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M. thermoresistible (build 8) TH_0195 (-)

annotation: metal dependent hydrolase
coordinates: 441848 - 442762
length: 305

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0195--100% (305)metal dependent hydrolase
M. thermoresistible (build 8)TH_2871-6e-1728.42% (278) PUTATIVE beta-lactamase domain protein
M. thermoresistible (build 8)TH_2455-2e-0526.41% (231) PUTATIVE -

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2322c-5e-0825.38% (197) hypothetical protein Mb2322c
M. gilvum PYR-GCKMflv_1675-2e-0827.08% (192) beta-lactamase domain-containing protein
M. tuberculosis H37RvRv2300c-5e-0825.38% (197) hypothetical protein Rv2300c
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4947-4e-0828.64% (220) Beta-lactamase-like protein
M. marinum MMMAR_3523-2e-1128.80% (191) hypothetical protein MMAR_3523
M. avium 104-----
M. smegmatis MC2 155MSMEG_3427-1e-12872.41% (290) metal dependent hydrolase
M. ulcerans Agy99MUL_2742-6e-1128.19% (188) hypothetical protein MUL_2742
M. vanbaalenii PYR-1Mvan_2949-1e-13574.34% (304) beta-lactamase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3523|M.marinum_M               --------------------------------------------------
MUL_2742|M.ulcerans_Agy99           --------------------------------------------------
Mb2322c|M.bovis_AF2122/97           MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Rv2300c|M.tuberculosis_H37Rv        MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Mflv_1675|M.gilvum_PYR-GCK          --------------------------------------------------
TH_0195|M.thermoresistible__bu      ---------------------------MSTTAVRPVAHPEHDELVPSRYA
Mvan_2949|M.vanbaalenii_PYR-1       ---------------------------MSLDGISRLGGQSTDELVPSRYV
MSMEG_3427|M.smegmatis_MC2_155      --------------------------MTTTDNTAHAGTQTIDELVPSRYA
MAB_4947|M.abscessus_ATCC_1997      -------------------------MFSAAVRTFTVGDATVTQLTELDVW
                                                                                      

MMAR_3523|M.marinum_M               MKVHHLNCGTMN--SPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-PR
MUL_2742|M.ulcerans_Agy99           MKVHHHNCGTMN--SPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-QR
Mb2322c|M.bovis_AF2122/97           VKVHHLNCGTMN--AFGIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Rv2300c|M.tuberculosis_H37Rv        VKVHHLNCGTMN--AFGIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Mflv_1675|M.gilvum_PYR-GCK          MKVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAH-PE
TH_0195|M.thermoresistible__bu      LRVGDIEVLVISDGVLPLPAATLATNADRAELAAWLHDMFLPADLFDWPL
Mvan_2949|M.vanbaalenii_PYR-1       QQVGEIEVTVICDGVLPITASTLATNADPAELAGWLDDMFLPPDVLDWPL
MSMEG_3427|M.smegmatis_MC2_155      VQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDILDWPL
MAB_4947|M.abscessus_ATCC_1997      PIKPHHWYPALSEEQLVFARANYAPSAVSDDGSELIFAIHNYVIELADTI
                                        .    .:       .    .  .        :   .          

MMAR_3523|M.marinum_M               RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHVVL
MUL_2742|M.ulcerans_Agy99           RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHIVL
Mb2322c|M.bovis_AF2122/97           RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Rv2300c|M.tuberculosis_H37Rv        RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Mflv_1675|M.gilvum_PYR-GCK          EFGRIRR-----------RIIRPDFERTETAAEQLAHLGYRLSDVRHIIV
TH_0195|M.thermoresistible__bu      NVAVVRSGDRTILIDSGLGLEFPEFPRAGRLAHRMQAAGIEPAAVTDVVL
Mvan_2949|M.vanbaalenii_PYR-1       NVVVVRTGGQTILVDAGLGVEFPDFPRAGQTVRRLEAAGIDPASVTDVVL
MSMEG_3427|M.smegmatis_MC2_155      NVVVVRSGDRTILVDAGLGVEFPDFPRAGRTVARLEAAGIDPSAVTDVVL
MAB_4947|M.abscessus_ATCC_1997      IVVDTCSGN-----HKNRPLFADLHMLNTDYLTRLEQSGYSPEAVDIVVN
                                     .                 .             ::   *     *  :: 

MMAR_3523|M.marinum_M               THFDFDHIGGLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGP
MUL_2742|M.ulcerans_Agy99           THFDSDHIGGLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGP
Mb2322c|M.bovis_AF2122/97           THFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRERLRYRRGQWAHGP
Rv2300c|M.tuberculosis_H37Rv        THFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRERLRYRRGQWAHGP
Mflv_1675|M.gilvum_PYR-GCK          THFDADHIGGLADFPDAQVHVTAQEVLSAMKSPSVQNRIRFQPSQWAHGP
TH_0195|M.thermoresistible__bu      THLHMDHVGGLLTDGLMGRLRPDLRVHLAAAEAEFWAAPDFSRTAMPHPV
Mvan_2949|M.vanbaalenii_PYR-1       THLHMDHVGGLLTDGLKARLRPDLRIHLAAAEAEFWAAPDFSQTAMPQPV
MSMEG_3427|M.smegmatis_MC2_155      THLHMDHIGGLLSHGLKERLRPDLRIHVASAEANFWESPDFSHTEMPAPV
MAB_4947|M.abscessus_ATCC_1997      THLHLDHCG----WNTRLVEGTWRPTFPAATYLFHHTELKYIRAQWESAP
                                    **:. ** *            .      *           :         

MMAR_3523|M.marinum_M               KLVEHGHDG---ESWRG-FAAAKPLDAIADGVVLVPMP----------GH
MUL_2742|M.ulcerans_Agy99           KLVEHGHDG---ESSPG-FAAAKTLDAIADGVVLVPMP----------GH
Mb2322c|M.bovis_AF2122/97           KLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP----------GH
Rv2300c|M.tuberculosis_H37Rv        KLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP----------GH
Mflv_1675|M.gilvum_PYR-GCK          RIVEHTADG---EPWRG-FAAAKELSEIGPGFALVPLP----------GH
TH_0195|M.thermoresistible__bu      PDVLRAVASRFLDVYRDRLRPFDTQYEVAPGVSVHRTG----------GH
Mvan_2949|M.vanbaalenii_PYR-1       PDVLRSVATRFLDEYHGRLRPFETEYEVAPGVLISRTG----------GH
MSMEG_3427|M.smegmatis_MC2_155      PPALRAIAGRFLDEYRGQIQTFDSEYDITPGVHVARTG----------GH
MAB_4947|M.abscessus_ATCC_1997      IDQWQDNGGWVYEDSILPVLEHAPYGFVKSGQVLHSYGSTHIRALDAGGH
                                        :       :     .        :  *  :              **

MMAR_3523|M.marinum_M               TRGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSF
MUL_2742|M.ulcerans_Agy99           TRGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSF
Mb2322c|M.bovis_AF2122/97           TRGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSY
Rv2300c|M.tuberculosis_H37Rv        TRGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSY
Mflv_1675|M.gilvum_PYR-GCK          TEGHACVAVDAGHRWLLHAGDAFYHHSEIDGGGPPPMPASLRAFEMAVAA
TH_0195|M.thermoresistible__bu      TPGHSIVRLESGKDRLTFAGDAVFQVGFDN----PQWHNGFEHDPEEAAR
Mvan_2949|M.vanbaalenii_PYR-1       TPGHSIVRVASGGEALTFAGDAVFAPGFDN----PEWHNGFEHDPEEAAR
MSMEG_3427|M.smegmatis_MC2_155      TPGHSVVRLASGEDRLTFAGDAVFAPGFDN----PQWHNGFEHDPEESVR
MAB_4947|M.abscessus_ATCC_1997      TPGHVAIEVRAADTGLLIAGDALHHPMQAQF---PDLPFYADADPAQAVA
                                    * **  : : :.   :  .***..     :                    

MMAR_3523|M.marinum_M               DRRQLRDNQARLAELQRRQDPGLLIICAHDP--SLYALAKDLS--
MUL_2742|M.ulcerans_Agy99           DRRQLRDNQARLAELQRRQDPGLLIICAHDP--SLYAVAKDLS--
Mb2322c|M.bovis_AF2122/97           NRNQLRDNQARIVELHRRHDPDLLIVCAHDP--DLYQLARDTA--
Rv2300c|M.tuberculosis_H37Rv        NRNQLRDNQARIVELHRRHDPDLLIVCAHDP--DLYQLARDTA--
Mflv_1675|M.gilvum_PYR-GCK          DRKMVLDNHSRLTELYRRQDPDLLIVCSHDR--KLYEHAKATAGD
TH_0195|M.thermoresistible__bu      VRVRLLQEIAASGETLVATHLPFPSLCRVAPRGEAFRFVPTVWDH
Mvan_2949|M.vanbaalenii_PYR-1       VRVRLLRELAATGEALVATHLPFPSVCRVATAGDVFRCVPSVWDY
MSMEG_3427|M.smegmatis_MC2_155      VRVELLRELAATGESLVATHLPFPSVCHVAAAGDAFRCVPAVWDY
MAB_4947|M.abscessus_ATCC_1997      TRRALLGRCADENLKLLTAHFPAHSPLGVRRSGAAFTWDGSRAID
                                     *  :  . :         .               :