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VKVHHHNCGTMNSPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLDQRRLGAFRHFLRPALLQNETAVHQI ERLGYRPSDVRHIVLTHFDSDHIGGLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGPKLVEH GHDGESSPGFAAAKTLDAIADGVVLVPMPGHTRGHAAVAVDAGDRWILHCGDAFYHVGTLDGQSKVPFVL RSQEELFSFDRRQLRDNQARLAELQRRQDPGLLIICAHDPSLYAVAKDLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2742 | - | - | 100% (260) | hypothetical protein MUL_2742 |
| M. ulcerans Agy99 | MUL_2815 | - | 8e-07 | 31.16% (138) | beta lactamase-like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2322c | - | 1e-117 | 75.97% (258) | hypothetical protein Mb2322c |
| M. gilvum PYR-GCK | Mflv_1675 | - | 1e-80 | 56.11% (262) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv2300c | - | 1e-117 | 75.97% (258) | hypothetical protein Rv2300c |
| M. leprae Br4923 | MLBr_00270 | - | 2e-05 | 28.57% (189) | hypothetical protein MLBr_00270 |
| M. abscessus ATCC 19977 | MAB_1114 | - | 4e-05 | 28.43% (204) | metallo-beta-lactamase superfamily |
| M. marinum M | MMAR_3523 | - | 1e-148 | 96.92% (260) | hypothetical protein MMAR_3523 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3427 | - | 1e-10 | 30.73% (192) | metal dependent hydrolase |
| M. thermoresistible (build 8) | TH_0195 | - | 5e-11 | 28.19% (188) | metal dependent hydrolase |
| M. vanbaalenii PYR-1 | Mvan_5078 | - | 4e-88 | 59.85% (259) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2742|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3523|M.marinum_M --------------------------------------------------
Mb2322c|M.bovis_AF2122/97 MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Rv2300c|M.tuberculosis_H37Rv MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Mflv_1675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5078|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3427|M.smegmatis_MC2_155 --------------------------MTTTDNTAHAGTQTIDELVPSRYA
TH_0195|M.thermoresistible__bu --------------------------MSTTAVRPVA-HPEHDELVPSRYA
MAB_1114|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00270|M.leprae_Br4923 --------------------------------------------------
MUL_2742|M.ulcerans_Agy99 MKVHHHNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-QR
MMAR_3523|M.marinum_M MKVHHLNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-PR
Mb2322c|M.bovis_AF2122/97 VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Rv2300c|M.tuberculosis_H37Rv VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Mflv_1675|M.gilvum_PYR-GCK MKVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAH-PE
Mvan_5078|M.vanbaalenii_PYR-1 MKVHHLNCGTIRPTGVGT-MVCHVLLVESADGLVLVDTGFGTHDCED-PN
MSMEG_3427|M.smegmatis_MC2_155 VQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDILDWPL
TH_0195|M.thermoresistible__bu LRVGDIEVLVISDGVLPLPAATLATNADRAELAAWLHDMFLPADLFDWPL
MAB_1114|M.abscessus_ATCC_1997 ---------MSSPDLQQLAPSLFRLRIPGGRAHLLNCYLWLAPDGVT---
MLBr_00270|M.leprae_Br4923 ---------MAAATLFQVTDSVHFARGDAVNWALVADDTG----------
MUL_2742|M.ulcerans_Agy99 RLGAFR------------HFLRPALLQ-NETAVHQIERLGYRPSDVRHIV
MMAR_3523|M.marinum_M RLGAFR------------HFLRPALLQ-NETAVHQIERLGYRPSDVRHVV
Mb2322c|M.bovis_AF2122/97 RVGLFR------------HVLRPAFLQ-AETAARQIEQLGYRTSDVRHIV
Rv2300c|M.tuberculosis_H37Rv RVGLFR------------HVLRPAFLQ-AETAARQIEQLGYRTSDVRHIV
Mflv_1675|M.gilvum_PYR-GCK EFGRIRR-----------RIIRPDFER-TETAAEQLAHLGYRLSDVRHII
Mvan_5078|M.vanbaalenii_PYR-1 RFGRIRS-----------RFIRPNFDR-GETALNQIRQLGFRRSDVRHVV
MSMEG_3427|M.smegmatis_MC2_155 NVVVVRSGDRTILVDAGLGVEFPDFPR-AGRTVARLEAAGIDPSAVTDVV
TH_0195|M.thermoresistible__bu NVAVVRSGDRTILIDSGLGLEFPEFPR-AGRLAHRMQAAGIEPAAVTDVV
MAB_1114|M.abscessus_ATCC_1997 -------------------LIDTGWPDSAELIEQALHQLGRGRTDIVRIV
MLBr_00270|M.leprae_Br4923 -----------------VMLIDTGYPGDRDDVVASLRQLGYEAGDVRAIL
. . : * : ::
MUL_2742|M.ulcerans_Agy99 LTHFDSDHIGGLADFPDAQVHVTSAEARGAIHAPSFRER--------VRY
MMAR_3523|M.marinum_M LTHFDFDHIGGLADFPDAQVHVTSAEARGAIHAPSFRER--------VRY
Mb2322c|M.bovis_AF2122/97 LTHFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRER--------LRY
Rv2300c|M.tuberculosis_H37Rv LTHFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRER--------LRY
Mflv_1675|M.gilvum_PYR-GCK VTHFDADHIGGLADFPDAQVHVTAQEVLSAMKSPSVQNR--------IRF
Mvan_5078|M.vanbaalenii_PYR-1 VTHFDADHIGGLADFPDALVHVTTTEAFGAMRSPSIQER--------IRF
MSMEG_3427|M.smegmatis_MC2_155 LTHLHMDHIGGLLSHGLKERLRPDLRIHVASAEANFWES--------PDF
TH_0195|M.thermoresistible__bu LTHLHMDHVGGLLTDGLMGRLRPDLRVHLAAAEAEFWAA--------PDF
MAB_1114|M.abscessus_ATCC_1997 LTHFHEDHVGAAAEIAAWSRAEVIAGEPDSPFITGERGGPV------PVL
MLBr_00270|M.leprae_Br4923 LTHAHIDHMGSAIWFASKHRTPVYCHADEVGHTKREYLEQVSLLNIAMRV
:** . **:*.
MUL_2742|M.ulcerans_Agy99 RSVQWAHGPKLVEHGHDG---ESSPG-FAAAKTLDAIADGVVLVPMPGHT
MMAR_3523|M.marinum_M RSVQWAHGPKLVEHGHDG---ESWRG-FAAAKPLDAIADGVVLVPMPGHT
Mb2322c|M.bovis_AF2122/97 RRGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMPGHT
Rv2300c|M.tuberculosis_H37Rv RRGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMPGHT
Mflv_1675|M.gilvum_PYR-GCK QPSQWAHGPRIVEHTADG---EPWRG-FAAAKELSEIGPGFALVPLPGHT
Mvan_5078|M.vanbaalenii_PYR-1 RPPQWAHGPRIVEHDIDG---EAWRG-FAAAKELTQIGPGFVLVSLPGHT
MSMEG_3427|M.smegmatis_MC2_155 SHTEMPAPVPPALRAIAGRFLDEYRGQIQTFDSEYDITPGVHVARTGGHT
TH_0195|M.thermoresistible__bu SRTAMPHPVPDVLRAVASRFLDVYRDRLRPFDTQYEVAPGVSVHRTGGHT
MAB_1114|M.abscessus_ATCC_1997 TAGEQALHPGFTEPPHGP---VCRVDRAVKDGEVLDFAGGAHVIAVPGHT
MLBr_00270|M.leprae_Br4923 WQPRWAIWSGHVLRSGGLIRGGIPTAQPLTAETAAGLPGHPMAIFTPGHT
. . . ***
MUL_2742|M.ulcerans_Agy99 RGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSFD
MMAR_3523|M.marinum_M RGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSFD
Mb2322c|M.bovis_AF2122/97 RGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSYN
Rv2300c|M.tuberculosis_H37Rv RGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSYN
Mflv_1675|M.gilvum_PYR-GCK EGHACVAVDAGHRWLLHAGDAFYHHSEIDGGGPPPMPASLRAFEMAVAAD
Mvan_5078|M.vanbaalenii_PYR-1 RGHACVAVDAGHRWLLHAGDSFYHPGTLAG--APPVPKWTARLEMLVASD
MSMEG_3427|M.smegmatis_MC2_155 PGHSVVRLASGEDRLTFAGDAVFAPGFDNPQWHNGFEHDPEESVRVRVEL
TH_0195|M.thermoresistible__bu PGHSIVRLESGKDRLTFAGDAVFQVGFDNPQWHNGFEHDPEEAARVRVRL
MAB_1114|M.abscessus_ATCC_1997 PGSIALYLPAADAVLTGDAVAEFNGQVILG--------VFNSDRQVAARS
MLBr_00270|M.leprae_Br4923 GGHCSYVVDG---VLISGDALITGHPLLRHRGPQLLTAVFSHSQKQCLRS
* : . :
MUL_2742|M.ulcerans_Agy99 RRQLRDNQARLAELQRRQDPGLLIICAHDPSLYAVAKDLS--
MMAR_3523|M.marinum_M RRQLRDNQARLAELQRRQDPGLLIICAHDPSLYALAKDLS--
Mb2322c|M.bovis_AF2122/97 RNQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLARDTA--
Rv2300c|M.tuberculosis_H37Rv RNQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLARDTA--
Mflv_1675|M.gilvum_PYR-GCK RKMVLDNHSRLTELYRRQDPDLLIVCSHDRKLYEHAKATAGD
Mvan_5078|M.vanbaalenii_PYR-1 KQKVKQNHVRLAELYRRQDPDLMILCSHDVTLYEQARATAQT
MSMEG_3427|M.smegmatis_MC2_155 LRELAATGESLVATHLP-FPSVCHVAAAGDAFRCVPAVWDY-
TH_0195|M.thermoresistible__bu LQEIAASGETLVATHLP-FPSLCRVAPRGEAFRFVPTVWDH-
MAB_1114|M.abscessus_ATCC_1997 LSRLAATGAEIGGFGHGEAILEKASARIATAIDAFGE-----
MLBr_00270|M.leprae_Br4923 LDALGLLETRILAPGHGELWHGPIREATEAALKQAGALTR--
: : :