------
Rv1913|M.tuberculosis_H37Rv ----KVVDAQFVRRQRAWLRTRASRQPRETPATLPCKR------------
TH_2173|M.thermoresistible__bu ----ATVDAAFVQRQRQWLAERV---------------------------
MAB_2020c|M.abscessus_ATCC_199 LLVDAEVDAAIDRGIAFWSDLHEQANRLYDQGVPAQDATALIDIAKYPEA
MUL_2742|M.ulcerans_Agy99 ----ARLAELQRRQDPGLLIICAHDPSLYAVAKDLS--------------
MSMEG_3427|M.smegmatis_MC2_155 ----ESLVATHLPFPSVCHVAAAGDAFRCVPAVWDY--------------
:
Mflv_3131|M.gilvum_PYR-GCK -------------------------------------------
Mvan_3402|M.vanbaalenii_PYR-1 -------------------------------------------
MMAR_2819|M.marinum_M -------------------------------------------
MAV_2782|M.avium_104 -------------------------------------------
Mb1948|M.bovis_AF2122/97 -------------------------------------------
Rv1913|M.tuberculosis_H37Rv -------------------------------------------
TH_2173|M.thermoresistible__bu -------------------------------------------
MAB_2020c|M.abscessus_ATCC_199 MVTLPIIVTAIYHERNPEIPFQSLTQALESISGQLAKAAAGPK
MUL_2742|M.ulcerans_Agy99 -------------------------------------------
MSMEG_3427|M.smegmatis_MC2_155 -------------------------------------------