For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
PGAHRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPATTSRANFLHARGSEVLDRMGALGTLPQES LRALRITNYLGDRPLATLEFGDPGMRTAAPPMVVSQAKVEAALRARLADLDVEPEWGRKVIDVREDADGV VADLADGARVRGQWLVGCDGTTSVVRRQTGIEFPGVRLSERFLLADIHLDWAVDRAGTTGWIHPDGVVGA MPMPSTDGRDDLWRLFVYDPSLDRKPTDSEILDRISELVPYRTGRRVKIGDAEWLSMFTVHRRLADTYRR GRVLIAGDAAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGLAADDLLDTYEAERRPLATQVLRGTSAIT RVNVAGNPIVRFLRDRVAPRVFGLPAVQRWTTYTASQLWVSYRNGPLGGRGSKPRPGDRIDDAPCSRPDG TATRLHGELGGRWALLLPRGVPAVGAAAVRGPAGYLADHVVTLHHDRDDVMLVRPDAHLAWRGAHDDPTG LDRWLATALHPGGTQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5009 | - | - | 100% (506) | monooxygenase, FAD-binding |
| M. gilvum PYR-GCK | Mflv_2401 | mhpA | 7e-40 | 30.90% (521) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. gilvum PYR-GCK | Mflv_5254 | - | 6e-10 | 29.65% (172) | geranylgeranyl reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1170c | - | 1e-10 | 32.37% (173) | putative oxidoreductase |
| M. tuberculosis H37Rv | Rv1138c | - | 1e-10 | 32.37% (173) | oxidoreductase |
| M. leprae Br4923 | MLBr_02276 | - | 7e-07 | 27.98% (168) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0857 | - | 2e-49 | 33.07% (508) | hypothetical protein MAB_0857 |
| M. marinum M | MMAR_4271 | - | 3e-48 | 34.59% (529) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 3e-52 | 34.52% (507) | hypothetical protein MAV_2736 |
| M. smegmatis MC2 155 | MSMEG_1499 | - | 0.0 | 79.16% (499) | oxygenase |
| M. thermoresistible (build 8) | TH_4641 | - | 1e-160 | 58.74% (509) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_0979 | - | 7e-11 | 27.55% (421) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0779 | - | 0.0 | 70.20% (500) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1170c|M.bovis_AF2122/97 --------MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPID
Rv1138c|M.tuberculosis_H37Rv --------MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPID
MUL_0979|M.ulcerans_Agy99 --------MTTYDTDVLVVGGGPGGLATALNARKRGLSVIVADPRESPID
Mflv_5009|M.gilvum_PYR-GCK -------MPGAHRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPAT
MSMEG_1499|M.smegmatis_MC2_155 --------MAATDCDVIVVGAGPTGLTLACSLRLHGLSVRVLDRAAGPAT
Mvan_0779|M.vanbaalenii_PYR-1 ----------MTDTDVVVVGAGPTGLTLACALRLHGLTVQVVDRAAGPAT
TH_4641|M.thermoresistible__bu -------MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPAT
MMAR_4271|M.marinum_M ----------MADHAVVVVGAGPTGLMLAGELALAGVDVAVVERRVSQDL
MAV_2736|M.avium_104 MRGVRFSERSVRGHAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQL
MAB_0857|M.abscessus_ATCC_1997 ----------MAEHAVVVAGAGPTGLMLAGELALAGIDVALLERRGSHEE
MLBr_02276|M.leprae_Br4923 -------MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRD
::*.*.** * * * * : :
Mb1170c|M.bovis_AF2122/97 KACGEGLMPGGLAELTSLGVDPVGLPFHGI------AYVGEHRRVQARFR
Rv1138c|M.tuberculosis_H37Rv KACGEGLMPGGLAELTSLGVDPVGLPFHGI------AYVGEHRRVQARFR
MUL_0979|M.ulcerans_Agy99 KACGEGLMPGGLAELKSLDVDPAGVPFQGI------AYVSQQRRAEARFR
Mflv_5009|M.gilvum_PYR-GCK T-SRANFLHARGSEVLDRMGALGTLPQESLRALRITNYLGDRPLATLEFG
MSMEG_1499|M.smegmatis_MC2_155 T-SRANFLHARGSEVLNRIGALGTLPDESLRAMRITNYLGDRPVMTLTFG
Mvan_0779|M.vanbaalenii_PYR-1 T-SRANFLHARGSEVLGRIGALGTLPDESLRAMRITNYLGDRPLVTLEFG
TH_4641|M.thermoresistible__bu T-SRANFLHARGSEVLDRLGALGGLPERSVRAMQITTHLGGEPVMRMQFG
MMAR_4271|M.marinum_M VGSRAGGLHSRTIEVLDQRGIADRFLAQGT-----ATQVARFAAIPLDIS
MAV_2736|M.avium_104 IGSRAGGLHARTLEILDQRGIVDRFLAEGQ-----VAQVAGFAQIRLDIS
MAB_0857|M.abscessus_ATCC_1997 VGSRAAGLHSRTIEVFDQRGIAERFLAQGR-----TGQVTHFSGIFMSIE
MLBr_02276|M.leprae_Br4923 KACGDG-LTPRAVAELKRLGLDDWLNTRIRHRGLRMSGFGGEVEVDWPGP
. : . . .
Mb1170c|M.bovis_AF2122/97 TGPGR------GVRRTTLHAALAARAKEQDTEWIR-SRVATIQQDAH--G
Rv1138c|M.tuberculosis_H37Rv TGPGR------GVRRTTLHAALAARAKEQDTEWIR-SRVATIQQDAH--G
MUL_0979|M.ulcerans_Agy99 TGPGR------GVRRTTVHATLAARAKEQDAEWIR-TRVTDVVQDAH--G
Mflv_5009|M.gilvum_PYR-GCK DPGMRTAAPPMVVSQAKVEAALRARLADLDVEPEWGRKVIDVREDAD--G
MSMEG_1499|M.smegmatis_MC2_155 DPGMRTAAPPMVVSQARVEAALRARLAQLGVEPEWGRKVAGVRQAGD--R
Mvan_0779|M.vanbaalenii_PYR-1 DPRMRTAAPPMVISQAKVEASLRSRLADLGAEPQWGNGLAALHRNDD--T
TH_4641|M.thermoresistible__bu DPGMRTAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDAS--T
MMAR_4271|M.marinum_M DFPTRHNYG-LALWQNRIERILAEWVAELRVRIYRGCEVTDITQDDN--G
MAV_2736|M.avium_104 DFPTRHPYG-LALWQNHIERILADWVGELGVPIYRGHRIATCTQDDT--G
MAB_0857|M.abscessus_ATCC_1997 DFPTRHPYA-LGLLQHYTEKTLAAWIDELGVPIYYNAEAVGLGQDDV--G
MLBr_02276|M.leprae_Br4923 SFPSTSS----AVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRRA
: : . : : .
Mb1170c|M.bovis_AF2122/97 VTAAG-----VRAKWLVAADGLHSAVRRAVGIKATAGTPRR----YGVRW
Rv1138c|M.tuberculosis_H37Rv VTAAG-----VRAKWLVAADGLHSAVRRAVGIKATAGTPRR----YGVRW
MUL_0979|M.ulcerans_Agy99 VTAAG-----VRAKWLVAADGLHSAVRRAVGITATAGTPRR----YGVRR
Mflv_5009|M.gilvum_PYR-GCK VVADLADGARVRGQWLVGCDGTTSVVRRQTGIEFPGVRLSERFLLADIHL
MSMEG_1499|M.smegmatis_MC2_155 VVADLADGAQVSGQWLVGCDGTSSATREQVGIPFPGVKLSERFLLADIHL
Mvan_0779|M.vanbaalenii_PYR-1 VVAELDDGTSVEARWLVGCDGTASTTRKLAGIGFPGVKLTERWLLADLHL
TH_4641|M.thermoresistible__bu VTAGIGGGGELRGRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLADVYL
MMAR_4271|M.marinum_M VDLTLSDGPPLRADYVVGCDGGRSLVRRAVGIDFPGWDPTTSSLIAEVEV
MAV_2736|M.avium_104 VDVVASDGRTLRGQYLVGCDGGRSVIRKAAGIDFPGWEATTSYLLAEAEM
MAB_0857|M.abscessus_ATCC_1997 VDVALADGSTLRGQYLVGCDGGRSTIRKAAGIGFPGHDPSCSAMLVDAEI
MLBr_02276|M.leprae_Br4923 ASVTLADGTEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTT
. : :: .** * . *
Mb1170c|M.bovis_AF2122/97 HYRLPVWS--DFVEVHWSRWGEAYVTPVEPD-----LVGVAILSR-----
Rv1138c|M.tuberculosis_H37Rv HYRLPVWS--DFVEVHWSRWGEAYVTPVEPD-----LVGVAILSR-----
MUL_0979|M.ulcerans_Agy99 HYRVPAWS--EFVEVHWSPWGEAYVTPVEPD-----LVGVAILSR-----
Mflv_5009|M.gilvum_PYR-GCK DWAVDRAG--TTGWIHPDG--VVGAMPMPSTDGRDDLWRLFVYDPSLDRK
MSMEG_1499|M.smegmatis_MC2_155 DWAVDRGG--TTGWIHPDG--VVGAMPMPSGDGRNDLWRLFVYDPALNRK
Mvan_0779|M.vanbaalenii_PYR-1 DWDLDRGG--TTGWIHPGG--LLGAMPMPDSSGAHDLWRVFAYDPGHTEK
TH_4641|M.thermoresistible__bu DWRLDRSG--TTGWIHPDG--MVGAMPMPDG-----LWRIIAYDPGPGDL
MMAR_4271|M.marinum_M AVGSESGP--NLGEVRHDALGVHGFTRLPDGGPLRVVVTERQLDAGGEP-
MAV_2736|M.avium_104 DWRTGQPP--QWG-IHHDSLGVHALSETEPAGGVRVLVTERQLRSAAEP-
MAB_0857|M.abscessus_ATCC_1997 ---TEQPL--EFGLLRKPGQAFLGILPFEEG-WCRLAFSTGLDRLGVEP-
MLBr_02276|M.leprae_Br4923 PRSDDLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSKRP-
Mb1170c|M.bovis_AF2122/97 -------QRPELAWFPSLAHHLQDASR--GHARGCGPLRQVVSRRVAGRV
Rv1138c|M.tuberculosis_H37Rv -------QRPELAWFPSLAHHLQDASR--GHARGCGPLRQVVSRRVAGRV
MUL_0979|M.ulcerans_Agy99 -------QRPEIDWFPWLAQQLRGASP--GAARGCGPLRQVVSRRVAGRV
Mflv_5009|M.gilvum_PYR-GCK PTDSEILDRISELVPYRTGRRVKIGDA--EWLSMFTVHRRLADTYRRGRV
MSMEG_1499|M.smegmatis_MC2_155 PSDSEILQRIEQIVPYRTGRAITIGQP--EWLSMFTVHRRLAQSYRRGRV
Mvan_0779|M.vanbaalenii_PYR-1 PAESEILERMRQVIPQRSGRRVHVGDP--EWLSVFTVHRRLADRYRQGRI
TH_4641|M.thermoresistible__bu DQG-----ALERLLYERTGHRVKVTGT--VWQSEFRVHRRLADTYRRGRV
MMAR_4271|M.marinum_M -----SLGDLSAALTAVYGTDYGIHSP--TWISRFTDLTRQAATYRQGRV
MAV_2736|M.avium_104 -----NLDDLRQALIAVYRTDYGIHSP--RWISRFTDAARQAARYRDRRV
MAB_0857|M.abscessus_ATCC_1997 -----TLEEAKEALIAIAGTDFGIHNP--RWISRFSDMTRQADRYRDGRV
MLBr_02276|M.leprae_Br4923 --ADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPNW
. .
Mb1170c|M.bovis_AF2122/97 LLVGDAAGYEDALTGEGIS--------LAVKQAAAAVSAIVDDTPASYEA
Rv1138c|M.tuberculosis_H37Rv LLVGDAAGYEDALTGEGIS--------LAVKQAAAAVSAIVDDTPASYEA
MUL_0979|M.ulcerans_Agy99 LLVGDAAGYEDALTGEGIT--------LAVKQAAAAVRAIADNDPASYEA
Mflv_5009|M.gilvum_PYR-GCK LIAGDAAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGLAADDLLDTYEA
MSMEG_1499|M.smegmatis_MC2_155 LIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALVIRGLAADALIDTYEA
Mvan_0779|M.vanbaalenii_PYR-1 LIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALVTRGLAADPFVDTYEA
TH_4641|M.thermoresistible__bu FIAGDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIRGYAGPALLDTYEA
MMAR_4271|M.marinum_M LIAGDAAHVHDPVGGQGLNTGVQDAVNLGWKLAQVVNRRSPESLLDTYHA
MAV_2736|M.avium_104 LLAGDAAHIHHPVGGQGLNTGVQDAVNLGWKLALVVGGASPPALLDTYHA
MAB_0857|M.abscessus_ATCC_1997 FLAGDSAHIHFPFGGQGLNTGIQDAVNLGWKLAAVIKGHAPDALLDTYHL
MLBr_02276|M.leprae_Br4923 MLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLSYVWPSLLQQHYG
:: **:* .. *:*: . :
Mb1170c|M.bovis_AF2122/97 AWHRITRDYRLVTRGLVLASTPR-------------------AARRAIVP
Rv1138c|M.tuberculosis_H37Rv AWHRITRDYRLVTRGLVLASTPR-------------------AARRAIVP
MUL_0979|M.ulcerans_Agy99 AWHRVTRSYRWLTRGLVLASAPR-------------------PARRAIVP
Mflv_5009|M.gilvum_PYR-GCK ERRPLATQVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRWTTY
MSMEG_1499|M.smegmatis_MC2_155 ERRFLATEVLRGTSAITRVNVASNPVGRFLRDRVATRIFGLPVVQRWTTY
Mvan_0779|M.vanbaalenii_PYR-1 ERRPLATEVLRGTSAVTRVNIAGNPVGRFLRDRVAPKVFGLAPVQRWTTY
TH_4641|M.thermoresistible__bu ERRPLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQRRLTY
MMAR_4271|M.marinum_M ERHPVAARVLRTTMAQVALRRLDYRKKALS--DTISELLMMDEPRKRFAA
MAV_2736|M.avium_104 ERHPVGERVLRNAIAQMALLRPDERTRALR--DLVTELLGMDEPRKRFAA
MAB_0857|M.abscessus_ATCC_1997 ERHPVAERVLHNTMAQTPLSEAGPRIDALR--DIVADLLAMDEPRKRIAG
MLBr_02276|M.leprae_Br4923 RGFSVARRLALLLTFKRCLPAIG------------------PSAMRSTSL
: :
Mb1170c|M.bovis_AF2122/97 LCALLPTAF---------------RYGVNILAY-----------------
Rv1138c|M.tuberculosis_H37Rv LCALLPTAF---------------RYGVNILAY-----------------
MUL_0979|M.ulcerans_Agy99 ACALLPPVFP-----------VWGKYPGKLTAQSGGHQADAAHPGHRLIP
Mflv_5009|M.gilvum_PYR-GCK TASQLWVSYRNGPLGGRGS---KPRPGDRIDDAPCSRPDGTATRLHGELG
MSMEG_1499|M.smegmatis_MC2_155 TASQLWVSYRKGPLGGHGR---RPRLGDRIGDRPCTRADGAATRLHSELA
Mvan_0779|M.vanbaalenii_PYR-1 TASQLWVSYRKGPLGGRGP---KPRAGDRIPDVACVRPDGTPSLLHRELS
TH_4641|M.thermoresistible__bu QTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRLYEQLG
MMAR_4271|M.marinum_M MMSGLDIRYHLGGG--------HPLLGRRMPDLDLTTADGPRRVFTHLHA
MAV_2736|M.avium_104 MISGLDVRYDLGPG--------HPLLGRRMPDLDLVTADGASRVFALLRN
MAB_0857|M.abscessus_ATCC_1997 MMSGLDIHYMLGDG--------HQLLGRRMPDLDVVTADGAVRVYEHLHT
MLBr_02276|M.leprae_Br4923 ITIAVRVMAN----------------------------------------
:
Mb1170c|M.bovis_AF2122/97 --------------------------------------------------
Rv1138c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0979|M.ulcerans_Agy99 APPKPSLPAR--------------------IQIGPIPSAAHCQPSAPGVP
Mflv_5009|M.gilvum_PYR-GCK GRWALLLPRG-----VPAVGAAAVRGPAGYLADHVVTLH---HDRDDVML
MSMEG_1499|M.smegmatis_MC2_155 GRWALLWPRD-----APAPGASLLAR----LGDFGVTLR---HDGAEAML
Mvan_0779|M.vanbaalenii_PYR-1 GRWALLAPPD-----APAGCADVARR---HLGDFVEPLT---FDGDEAML
TH_4641|M.thermoresistible__bu GRWAVLEPGSGR---HHREGPGLLGTAHTFLGEYVVGLRGAEMRGCDAFL
MMAR_4271|M.marinum_M ARPVLLNLAEPGRFDIAGWRHRVLLIDAKYVGVWELPVLG-AIAAPAAAL
MAV_2736|M.avium_104 ARPVLLNFAGAGRRSVAGWADRVRVVDAKCVADWELPVLG-RVSAPPAVL
MAB_0857|M.abscessus_ATCC_1997 ARPVLFNFGARQILNVEGWEDRVHVVDAKYSGIWELPVLG-EVSAPDAVL
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mb1170c|M.bovis_AF2122/97 ------------------------------------------
Rv1138c|M.tuberculosis_H37Rv ------------------------------------------
MUL_0979|M.ulcerans_Agy99 LLPSAPAAPLPNWPYPPAPPEAAPPPAPPGPPG---------
Mflv_5009|M.gilvum_PYR-GCK VRPDAHLAWRGAHDDPTGLDRWLATALHPGGTQ---------
MSMEG_1499|M.smegmatis_MC2_155 IRPDAHLAWRGAPDDTAGLDHWLAKALGSGAVR---------
Mvan_0779|M.vanbaalenii_PYR-1 IRPDGHLAWRGDAGDADGVNLWLTRALTTGNAR---------
TH_4641|M.thermoresistible__bu VRPDGHLAWRGR--DATDLADWLKSALTVGRVR---------
MMAR_4271|M.marinum_M IRPDGYVAWVGDDLTDRGLFDALTAWFGRPAVPSPRLRASAP
MAV_2736|M.avium_104 IRPDGHVAWAGD-PNDPGLHDALTTWCGPPAAGG--------
MAB_0857|M.abscessus_ATCC_1997 VRPDGYVAWVGE-GSADGLRGALTRWVGSPSRA---------
MLBr_02276|M.leprae_Br4923 LVTDDDADWVARVWRSGGWASWLVDRRPPFS-----------