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KVHHLNCGTMNSPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLDPRRLGAFRHFLRPALLQNETAVHQIE RLGYRPSDVRHVVLTHFDFDHIGGLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGPKLVEHG HDGESWRGFAAAKPLDAIADGVVLVPMPGHTRGHAAVAVDAGDRWILHCGDAFYHVGTLDGQSKVPFVLR SQEELFSFDRRQLRDNQARLAELQRRQDPGLLIICAHDPSLYALAKDLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3523 | - | - | 100% (260) | hypothetical protein MMAR_3523 |
| M. marinum M | MMAR_0708 | - | 1e-05 | 29.71% (138) | beta lactamase-like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2322c | - | 1e-123 | 78.29% (258) | hypothetical protein Mb2322c |
| M. gilvum PYR-GCK | Mflv_1675 | - | 2e-84 | 57.25% (262) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv2300c | - | 1e-123 | 78.29% (258) | hypothetical protein Rv2300c |
| M. leprae Br4923 | MLBr_00270 | - | 4e-06 | 28.57% (189) | hypothetical protein MLBr_00270 |
| M. abscessus ATCC 19977 | MAB_4947 | - | 4e-09 | 25.51% (247) | Beta-lactamase-like protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3427 | - | 3e-11 | 31.75% (189) | metal dependent hydrolase |
| M. thermoresistible (build 8) | TH_0195 | - | 1e-11 | 28.80% (191) | metal dependent hydrolase |
| M. ulcerans Agy99 | MUL_2742 | - | 1e-148 | 96.92% (260) | hypothetical protein MUL_2742 |
| M. vanbaalenii PYR-1 | Mvan_5078 | - | 5e-92 | 61.78% (259) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3523|M.marinum_M --------------------------------------------------
MUL_2742|M.ulcerans_Agy99 --------------------------------------------------
Mb2322c|M.bovis_AF2122/97 MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Rv2300c|M.tuberculosis_H37Rv MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Mflv_1675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5078|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3427|M.smegmatis_MC2_155 --------------------------MTTTDNTAHAGTQTIDELVPSRYA
TH_0195|M.thermoresistible__bu --------------------------MSTTAVRPVA-HPEHDELVPSRYA
MAB_4947|M.abscessus_ATCC_1997 ------------------------MFSAAVRTFTVGDATVTQLTELDVWP
MLBr_00270|M.leprae_Br4923 --------------------------------------------------
MMAR_3523|M.marinum_M MKVHHLNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-PR
MUL_2742|M.ulcerans_Agy99 MKVHHHNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-QR
Mb2322c|M.bovis_AF2122/97 VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Rv2300c|M.tuberculosis_H37Rv VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Mflv_1675|M.gilvum_PYR-GCK MKVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAH-PE
Mvan_5078|M.vanbaalenii_PYR-1 MKVHHLNCGTIRPTGVGT-MVCHVLLVESADGLVLVDTGFGTHDCED-PN
MSMEG_3427|M.smegmatis_MC2_155 VQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDILDWPL
TH_0195|M.thermoresistible__bu LRVGDIEVLVISDGVLPLPAATLATNADRAELAAWLHDMFLPADLFDWPL
MAB_4947|M.abscessus_ATCC_1997 IKPHHWYPALSEEQLVFARANYAPSAVSDDGSELIFAIHNYVIELADTII
MLBr_00270|M.leprae_Br4923 -MAAATLFQVTDSVHFARGDAVNWALVADDTGVMLIDTGYPGD-------
. .
MMAR_3523|M.marinum_M RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHVVL
MUL_2742|M.ulcerans_Agy99 RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHIVL
Mb2322c|M.bovis_AF2122/97 RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Rv2300c|M.tuberculosis_H37Rv RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Mflv_1675|M.gilvum_PYR-GCK EFGRIRR-----------RIIRPDFERTETAAEQLAHLGYRLSDVRHIIV
Mvan_5078|M.vanbaalenii_PYR-1 RFGRIRS-----------RFIRPNFDRGETALNQIRQLGFRRSDVRHVVV
MSMEG_3427|M.smegmatis_MC2_155 NVVVVRSGDRTILVDAGLGVEFPDFPRAGRTVARLEAAGIDPSAVTDVVL
TH_0195|M.thermoresistible__bu NVAVVRSGDRTILIDSGLGLEFPEFPRAGRLAHRMQAAGIEPAAVTDVVL
MAB_4947|M.abscessus_ATCC_1997 VVDTCSGN------HKNRPLFADLHMLNTDYLTRLEQSGYSPEAVDIVVN
MLBr_00270|M.leprae_Br4923 ---------------------------RDDVVASLRQLGYEAGDVRAILL
: * * ::
MMAR_3523|M.marinum_M THFDFDHIGGLADFPDAQVHVTSAEARGAIHAP--------SFRERVRYR
MUL_2742|M.ulcerans_Agy99 THFDSDHIGGLADFPDAQVHVTSAEARGAIHAP--------SFRERVRYR
Mb2322c|M.bovis_AF2122/97 THFDFDHIGGIADFPEAHLHVTAAEARGAIHAP--------SLRERLRYR
Rv2300c|M.tuberculosis_H37Rv THFDFDHIGGIADFPEAHLHVTAAEARGAIHAP--------SLRERLRYR
Mflv_1675|M.gilvum_PYR-GCK THFDADHIGGLADFPDAQVHVTAQEVLSAMKSP--------SVQNRIRFQ
Mvan_5078|M.vanbaalenii_PYR-1 THFDADHIGGLADFPDALVHVTTTEAFGAMRSP--------SIQERIRFR
MSMEG_3427|M.smegmatis_MC2_155 THLHMDHIGGLLSHGLKERLRPDLRIHVASAEA--------NFWESPDFS
TH_0195|M.thermoresistible__bu THLHMDHVGGLLTDGLMGRLRPDLRVHLAAAEA--------EFWAAPDFS
MAB_4947|M.abscessus_ATCC_1997 THLHLDHCG----WNTRLVEGTWRPTFPAATYL--------FHHTELKYI
MLBr_00270|M.leprae_Br4923 THAHIDHMGSAIWFASKHRTPVYCHADEVGHTKREYLEQVSLLNIAMRVW
** . ** * .
MMAR_3523|M.marinum_M SVQWAHGPKLVEHGHDG---ESWRG-FAAAKPLDAIADGVVLVPMP----
MUL_2742|M.ulcerans_Agy99 SVQWAHGPKLVEHGHDG---ESSPG-FAAAKTLDAIADGVVLVPMP----
Mb2322c|M.bovis_AF2122/97 RGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP----
Rv2300c|M.tuberculosis_H37Rv RGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP----
Mflv_1675|M.gilvum_PYR-GCK PSQWAHGPRIVEHTADG---EPWRG-FAAAKELSEIGPGFALVPLP----
Mvan_5078|M.vanbaalenii_PYR-1 PPQWAHGPRIVEHDIDG---EAWRG-FAAAKELTQIGPGFVLVSLP----
MSMEG_3427|M.smegmatis_MC2_155 HTEMPAPVPPALRAIAGRFLDEYRGQIQTFDSEYDITPGVHVARTG----
TH_0195|M.thermoresistible__bu RTAMPHPVPDVLRAVASRFLDVYRDRLRPFDTQYEVAPGVSVHRTG----
MAB_4947|M.abscessus_ATCC_1997 RAQWESAPIDQWQDNGGWVYEDSILPVLEHAPYGFVKSGQVLHSYGSTHI
MLBr_00270|M.leprae_Br4923 QPRWAIWSGHVLRSGGLIRGGIPTAQPLTAETAAGLPGHPMAIFTP----
: :
MMAR_3523|M.marinum_M ------GHTRGHAAVAVDAGDRWILHCGDAFYHVG-TLDG--QSKVPFVL
MUL_2742|M.ulcerans_Agy99 ------GHTRGHAAVAVDAGDRWILHCGDAFYHVG-TLDG--QSKVPFVL
Mb2322c|M.bovis_AF2122/97 ------GHTRGHAAVAVDAGHRWVLHCGDAFYHRG-TLDG--RFRVPFVM
Rv2300c|M.tuberculosis_H37Rv ------GHTRGHAAVAVDAGHRWVLHCGDAFYHRG-TLDG--RFRVPFVM
Mflv_1675|M.gilvum_PYR-GCK ------GHTEGHACVAVDAGHRWLLHAGDAFYHHS-EIDGGGPPPMPASL
Mvan_5078|M.vanbaalenii_PYR-1 ------GHTRGHACVAVDAGHRWLLHAGDSFYHPG-TLAG--APPVPKWT
MSMEG_3427|M.smegmatis_MC2_155 ------GHTPGHSVVRLASGEDRLTFAGDAVFAPG-FDNPQWHNGFEHDP
TH_0195|M.thermoresistible__bu ------GHTPGHSIVRLESGKDRLTFAGDAVFQVG-FDNPQWHNGFEHDP
MAB_4947|M.abscessus_ATCC_1997 RALDAGGHTPGHVAIEVRAADTGLLIAGDALHHPMQAQFPDLPFYADADP
MLBr_00270|M.leprae_Br4923 ------GHTGGHCSYVVDG----VLISGDALITGHPLLRHRGPQLLTAVF
*** ** : . : .**:.
MMAR_3523|M.marinum_M RSQEELFSFDRRQLRDNQARLAELQRRQDPGLLIICAHDPSLYALAKDLS
MUL_2742|M.ulcerans_Agy99 RSQEELFSFDRRQLRDNQARLAELQRRQDPGLLIICAHDPSLYAVAKDLS
Mb2322c|M.bovis_AF2122/97 RAEEKLLSYNRNQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLARDTA
Rv2300c|M.tuberculosis_H37Rv RAEEKLLSYNRNQLRDNQARIVELHRRHDPDLLIVCAHDPDLYQLARDTA
Mflv_1675|M.gilvum_PYR-GCK RAFEMAVAADRKMVLDNHSRLTELYRRQDPDLLIVCSHDRKLYEHAKATA
Mvan_5078|M.vanbaalenii_PYR-1 ARLEMLVASDKQKVKQNHVRLAELYRRQDPDLMILCSHDVTLYEQARATA
MSMEG_3427|M.smegmatis_MC2_155 EESVRVRVELLRELAATGESLVATHLP-FPSVCHVAAAGDAFRCVPAVWD
TH_0195|M.thermoresistible__bu EEAARVRVRLLQEIAASGETLVATHLP-FPSLCRVAPRGEAFRFVPTVWD
MAB_4947|M.abscessus_ATCC_1997 AQAVATRRALLGRCADENLKLLTAHFPAHSPLGVRRSGAAFTWDGSRAID
MLBr_00270|M.leprae_Br4923 SHSQKQCLRSLDALGLLETRILAPGHGELWHGPIREATEAALKQAGALTR
: .
MMAR_3523|M.marinum_M --
MUL_2742|M.ulcerans_Agy99 --
Mb2322c|M.bovis_AF2122/97 --
Rv2300c|M.tuberculosis_H37Rv --
Mflv_1675|M.gilvum_PYR-GCK GD
Mvan_5078|M.vanbaalenii_PYR-1 QT
MSMEG_3427|M.smegmatis_MC2_155 Y-
TH_0195|M.thermoresistible__bu H-
MAB_4947|M.abscessus_ATCC_1997 --
MLBr_00270|M.leprae_Br4923 --