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MSLDGISRLGGQSTDELVPSRYVQQVGEIEVTVICDGVLPITASTLATNADPAELAGWLDDMFLPPDVLD WPLNVVVVRTGGQTILVDAGLGVEFPDFPRAGQTVRRLEAAGIDPASVTDVVLTHLHMDHVGGLLTDGLK ARLRPDLRIHLAAAEAEFWAAPDFSQTAMPQPVPDVLRSVATRFLDEYHGRLRPFETEYEVAPGVLISRT GGHTPGHSIVRVASGGEALTFAGDAVFAPGFDNPEWHNGFEHDPEEAARVRVRLLRELAATGEALVATHL PFPSVCRVATAGDVFRCVPSVWDY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2949 | - | - | 100% (304) | beta-lactamase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5633 | - | 8e-15 | 26.98% (252) | beta-lactamase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5078 | - | 5e-09 | 27.13% (188) | beta-lactamase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2322c | - | 5e-08 | 25.00% (188) | hypothetical protein Mb2322c |
| M. gilvum PYR-GCK | Mflv_1675 | - | 9e-10 | 27.42% (186) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv2300c | - | 5e-08 | 25.00% (188) | hypothetical protein Rv2300c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4947 | - | 6e-08 | 27.49% (211) | Beta-lactamase-like protein |
| M. marinum M | MMAR_3523 | - | 4e-11 | 28.72% (188) | hypothetical protein MMAR_3523 |
| M. avium 104 | MAV_1774 | - | 1e-06 | 43.10% (58) | ribonuclease Z |
| M. smegmatis MC2 155 | MSMEG_3427 | - | 1e-137 | 75.08% (301) | metal dependent hydrolase |
| M. thermoresistible (build 8) | TH_0195 | - | 1e-135 | 74.34% (304) | metal dependent hydrolase |
| M. ulcerans Agy99 | MUL_2742 | - | 2e-11 | 29.26% (188) | hypothetical protein MUL_2742 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2949|M.vanbaalenii_PYR-1 ---------------------------MSLDGISRLGGQSTDELVPSRYV
TH_0195|M.thermoresistible__bu ---------------------------MSTTAVRPVAHPEHDELVPSRYA
MSMEG_3427|M.smegmatis_MC2_155 --------------------------MTTTDNTAHAGTQTIDELVPSRYA
MMAR_3523|M.marinum_M --------------------------------------------------
MUL_2742|M.ulcerans_Agy99 --------------------------------------------------
Mb2322c|M.bovis_AF2122/97 MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Rv2300c|M.tuberculosis_H37Rv MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Mflv_1675|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4947|M.abscessus_ATCC_1997 -------------------------MFSAAVRTFTVGDATVTQLTELDVW
MAV_1774|M.avium_104 ----------------------------MIEVTLLGTGSPIPDPNRAGPS
Mvan_2949|M.vanbaalenii_PYR-1 QQVGEIEVTVICDGVLPITASTLATNADPAELAGWLDDMFLPPDVLDWPL
TH_0195|M.thermoresistible__bu LRVGDIEVLVISDGVLPLPAATLATNADRAELAAWLHDMFLPADLFDWPL
MSMEG_3427|M.smegmatis_MC2_155 VQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDILDWPL
MMAR_3523|M.marinum_M MKVHHLNCGTMN--SPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-PR
MUL_2742|M.ulcerans_Agy99 MKVHHHNCGTMN--SPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-QR
Mb2322c|M.bovis_AF2122/97 VKVHHLNCGTMN--AFGIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Rv2300c|M.tuberculosis_H37Rv VKVHHLNCGTMN--AFGIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Mflv_1675|M.gilvum_PYR-GCK MKVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAH-PE
MAB_4947|M.abscessus_ATCC_1997 PIKPHHWYPALSEEQLVFARANYAPSAVSDDGSELIFAIHNYVIELADTI
MAV_1774|M.avium_104 TLVRAGGQVFLVDCGRGVLQRAAAVGVGAAGLSTLLLTHLHSDHVGD-LG
: . . :
Mvan_2949|M.vanbaalenii_PYR-1 NVVVVRTGGQTILVDAGLGVEFPDFPRAGQTVRRLEAAGIDPASVTDVVL
TH_0195|M.thermoresistible__bu NVAVVRSGDRTILIDSGLGLEFPEFPRAGRLAHRMQAAGIEPAAVTDVVL
MSMEG_3427|M.smegmatis_MC2_155 NVVVVRSGDRTILVDAGLGVEFPDFPRAGRTVARLEAAGIDPSAVTDVVL
MMAR_3523|M.marinum_M RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHVVL
MUL_2742|M.ulcerans_Agy99 RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHIVL
Mb2322c|M.bovis_AF2122/97 RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Rv2300c|M.tuberculosis_H37Rv RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Mflv_1675|M.gilvum_PYR-GCK EFGRIRR-----------RIIRPDFERTETAAEQLAHLGYRLSDVRHIIV
MAB_4947|M.abscessus_ATCC_1997 IVVDTCSGN-----HKNRPLFADLHMLNTDYLTRLEQSGYSPEAVDIVVN
MAV_1774|M.avium_104 DVLITR--------------WVSTFTPDPVPLPIIGP----PGTAELVAA
. : . :
Mvan_2949|M.vanbaalenii_PYR-1 THLHMDHVGGLLTDGLKARLRPDLRIHLAAAEAEFWAAPDFSQTAMPQPV
TH_0195|M.thermoresistible__bu THLHMDHVGGLLTDGLMGRLRPDLRVHLAAAEAEFWAAPDFSRTAMPHPV
MSMEG_3427|M.smegmatis_MC2_155 THLHMDHIGGLLSHGLKERLRPDLRIHVASAEANFWESPDFSHTEMPAPV
MMAR_3523|M.marinum_M THFDFDHIGGLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGP
MUL_2742|M.ulcerans_Agy99 THFDSDHIGGLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGP
Mb2322c|M.bovis_AF2122/97 THFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRERLRYRRGQWAHGP
Rv2300c|M.tuberculosis_H37Rv THFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRERLRYRRGQWAHGP
Mflv_1675|M.gilvum_PYR-GCK THFDADHIGGLADFPDAQVHVTAQEVLSAMKSPSVQNRIRFQPSQWAHGP
MAB_4947|M.abscessus_ATCC_1997 THLHLDHCG----WNTRLVEGTWRPTFPAATYLFHHTELKYIRAQWESAP
MAV_1774|M.avium_104 TLNALRHDIGYRIAHHADLNAPPAVDVREHTDGPVWDRDGVSIRVAPTDH
* * .
Mvan_2949|M.vanbaalenii_PYR-1 PDVLRSVATRFLDEYHGRLRPFETEYEVAPGVLISRTG----------GH
TH_0195|M.thermoresistible__bu PDVLRAVASRFLDVYRDRLRPFDTQYEVAPGVSVHRTG----------GH
MSMEG_3427|M.smegmatis_MC2_155 PPALRAIAGRFLDEYRGQIQTFDSEYDITPGVHVARTG----------GH
MMAR_3523|M.marinum_M KLVEHGHDG---ESWRG-FAAAKPLDAIADGVVLVPMP----------GH
MUL_2742|M.ulcerans_Agy99 KLVEHGHDG---ESSPG-FAAAKTLDAIADGVVLVPMP----------GH
Mb2322c|M.bovis_AF2122/97 KLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP----------GH
Rv2300c|M.tuberculosis_H37Rv KLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP----------GH
Mflv_1675|M.gilvum_PYR-GCK RIVEHTADG---EPWRG-FAAAKELSEIGPGFALVPLP----------GH
MAB_4947|M.abscessus_ATCC_1997 IDQWQDNGGWVYEDSILPVLEHAPYGFVKSGQVLHSYGSTHIRALDAGGH
MAV_1774|M.avium_104 RPVAPTIGFR--VDYQGASVVLAGDTVPCAGLDELAAG------------
*
Mvan_2949|M.vanbaalenii_PYR-1 TPGHSIVRVASGGEALTFAGDAVFAPGFDN----PEWHNGFEHDPEEAAR
TH_0195|M.thermoresistible__bu TPGHSIVRLESGKDRLTFAGDAVFQVGFDN----PQWHNGFEHDPEEAAR
MSMEG_3427|M.smegmatis_MC2_155 TPGHSVVRLASGEDRLTFAGDAVFAPGFDN----PQWHNGFEHDPEESVR
MMAR_3523|M.marinum_M TRGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSF
MUL_2742|M.ulcerans_Agy99 TRGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSF
Mb2322c|M.bovis_AF2122/97 TRGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSY
Rv2300c|M.tuberculosis_H37Rv TRGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSY
Mflv_1675|M.gilvum_PYR-GCK TEGHACVAVDAGHRWLLHAGDAFYHHSEIDGGGPPPMPASLRAFEMAVAA
MAB_4947|M.abscessus_ATCC_1997 TPGHVAIEVRAADTGLLIAGDALHHPMQAQF---PDLPFYADADPAQAVA
MAV_1774|M.avium_104 -AGALVHTVIRKDIVATIPQQRLQDICDYHS--SVEQAAATAARAGVGTL
* : : . .
Mvan_2949|M.vanbaalenii_PYR-1 VRVRLLRELAATGEALVATHLPFPSVCRVATAGDVFRCVPSVWDY
TH_0195|M.thermoresistible__bu VRVRLLQEIAASGETLVATHLPFPSLCRVAPRGEAFRFVPTVWDH
MSMEG_3427|M.smegmatis_MC2_155 VRVELLRELAATGESLVATHLPFPSVCHVAAAGDAFRCVPAVWDY
MMAR_3523|M.marinum_M DRRQLRDNQARLAELQRRQDPGLLIICAHDP--SLYALAKDLS--
MUL_2742|M.ulcerans_Agy99 DRRQLRDNQARLAELQRRQDPGLLIICAHDP--SLYAVAKDLS--
Mb2322c|M.bovis_AF2122/97 NRNQLRDNQARIVELHRRHDPDLLIVCAHDP--DLYQLARDTA--
Rv2300c|M.tuberculosis_H37Rv NRNQLRDNQARIVELHRRHDPDLLIVCAHDP--DLYQLARDTA--
Mflv_1675|M.gilvum_PYR-GCK DRKMVLDNHSRLTELYRRQDPDLLIVCSHDR--KLYEHAKATAGD
MAB_4947|M.abscessus_ATCC_1997 TRRALLGRCADENLKLLTAHFPAHSPLGVRRSGAAFTWDGSRAID
MAV_1774|M.avium_104 VMTHYVPALVAGQEEQWRALAAREFAGRVELGDDLHRVQVDAPS-
.