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MAEHAVVVAGAGPTGLMLAGELALAGIDVALLERRGSHEEVGSRAAGLHSRTIEVFDQRGIAERFLAQGR TGQVTHFSGIFMSIEDFPTRHPYALGLLQHYTEKTLAAWIDELGVPIYYNAEAVGLGQDDVGVDVALADG STLRGQYLVGCDGGRSTIRKAAGIGFPGHDPSCSAMLVDAEITEQPLEFGLLRKPGQAFLGILPFEEGWC RLAFSTGLDRLGVEPTLEEAKEALIAIAGTDFGIHNPRWISRFSDMTRQADRYRDGRVFLAGDSAHIHFP FGGQGLNTGIQDAVNLGWKLAAVIKGHAPDALLDTYHLERHPVAERVLHNTMAQTPLSEAGPRIDALRDI VADLLAMDEPRKRIAGMMSGLDIHYMLGDGHQLLGRRMPDLDVVTADGAVRVYEHLHTARPVLFNFGARQ ILNVEGWEDRVHVVDAKYSGIWELPVLGEVSAPDAVLVRPDGYVAWVGEGSADGLRGALTRWVGSPSRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0857 | - | - | 100% (489) | hypothetical protein MAB_0857 |
| M. abscessus ATCC 19977 | MAB_3483 | - | e-164 | 60.61% (490) | hypothetical protein MAB_3483 |
| M. abscessus ATCC 19977 | MAB_1496c | - | 8e-48 | 34.07% (499) | putative FAD-binding monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 9e-16 | 29.05% (327) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_5009 | - | 2e-49 | 33.07% (508) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1751 | - | 3e-15 | 27.50% (320) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4271 | - | 1e-160 | 58.13% (492) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 1e-165 | 60.29% (491) | hypothetical protein MAV_2736 |
| M. smegmatis MC2 155 | MSMEG_2252 | - | 1e-102 | 44.22% (493) | flavin-type hydroxylase |
| M. thermoresistible (build 8) | TH_1880 | - | 1e-109 | 46.14% (492) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_3663 | - | 7e-10 | 23.43% (414) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_2422 | - | 1e-148 | 55.01% (489) | hypothetical protein Mvan_2422 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2736|M.avium_104 ---------------MRGVRFSE--RSVRG--------------------
Mvan_2422|M.vanbaalenii_PYR-1 ---------------MTTTRHKDTHKDTREDTREDTRDDSRDDGGDPNGD
MMAR_4271|M.marinum_M ---------------MAD--------------------------------
MAB_0857|M.abscessus_ATCC_1997 ---------------MAE--------------------------------
MSMEG_2252|M.smegmatis_MC2_155 ---------------MADAESLAAHGSRVAG----------------KGI
TH_1880|M.thermoresistible__bu --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK ---------------MPGAHR-----------------------------
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
MUL_3663|M.ulcerans_Agy99 -------------------------------------MPQPS--------
MAV_2736|M.avium_104 --HAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQLIGSRAGGLHAR
Mvan_2422|M.vanbaalenii_PYR-1 TDHAVVVGGGGPTGMMTAAELALAGVDVAVVERRTTPEITGSRAGGLLSR
MMAR_4271|M.marinum_M --HAVVVVGAGPTGLMLAGELALAGVDVAVVERRVSQDLVGSRAGGLHSR
MAB_0857|M.abscessus_ATCC_1997 --HAVVVAGAGPTGLMLAGELALAGIDVALLERRGSHEEVGSRAAGLHSR
MSMEG_2252|M.smegmatis_MC2_155 SVKDVVIVGGGPTGAMLAGELRLYEVDVMVLDKDIEPTKV-VRSLGLHAR
TH_1880|M.thermoresistible__bu -VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAH-VRSLGLHVR
Mflv_5009|M.gilvum_PYR-GCK --SDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAG-PATTSRANFLHAR
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRD-FRGDTVHPT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRD-SRGDTVHAS
: *.**:* . * : * ::: *. :
MAV_2736|M.avium_104 TLEILDQRGIVDRFLAE-GQVAQVAG-FAQIRL-DISDFP----TRHPYG
Mvan_2422|M.vanbaalenii_PYR-1 TLEILDQRGVVDRFLSA-GETMQVHG-FAQVRL-DVSDLP----TRHPYG
MMAR_4271|M.marinum_M TIEVLDQRGIADRFLAQ-GTATQVAR-FAAIPL-DISDFP----TRHNYG
MAB_0857|M.abscessus_ATCC_1997 TIEVFDQRGIAERFLAQ-GRTGQVTH-FSGIFM-SIEDFP----TRHPYA
MSMEG_2252|M.smegmatis_MC2_155 SIEIMDQRGLLDRFLEV-GRRHPVGGYFAGITKAPPRTLD----TAHPYV
TH_1880|M.thermoresistible__bu SIEMLDQRGLLDRFLAH-GQRHPVGGFFAAIAK-PPAELD----TAHGYV
Mflv_5009|M.gilvum_PYR-GCK GSEVLDRMGALGTLPQE-SLRALRITNYLGDRPLATLEFGDPGMRTAAPP
Mb1780|M.bovis_AF2122/97 TMRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVA
Rv1751|M.tuberculosis_H37Rv TMRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLHQPYPYVA
MUL_3663|M.ulcerans_Agy99 TLRLLDELGLGSQFAQIPHRLIDTISMKVQGQPVD-LDLKHLPGAHQHIA
.::*. * : :
MAV_2736|M.avium_104 LALWQNHIERILADWVGELGVPIYRGHRIATCTQ-------DDTGVDVVA
Mvan_2422|M.vanbaalenii_PYR-1 LALWQKHIERILAEWVDELAVPVYRGREVVGVRQ-------DGAGVDIEL
MMAR_4271|M.marinum_M LALWQNRIERILAEWVAELRVRIYRGCEVTDITQ-------DDNGVDLTL
MAB_0857|M.abscessus_ATCC_1997 LGLLQHYTEKTLAAWIDELGVPIYYNAEAVGLGQ-------DDVGVDVAL
MSMEG_2252|M.smegmatis_MC2_155 LGIPQPVTDRILVEHAVASGAVLRRGCEAVGLAQ-------DDDGVSVTL
TH_1880|M.thermoresistible__bu LGIRQPVTDRLLAEWAAERGAVIRRGCAVVGLDQ-------DAAGITVEL
Mflv_5009|M.gilvum_PYR-GCK MVVSQAKVEAALRARLADLDVEPEWGRKVIDVRE-------DADGVVADL
Mb1780|M.bovis_AF2122/97 MVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVRYQG
Rv1751|M.tuberculosis_H37Rv MVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVRYQG
MUL_3663|M.ulcerans_Agy99 LVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSATYRA
: : .
MAV_2736|M.avium_104 SDG--RTLRGQYLVGCDGGRSVIRKAAGIDFPGWEATTSYLLAEAEMDWR
Mvan_2422|M.vanbaalenii_PYR-1 SDG--RVLRAGYLVGCDGGRSLIRKSAGIEFPGWEPTTSYLLAEVEIAPE
MMAR_4271|M.marinum_M SDG--PPLRADYVVGCDGGRSLVRRAVGIDFPGWDPTTSSLIAEVEVAVG
MAB_0857|M.abscessus_ATCC_1997 ADG--STLRGQYLVGCDGGRSTIRKAAGIGFPGHDPSCSAMLVDAEIT--
MSMEG_2252|M.smegmatis_MC2_155 ADG--TQVRARYVVGCDGGRSTVRKLMGVGFPGEPSRVDTLIGEMQVGVT
TH_1880|M.thermoresistible__bu ADG--SVQRARYLVGCDGGRSTVRKLAGIGFPGEPARSETLLGEMSLSAD
Mflv_5009|M.gilvum_PYR-GCK ADG--ARVRGQWLVGCDGTTSVVRRQTGIEFPGVRLSERFLLADIHLDWA
Mb1780|M.bovis_AF2122/97 AEG-PGELRAELTVACDGRWSIARHEAGLKAREFP--VNFDVWWFKLPRE
Rv1751|M.tuberculosis_H37Rv AEG-PGELRAELTVACDGRWSIARHEAGLKAREFP--VNFDVWWFKLPRE
MUL_3663|M.ulcerans_Agy99 QSGETKHMHADLTVACDGRGSTVRSALGMATRSFG--APMDVWWFRLPRR
.* :. *.*** * * *: : :
MAV_2736|M.avium_104 TGQPPQWG-IHHDSLGVHALSETEP--AGGVRVLVTERQLRSAA--EPNL
Mvan_2422|M.vanbaalenii_PYR-1 DGREPEWG-IRRDALGVHALSRSD---DGPVRIMVTEQDLRRSG--VPDL
MMAR_4271|M.marinum_M SESGPNLGEVRHDALGVHGFTRLPD--GGPLRVVVTERQLDAGG--EPSL
MAB_0857|M.abscessus_ATCC_1997 -EQPLEFGLLRKPGQAFLGILPFE---EGWCRLAFSTGLDRLGV--EPTL
MSMEG_2252|M.smegmatis_MC2_155 PEQVTAVVAEVRKMQLRFGAGPLG---DGLYRVMVPAAEVVEDRSATPTL
TH_1880|M.thermoresistible__bu PATVAAVVAEVRKTQLRFGAMPLG---DGVYRVIVPAEGVAGDR-AEPTL
Mflv_5009|M.gilvum_PYR-GCK VDRAGTTGWIHPDGVVGAMPMPSTDGRDDLWRLFVYDPSLDRKPTDSEIL
Mb1780|M.bovis_AF2122/97 GDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERG-IEEFR
Rv1751|M.tuberculosis_H37Rv GDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERG-IEEFR
MUL_3663|M.ulcerans_Agy99 PDDPTGLAGIFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQG-IEALH
MAV_2736|M.avium_104 DDLRQALIAVYRTDYGIHSPRWISRFTDAARQAARYRDRRVLLAGDAAHI
Mvan_2422|M.vanbaalenii_PYR-1 AELREALVTVYGTDFGIHSPTSISRFTDTARQAVAYRSGRILLVGDAAHV
MMAR_4271|M.marinum_M GDLSAALTAVYGTDYGIHSPTWISRFTDLTRQAATYRQGRVLIAGDAAHV
MAB_0857|M.abscessus_ATCC_1997 EEAKEALIAIAGTDFGIHNPRWISRFSDMTRQADRYRDGRVFLAGDSAHI
MSMEG_2252|M.smegmatis_MC2_155 DEFRQQLRATAGTDLGVHSPRWLSRFGDGTRLADRYRTGRVLLAGDAAHV
TH_1880|M.thermoresistible__bu DEFRRRLKAFAGTDFGAHTPRWLSRFGDATRLAERYRAGRVFLAGDAAHV
Mflv_5009|M.gilvum_PYR-GCK DRISELVPYRTGRRVKIGDAEWLSMFTVHRRLADTYRRGRVLIAGDAAHV
Mb1780|M.bovis_AF2122/97 RDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAHA
Rv1751|M.tuberculosis_H37Rv RDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAHA
MUL_3663|M.ulcerans_Agy99 RALADLMPWLADRVDALKSFDDVKLLDVQLNRLRRWYCDGALCIGDAAHA
: :. : . : : **:**
MAV_2736|M.avium_104 HHPVGGQGLNTGVQDAVNLGWKLALVVGGA--SPPALLDTYHAERHPVGE
Mvan_2422|M.vanbaalenii_PYR-1 HHPVGGQGLNTGMQDAVNLGWKLAQVVQGW--SPDTLLDTYHDERQPVGA
MMAR_4271|M.marinum_M HDPVGGQGLNTGVQDAVNLGWKLAQVVNRR--SPESLLDTYHAERHPVAA
MAB_0857|M.abscessus_ATCC_1997 HFPFGGQGLNTGIQDAVNLGWKLAAVIKGH--APDALLDTYHLERHPVAE
MSMEG_2252|M.smegmatis_MC2_155 HPPVGGQGLNLGVQDAFNLGWKLAASINGW--APDGLLDSYEAERRPVAA
TH_1880|M.thermoresistible__bu HPPAGGQGLNLGIQDAFNLGWKLAAAVGGW--APDGLLDTYHAERHPVAA
Mflv_5009|M.gilvum_PYR-GCK HAPFGGQGMLTGIGDAENVGFKLALVVRGL--AADDLLDTYEAERRPLAT
Mb1780|M.bovis_AF2122/97 MSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAV
Rv1751|M.tuberculosis_H37Rv MSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAV
MUL_3663|M.ulcerans_Agy99 MSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWAPTAF
* .* *: .: ** . ** : :. * . * .
MAV_2736|M.avium_104 RVLRNAIAQMALLRP-DERTRALRDLVT-ELLGMDEPRKRFAAMISGLDV
Mvan_2422|M.vanbaalenii_PYR-1 RVLRNAVAQMALLRP-DDRTTVLHGVVS-DMLDMDEPRRRFAAMMSGLDI
MMAR_4271|M.marinum_M RVLRTTMAQVALRRL-DYRKKALSDTIS-ELLMMDEPRKRFAAMMSGLDI
MAB_0857|M.abscessus_ATCC_1997 RVLHNTMAQTPLSEA-GPRIDALRDIVA-DLLAMDEPRKRIAGMMSGLDI
MSMEG_2252|M.smegmatis_MC2_155 AVLDNTRAQMELLSP-EPGPQAVRRLLA-QLMAFEEVNRYLTEMITATGI
TH_1880|M.thermoresistible__bu DVLNNTRAQMELMSP-EPGPRAVRWLLA-ELMDFEEVNRYLTEKITAIGV
Mflv_5009|M.gilvum_PYR-GCK QVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRWTTYTASQLWV
Mb1780|M.bovis_AF2122/97 TQAVQRVLHRRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGV
Rv1751|M.tuberculosis_H37Rv TQAVQRVLHRRLLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGV
MUL_3663|M.ulcerans_Agy99 LQGIQRAIHAAIVAVAVTGGPPQPPPVVR-LVSRSVPVRRIMGYLVAIGP
: :.
MAV_2736|M.avium_104 RYD-----LGPGHPLLGRRMPDLDLVTADGASRVFALLRNARPVLLNFAG
Mvan_2422|M.vanbaalenii_PYR-1 HYD-----LGDGHPLLGLRMPDLDLETAHGPTRVSALLRQARPVLLDLGA
MMAR_4271|M.marinum_M RYH-----LGGGHPLLGRRMPDLDLTTADGPRRVFTHLHAARPVLLNLAE
MAB_0857|M.abscessus_ATCC_1997 HYM-----LGDGHQLLGRRMPDLDVVTADGAVRVYEHLHTARPVLFNFGA
MSMEG_2252|M.smegmatis_MC2_155 RYD-----FGAEDDLVGRRLRDIRLRRG----RLYELTRTGRGLLLDQTG
TH_1880|M.thermoresistible__bu RYHT----MGDGHGLLGRRMRDIPLTGG----RLYARMHAGRGVLLDRTG
Mflv_5009|M.gilvum_PYR-GCK SYRNGPLGGRGSKPRPGDRIDDAPCSRPDGTATRLHGELGGRWALLLPRG
Mb1780|M.bovis_AF2122/97 RPEH--------APAFARRGPGNRKGP-----------------------
Rv1751|M.tuberculosis_H37Rv RPEH--------APAFARRGPGNRKGP-----------------------
MUL_3663|M.ulcerans_Agy99 LPEH--------APKYPRRAR-----------------------------
*
MAV_2736|M.avium_104 AGRRSVAGWADRVRVVDAKCVADWELPVLGRVSAPPAVLIRPDGHVAWAG
Mvan_2422|M.vanbaalenii_PYR-1 PDAVDLTGWEARVRMVRANAATVWELPVIGEVPAPAAVLIRPDGHVAWVA
MMAR_4271|M.marinum_M PGRFDIAGWRHRVLLIDAKYVGVWELPVLGAIAAPAAALIRPDGYVAWVG
MAB_0857|M.abscessus_ATCC_1997 RQILNVEGWEDRVHVVDAKYSGIWELPVLGEVSAPDAVLVRPDGYVAWVG
MSMEG_2252|M.smegmatis_MC2_155 --QLSAAGWSDRVDHVVD----------VSDELDVPAVLLRPDGHIAWVG
TH_1880|M.thermoresistible__bu --TLSVSGWADRVDHIVD----------PGAALDVPAVLLRPDGHVAWVG
Mflv_5009|M.gilvum_PYR-GCK VPAVGAAAVRGPAGYLADH-------VVTLHHDRDDVMLVRPDAHLAWRG
Mb1780|M.bovis_AF2122/97 --------------------------------------------------
Rv1751|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3663|M.ulcerans_Agy99 --------------------------------------------------
MAV_2736|M.avium_104 DP--NDPGLHDALTTWCGPPAAGG--------
Mvan_2422|M.vanbaalenii_PYR-1 GD--SAAAPAEAAARWFGAPTGRR--------
MMAR_4271|M.marinum_M DDL-TDRGLFDALTAWFGRPAVPSPRLRASAP
MAB_0857|M.abscessus_ATCC_1997 EG--SADGLRGALTRWVGSPSRA---------
MSMEG_2252|M.smegmatis_MC2_155 DE---QGDLEGCLVRWFGVPA-----------
TH_1880|M.thermoresistible__bu ADHPGQQDLTARLSRWFGAPA-----------
Mflv_5009|M.gilvum_PYR-GCK AHD-DPTGLDRWLATALHPGGTQ---------
Mb1780|M.bovis_AF2122/97 --------------------------------
Rv1751|M.tuberculosis_H37Rv --------------------------------
MUL_3663|M.ulcerans_Agy99 --------------------------------