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KVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAHPEEFGRIRRRIIRPDFERTETAAE QLAHLGYRLSDVRHIIVTHFDADHIGGLADFPDAQVHVTAQEVLSAMKSPSVQNRIRFQPSQWAHGPRIV EHTADGEPWRGFAAAKELSEIGPGFALVPLPGHTEGHACVAVDAGHRWLLHAGDAFYHHSEIDGGGPPPM PASLRAFEMAVAADRKMVLDNHSRLTELYRRQDPDLLIVCSHDRKLYEHAKATAGD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1675 | - | - | 100% (267) | beta-lactamase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0212 | - | 2e-06 | 26.81% (235) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2322c | - | 4e-89 | 57.74% (265) | hypothetical protein Mb2322c |
| M. tuberculosis H37Rv | Rv2300c | - | 4e-89 | 57.74% (265) | hypothetical protein Rv2300c |
| M. leprae Br4923 | MLBr_00270 | - | 2e-06 | 27.54% (207) | hypothetical protein MLBr_00270 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3523 | - | 2e-84 | 57.25% (262) | hypothetical protein MMAR_3523 |
| M. avium 104 | MAV_4762 | - | 2e-07 | 27.78% (234) | metallo-beta-lactamase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3427 | - | 3e-09 | 28.34% (187) | metal dependent hydrolase |
| M. thermoresistible (build 8) | TH_0195 | - | 1e-08 | 27.08% (192) | metal dependent hydrolase |
| M. ulcerans Agy99 | MUL_2742 | - | 8e-81 | 56.11% (262) | hypothetical protein MUL_2742 |
| M. vanbaalenii PYR-1 | Mvan_5078 | - | 1e-109 | 70.57% (265) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2322c|M.bovis_AF2122/97 MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Rv2300c|M.tuberculosis_H37Rv MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
MMAR_3523|M.marinum_M --------------------------------------------------
MUL_2742|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5078|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3427|M.smegmatis_MC2_155 --------------------------MTTTDNTAHAGTQTIDELVPSRYA
TH_0195|M.thermoresistible__bu --------------------------MSTTAVRPVA-HPEHDELVPSRYA
MLBr_00270|M.leprae_Br4923 --------------------------------------------------
MAV_4762|M.avium_104 --------------------------------------------------
Mb2322c|M.bovis_AF2122/97 VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Rv2300c|M.tuberculosis_H37Rv VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
MMAR_3523|M.marinum_M MKVHHLNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-PR
MUL_2742|M.ulcerans_Agy99 MKVHHHNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-QR
Mflv_1675|M.gilvum_PYR-GCK MKVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAH-PE
Mvan_5078|M.vanbaalenii_PYR-1 MKVHHLNCGTIRPTGVGT-MVCHVLLVESADGLVLVDTGFGTHDCED-PN
MSMEG_3427|M.smegmatis_MC2_155 VQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDILDWPL
TH_0195|M.thermoresistible__bu LRVGDIEVLVISDGVLPLPAATLATNADRAELAAWLHDMFLPADLFDWPL
MLBr_00270|M.leprae_Br4923 -MAAATLFQVTDSVHFARGDAVNWALVADDTGVMLIDTGY-PGDRDD---
MAV_4762|M.avium_104 ---MAELVQVTDAVHLARGDAVNWTLVADDTGVMLVDAGY-PGDRED---
. . : : * .
Mb2322c|M.bovis_AF2122/97 RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Rv2300c|M.tuberculosis_H37Rv RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
MMAR_3523|M.marinum_M RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHVVL
MUL_2742|M.ulcerans_Agy99 RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHIVL
Mflv_1675|M.gilvum_PYR-GCK EFGRIRR-----------RIIRPDFERTETAAEQLAHLGYRLSDVRHIIV
Mvan_5078|M.vanbaalenii_PYR-1 RFGRIRS-----------RFIRPNFDRGETALNQIRQLGFRRSDVRHVVV
MSMEG_3427|M.smegmatis_MC2_155 NVVVVRSGDRTILVDAGLGVEFPDFPRAGRTVARLEAAGIDPSAVTDVVL
TH_0195|M.thermoresistible__bu NVAVVRSGDRTILIDSGLGLEFPEFPRAGRLAHRMQAAGIEPAAVTDVVL
MLBr_00270|M.leprae_Br4923 ------------------------------VVASLRQLGYEAGDVRAILL
MAV_4762|M.avium_104 ------------------------------VLGSLAELGYGPGDVRAIVL
: * . * :::
Mb2322c|M.bovis_AF2122/97 THFDFDHIGGIADFPEAHLHVTAAEARGAIHAP-SLRERL-------RYR
Rv2300c|M.tuberculosis_H37Rv THFDFDHIGGIADFPEAHLHVTAAEARGAIHAP-SLRERL-------RYR
MMAR_3523|M.marinum_M THFDFDHIGGLADFPDAQVHVTSAEARGAIHAP-SFRERV-------RYR
MUL_2742|M.ulcerans_Agy99 THFDSDHIGGLADFPDAQVHVTSAEARGAIHAP-SFRERV-------RYR
Mflv_1675|M.gilvum_PYR-GCK THFDADHIGGLADFPDAQVHVTAQEVLSAMKSP-SVQNRI-------RFQ
Mvan_5078|M.vanbaalenii_PYR-1 THFDADHIGGLADFPDALVHVTTTEAFGAMRSP-SIQERI-------RFR
MSMEG_3427|M.smegmatis_MC2_155 THLHMDHIGGLLSHGLKERLRPDLRIHVASAEA-NFWESP-------DFS
TH_0195|M.thermoresistible__bu THLHMDHVGGLLTDGLMGRLRPDLRVHLAAAEA-EFWAAP-------DFS
MLBr_00270|M.leprae_Br4923 THAHIDHMGSAIWFASKHRTPVYCHADEVGHTKREYLEQVSLLNIAMRVW
MAV_4762|M.avium_104 THAHIDHLGTAIWLASEHGIPVYCHADEVGHAKREYLEQVSIVDVALRIW
** . **:* . . .
Mb2322c|M.bovis_AF2122/97 RGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMPGHTR
Rv2300c|M.tuberculosis_H37Rv RGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMPGHTR
MMAR_3523|M.marinum_M SVQWAHGPKLVEHGHDG---ESWRG-FAAAKPLDAIADGVVLVPMPGHTR
MUL_2742|M.ulcerans_Agy99 SVQWAHGPKLVEHGHDG---ESSPG-FAAAKTLDAIADGVVLVPMPGHTR
Mflv_1675|M.gilvum_PYR-GCK PSQWAHGPRIVEHTADG---EPWRG-FAAAKELSEIGPGFALVPLPGHTE
Mvan_5078|M.vanbaalenii_PYR-1 PPQWAHGPRIVEHDIDG---EAWRG-FAAAKELTQIGPGFVLVSLPGHTR
MSMEG_3427|M.smegmatis_MC2_155 HTEMPAPVPPALRAIAGRFLDEYRGQIQTFDSEYDITPGVHVARTGGHTP
TH_0195|M.thermoresistible__bu RTAMPHPVPDVLRAVASRFLDVYRDRLRPFDTQYEVAPGVSVHRTGGHTP
MLBr_00270|M.leprae_Br4923 QPRWAIWSGHVLRSGGLIRGGIPTAQPLTAETAAGLPGHPMAIFTPGHTG
MAV_4762|M.avium_104 RPRWAKWTAHVVRSGGLIRDGIPTAQPLTAEVAAGLPGRPTPVFSPGHTN
. . : . . : ***
Mb2322c|M.bovis_AF2122/97 GHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSYNR
Rv2300c|M.tuberculosis_H37Rv GHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSYNR
MMAR_3523|M.marinum_M GHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSFDR
MUL_2742|M.ulcerans_Agy99 GHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSFDR
Mflv_1675|M.gilvum_PYR-GCK GHACVAVDAGHRWLLHAGDAFYHHSEIDGGGPPPMPASLRAFEMAVAADR
Mvan_5078|M.vanbaalenii_PYR-1 GHACVAVDAGHRWLLHAGDSFYHPGTLAG--APPVPKWTARLEMLVASDK
MSMEG_3427|M.smegmatis_MC2_155 GHSVVRLASGEDRLTFAGDAVFAPGFDNPQWHNGFEHDPEESVRVRVELL
TH_0195|M.thermoresistible__bu GHSIVRLESGKDRLTFAGDAVFQVGFDNPQWHNGFEHDPEEAARVRVRLL
MLBr_00270|M.leprae_Br4923 GHCSYVVDG----VLISGDALITGHPLLR--HRGPQLLTAVFSHSQKQCL
MAV_4762|M.avium_104 GHCSYLIDG----VLVSGDALITGHPLLR--HRGPQLLPAIFSYSQRDCI
**. : . : .**:.
Mb2322c|M.bovis_AF2122/97 NQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLARDTA---
Rv2300c|M.tuberculosis_H37Rv NQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLARDTA---
MMAR_3523|M.marinum_M RQLRDNQARLAELQRRQDPGLLIICAHDPSLYALAKDLS---
MUL_2742|M.ulcerans_Agy99 RQLRDNQARLAELQRRQDPGLLIICAHDPSLYAVAKDLS---
Mflv_1675|M.gilvum_PYR-GCK KMVLDNHSRLTELYRRQDPDLLIVCSHDRKLYEHAKATAGD-
Mvan_5078|M.vanbaalenii_PYR-1 QKVKQNHVRLAELYRRQDPDLMILCSHDVTLYEQARATAQT-
MSMEG_3427|M.smegmatis_MC2_155 RELAATGESLVATHLP-FPSVCHVAAAGDAFRCVPAVWDY--
TH_0195|M.thermoresistible__bu QEIAASGETLVATHLP-FPSLCRVAPRGEAFRFVPTVWDH--
MLBr_00270|M.leprae_Br4923 RSLDALGLLETRILAPGHGELWHGPIREATEAALKQAGALTR
MAV_4762|M.avium_104 RTLSALALLDTEVLLPGHGDVWRGPIKEATDAALALATGR--
. : . :